{"id":"https://openalex.org/W2524253672","doi":"https://doi.org/10.1152/jn.00603.2016","title":"Callosal dysfunction explains injury sequelae in a computational network model of axonal injury","display_name":"Callosal dysfunction explains injury sequelae in a computational network model of axonal injury","publication_year":2016,"publication_date":"2016-09-28","ids":{"openalex":"https://openalex.org/W2524253672","doi":"https://doi.org/10.1152/jn.00603.2016","mag":"2524253672","pmid":"https://pubmed.ncbi.nlm.nih.gov/27683891","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5174154"},"language":"en","primary_location":{"id":"doi:10.1152/jn.00603.2016","doi":"https://doi.org/10.1152/jn.00603.2016","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.00603.2016","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5174154","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103757338","display_name":"Jianxia Cui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianxia Cui","raw_affiliation_strings":["L-3 Applied Technologies, Inc., San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L-3 Applied Technologies, Inc., San Diego, California","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054165786","display_name":"Laurel J. Ng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laurel J. Ng","raw_affiliation_strings":["L-3 Applied Technologies, Inc., San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L-3 Applied Technologies, Inc., San Diego, California","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044256936","display_name":"Vladislav Volman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vladislav Volman","raw_affiliation_strings":["L-3 Applied Technologies, Inc., San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L-3 Applied Technologies, Inc., San Diego, California","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5044256936"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1288,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.77442829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"116","issue":"6","first_page":"2892","last_page":"2908"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mild-traumatic-brain-injury","display_name":"mild traumatic brain injury","score":0.9950000047683716},{"id":"https://openalex.org/keywords/corpus-callosum","display_name":"corpus callosum","score":0.968999981880188},{"id":"https://openalex.org/keywords/axonal-injury","display_name":"axonal injury","score":0.8539999723434448},{"id":"https://openalex.org/keywords/myelinated-nerve-fibers","display_name":"myelinated axons","score":0.9160000085830688},{"id":"https://openalex.org/keywords/interhemispheric-connectivity","display_name":"interhemispheric connectivity","score":0.8009999990463257},{"id":"https://openalex.org/keywords/axonal-conduction-delay","display_name":"axonal conduction delay","score":0.7699999809265137},{"id":"https://openalex.org/keywords/resting-state-oscillations","display_name":"resting-state oscillations","score":0.656000018119812},{"id":"https://openalex.org/keywords/alpha-band","display_name":"alpha band","score":0.5950000286102295},{"id":"https://openalex.org/keywords/theta-band","display_name":"theta band","score":0.7720000147819519},{"id":"https://openalex.org/keywords/attention","display_name":"attention","score":0.6970000267028809},{"id":"https://openalex.org/keywords/reaction-time","display_name":"reaction time","score":0.8040000200271606},{"id":"https://openalex.org/keywords/neurobehavioral-sequelae","display_name":"neurobehavioral sequelae","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6720110177993774},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4545615315437317},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.4106357991695404},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.32786184549331665},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3075241446495056},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003337","descriptor_name":"Corpus Callosum","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007839","descriptor_name":"Functional Laterality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1152/jn.00603.2016","doi":"https://doi.org/10.1152/jn.00603.2016","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.00603.2016","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4621446","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5174154","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5174154","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5174154","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurophysiol","raw_type":"Text"},{"id":"pmid:27683891","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27683891","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurophysiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4621446","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5174154","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320338280","display_name":"Medical Research and Materiel Command","ror":"https://ror.org/03cd02q50"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":127,"referenced_works":["https://openalex.org/W12768585","https://openalex.org/W1497157822","https://openalex.org/W1501360999","https://openalex.org/W1529598366","https://openalex.org/W1531745698","https://openalex.org/W1537625976","https://openalex.org/W1538503824","https://openalex.org/W1553959446","https://openalex.org/W1673584506","https://openalex.org/W1739404820","https://openalex.org/W1753091109","https://openalex.org/W1823258564","https://openalex.org/W1932115741","https://openalex.org/W1953513934","https://openalex.org/W1965432565","https://openalex.org/W1968586481","https://openalex.org/W1972748922","https://openalex.org/W1973275441","https://openalex.org/W1974844073","https://openalex.org/W1976017630","https://openalex.org/W1977150900","https://openalex.org/W1979502536","https://openalex.org/W1983953603","https://openalex.org/W1994053478","https://openalex.org/W1997163669","https://openalex.org/W1999567494","https://openalex.org/W2000244131","https://openalex.org/W2000965942","https://openalex.org/W2001603929","https://openalex.org/W2002954340","https://openalex.org/W2003046304","https://openalex.org/W2013186737","https://openalex.org/W2013225603","https://openalex.org/W2019016101","https://openalex.org/W2025198671","https://openalex.org/W2025275866","https://openalex.org/W2028767115","https://openalex.org/W2029934068","https://openalex.org/W2031030159","https://openalex.org/W2031543773","https://openalex.org/W2033707011","https://openalex.org/W2036923762","https://openalex.org/W2043159644","https://openalex.org/W2043957369","https://openalex.org/W2045695914","https://openalex.org/W2046198005","https://openalex.org/W2046424015","https://openalex.org/W2048165706","https://openalex.org/W2050873013","https://openalex.org/W2055859677","https://openalex.org/W2056018333","https://openalex.org/W2057849466","https://openalex.org/W2058227754","https://openalex.org/W2058582588","https://openalex.org/W2059455555","https://openalex.org/W2060298007","https://openalex.org/W2063062105","https://openalex.org/W2068027701","https://openalex.org/W2068365521","https://openalex.org/W2073486940","https://openalex.org/W2076708879","https://openalex.org/W2076750015","https://openalex.org/W2076783616","https://openalex.org/W2079948225","https://openalex.org/W2080656638","https://openalex.org/W2081771004","https://openalex.org/W2082326637","https://openalex.org/W2085690507","https://openalex.org/W2091172904","https://openalex.org/W2093147179","https://openalex.org/W2093671548","https://openalex.org/W2094561781","https://openalex.org/W2094778668","https://openalex.org/W2095265457","https://openalex.org/W2096698246","https://openalex.org/W2096859537","https://openalex.org/W2098330912","https://openalex.org/W2100446982","https://openalex.org/W2102291861","https://openalex.org/W2104098344","https://openalex.org/W2104159920","https://openalex.org/W2104695012","https://openalex.org/W2106439941","https://openalex.org/W2107534651","https://openalex.org/W2107566823","https://openalex.org/W2109870708","https://openalex.org/W2115083032","https://openalex.org/W2115428913","https://openalex.org/W2117144089","https://openalex.org/W2119053925","https://openalex.org/W2122988433","https://openalex.org/W2123076424","https://openalex.org/W2123204198","https://openalex.org/W2124210840","https://openalex.org/W2124496726","https://openalex.org/W2126765806","https://openalex.org/W2127389037","https://openalex.org/W2127635031","https://openalex.org/W2129285116","https://openalex.org/W2131040632","https://openalex.org/W2132029553","https://openalex.org/W2132167023","https://openalex.org/W2132907436","https://openalex.org/W2133125918","https://openalex.org/W2133366903","https://openalex.org/W2135997508","https://openalex.org/W2136680209","https://openalex.org/W2137107462","https://openalex.org/W2143460468","https://openalex.org/W2143812931","https://openalex.org/W2148452798","https://openalex.org/W2154323800","https://openalex.org/W2154480805","https://openalex.org/W2154731415","https://openalex.org/W2155916251","https://openalex.org/W2156366271","https://openalex.org/W2156664946","https://openalex.org/W2163452374","https://openalex.org/W2172274087","https://openalex.org/W2200681203","https://openalex.org/W2205320989","https://openalex.org/W2267908377","https://openalex.org/W2348258443","https://openalex.org/W2399759608","https://openalex.org/W2408961640","https://openalex.org/W3081913253","https://openalex.org/W4231143084"],"related_works":["https://openalex.org/W2739249774","https://openalex.org/W2007530842","https://openalex.org/W1994314634","https://openalex.org/W2088637934","https://openalex.org/W2012575744","https://openalex.org/W7097702941","https://openalex.org/W2131040632","https://openalex.org/W4205600686","https://openalex.org/W2137938185","https://openalex.org/W3208128805"],"abstract_inverted_index":{"Mild":[0],"traumatic":[1],"brain":[2],"injury":[3,60,137,191,218],"(mTBI)":[4],"often":[5],"results":[6],"in":[7,31,49,180,223],"neurobehavioral":[8,67,197,226],"aberrations":[9],"such":[10],"as":[11,151,166,199],"impaired":[12],"attention":[13],"and":[14,20,77,95,102,174],"increased":[15,153,176],"reaction":[16],"time.":[17],"Diffusion":[18],"imaging":[19],"postmortem":[21],"analysis":[22],"studies":[23],"suggest":[24],"that":[25],"mTBI":[26],"primarily":[27],"affects":[28],"myelinated":[29,62,99,221],"axons":[30,64,101,222],"white":[32],"matter":[33],"tracts.":[34],"In":[35,107],"particular,":[36],"corpus":[37],"callosum,":[38],"mediating":[39],"interhemispheric":[40,96],"information":[41],"exchange,":[42],"has":[43],"been":[44],"shown":[45],"to":[46,65,161,182,195,211],"be":[47],"affected":[48],"mTBI.":[50,70,229],"Yet":[51],"little":[52],"is":[53],"known":[54],"about":[55],"the":[56,59,66,90,108,111,147,203,213,217,225],"mechanisms":[57],"linking":[58],"of":[61,69,86,129,135,146,171,205,219,228],"callosal":[63,100,136,220],"sequelae":[68,227],"To":[71],"address":[72],"this":[73],"issue,":[74],"we":[75],"devised":[76],"studied":[78],"a":[79,167],"large,":[80],"biologically":[81],"plausible":[82],"neuronal":[83],"network":[84,114,133,148,163],"model":[85,91,113,134],"cortical":[87],"tissue.":[88],"Importantly,":[89,184],"architecture":[92],"incorporated":[93],"intra-":[94],"organization,":[97],"including":[98,119,142],"distance-dependent":[103],"axonal":[104],"conduction":[105],"delays.":[106],"resting":[109],"state,":[110],"intact":[112],"exhibited":[115],"several":[116,139],"salient":[117],"features,":[118],"alpha-band":[120],"(8-12":[121],"Hz)":[122],"collective":[123,172],"activity":[124],"with":[125,190],"low-frequency":[126],"irregular":[127],"spiking":[128],"individual":[130],"neurons.":[131],"The":[132],"captured":[138],"clinical":[140],"observations,":[141],"1)":[143],"\"slowing":[144],"down\"":[145],"rhythms,":[149],"manifested":[150,165],"an":[152],"resting-state":[154],"theta-to-alpha":[155],"power":[156,170],"ratio,":[157],"2)":[158],"reduced":[159,168],"response":[160,178,181],"attention-like":[162],"stimulation,":[164],"spectral":[169],"activity,":[173],"3)":[175],"population":[177],"time":[179],"stimulation.":[183],"these":[185],"changes":[186],"were":[187],"positively":[188],"correlated":[189],"severity,":[192],"supporting":[193],"proposals":[194],"use":[196],"indices":[198],"biomarkers":[200],"for":[201],"determining":[202],"severity":[204],"injury.":[206],"Our":[207],"modeling":[208],"effort":[209],"helps":[210],"understand":[212],"role":[214],"played":[215],"by":[216],"defining":[224]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-10-07T00:00:00"}