{"id":"https://openalex.org/W2524256535","doi":"https://doi.org/10.1182/blood.v114.22.2062.2062","title":"Count Recovery in AML Patients Achieving a Complete Response.","display_name":"Count Recovery in AML Patients Achieving a Complete Response.","publication_year":2009,"publication_date":"2009-11-20","ids":{"openalex":"https://openalex.org/W2524256535","doi":"https://doi.org/10.1182/blood.v114.22.2062.2062","mag":"2524256535"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v114.22.2062.2062","doi":"https://doi.org/10.1182/blood.v114.22.2062.2062","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v114.22.2062.2062","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073763489","display_name":"Steven Lawrence Rosinski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven Lawrence Rosinski","raw_affiliation_strings":["Hematology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000750846","display_name":"Farhad Ravandi","orcid":"https://orcid.org/0000-0002-7621-377X","observed_orcids":["https://orcid.org/0000-0002-7621-377X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Farhad Ravandi","raw_affiliation_strings":["Department of Leukemia, U.T. M.D. Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, U.T. M.D. Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046097970","display_name":"Stefan H Faderl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Faderl","raw_affiliation_strings":["Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061026876","display_name":"Guillermo Garcia\u2010Manero","orcid":"https://orcid.org/0000-0002-3631-2482","observed_orcids":["https://orcid.org/0000-0002-3631-2482"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Guillermo Garcia-Manero","raw_affiliation_strings":["Leukemia, U.T. M.D. Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia, U.T. M.D. Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030500582","display_name":"Sherry A. Pierce","orcid":"https://orcid.org/0000-0002-9542-1558","observed_orcids":["https://orcid.org/0000-0002-9542-1558"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sherry Pierce","raw_affiliation_strings":["Leukemia, U.T. M.D. Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia, U.T. M.D. Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090435894","display_name":"Hagop M. Kantarjian","orcid":"https://orcid.org/0000-0002-1908-3307","observed_orcids":["https://orcid.org/0000-0002-1908-3307"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hagop M. Kantarjian","raw_affiliation_strings":["Leukemia, MD Anderson Cancer Center, Houston, TX, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia, MD Anderson Cancer Center, Houston, TX, USA,","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057920623","display_name":"Elihu H. Estey","orcid":"https://orcid.org/0000-0002-0987-8077","observed_orcids":["https://orcid.org/0000-0002-0987-8077"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elihu H. Estey","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000750846","https://openalex.org/A5030500582","https://openalex.org/A5057920623","https://openalex.org/A5061026876","https://openalex.org/A5073763489"],"corresponding_institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I4210089486"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.2191,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.65289113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"114","issue":"22","first_page":"2062","last_page":"2062"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/secondary-acute-myeloid-leukemia","display_name":"secondary acute myeloid leukemia","score":0.828000009059906},{"id":"https://openalex.org/keywords/prior-chemotherapy","display_name":"prior chemotherapy","score":0.578000009059906},{"id":"https://openalex.org/keywords/neutrophil-recovery","display_name":"neutrophil recovery","score":0.8180000185966492},{"id":"https://openalex.org/keywords/platelet-recovery","display_name":"platelet recovery","score":1.0},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cytogenetics","display_name":"cytogenetics","score":0.8209999799728394},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7876960039138794},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6281630992889404},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5875375270843506},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5631241202354431},{"id":"https://openalex.org/C2776611710","wikidata":"https://www.wikidata.org/wiki/Q16888295","display_name":"Induction chemotherapy","level":3,"score":0.5195329785346985},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.503889262676239},{"id":"https://openalex.org/C74133956","wikidata":"https://www.wikidata.org/wiki/Q4669824","display_name":"Absolute neutrophil count","level":4,"score":0.4654209315776825},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4604419469833374},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4585876166820526},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.25104546546936035}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v114.22.2062.2062","doi":"https://doi.org/10.1182/blood.v114.22.2062.2062","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v114.22.2062.2062","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7400000095367432,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4310117097","https://openalex.org/W2578174336","https://openalex.org/W2587954055","https://openalex.org/W2971563117","https://openalex.org/W2946484371","https://openalex.org/W2991334718","https://openalex.org/W2914576346","https://openalex.org/W7097907417","https://openalex.org/W2549007107","https://openalex.org/W3030468384"],"abstract_inverted_index":{"Abstract":[0,1],"2062":[2],"Poster":[3],"Board":[4],"II-39":[5],"AML":[6,39,309,329],"is":[7],"typically":[8],"defined":[9],"as":[10,102],"\u201cde":[11],"novo\u201d":[12],"or":[13,28,163,235,241,270,274,322,413],"\u201csecondary\u201d,":[14],"the":[15,99,148,296,301],"latter":[16],"referring":[17],"to":[18,48,66,95,132,152,171,232,343,352,358,425],"patients":[19,76,101,144,175,183,221,281,319,326],"diagnosed":[20],"only":[21],"after":[22,29],"persistent":[23],"blood":[24],"count":[25,311,344],"abnormalities":[26],"(AHD)":[27],"prior":[30],"\u201cchemotherapy\u201d":[31],"(PCT)":[32],"for":[33],"other":[34],"illnesses.":[35],"Patients":[36],"with":[37,85,202,320,327],"secondary":[38,328],"may":[40,134],"have":[41],"a":[42,79,187,215,245],"different":[43],"bone":[44],"marrow":[45],"microenvironment":[46],"leading":[47],"prolonged":[49,341],"neutrophil":[50,67,172,233],"and":[51,70,123,126,140,158,194,272,305,325],"platelet":[52,71,236],"recovery":[53,68,72,133,173,205,262],"times":[54],"following":[55,83],"induction":[56,87],"chemotherapy.":[57],"Accordingly,":[58],"we":[59,142],"compared":[60],"time":[61,131,170,231,342],"from":[62,93,186,334],"start":[63],"of":[64,147,217,257,289,303,307,338,423],"chemotherapy":[65,304],"(>1,000/\u03bcl)":[69],"(>100,000/\u03bcl)":[73],"in":[74,145,174,181,220,280,298],"424":[75,100],"who":[77,222,282],"achieved":[78],"complete":[80],"response":[81],"(CR)":[82],"treatment":[84],"ara-C-containing":[86],"therapy":[88],"at":[89],"MD":[90],"Anderson":[91],"Hospital":[92],"1995":[94],"2008.":[96],"We":[97],"divided":[98],"follows:":[103],"(1)":[104],"no":[105,107,113,119,228,266,364,371,378],"AHD,":[106,112],"PCT":[108,114,127,182,195,275,365,372,377,386],"(236":[109],"patients);":[110,116,122],"(2)":[111],"(131":[115],"(3)":[117],"PCT,":[118],"AHD":[120,125,193,273,363,370,379,384],"(28":[121],"(4)":[124],"(29":[128],"patients).":[129],"Because":[130],"also":[135],"be":[136,288,293,332],"influenced":[137],"by":[138,192,208,214,295],"cytogenetics":[139,159,243,271],"age":[141,153,269],"subdivided":[143],"each":[146],"four":[149],"groups":[150],"according":[151],"(<":[154],"vs.":[155,161],"\u2265":[156,399],"60)":[157],"(normal":[160],"complex":[162,240,321],"-5/-7).":[164],"Despite":[165],"very":[166],"differing":[167],"CR":[168,177,286,348],"rates,":[169],"achieving":[176],"while":[178,239],"statistically":[179,246],"longer":[180],"(p=0.05)":[184],"was":[185,206,265],"medical":[188],"standpoint":[189],"essentially":[190],"uninfluenced":[191],"status":[196,210],"(table,":[197],"median":[198,216],"delays":[199,256],"2":[200,258],"days":[201,219],"PCT).":[203],"Platelet":[204],"affected":[207],"such":[209],"(p<0.001)":[211],"being":[212],"delayed":[213],"6-8":[218],"had":[223,227,244],"received":[224],"PCT.":[225],"Age":[226,391,398],"effect":[229,260],"on":[230,261,310],"(p=0.42)":[234],"(p=0.23)":[237],"recovery,":[238],"-5/-7":[242,323,414],"significant":[247],"(p=0.002":[248],"neutrophils,":[249],"0.009":[250],"platelets)":[251],"but":[252,291],"medically":[253],"insignificant":[254],"(median":[255],"days)":[259],"time.":[263],"There":[264],"interaction":[267],"between":[268,300],"status.":[276],"A":[277],"similar":[278],"analysis":[279],"do":[283],"not":[284,331],"achieve":[285],"would":[287],"interest,":[290],"might":[292],"confounded":[294],"difficulty":[297],"distinguishing":[299],"effects":[302],"those":[306],"residual":[308],"recovery.":[312,345],"Our":[313],"data":[314],"suggest":[315],"that":[316],"older":[317],"patients,":[318],"cytogenetics,":[324],"should":[330],"excluded":[333],"clinical":[335],"trials":[336],"because":[337],"concern":[339],"about":[340],"Group":[346],"CRs":[347],"Rate":[349],"Median":[350,356],"Days":[351,357],">":[353,359],"1000":[354],"Neut":[355],"100,000":[360],"Plt":[361],"No":[362,420],"236":[366],"68%":[367],"27":[368,375,409],"28":[369,380,396],"131":[373],"50%":[374],"30":[376,389,404],"44%":[381],"29":[382,387,397,410,417],"34":[383],"+":[385],"35%":[388],"36":[390],"<":[392],"60":[393,400],"255":[394],"64%":[395],"169":[401],"48%":[402],"26":[403],"Normal":[405],"cyto":[406,412],"281":[407],"69%":[408],"Complex":[411],"143":[415],"41%":[416],"31":[418],"Disclosures:":[419],"relevant":[421],"conflicts":[422],"interest":[424],"declare.":[426]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-10-07T00:00:00"}
