{"id":"https://openalex.org/W2524354592","doi":null,"title":"Effect of amyloid precursor protein and tau on dendritic spines and cell survival in an ex vivo model of Alzheimer s disease","display_name":"Effect of amyloid precursor protein and tau on dendritic spines and cell survival in an ex vivo model of Alzheimer s disease","publication_year":2009,"publication_date":"2009-12-11","ids":{"openalex":"https://openalex.org/W2524354592","mag":"2524354592"},"language":"en","primary_location":{"id":"pmh:oai:osnadocs.ub.uni-osnabrueck.de:urn:nbn:de:gbv:700-2009121414","doi":null,"is_oa":false,"landing_page_url":"https://repositorium.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2009121414","pdf_url":null,"source":{"id":"https://openalex.org/S4377196933","display_name":"osnaDocs (Osnabr\u00fcck University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170658231","host_organization_name":"Osnabr\u00fcck University","host_organization_lineage":["https://openalex.org/I170658231"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doc-type:doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031131523","display_name":"Christian Tackenberg","orcid":"https://orcid.org/0000-0002-0019-3055","observed_orcids":["https://orcid.org/0000-0002-0019-3055"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Christian Tackenberg","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0019-3055","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031131523"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9829999804496765},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.6740000247955322},{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.9559999704360962},{"id":"https://openalex.org/keywords/spine-loss","display_name":"spine loss","score":0.5559999942779541},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8479999899864197},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9620000123977661},{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.9139999747276306},{"id":"https://openalex.org/keywords/calcineurin","display_name":"calcineurin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tau-phosphorylation","display_name":"tau phosphorylation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/ftdp-17","display_name":"FTDP-17","score":0.7229999899864197},{"id":"https://openalex.org/keywords/p301l-tau","display_name":"P301L tau","score":0.996999979019165},{"id":"https://openalex.org/keywords/amyloid-precursor-protein-transgenic-mice","display_name":"amyloid precursor protein transgenic mice","score":0.7960000038146973},{"id":"https://openalex.org/keywords/organotypic-hippocampal-slice-cultures","display_name":"organotypic hippocampal slice cultures","score":0.9160000085830688},{"id":"https://openalex.org/keywords/synaptic-changes","display_name":"synaptic changes","score":0.4729999899864197},{"id":"https://openalex.org/keywords/tau-aggregation","display_name":"tau aggregation","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.7794837951660156},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5385310649871826},{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.5073525309562683},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.4748668372631073},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.46392783522605896},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4363752603530884},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.36391353607177734},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3610617518424988},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34954923391342163},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3413708508014679},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3115138113498688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2752802073955536},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24067002534866333},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:osnadocs.ub.uni-osnabrueck.de:urn:nbn:de:gbv:700-2009121414","doi":null,"is_oa":false,"landing_page_url":"https://repositorium.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2009121414","pdf_url":null,"source":{"id":"https://openalex.org/S4377196933","display_name":"osnaDocs (Osnabr\u00fcck University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170658231","host_organization_name":"Osnabr\u00fcck University","host_organization_lineage":["https://openalex.org/I170658231"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doc-type:doctoralThesis"},{"id":"pmh:oai:repositorium.ub.uni-osnabrueck.de:urn:nbn:de:gbv:700-2009121414","doi":null,"is_oa":false,"landing_page_url":"https://repositorium.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2009121414","pdf_url":null,"source":{"id":"https://openalex.org/S4377196933","display_name":"osnaDocs (Osnabr\u00fcck University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170658231","host_organization_name":"Osnabr\u00fcck University","host_organization_lineage":["https://openalex.org/I170658231"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doc-type:doctoralThesis"},{"id":"mag:2524354592","doi":null,"is_oa":false,"landing_page_url":"https://repositorium.ub.uni-osnabrueck.de/bitstream/urn:nbn:de:gbv:700-2009121414/2/E-Diss973_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W64194567","https://openalex.org/W1480786153","https://openalex.org/W1515728609","https://openalex.org/W1600934558","https://openalex.org/W1665045511","https://openalex.org/W1971125966","https://openalex.org/W1972355725","https://openalex.org/W1973130935","https://openalex.org/W1976732198","https://openalex.org/W1980044002","https://openalex.org/W1980107994","https://openalex.org/W1980252074","https://openalex.org/W1980825524","https://openalex.org/W1984924722","https://openalex.org/W1985446830","https://openalex.org/W1987095222","https://openalex.org/W1987208997","https://openalex.org/W1993465897","https://openalex.org/W1994030229","https://openalex.org/W1994336523","https://openalex.org/W1999629716","https://openalex.org/W2001894948","https://openalex.org/W2003114283","https://openalex.org/W2006085006","https://openalex.org/W2009894093","https://openalex.org/W2011353108","https://openalex.org/W2016486722","https://openalex.org/W2017842551","https://openalex.org/W2030892371","https://openalex.org/W2033430237","https://openalex.org/W2036963269","https://openalex.org/W2038072430","https://openalex.org/W2038120434","https://openalex.org/W2039468514","https://openalex.org/W2044974101","https://openalex.org/W2046847750","https://openalex.org/W2047514208","https://openalex.org/W2050553218","https://openalex.org/W2052742260","https://openalex.org/W2058371877","https://openalex.org/W2058459224","https://openalex.org/W2058561815","https://openalex.org/W2059148040","https://openalex.org/W2060458492","https://openalex.org/W2064244929","https://openalex.org/W2066068917","https://openalex.org/W2070337522","https://openalex.org/W2075481535","https://openalex.org/W2079054696","https://openalex.org/W2080516466","https://openalex.org/W2081768153","https://openalex.org/W2082151254","https://openalex.org/W2083337183","https://openalex.org/W2089894184","https://openalex.org/W2090793855","https://openalex.org/W2095422335","https://openalex.org/W2096410114","https://openalex.org/W2100722409","https://openalex.org/W2105579656","https://openalex.org/W2105704879","https://openalex.org/W2106274713","https://openalex.org/W2109727228","https://openalex.org/W2111155182","https://openalex.org/W2112610528","https://openalex.org/W2117374256","https://openalex.org/W2127004861","https://openalex.org/W2129830770","https://openalex.org/W2130723719","https://openalex.org/W2134465569","https://openalex.org/W2135309154","https://openalex.org/W2137979527","https://openalex.org/W2145768048","https://openalex.org/W2151123745","https://openalex.org/W2159242834","https://openalex.org/W2167428060","https://openalex.org/W2169217121","https://openalex.org/W2374804331","https://openalex.org/W2412462798"],"related_works":["https://openalex.org/W2100722409","https://openalex.org/W2184345183","https://openalex.org/W1997890299","https://openalex.org/W2042104574","https://openalex.org/W2055275688","https://openalex.org/W2022532556","https://openalex.org/W2001900506","https://openalex.org/W1975110703","https://openalex.org/W4391640751","https://openalex.org/W7099884496"],"abstract_inverted_index":{"Alzheimer":[0],"s":[1],"disease":[2],"is":[3,172],"characterized":[4],"by":[5,116,157,206,226,244],"synaptic":[6,27],"alterations":[7],"and":[8,18,29,65,74,86,102,135,186,221,234,240],"neurodegeneration.":[9,75],"Histopathological":[10],"hallmarks":[11],"represent":[12],"amyloidplaques":[13],"composed":[14],"of":[15,54,63,118,142,149,168,183,191,197,202,230,248],"amyloid-beta":[16],"(Abeta)":[17],"neurofibrillary":[19],"tangles":[20],"containing":[21],"hyperphosphorylated":[22],"tau.":[23,150,176],"To":[24],"determine":[25,71],"whether":[26],"changes":[28,73],"neurodegeneration":[30,112,223],"share":[31],"common":[32],"pathways":[33,228,246],"we":[34],"established":[35],"an":[36],"ex":[37],"vivo":[38],"model":[39],"using":[40],"organotypic":[41],"hippocampal":[42],"slicecultures":[43],"from":[44,90],"amyloid":[45],"precursor":[46],"protein":[47],"transgenic":[48,133],"mice":[49],"combined":[50],"with":[51,174,213],"virus-mediated":[52],"expression":[53],"EGFP-tagged":[55],"tau":[56,82,120,144,152,161,199,204,242],"constructs.":[57],"Confocal":[58],"high-resolution":[59],"imaging,":[60],"algorithm-based":[61],"evaluation":[62],"spines":[64],"live":[66],"imaging":[67],"was":[68],"employed":[69],"to":[70,92],"spine":[72,84,88,219],"We":[76,125,215],"report":[77],"that":[78,136,217,236],"Abeta":[79,107,237],"but":[80,113,200],"not":[81,110,201,211],"induces":[83,114],"loss":[85],"shifts":[87],"shape":[89],"mushroom":[91],"stubby":[93],"through":[94],"a":[95,122],"mechanism":[96],"involving":[97],"NMDA":[98,231],"receptor":[99,232],"(NMDAR),":[100],"calcineurin":[101],"GSK-3beta":[103,138,192],"activation.":[104],"In":[105],"contrast,":[106],"alone":[108],"does":[109,210],"cause":[111],"toxicity":[115,148,164,182,196,243],"phosphorylation":[117],"wt":[119,185,198,239],"in":[121,131,165],"NMDAR-dependent":[123],"pathway.":[124],"show":[126],"thatGSK-3beta":[127],"levels":[128],"are":[129,154,224],"elevated":[130],"APP":[132],"cultures":[134],"inhibiting":[137],"activity":[139,180],"or":[140],"use":[141],"phosphorylation-blocking":[143],"mutations":[145],"prevent":[146],"Abeta-induced":[147,218],"FTDP-17":[151],"mutants":[153],"differentially":[155],"affected":[156],"Abeta.":[158,207],"While":[159,177],"R406W":[160,187,203,241],"shows":[162],"increased":[163],"the":[166,189],"presence":[167],"Abeta,":[169],"no":[170],"change":[171],"observed":[173],"P301L":[175],"blocking":[178],"NMDAR":[179,249],"abolishes":[181],"both":[184],"tau,":[188],"inhibition":[190],"only":[193],"protects":[194],"against":[195],"induced":[205],"Tau":[208],"aggregation":[209],"correlate":[212],"toxicity.":[214],"propose":[216],"pathology":[220],"tau-dependent":[222],"mediated":[225],"divergent":[227],"downstream":[229,247],"activation":[233],"suggest":[235],"affects":[238],"different":[245],"activity.":[250]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-10-07T00:00:00"}