{"id":"https://openalex.org/W2523720409","doi":"https://doi.org/10.3233/jrs-160726","title":"Links between serotonin reuptake inhibition during pregnancy and neurodevelopmental delay/spectrum disorders: A systematic review of epidemiological and physiological evidence","display_name":"Links between serotonin reuptake inhibition during pregnancy and neurodevelopmental delay/spectrum disorders: A systematic review of epidemiological and physiological evidence","publication_year":2016,"publication_date":"2016-09-17","ids":{"openalex":"https://openalex.org/W2523720409","doi":"https://doi.org/10.3233/jrs-160726","mag":"2523720409","pmid":"https://pubmed.ncbi.nlm.nih.gov/27662278"},"language":"en","primary_location":{"id":"doi:10.3233/jrs-160726","doi":"https://doi.org/10.3233/jrs-160726","is_oa":true,"landing_page_url":"https://doi.org/10.3233/jrs-160726","pdf_url":"https://content.iospress.com:443/download/international-journal-of-risk-and-safety-in-medicine/jrs726?id=international-journal-of-risk-and-safety-in-medicine%2Fjrs726","source":{"id":"https://openalex.org/S2764569153","display_name":"International Journal of Risk & Safety in Medicine","issn_l":"0924-6479","issn":["0924-6479","1878-6847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Risk & Safety in Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://content.iospress.com:443/download/international-journal-of-risk-and-safety-in-medicine/jrs726?id=international-journal-of-risk-and-safety-in-medicine%2Fjrs726","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101910905","display_name":"David Healy","orcid":"https://orcid.org/0000-0002-6340-9247","observed_orcids":["https://orcid.org/0000-0002-6340-9247"]},"institutions":[{"id":"https://openalex.org/I161548249","display_name":"Bangor University","ror":"https://ror.org/006jb1a24","country_code":"GB","type":"education","lineage":["https://openalex.org/I161548249"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. Healy","raw_affiliation_strings":["North Wales Department of Psychological Medicine, Bangor University, Wales, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Wales Department of Psychological Medicine, Bangor University, Wales, UK","institution_ids":["https://openalex.org/I161548249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111393085","display_name":"Joanna C Le Noury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161548249","display_name":"Bangor University","ror":"https://ror.org/006jb1a24","country_code":"GB","type":"education","lineage":["https://openalex.org/I161548249"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Le Noury","raw_affiliation_strings":["North Wales Department of Psychological Medicine, Bangor University, Wales, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Wales Department of Psychological Medicine, Bangor University, Wales, UK","institution_ids":["https://openalex.org/I161548249"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071924399","display_name":"Dee A. Mangin","orcid":"https://orcid.org/0000-0003-2149-9376","observed_orcids":["https://orcid.org/0000-0003-2149-9376"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D. Mangin","raw_affiliation_strings":["David Braley Nancy Gordon Chair in Family Medicine, Department of Family Medicine, McMaster University, Hamilton, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"David Braley Nancy Gordon Chair in Family Medicine, Department of Family Medicine, McMaster University, Hamilton, ON, Canada","institution_ids":["https://openalex.org/I98251732"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":0.4695,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.48755811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"28","issue":"3","first_page":"125","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.7494999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.7494999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.13500000536441803,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.05810000002384186,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin-reuptake-inhibitors","display_name":"serotonin reuptake inhibitors","score":0.9580000042915344},{"id":"https://openalex.org/keywords/antidepressant-use-in-pregnancy","display_name":"antidepressant use in pregnancy","score":0.7799999713897705},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.8209999799728394},{"id":"https://openalex.org/keywords/neurodevelopmental-delay","display_name":"neurodevelopmental delay","score":0.953000009059906},{"id":"https://openalex.org/keywords/prenatal-drug-exposure","display_name":"prenatal drug exposure","score":0.6790000200271606},{"id":"https://openalex.org/keywords/maternal-medication-use","display_name":"maternal medication use","score":0.6320000290870667},{"id":"https://openalex.org/keywords/children-s-cognitive-development","display_name":"child cognitive development","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5090588927268982},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49748852849006653},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.45584505796432495},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4475407004356384},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.44244688749313354},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.41820794343948364},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.3897084593772888},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3547251224517822},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3254414200782776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2608334422111511},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10686641931533813},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05713537335395813},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002659","descriptor_name":"Child Development Disorders, Pervasive","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3233/jrs-160726","doi":"https://doi.org/10.3233/jrs-160726","is_oa":true,"landing_page_url":"https://doi.org/10.3233/jrs-160726","pdf_url":"https://content.iospress.com:443/download/international-journal-of-risk-and-safety-in-medicine/jrs726?id=international-journal-of-risk-and-safety-in-medicine%2Fjrs726","source":{"id":"https://openalex.org/S2764569153","display_name":"International Journal of Risk & Safety in Medicine","issn_l":"0924-6479","issn":["0924-6479","1878-6847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Risk & Safety in Medicine","raw_type":"journal-article"},{"id":"pmid:27662278","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27662278","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of risk & safety in medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3233/jrs-160726","doi":"https://doi.org/10.3233/jrs-160726","is_oa":true,"landing_page_url":"https://doi.org/10.3233/jrs-160726","pdf_url":"https://content.iospress.com:443/download/international-journal-of-risk-and-safety-in-medicine/jrs726?id=international-journal-of-risk-and-safety-in-medicine%2Fjrs726","source":{"id":"https://openalex.org/S2764569153","display_name":"International Journal of Risk & Safety in Medicine","issn_l":"0924-6479","issn":["0924-6479","1878-6847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Risk & Safety in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2523720409.pdf","grobid_xml":"https://content.openalex.org/works/W2523720409.grobid-xml"},"referenced_works_count":127,"referenced_works":["https://openalex.org/W60580434","https://openalex.org/W114494166","https://openalex.org/W169502853","https://openalex.org/W567111790","https://openalex.org/W598418317","https://openalex.org/W1492569724","https://openalex.org/W1496824121","https://openalex.org/W1547319025","https://openalex.org/W1686823034","https://openalex.org/W1715685834","https://openalex.org/W1838960985","https://openalex.org/W1860895670","https://openalex.org/W1904332195","https://openalex.org/W1925988505","https://openalex.org/W1964387971","https://openalex.org/W1965307386","https://openalex.org/W1966526645","https://openalex.org/W1967261707","https://openalex.org/W1967436276","https://openalex.org/W1967585087","https://openalex.org/W1967704718","https://openalex.org/W1971824295","https://openalex.org/W1972427998","https://openalex.org/W1974546287","https://openalex.org/W1975689471","https://openalex.org/W1976388899","https://openalex.org/W1977605690","https://openalex.org/W1978231228","https://openalex.org/W1978522713","https://openalex.org/W1978691050","https://openalex.org/W1979423827","https://openalex.org/W1980524281","https://openalex.org/W1981456496","https://openalex.org/W1981640001","https://openalex.org/W1986303858","https://openalex.org/W1988538570","https://openalex.org/W1988991234","https://openalex.org/W1993629398","https://openalex.org/W1993934890","https://openalex.org/W2001521832","https://openalex.org/W2003705015","https://openalex.org/W2004518972","https://openalex.org/W2004777672","https://openalex.org/W2004924428","https://openalex.org/W2008567973","https://openalex.org/W2011812102","https://openalex.org/W2013822799","https://openalex.org/W2019056171","https://openalex.org/W2021087453","https://openalex.org/W2024274215","https://openalex.org/W2032234096","https://openalex.org/W2034396455","https://openalex.org/W2039857111","https://openalex.org/W2040939072","https://openalex.org/W2043406379","https://openalex.org/W2052092268","https://openalex.org/W2052747743","https://openalex.org/W2054586661","https://openalex.org/W2055099023","https://openalex.org/W2057847288","https://openalex.org/W2059378464","https://openalex.org/W2059778872","https://openalex.org/W2061360351","https://openalex.org/W2061787422","https://openalex.org/W2061869560","https://openalex.org/W2062240933","https://openalex.org/W2062812406","https://openalex.org/W2065365546","https://openalex.org/W2065523950","https://openalex.org/W2067151668","https://openalex.org/W2069385885","https://openalex.org/W2072992689","https://openalex.org/W2082648614","https://openalex.org/W2082717009","https://openalex.org/W2082979044","https://openalex.org/W2089803120","https://openalex.org/W2090514581","https://openalex.org/W2092075399","https://openalex.org/W2092861046","https://openalex.org/W2095446576","https://openalex.org/W2096625287","https://openalex.org/W2097538067","https://openalex.org/W2099051791","https://openalex.org/W2104302525","https://openalex.org/W2105840567","https://openalex.org/W2105930613","https://openalex.org/W2106510144","https://openalex.org/W2107767428","https://openalex.org/W2108194202","https://openalex.org/W2111674205","https://openalex.org/W2114200126","https://openalex.org/W2119119176","https://openalex.org/W2120734658","https://openalex.org/W2129626993","https://openalex.org/W2130941553","https://openalex.org/W2132031492","https://openalex.org/W2136302682","https://openalex.org/W2145750561","https://openalex.org/W2150537415","https://openalex.org/W2153393350","https://openalex.org/W2154007845","https://openalex.org/W2154912010","https://openalex.org/W2160563224","https://openalex.org/W2161063401","https://openalex.org/W2162025049","https://openalex.org/W2163736307","https://openalex.org/W2166861971","https://openalex.org/W2167909952","https://openalex.org/W2168495021","https://openalex.org/W2177099710","https://openalex.org/W2255119171","https://openalex.org/W2268856865","https://openalex.org/W2272466511","https://openalex.org/W2315374784","https://openalex.org/W2335578979","https://openalex.org/W2399616748","https://openalex.org/W2405117596","https://openalex.org/W2414343809","https://openalex.org/W2463774834","https://openalex.org/W2581739005","https://openalex.org/W4205253110","https://openalex.org/W4233397445","https://openalex.org/W4239171424","https://openalex.org/W4239211543","https://openalex.org/W4253045128","https://openalex.org/W4388164962","https://openalex.org/W6647049371"],"related_works":["https://openalex.org/W2774968404","https://openalex.org/W1990805714","https://openalex.org/W2482083083","https://openalex.org/W2540620999","https://openalex.org/W6489411","https://openalex.org/W1618574694","https://openalex.org/W4205756589","https://openalex.org/W2734884375","https://openalex.org/W2891094870","https://openalex.org/W3154444259"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"possible":[3,69,92,180],"linkages":[4],"between":[5,144],"neurodevelopmental":[6,9,41],"delay":[7,152],"and":[8,12,44,59,126,150,153,179],"spectrum":[10,42,154],"disorders":[11,155],"exposure":[13],"to":[14,56,68,86,90,107,140,159,167,170],"medication":[15],"with":[16,40,78],"effects":[17,74],"on":[18,34,75],"serotonin":[19,53,76,110,145],"reuptake":[20,54,77,111,146],"inhibition":[21,147],"during":[22,114],"pregnancy.":[23],"METHODS:":[24],"We":[25],"systematically":[26],"reviewed":[27,62],"the":[28,63,174,177],"epidemiological":[29,82],"literature":[30,64],"for":[31,65],"studies":[32,51,83,119,130],"bearing":[33],"this":[35,184],"relationship":[36],"in":[37,60,104,116,127,148,156,162],"children":[38,105],"born":[39,106],"disorder":[43],"related":[45,102],"conditions,":[46],"as":[47,49,67],"well":[48],"animal":[50],"giving":[52],"inhibitors":[55],"pregnant":[57],"animals":[58],"addition":[61],"proposals":[66],"mechanisms":[70,181],"that":[71],"might":[72,186],"link":[73,143,185],"cognitive":[79,160],"changes":[80],"post-partum.The":[81],"were":[84],"analysed":[85],"produce":[87],"Forest":[88],"plots":[89],"illustrate":[91],"relations.":[93],"RESULTS:":[94],"The":[95],"odds":[96],"ratio":[97],"of":[98,176],"Autistic":[99],"Spectrum":[100],"or":[101],"Disorders":[103],"women":[108],"taking":[109],"inhibiting":[112],"antidepressants":[113],"pregnancy":[115,149],"case":[117],"control":[118],"was":[120,131],"1.95":[121],"(95%":[122,133],"C.I.":[123,134],"1.63,":[124],"2.34)":[125],"prospective":[128],"cohort":[129],"1.96":[132],"1.33,":[135],"2.90).":[136],"CONCLUSIONS:":[137],"There":[138],"appears":[139],"be":[141,168,187],"a":[142],"developmental":[151],"infancy":[157],"leading":[158],"difficulties":[161,178],"childhood.":[163],"More":[164],"work":[165],"needs":[166],"done":[169],"establish":[171],"more":[172],"precisely":[173],"nature":[175],"through":[182],"which":[183],"mediated.":[188]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-09-30T00:00:00"}