{"id":"https://openalex.org/W25251697","doi":null,"title":"Cisplatin and platinum analogues in breast cancer.","display_name":"Cisplatin and platinum analogues in breast cancer.","publication_year":1992,"publication_date":"1992-02-01","ids":{"openalex":"https://openalex.org/W25251697","mag":"25251697","pmid":"https://pubmed.ncbi.nlm.nih.gov/1411630"},"language":"en","primary_location":{"id":"pmid:1411630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1411630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in oncology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066769011","display_name":"George W. Sledge","orcid":"https://orcid.org/0000-0003-0297-0775","observed_orcids":["https://orcid.org/0000-0003-0297-0775"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"G W Sledge","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis 46202","institution_ids":["https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066769011"],"corresponding_institution_ids":["https://openalex.org/I4394709130"],"apc_list":null,"apc_paid":null,"fwci":0.6559,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.70456624,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"19","issue":"1 Suppl 2","first_page":"78","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.6304000020027161,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.6304000020027161,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.1598999947309494,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.1509000062942505,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":1.0},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/platinum-analogues","display_name":"platinum analogues","score":0.9089999794960022},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9900000095367432},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.781000018119812},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9980000257492065},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.8790000081062317},{"id":"https://openalex.org/keywords/autologous-bone-marrow-transplantation","display_name":"autologous bone marrow transplantation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/high-dose-chemotherapy","display_name":"high-dose chemotherapy","score":0.722000002861023},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.914114236831665},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.8955574035644531},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.8366445302963257},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.7083835601806641},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6951777935028076},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6397631168365479},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.5770729780197144},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5321834087371826},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5067806839942932},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47468850016593933},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.42358285188674927},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.41797709465026855}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1411630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1411630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in oncology","raw_type":"Journal Article"},{"id":"mag:25251697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1411630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W37563095","https://openalex.org/W108561042","https://openalex.org/W157661348","https://openalex.org/W163658214","https://openalex.org/W1499782434","https://openalex.org/W1538751050","https://openalex.org/W1776780213","https://openalex.org/W1813712453","https://openalex.org/W1970775642","https://openalex.org/W1972996049","https://openalex.org/W1983254849","https://openalex.org/W1985417646","https://openalex.org/W1986321933","https://openalex.org/W2010818849","https://openalex.org/W2012803847","https://openalex.org/W2017672107","https://openalex.org/W2019490494","https://openalex.org/W2025057739","https://openalex.org/W2037710682","https://openalex.org/W2039118565","https://openalex.org/W2042937317","https://openalex.org/W2050281540","https://openalex.org/W2054213733","https://openalex.org/W2054554470","https://openalex.org/W2059603865","https://openalex.org/W2063289987","https://openalex.org/W2063452171","https://openalex.org/W2066807132","https://openalex.org/W2070481599","https://openalex.org/W2075083394","https://openalex.org/W2080914545","https://openalex.org/W2109860105","https://openalex.org/W2110448405","https://openalex.org/W2111843753","https://openalex.org/W2124287915","https://openalex.org/W2125084268","https://openalex.org/W2126183965","https://openalex.org/W2132844513","https://openalex.org/W2134356406","https://openalex.org/W2155454254","https://openalex.org/W2178095745","https://openalex.org/W2293121472","https://openalex.org/W2430497949"],"related_works":["https://openalex.org/W37563095","https://openalex.org/W2216172761","https://openalex.org/W2009338130","https://openalex.org/W1969000061","https://openalex.org/W2031496974","https://openalex.org/W2080920993","https://openalex.org/W2170016968","https://openalex.org/W2102506813","https://openalex.org/W1969485166","https://openalex.org/W2052771009"],"abstract_inverted_index":{"Therapy":[0],"for":[1,114],"metastatic":[2,36,46,118],"breast":[3,37,47,135],"cancer":[4],"can":[5],"palliate":[6],"disease":[7],"and":[8,25,85,94],"prolong":[9],"life,":[10],"but":[11],"cannot":[12],"cure.":[13],"New":[14],"drugs":[15],"will":[16],"be":[17,111],"required":[18],"if":[19],"this":[20],"is":[21,75,122],"to":[22,32,63,110,124],"change.":[23],"Cisplatin":[24,39],"its":[26],"analogue":[27],"carboplatin":[28,70],"offer":[29],"new":[30],"approaches":[31],"the":[33,102,115,126,132],"treatment":[34,116,133],"of":[35,69,80,104,117,128,134],"cancer.":[38,48,136],"has":[40],"significant":[41],"single-agent,":[42],"front-line":[43,65],"activity":[44,68],"in":[45,82,98,101,131],"In":[49],"combination":[50,87],"with":[51],"other":[52,64],"agents":[53,113],"(eg,":[54],"etoposide":[55],"or":[56],"5-fluorouracil),":[57],"it":[58],"provides":[59],"response":[60],"rates":[61],"equivalent":[62],"combinations.":[66],"The":[67],"as":[71],"a":[72],"single":[73],"agent":[74],"reportedly":[76],"less":[77],"than":[78],"that":[79],"cisplatin":[81,93],"single-agent":[83],"trials,":[84],"few":[86],"trials":[88],"have":[89],"been":[90],"reported.":[91],"Both":[92],"carboplatin,":[95],"when":[96],"used":[97],"high":[99],"doses":[100],"setting":[103],"autologous":[105],"bone":[106],"marrow":[107],"transplantation,":[108],"appear":[109],"useful":[112],"disease.":[119],"Further":[120],"research":[121],"needed":[123],"define":[125],"role":[127],"these":[129],"compounds":[130]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
