{"id":"https://openalex.org/W252425177","doi":null,"title":"Novel smart polymer based in situ gels","display_name":"Novel smart polymer based in situ gels","publication_year":2010,"publication_date":"2010-12-14","ids":{"openalex":"https://openalex.org/W252425177","mag":"252425177"},"language":"en","primary_location":{"id":"pmh:oai:cdr.creighton.edu:10504/16049","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10504/16049","pdf_url":null,"source":{"id":"https://openalex.org/S7407097583","display_name":"Creighton Digital Repository (CDR)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114493937","host_organization_name":"Creighton University","host_organization_lineage":["https://openalex.org/I114493937"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046423209","display_name":"Laxmi R. Fogueri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Laxmi R. Fogueri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5046423209"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.8920999765396118,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.09679999947547913,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-situ-gel","display_name":"in situ gel","score":0.8240000009536743},{"id":"https://openalex.org/keywords/stimuli-responsive-polymers","display_name":"stimuli-responsive polymers","score":0.8320000171661377},{"id":"https://openalex.org/keywords/polylactic-acid","display_name":"polylactic acid","score":0.718999981880188},{"id":"https://openalex.org/keywords/polycaprolactone","display_name":"polycaprolactone","score":0.8870000243186951},{"id":"https://openalex.org/keywords/glycolide","display_name":"glycolide","score":0.6069999933242798},{"id":"https://openalex.org/keywords/lactide","display_name":"lactide","score":0.7549999952316284},{"id":"https://openalex.org/keywords/polymer-end-groups","display_name":"polymer end groups","score":0.7200000286102295},{"id":"https://openalex.org/keywords/protein-encapsulation","display_name":"protein encapsulation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/lysozyme","display_name":"lysozyme","score":0.9200000166893005},{"id":"https://openalex.org/keywords/bromelain","display_name":"bromelain","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bovine-serum-albumin","display_name":"bovine serum albumin","score":1.0},{"id":"https://openalex.org/keywords/protein-release-kinetics","display_name":"protein release kinetics","score":0.6489999890327454},{"id":"https://openalex.org/keywords/burst-release","display_name":"burst release","score":0.8849999904632568},{"id":"https://openalex.org/keywords/injectability","display_name":"injectability","score":0.6150000095367432},{"id":"https://openalex.org/keywords/protein-conformational-stability","display_name":"protein conformational stability","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.7295796275138855},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.47703880071640015},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.41675469279289246},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3697752356529236},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24556881189346313},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.14319714903831482},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07827064394950867}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:cdr.creighton.edu:10504/16049","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10504/16049","pdf_url":null,"source":{"id":"https://openalex.org/S7407097583","display_name":"Creighton Digital Repository (CDR)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114493937","host_organization_name":"Creighton University","host_organization_lineage":["https://openalex.org/I114493937"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:252425177","doi":null,"is_oa":false,"landing_page_url":"https://dspace.creighton.edu/xmlui/bitstream/handle/10504/16049/L-Fogueri-thesis.pdf;sequence=4","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":110,"referenced_works":["https://openalex.org/W16822270","https://openalex.org/W43364079","https://openalex.org/W121436712","https://openalex.org/W170914365","https://openalex.org/W422406868","https://openalex.org/W1009221267","https://openalex.org/W1480779500","https://openalex.org/W1494228633","https://openalex.org/W1511036913","https://openalex.org/W1513861898","https://openalex.org/W1581858536","https://openalex.org/W1592957255","https://openalex.org/W1831131816","https://openalex.org/W1927899726","https://openalex.org/W1969206818","https://openalex.org/W1970168185","https://openalex.org/W1970417486","https://openalex.org/W1974371653","https://openalex.org/W1981000246","https://openalex.org/W1986135931","https://openalex.org/W1987042142","https://openalex.org/W1989075367","https://openalex.org/W1991476865","https://openalex.org/W1991997373","https://openalex.org/W1992155535","https://openalex.org/W1993002290","https://openalex.org/W1994860339","https://openalex.org/W1997488570","https://openalex.org/W1998935458","https://openalex.org/W2000229917","https://openalex.org/W2002257633","https://openalex.org/W2004616899","https://openalex.org/W2004937424","https://openalex.org/W2007299616","https://openalex.org/W2011417528","https://openalex.org/W2011772684","https://openalex.org/W2015971173","https://openalex.org/W2016718542","https://openalex.org/W2019166471","https://openalex.org/W2021244409","https://openalex.org/W2021519473","https://openalex.org/W2021702303","https://openalex.org/W2027854362","https://openalex.org/W2030557341","https://openalex.org/W2031448189","https://openalex.org/W2031519926","https://openalex.org/W2031552233","https://openalex.org/W2032097496","https://openalex.org/W2033612649","https://openalex.org/W2034783507","https://openalex.org/W2036026377","https://openalex.org/W2038499330","https://openalex.org/W2043572851","https://openalex.org/W2043613444","https://openalex.org/W2043813618","https://openalex.org/W2044430876","https://openalex.org/W2047350555","https://openalex.org/W2049068611","https://openalex.org/W2049483740","https://openalex.org/W2052306144","https://openalex.org/W2052658732","https://openalex.org/W2057964462","https://openalex.org/W2058317327","https://openalex.org/W2060703479","https://openalex.org/W2063385184","https://openalex.org/W2064448367","https://openalex.org/W2064688118","https://openalex.org/W2068222286","https://openalex.org/W2068769109","https://openalex.org/W2071650593","https://openalex.org/W2072545864","https://openalex.org/W2072624182","https://openalex.org/W2073304863","https://openalex.org/W2073822432","https://openalex.org/W2076296523","https://openalex.org/W2077284777","https://openalex.org/W2081266301","https://openalex.org/W2082270329","https://openalex.org/W2082393473","https://openalex.org/W2082908153","https://openalex.org/W2083223205","https://openalex.org/W2086785905","https://openalex.org/W2087834130","https://openalex.org/W2094276417","https://openalex.org/W2094505929","https://openalex.org/W2099137240","https://openalex.org/W2099526972","https://openalex.org/W2099764148","https://openalex.org/W2100670989","https://openalex.org/W2103043372","https://openalex.org/W2103678678","https://openalex.org/W2105973511","https://openalex.org/W2116466041","https://openalex.org/W2117755959","https://openalex.org/W2127955898","https://openalex.org/W2128791326","https://openalex.org/W2130726029","https://openalex.org/W2141917514","https://openalex.org/W2144081123","https://openalex.org/W2147584651","https://openalex.org/W2148792419","https://openalex.org/W2153962345","https://openalex.org/W2157520093","https://openalex.org/W2170060628","https://openalex.org/W2235129190","https://openalex.org/W2239384431","https://openalex.org/W2245726981","https://openalex.org/W2277818172","https://openalex.org/W2313186189","https://openalex.org/W2577842378"],"related_works":["https://openalex.org/W2082270329","https://openalex.org/W2043509791","https://openalex.org/W2165016939","https://openalex.org/W2105446669","https://openalex.org/W1970417486","https://openalex.org/W2784315364","https://openalex.org/W1983052470","https://openalex.org/W2081494042","https://openalex.org/W1966748944","https://openalex.org/W2042273891"],"abstract_inverted_index":{"The":[0,79,178,331,363,384,406,426,447,496,512,533,554],"objectives":[1],"of":[2,10,12,25,60,63,183,190,193,200,269,312,324,329,333,346,348,354,356,373,387,400,408,418,428,439,449,460,477,491,515,536,557,589,595,603,628,637,670],"this":[3],"investigation":[4],"were":[5,53,71,82,115,152,188,206,243,256,263,341,500],"to":[6,42,240,377,396,473,502,508,626],"investigate":[7],"the":[8,21,85,118,128,181,194,272,321,325,344,352,357,378,388,397,401,419,440,461,474,478,481,489,509,528,549,570,580,592,596,635],"effect":[9,476],"interaction":[11,636],"protein":[13,129,389,402,482,497,510,581,597,604,646],"and":[14,30,66,125,137,141,173,198,232,271,336,416,437,458,526,547,568,612,622,661],"polymers":[15,38,270,364,479],"with":[16,266,288,304,316,365,380,404,494,587,645],"varying":[17],"end":[18,47,254,291,297,306,318,349,368,382,639],"groups":[19,48,307,319,350,369,640,648],"on":[20,343,351,411,431,452,480,521,542,563,606],"overall":[22],"release":[23,281,300,313,335,339,660],"profile":[24],"model":[26,80,195],"proteins":[27,81,671],"(Lysozyme,":[28],"Bromelain":[29,142,429,441,540,550],"Bovine":[31],"Serum":[32],"Albumin":[33,450,462,561,571],"(BSA)).":[34],"Lactide":[35],"and/or":[36],"glycolide-based":[37],"(intrinsic":[39],"viscosity":[40],"0.15":[41],"0.22":[43],"d/L)":[44],"differing":[45],"in":[46,55,100,180,185,203,259,320,488,624,673],"(carboxylic":[49],"acid":[50,253,290,305,644],"or":[51,652],"ester),":[52],"dissolved":[54],"an":[56],"organic":[57],"solvent":[58,273],"mixture":[59],"various":[61],"ratios":[62],"benzyl":[64,67],"benzoate":[65],"alcohol.":[68],"Polymer":[69,237],"solutions":[70,390,605],"tested":[72],"for":[73,92,127,227,230,235,518,527,539,548,560,569,657],"injectability":[74],"through":[75,246],"22":[76,247],"gauge":[77],"needle.":[78,249],"incorporated":[83,672],"into":[84],"polymer":[86,287,379,638,676],"solution":[87,97,410,430,451,520,541,562],"by":[88,157,166,218],"sonicating":[89],"at":[90,121,146,154],"40W":[91],"20":[93],"seconds.":[94],"When":[95],"polymer-protein":[96],"was":[98,144,164,216,414,422,434,443,455,464,524,531,545,552,566,573,599],"injected":[99],"releasing":[101,119],"media":[102,120],"(phosphate":[103],"buffered":[104],"saline,":[105],"pH":[106],"7.4),":[107],"it":[108],"instantaneously":[109],"formed":[110],"a":[111,159,278,309],"gel":[112],"depot.":[113],"Samples":[114],"withdrawn":[116],"from":[117,284],"specific":[122],"time":[123],"points":[124],"analyzed":[126],"content":[130,143],"as":[131,133,208,225,375,506,642,650,665,667],"well":[132,264,666],"its":[134],"conformational":[135,212,393,620,663],"stability":[136,163,394,505,621,664],"biological":[138,585,593,668],"activity.":[139],"Lysozyme":[140,409,420,519,529],"determined":[145,153,165,217],"280":[147],"nm":[148,156],"while":[149],"BSA":[150],"contents":[151],"277.8":[155],"using":[158,222],"UV":[160],"spectrophotometer.":[161],"Conformational":[162],"Fourier":[167],"Transform":[168],"Infra":[169],"Red":[170],"(FTIR)":[171],"Spectroscopy":[172],"Differential":[174],"Scanning":[175],"Calorimeter":[176],"(DSC).":[177],"peaks":[179],"range":[182],"1620-1695nm":[184],"FTIR":[186,484],"spectrum":[187],"indicative":[189],"secondary":[191,492,516,537,558],"structures":[192,493,517,538,559],"proteins.":[196],"Enthalpy":[197],"mid-point":[199],"thermal":[201],"transition":[202],"DSC":[204,385,398],"thermogram":[205],"used":[207,656],"thermodynamic":[209],"parameters":[210],"indicating":[211],"stability.":[213],"Biological":[214,575],"activity":[215,220,576,586,594,614,623,669],"enzyme":[219,613],"assay":[221],"Micrococcus":[223],"Lysodeikticus":[224],"substrate":[226],"Lysozyme,":[228],"Tyrosinase":[229],"albumin,":[231],"Z-L-Lys-ONp":[233],"hydrochloride":[234],"Bromelain.":[236],"concentrations":[238],"up":[239],"25%":[241],"(w/w)":[242],"found":[244,501],"injectable":[245],"gauze":[248],"Polymers":[250,303],"bearing":[251],"carboxylic":[252,289,367,643],"group":[255,292,298],"not":[257],"soluble":[258],"100%":[260],"BB":[261],"which":[262],"correlated":[265],"hydrophilic-lipophilic":[267],"profiles":[268,340],"systems.":[274,362],"Release":[275],"studies":[276],"indicated":[277,616],"lower":[279],"burst":[280,334,659],"(<":[282],"15%)":[283],"formulations":[285,403,421,442,463,498,530,551,572,582,598],"containing":[286,295],"than":[293,314,601],"those":[294,315,627],"ester":[296,317,381],"(burst":[299],">":[301,423,444,465],"25%).":[302],"showed":[308,370,391,486,578],"faster":[310,371],"rate":[311,353,372],"second":[322],"phase":[323],"observed":[326],"biphasic":[327],"pattern":[328],"release.":[330],"amount":[332],"over":[337],"all":[338],"explained":[342],"basis":[345],"influence":[347],"gelation":[355,374],"phase-sensitive":[358,674],"smart":[359,675],"polymer-based":[360],"delivery":[361],"free":[366],"compared":[376,395,507],"groups.":[383],"thermograms":[386,399],"decreased":[392],"time.":[405,495],"Tm":[407,427,448],"day":[412,432,453,522,543,564],"84":[413,433,523],"26.94\u00b10.096\u00baC":[415],"that":[417,438,459,579,602,634],"47":[424],"\u00baC.":[425,446,467],"45.00\u00b10.023":[435],"\u00baC":[436,457],"59":[445],"49":[454,544,565],"51.86\u00b10.039":[456],"54":[466],"This":[468],"may":[469],"be":[470,655],"occurring":[471],"due":[472],"protective":[475],"formulations.":[483,677],"data":[485,577,615],"decrease":[487],"area":[490],"however":[499],"have":[503],"more":[504,600],"solutions.":[511],"corrected":[513,534,555],"areas":[514,535,556],"0.001":[525],">0.014.":[532],"0.0015":[546],">0.042.":[553],"0.04":[567],">0.2.":[574],"lost":[583],"their":[584],"passage":[588],"time,":[590],"but":[591],"any":[607],"given":[608],"day.":[609],"FTIR,":[610],"DSC,":[611],"significantly":[617],"greater":[618],"(p<0.05)":[619],"comparison":[625],"control":[629],"samples.":[630],"It":[631],"is":[632],"concluded":[633],"such":[641,649],"functional":[647],"hydroxyl":[651],"amino":[653],"can":[654],"reducing":[658],"protecting":[662]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
