{"id":"https://openalex.org/W2524809291","doi":"https://doi.org/10.3797/scipharm.aut-04-27","title":"Effect of Granules Properties on the In-vitro and In-vivo Performance of Ibuprofen Sustained Release Matrix Tablets","display_name":"Effect of Granules Properties on the In-vitro and In-vivo Performance of Ibuprofen Sustained Release Matrix Tablets","publication_year":2004,"publication_date":"2004-12-11","ids":{"openalex":"https://openalex.org/W2524809291","doi":"https://doi.org/10.3797/scipharm.aut-04-27","mag":"2524809291"},"language":"en","primary_location":{"id":"doi:10.3797/scipharm.aut-04-27","doi":"https://doi.org/10.3797/scipharm.aut-04-27","is_oa":true,"landing_page_url":"https://doi.org/10.3797/scipharm.aut-04-27","pdf_url":"https://www.mdpi.com/2218-0532/72/4/27/pdf?version=1502699308","source":{"id":"https://openalex.org/S70157725","display_name":"Scientia Pharmaceutica","issn_l":"0036-8709","issn":["0036-8709","2218-0532"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317866","host_organization_name":"\u00d6sterreichische Apotheker-Verlagsgesellschaft m. b. H.","host_organization_lineage":["https://openalex.org/P4310317866"],"host_organization_lineage_names":["\u00d6sterreichische Apotheker-Verlagsgesellschaft m. b. H."],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientia Pharmaceutica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2218-0532/72/4/27/pdf?version=1502699308","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109934586","display_name":"M. S. Shubair","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36622005","display_name":"Petra University","ror":"https://ror.org/039d9es10","country_code":"JO","type":"education","lineage":["https://openalex.org/I36622005"]}],"countries":["JO"],"is_corresponding":true,"raw_author_name":"M. S. Shubair","raw_affiliation_strings":["Faculty of Pharmacy, University of Petra, P.O. Box: 961 343, Amman, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, University of Petra, P.O. Box: 961 343, Amman, Jordan","institution_ids":["https://openalex.org/I36622005"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109934586"],"corresponding_institution_ids":["https://openalex.org/I36622005"],"apc_list":{"value":1000,"currency":"CHF","value_usd":1207},"apc_paid":{"value":1000,"currency":"CHF","value_usd":1207},"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"72","issue":"4","first_page":"317","last_page":"332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.7074999809265137,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.7074999809265137,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10615","display_name":"Granular flow and fluidized beds","score":0.1753000020980835,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.06809999793767929,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ibuprofen","display_name":"ibuprofen","score":0.9950000047683716},{"id":"https://openalex.org/keywords/sustained-release-tablets","display_name":"sustained-release tablets","score":0.8130000233650208},{"id":"https://openalex.org/keywords/matrix-tablets","display_name":"matrix tablets","score":0.9750000238418579},{"id":"https://openalex.org/keywords/wet-granulation","display_name":"wet granulation","score":0.953000009059906},{"id":"https://openalex.org/keywords/granule-properties","display_name":"granule properties","score":0.9800000190734863},{"id":"https://openalex.org/keywords/bulk-density","display_name":"bulk density","score":0.972000002861023},{"id":"https://openalex.org/keywords/fines","display_name":"fines","score":0.6209999918937683},{"id":"https://openalex.org/keywords/granule-size","display_name":"granule size","score":0.8519999980926514},{"id":"https://openalex.org/keywords/in-vitro-drug-release","display_name":"in vitro drug release","score":0.7829999923706055},{"id":"https://openalex.org/keywords/bioequivalence","display_name":"bioequivalence","score":0.8709999918937683},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C88463166","wikidata":"https://www.wikidata.org/wiki/Q1543243","display_name":"Granulation","level":2,"score":0.9203002452850342},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.6871184706687927},{"id":"https://openalex.org/C2779944601","wikidata":"https://www.wikidata.org/wiki/Q186969","display_name":"Ibuprofen","level":2,"score":0.6719578504562378},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.634631335735321},{"id":"https://openalex.org/C42404028","wikidata":"https://www.wikidata.org/wiki/Q864940","display_name":"Bioequivalence","level":3,"score":0.5035802721977234},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4858119487762451},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4493362307548523},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.44831517338752747},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4307924211025238},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4153890609741211},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.24228337407112122},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.21322274208068848},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.17622995376586914},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.1060398519039154},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10351791977882385},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0774398148059845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3797/scipharm.aut-04-27","doi":"https://doi.org/10.3797/scipharm.aut-04-27","is_oa":true,"landing_page_url":"https://doi.org/10.3797/scipharm.aut-04-27","pdf_url":"https://www.mdpi.com/2218-0532/72/4/27/pdf?version=1502699308","source":{"id":"https://openalex.org/S70157725","display_name":"Scientia Pharmaceutica","issn_l":"0036-8709","issn":["0036-8709","2218-0532"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317866","host_organization_name":"\u00d6sterreichische Apotheker-Verlagsgesellschaft m. b. H.","host_organization_lineage":["https://openalex.org/P4310317866"],"host_organization_lineage_names":["\u00d6sterreichische Apotheker-Verlagsgesellschaft m. b. H."],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientia Pharmaceutica","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3797/scipharm.aut-04-27","doi":"https://doi.org/10.3797/scipharm.aut-04-27","is_oa":true,"landing_page_url":"https://doi.org/10.3797/scipharm.aut-04-27","pdf_url":"https://www.mdpi.com/2218-0532/72/4/27/pdf?version=1502699308","source":{"id":"https://openalex.org/S70157725","display_name":"Scientia Pharmaceutica","issn_l":"0036-8709","issn":["0036-8709","2218-0532"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317866","host_organization_name":"\u00d6sterreichische Apotheker-Verlagsgesellschaft m. b. H.","host_organization_lineage":["https://openalex.org/P4310317866"],"host_organization_lineage_names":["\u00d6sterreichische Apotheker-Verlagsgesellschaft m. b. H."],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientia Pharmaceutica","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319684","display_name":"University of Petra","ror":"https://ror.org/039d9es10"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2524809291.pdf","grobid_xml":"https://content.openalex.org/works/W2524809291.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W348441954","https://openalex.org/W2010155469","https://openalex.org/W2055975486","https://openalex.org/W2066025134","https://openalex.org/W2115439624","https://openalex.org/W2152186576"],"related_works":["https://openalex.org/W4212965052","https://openalex.org/W2393962660","https://openalex.org/W2008247436","https://openalex.org/W2159501199","https://openalex.org/W2018699515","https://openalex.org/W2382263863","https://openalex.org/W2168575795","https://openalex.org/W7114768087","https://openalex.org/W1547525455","https://openalex.org/W4250188881"],"abstract_inverted_index":{"The":[0,36],"impact":[1],"of":[2,19,38,56,72,92,128,140],"variations":[3],"in":[4],"the":[5,10,14,39,70],"wet":[6,33],"granulation":[7,34],"step":[8],"during":[9],"manufacturing":[11],"process":[12],"on":[13],"in-vitro":[15],"and":[16,60,96,115,153,158,166],"in-vivo":[17],"performance":[18],"ibuprofen":[20],"sustained":[21,174],"release":[22,135,175],"matrix":[23],"tablets":[24,127,139],"was":[25],"investigated.":[26],"Two":[27],"batches":[28,106],"were":[29,43,75,110,149,160],"produced":[30],"under":[31],"different":[32],"conditions.":[35],"granules":[37,71,119],"first":[40],"batch":[41,73],"(T1)":[42],"characterized":[44,76],"by":[45,77],"having":[46,78],"a":[47,53,61,79,83,89,97,131,170],"lower":[48,90],"bulk":[49,85],"density":[50,86],"(0.56":[51],"g/ml),":[52,88],"higher":[54,84,134],"percentage":[55,91],"fines":[57,93],"(56.7%":[58],"w/w)":[59,95],"smaller":[62],"geometric":[63],"mean":[64],"diameter":[65],"(dg),":[66],"600":[67],"\u00b5m.":[68,101],"While":[69],"(T2)":[74],"more":[80],"coherent":[81],"properties,":[82],"(0.66":[87],"(36.9%":[94],"larger":[98],"dg,":[99],"720":[100],"Three":[102],"large":[103],"scale":[104],"production":[105],"(B1,":[107],"B2,":[108],"B3)":[109],"manufactured":[111],"similarly":[112],"to":[113,117,164],"T2":[114,154,159,168],"found":[116],"have":[118],"possessing":[120],"similar":[121],"properties.":[122],"In-vitro":[123],"tests":[124,148],"showed":[125],"that":[126],"T1":[129,152,157,178],"had":[130],"statistically":[132,171],"significant":[133,172],"rate":[136],"constant":[137],"than":[138,177],"either":[141],"T2,":[142],"B1":[143],",B2":[144],"or":[145],"B3.":[146],"In-vivo":[147],"done":[150],"using":[151],"tablets.":[155],"Although":[156],"bioequivalent":[161],"with":[162],"respect":[163],"Cmax":[165],"AUC,":[167],"exhibited":[169],"longer":[173],"characteristics":[176],"(P<0.05).":[179]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-10-07T00:00:00"}
