{"id":"https://openalex.org/W2524600070","doi":"https://doi.org/10.7554/elife.17936","title":"Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses","display_name":"Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses","publication_year":2016,"publication_date":"2016-09-30","ids":{"openalex":"https://openalex.org/W2524600070","doi":"https://doi.org/10.7554/elife.17936","mag":"2524600070","pmid":"https://pubmed.ncbi.nlm.nih.gov/27690224"},"language":"en","primary_location":{"id":"doi:10.7554/elife.17936","doi":"https://doi.org/10.7554/elife.17936","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.17936","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.17936","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087811945","display_name":"Jialong Yang","orcid":"https://orcid.org/0000-0002-3112-5012","observed_orcids":["https://orcid.org/0000-0002-3112-5012"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jialong Yang","raw_affiliation_strings":["Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, United States","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059183916","display_name":"Xingguang Lin","orcid":"https://orcid.org/0000-0001-7950-337X","observed_orcids":["https://orcid.org/0000-0001-7950-337X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xingguang Lin","raw_affiliation_strings":["Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, United States","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101769739","display_name":"Yun Pan","orcid":"https://orcid.org/0000-0002-3832-3433","observed_orcids":["https://orcid.org/0000-0002-3832-3433"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun Pan","raw_affiliation_strings":["Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, United States","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100715583","display_name":"Jinli Wang","orcid":"https://orcid.org/0000-0003-3453-3692","observed_orcids":["https://orcid.org/0000-0003-3453-3692"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinli Wang","raw_affiliation_strings":["School of Laboratory Medicine, Wenzhou Medical University, Wenzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Laboratory Medicine, Wenzhou Medical University, Wenzhou, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101979964","display_name":"Pengcheng Chen","orcid":"https://orcid.org/0000-0002-7989-0194","observed_orcids":["https://orcid.org/0000-0002-7989-0194"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengcheng Chen","raw_affiliation_strings":["School of Laboratory Medicine, Wenzhou Medical University, Wenzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Laboratory Medicine, Wenzhou Medical University, Wenzhou, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102495076","display_name":"Hongxiang Huang","orcid":"https://orcid.org/0009-0003-1558-1231","observed_orcids":["https://orcid.org/0009-0003-1558-1231"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongxiang Huang","raw_affiliation_strings":["Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, United States","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008319091","display_name":"Hai\u2010Hui Xue","orcid":"https://orcid.org/0000-0002-9163-7669","observed_orcids":["https://orcid.org/0000-0002-9163-7669"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hai-Hui Xue","raw_affiliation_strings":["Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa, United States","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088772562","display_name":"Jimin Gao","orcid":"https://orcid.org/0000-0002-3911-043X","observed_orcids":["https://orcid.org/0000-0002-3911-043X"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jimin Gao","raw_affiliation_strings":["School of Laboratory Medicine, Wenzhou Medical University, Wenzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Laboratory Medicine, Wenzhou Medical University, Wenzhou, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011304020","display_name":"Xiao\u2010Ping Zhong","orcid":"https://orcid.org/0000-0002-4619-8783","observed_orcids":["https://orcid.org/0000-0002-4619-8783"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao-Ping Zhong","raw_affiliation_strings":["Department of Immunology, Duke University Medical Center, Durham, United States","Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, United States","Hematologic Malignancies and Cellular Therapies Program, Duke Cancer Institute, Duke University Medical Center, Durham, United States"],"raw_orcid":"https://orcid.org/0000-0002-4619-8783","affiliations":[{"raw_affiliation_string":"Department of Immunology, Duke University Medical Center, Durham, United States","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Pediatrics, Division of Allergy and Immunology, Duke University Medical Center, Durham, United States","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Hematologic Malignancies and Cellular Therapies Program, Duke Cancer Institute, Duke University Medical Center, Durham, United States","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4390039326"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":7.0691,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.97375057,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"5","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.8230000138282776},{"id":"https://openalex.org/keywords/mtorc2","display_name":"mTORC2","score":1.0},{"id":"https://openalex.org/keywords/t-follicular-helper-cells","display_name":"T follicular helper cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/germinal-center","display_name":"germinal center","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.8709999918937683},{"id":"https://openalex.org/keywords/rictor","display_name":"Rictor","score":0.906000018119812},{"id":"https://openalex.org/keywords/akt-activation","display_name":"Akt activation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tcf1","display_name":"TCF1","score":0.9539999961853027},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.6370000243186951},{"id":"https://openalex.org/keywords/antibody-production","display_name":"antibody production","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.9320245981216431},{"id":"https://openalex.org/C107846503","wikidata":"https://www.wikidata.org/wiki/Q14876061","display_name":"mTORC2","level":5,"score":0.8233376741409302},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.7899017333984375},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6438555717468262},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6172699928283691},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5316506028175354},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.43920210003852844},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4349004626274109},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.3495942950248718},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2642599046230316},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1976650357246399},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.13823193311691284},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09310925006866455},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05173373222351074}],"mesh":[{"descriptor_ui":"D000076222","descriptor_name":"Mechanistic Target of Rapamycin Complex 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000076222","descriptor_name":"Mechanistic Target of Rapamycin Complex 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000076222","descriptor_name":"Mechanistic Target of Rapamycin Complex 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000076225","descriptor_name":"Mechanistic Target of Rapamycin Complex 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000076225","descriptor_name":"Mechanistic Target of Rapamycin Complex 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000076225","descriptor_name":"Mechanistic Target of Rapamycin Complex 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.7554/elife.17936","doi":"https://doi.org/10.7554/elife.17936","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.17936","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"pmid:27690224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27690224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5063587","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5063587","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2e87f5f1f3c44947a432438718e563f8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2e87f5f1f3c44947a432438718e563f8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 5 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7554/elife.17936","doi":"https://doi.org/10.7554/elife.17936","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.17936","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G251338959","display_name":null,"funder_award_id":"R21 AI115149","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4217087388","display_name":"Molecular mechanisms controlling differentiation of memory CD8 T cells","funder_award_id":"R21AI119160","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4585865534","display_name":null,"funder_award_id":"R01 AI101206","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6808003070","display_name":null,"funder_award_id":"R01 AI112579","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7249794475","display_name":"Regulating peripheral T cell tolerance","funder_award_id":"R01AI079088","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000040848","display_name":null,"funder_award_id":"R01AI101206","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000146761","display_name":null,"funder_award_id":"R01AI112579","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000198175","display_name":null,"funder_award_id":"R01AI115149","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000230382","display_name":null,"funder_award_id":"R01AI119160","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W266326952","https://openalex.org/W1082744614","https://openalex.org/W1434467868","https://openalex.org/W1544319069","https://openalex.org/W1608649377","https://openalex.org/W1656309523","https://openalex.org/W1758151596","https://openalex.org/W1812517801","https://openalex.org/W1854615013","https://openalex.org/W1867136150","https://openalex.org/W1903032141","https://openalex.org/W1963232095","https://openalex.org/W1968346036","https://openalex.org/W1970480652","https://openalex.org/W1974595623","https://openalex.org/W1981904703","https://openalex.org/W1987076250","https://openalex.org/W1990174512","https://openalex.org/W1990312329","https://openalex.org/W1990524611","https://openalex.org/W1991162956","https://openalex.org/W1992425170","https://openalex.org/W1995635569","https://openalex.org/W1998579865","https://openalex.org/W2000049562","https://openalex.org/W2001775594","https://openalex.org/W2003379860","https://openalex.org/W2003413375","https://openalex.org/W2004629226","https://openalex.org/W2007870480","https://openalex.org/W2008663208","https://openalex.org/W2016366885","https://openalex.org/W2018701868","https://openalex.org/W2019968246","https://openalex.org/W2020303255","https://openalex.org/W2028476437","https://openalex.org/W2029643611","https://openalex.org/W2032917789","https://openalex.org/W2034360108","https://openalex.org/W2038976543","https://openalex.org/W2051058933","https://openalex.org/W2051822277","https://openalex.org/W2056721231","https://openalex.org/W2059689009","https://openalex.org/W2063888187","https://openalex.org/W2064876347","https://openalex.org/W2065338955","https://openalex.org/W2066489069","https://openalex.org/W2071969437","https://openalex.org/W2073025161","https://openalex.org/W2075175827","https://openalex.org/W2076599494","https://openalex.org/W2078390854","https://openalex.org/W2080727065","https://openalex.org/W2084561923","https://openalex.org/W2085213883","https://openalex.org/W2093230148","https://openalex.org/W2095096783","https://openalex.org/W2096323879","https://openalex.org/W2096475468","https://openalex.org/W2102411973","https://openalex.org/W2105048034","https://openalex.org/W2110043839","https://openalex.org/W2123130879","https://openalex.org/W2127063807","https://openalex.org/W2128243696","https://openalex.org/W2129302556","https://openalex.org/W2137446997","https://openalex.org/W2141730355","https://openalex.org/W2146604395","https://openalex.org/W2149212275","https://openalex.org/W2155759076","https://openalex.org/W2158652033","https://openalex.org/W2163150086","https://openalex.org/W2173451424","https://openalex.org/W2279892641","https://openalex.org/W2343888903","https://openalex.org/W2394759216","https://openalex.org/W2419191053"],"related_works":["https://openalex.org/W2051648135","https://openalex.org/W2074266971","https://openalex.org/W2158216631","https://openalex.org/W2899214804","https://openalex.org/W2193455248","https://openalex.org/W107662779","https://openalex.org/W2230497973","https://openalex.org/W4231929928","https://openalex.org/W2133625272","https://openalex.org/W2035521247"],"abstract_inverted_index":{"T":[0,23,77,104,121],"follicular":[1],"helper":[2],"(Tfh)":[3],"cells":[4,24,122],"play":[5],"critical":[6],"roles":[7,114],"for":[8,27,86,115],"germinal":[9,45,127],"center":[10,46,128],"responses":[11],"and":[12,35,50,56,61,98,117,126],"effective":[13],"humoral":[14],"immunity.":[15],"We":[16],"report":[17],"here":[18],"that":[19],"mTOR":[20],"in":[21,119],"CD4":[22,76,120],"is":[25,39],"essential":[26],"Tfh":[28,37,60,87,92,124],"differentiation.":[29],"In":[30],"Mtorf/f-Cd4Cre":[31],"mice,":[32],"both":[33,54],"constitutive":[34],"inducible":[36],"differentiation":[38,93,125],"severely":[40],"impaired,":[41],"leading":[42],"to":[43,59,80],"defective":[44],"B":[47,63],"cell":[48,64,78,83,105],"formation":[49],"antibody":[51],"production.":[52],"Moreover,":[53],"mTORC1":[55,73,116],"mTORC2":[57,118],"contribute":[58],"GC":[62],"development":[65],"but":[66,112],"may":[67],"do":[68],"so":[69],"via":[70],"distinct":[71,113],"mechanisms.":[72],"mainly":[74],"promotes":[75],"proliferation":[79],"reach":[81],"the":[82],"divisions":[84],"necessary":[85],"differentiation,":[88],"while":[89],"Rictor/mTORC2":[90],"regulates":[91],"by":[94],"promoting":[95],"Akt":[96],"activation":[97],"TCF1":[99],"expression":[100],"without":[101],"grossly":[102],"influencing":[103],"proliferation.":[106],"Together,":[107],"our":[108],"results":[109],"reveal":[110],"crucial":[111],"during":[123],"responses.":[129]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":11}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
