{"id":"https://openalex.org/W2523429203","doi":"https://doi.org/10.17615/3qh6-tg14","title":"Extracellular and Intracellular Regulation of G Protein-Coupled Receptor Signaling","display_name":"Extracellular and Intracellular Regulation of G Protein-Coupled Receptor Signaling","publication_year":2019,"publication_date":"2019-08-12","ids":{"openalex":"https://openalex.org/W2523429203","doi":"https://doi.org/10.17615/3qh6-tg14","mag":"2523429203"},"language":"en","primary_location":{"id":"pmh:oai:cdr.lib.unc.edu:uuid:8cb4b30e-8062-4e31-9a11-7a5cce091b7e","doi":null,"is_oa":true,"landing_page_url":"https://cdr.lib.unc.edu/record/uuid:8cb4b30e-8062-4e31-9a11-7a5cce091b7e","pdf_url":"https://cdr.lib.unc.edu/record/uuid:8cb4b30e-8062-4e31-9a11-7a5cce091b7e","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://cdr.lib.unc.edu/record/uuid:8cb4b30e-8062-4e31-9a11-7a5cce091b7e","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044093065","display_name":"Joseph E. Rittiner","orcid":"https://orcid.org/0000-0003-3592-6500","observed_orcids":["https://orcid.org/0000-0003-3592-6500"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rittiner, Joseph","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044093065"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00188055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.06509999930858612,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/adenosine-a1-receptor","display_name":"adenosine A1 receptor","score":0.8610000014305115},{"id":"https://openalex.org/keywords/adenosine-a2b-receptor","display_name":"adenosine A2B receptor","score":0.8809999823570251},{"id":"https://openalex.org/keywords/extracellular-loop-2","display_name":"second extracellular loop","score":0.6740000247955322},{"id":"https://openalex.org/keywords/muscarinic-receptors","display_name":"muscarinic receptors","score":0.8069999814033508},{"id":"https://openalex.org/keywords/purinergic-receptors","display_name":"purinergic receptors","score":0.9800000190734863},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9769999980926514},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.9850000143051147},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.875},{"id":"https://openalex.org/keywords/functional-selectivity","display_name":"functional selectivity","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.7884670495986938},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6074230670928955},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5632801055908203},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.47562578320503235},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4579436182975769},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43454402685165405},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.4100010097026825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33978164196014404},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31333690881729126}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:cdr.lib.unc.edu:uuid:8cb4b30e-8062-4e31-9a11-7a5cce091b7e","doi":null,"is_oa":true,"landing_page_url":"https://cdr.lib.unc.edu/record/uuid:8cb4b30e-8062-4e31-9a11-7a5cce091b7e","pdf_url":"https://cdr.lib.unc.edu/record/uuid:8cb4b30e-8062-4e31-9a11-7a5cce091b7e","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:cdr.lib.unc.edu:3t945r493","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.17615/3qh6-tg14","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2523429203","doi":null,"is_oa":false,"landing_page_url":"https://cdr.lib.unc.edu/concern/dissertations/3t945r493","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"doi:10.17615/3qh6-tg14","doi":"https://doi.org/10.17615/3qh6-tg14","is_oa":true,"landing_page_url":"https://doi.org/10.17615/3qh6-tg14","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"}],"best_oa_location":{"id":"pmh:oai:cdr.lib.unc.edu:uuid:8cb4b30e-8062-4e31-9a11-7a5cce091b7e","doi":null,"is_oa":true,"landing_page_url":"https://cdr.lib.unc.edu/record/uuid:8cb4b30e-8062-4e31-9a11-7a5cce091b7e","pdf_url":"https://cdr.lib.unc.edu/record/uuid:8cb4b30e-8062-4e31-9a11-7a5cce091b7e","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2523429203.pdf","grobid_xml":"https://content.openalex.org/works/W2523429203.grobid-xml"},"referenced_works_count":221,"referenced_works":["https://openalex.org/W116816145","https://openalex.org/W251850038","https://openalex.org/W261289257","https://openalex.org/W1150028167","https://openalex.org/W1480719130","https://openalex.org/W1482828226","https://openalex.org/W1486156227","https://openalex.org/W1486424890","https://openalex.org/W1496517521","https://openalex.org/W1510556999","https://openalex.org/W1522965874","https://openalex.org/W1523338753","https://openalex.org/W1580968401","https://openalex.org/W1587862541","https://openalex.org/W1591707154","https://openalex.org/W1604209299","https://openalex.org/W1674184175","https://openalex.org/W1690102379","https://openalex.org/W1699017532","https://openalex.org/W1718009280","https://openalex.org/W1769585641","https://openalex.org/W1825353903","https://openalex.org/W1933410007","https://openalex.org/W1956388268","https://openalex.org/W1966212997","https://openalex.org/W1967430693","https://openalex.org/W1971024460","https://openalex.org/W1972985963","https://openalex.org/W1973516763","https://openalex.org/W1973637837","https://openalex.org/W1975507912","https://openalex.org/W1975536445","https://openalex.org/W1975740938","https://openalex.org/W1975979472","https://openalex.org/W1977030607","https://openalex.org/W1978406137","https://openalex.org/W1978445242","https://openalex.org/W1978777321","https://openalex.org/W1978997108","https://openalex.org/W1979420700","https://openalex.org/W1979541885","https://openalex.org/W1979657192","https://openalex.org/W1980508023","https://openalex.org/W1980962873","https://openalex.org/W1982943052","https://openalex.org/W1983654099","https://openalex.org/W1985598247","https://openalex.org/W1987896609","https://openalex.org/W1988020128","https://openalex.org/W1989052524","https://openalex.org/W1990576861","https://openalex.org/W1992547494","https://openalex.org/W1992839998","https://openalex.org/W1994590994","https://openalex.org/W1995155014","https://openalex.org/W1995952358","https://openalex.org/W1996658120","https://openalex.org/W1998137686","https://openalex.org/W1999405361","https://openalex.org/W2000510012","https://openalex.org/W2001692359","https://openalex.org/W2002183064","https://openalex.org/W2002620715","https://openalex.org/W2003736358","https://openalex.org/W2005542488","https://openalex.org/W2007480243","https://openalex.org/W2012072483","https://openalex.org/W2013706577","https://openalex.org/W2013978625","https://openalex.org/W2014862487","https://openalex.org/W2015075408","https://openalex.org/W2016542329","https://openalex.org/W2019176798","https://openalex.org/W2019268044","https://openalex.org/W2019684029","https://openalex.org/W2021364120","https://openalex.org/W2022102563","https://openalex.org/W2022710607","https://openalex.org/W2025472785","https://openalex.org/W2025976079","https://openalex.org/W2027072899","https://openalex.org/W2028052569","https://openalex.org/W2030242161","https://openalex.org/W2030641968","https://openalex.org/W2036842366","https://openalex.org/W2037764311","https://openalex.org/W2039668688","https://openalex.org/W2041654178","https://openalex.org/W2043774463","https://openalex.org/W2045883944","https://openalex.org/W2046082819","https://openalex.org/W2046746010","https://openalex.org/W2047540491","https://openalex.org/W2047896617","https://openalex.org/W2049611742","https://openalex.org/W2049831696","https://openalex.org/W2050083058","https://openalex.org/W2051262966","https://openalex.org/W2051877370","https://openalex.org/W2052366943","https://openalex.org/W2052745304","https://openalex.org/W2052818515","https://openalex.org/W2053549636","https://openalex.org/W2056123178","https://openalex.org/W2056402692","https://openalex.org/W2057779233","https://openalex.org/W2059059769","https://openalex.org/W2059628641","https://openalex.org/W2061286602","https://openalex.org/W2062431479","https://openalex.org/W2063272225","https://openalex.org/W2064432631","https://openalex.org/W2064566190","https://openalex.org/W2064611637","https://openalex.org/W2066349956","https://openalex.org/W2067128597","https://openalex.org/W2068250355","https://openalex.org/W2069712437","https://openalex.org/W2069771677","https://openalex.org/W2072125742","https://openalex.org/W2073260721","https://openalex.org/W2074054214","https://openalex.org/W2074370114","https://openalex.org/W2075757856","https://openalex.org/W2077102469","https://openalex.org/W2079858948","https://openalex.org/W2080231167","https://openalex.org/W2083833577","https://openalex.org/W2083896254","https://openalex.org/W2083974494","https://openalex.org/W2084417841","https://openalex.org/W2085801794","https://openalex.org/W2086015992","https://openalex.org/W2089109453","https://openalex.org/W2089242580","https://openalex.org/W2089292241","https://openalex.org/W2089435101","https://openalex.org/W2091112155","https://openalex.org/W2091352240","https://openalex.org/W2092318838","https://openalex.org/W2092439632","https://openalex.org/W2094937695","https://openalex.org/W2095073811","https://openalex.org/W2099228763","https://openalex.org/W2100452437","https://openalex.org/W2101267046","https://openalex.org/W2101442845","https://openalex.org/W2101535048","https://openalex.org/W2102513649","https://openalex.org/W2103528208","https://openalex.org/W2104969843","https://openalex.org/W2106861254","https://openalex.org/W2109519875","https://openalex.org/W2109757013","https://openalex.org/W2111106575","https://openalex.org/W2114429916","https://openalex.org/W2115476261","https://openalex.org/W2115516116","https://openalex.org/W2116863239","https://openalex.org/W2117457196","https://openalex.org/W2117979776","https://openalex.org/W2119826244","https://openalex.org/W2120144854","https://openalex.org/W2121473111","https://openalex.org/W2121864128","https://openalex.org/W2121975625","https://openalex.org/W2122054000","https://openalex.org/W2122995608","https://openalex.org/W2123482117","https://openalex.org/W2126082233","https://openalex.org/W2126388474","https://openalex.org/W2128725190","https://openalex.org/W2128989913","https://openalex.org/W2129994873","https://openalex.org/W2130632774","https://openalex.org/W2130981805","https://openalex.org/W2137588110","https://openalex.org/W2138512826","https://openalex.org/W2138599948","https://openalex.org/W2138754505","https://openalex.org/W2139699538","https://openalex.org/W2139945041","https://openalex.org/W2141815299","https://openalex.org/W2148882351","https://openalex.org/W2149963584","https://openalex.org/W2150601291","https://openalex.org/W2150862082","https://openalex.org/W2151140831","https://openalex.org/W2153146698","https://openalex.org/W2154288976","https://openalex.org/W2156005120","https://openalex.org/W2156753857","https://openalex.org/W2158833117","https://openalex.org/W2159760953","https://openalex.org/W2160262187","https://openalex.org/W2160448209","https://openalex.org/W2161104113","https://openalex.org/W2162896964","https://openalex.org/W2163865126","https://openalex.org/W2164915356","https://openalex.org/W2166748873","https://openalex.org/W2166817392","https://openalex.org/W2167742611","https://openalex.org/W2167857702","https://openalex.org/W2168363131","https://openalex.org/W2169728426","https://openalex.org/W2170542169","https://openalex.org/W2171008621","https://openalex.org/W2171685713","https://openalex.org/W2181778583","https://openalex.org/W2266635801","https://openalex.org/W2279450809","https://openalex.org/W2282343116","https://openalex.org/W2325795238","https://openalex.org/W2396028691","https://openalex.org/W2408018686","https://openalex.org/W2415729053","https://openalex.org/W2418054660","https://openalex.org/W2418348314","https://openalex.org/W4237468233","https://openalex.org/W4405992943"],"related_works":["https://openalex.org/W4408107845","https://openalex.org/W102924921","https://openalex.org/W7208528995","https://openalex.org/W2794597614","https://openalex.org/W2024918057","https://openalex.org/W3173594770","https://openalex.org/W7095916426","https://openalex.org/W2161537746","https://openalex.org/W2588180695","https://openalex.org/W2048999929"],"abstract_inverted_index":{"Signaling":[0],"through":[1],"G":[2],"protein-coupled":[3],"receptors":[4],"(GPCRs)":[5],"is":[6,33,67,278],"an":[7,68,325],"essential":[8],"part":[9],"of":[10,16,43,70,99,111,118,152,188,192,212,228,241,251,276,293,311,320],"cellular":[11],"communication,":[12],"and":[13,46,55,86,181,214,246,249,295,300,332,339],"nearly":[14],"half":[15],"modern":[17],"pharmaceuticals":[18],"target":[19],"GPCRs":[20,24],"in":[21,133,161,298,335],"some":[22,151],"way.":[23],"are":[25],"also":[26,128,233],"subject":[27],"to":[28,79,84,92,113,125,158,179,280,290],"extensive":[29],"biological":[30],"regulation,":[31],"which":[32,50],"incompletely":[34],"understood.":[35],"Here,":[36],"I":[37,58,103,127,169,197],"examined":[38],"both":[39,247],"extracellular":[40,172,235],"metabolic":[41],"control":[42],"GPCR":[44,258,264,294,337],"signaling,":[45,259,323,338],"intracellular":[47],"feedback":[48],"mechanisms":[49],"regulate":[51],"downstream":[52,191,211,240],"signal":[53,80],"transduction":[54],"receptor":[56,89,101,122,140,272,322],"desensitization.":[57,273],"first":[59],"found":[60,170,198],"that":[61,105,116,150,171,182,199,261,285,301],"the":[62,71,119,134,153,200,254,291,309,317],"nucleotide":[63],"adenosine":[64,73,100,120,159,321],"5'-monophosphate":[65],"(AMP)":[66],"agonist":[69],"A1":[72],"receptor.":[74],"Previously,":[75],"AMP":[76,88,106,183],"was":[77,90],"thought":[78],"exclusively":[81],"via":[82],"hydrolysis":[83,112,124],"adenosine,":[85,114],"no":[87],"known":[91],"exist.":[93],"Using":[94],"a":[95,130,225],"novel":[96,201],"real-time":[97],"assay":[98],"activity,":[102,222],"showed":[104],"directly":[107,164],"activates":[108],"A1R":[109,135,177],"independent":[110],"but":[115,144,223],"activation":[117,141,187,248],"A2B":[121],"required":[123,219],"adenosine.":[126,146],"identified":[129],"histidine":[131],"residue":[132],"binding":[136],"pocket":[137],"critical":[138],"for":[139,308,328,345],"by":[142,166,266],"AMP,":[143,180],"not":[145],"These":[147],"results":[148],"suggest":[149],"A1R-mediated":[154],"physiological":[155,336],"effects":[156],"attributed":[157],"may":[160,304],"fact":[162],"be":[163],"caused":[165],"AMP.":[167],"Furthermore,":[168],"loop":[173],"2":[174],"partially":[175],"determines":[176],"sensitivity":[178],"stimulation":[184],"elicits":[185],"differential":[186],"signaling":[189,210,265,297],"cascades":[190],"A1R.":[193],"In":[194],"subsequent":[195],"work,":[196],"lipid":[202],"kinase":[203,205,237,243],"diacylglycerol":[204],"eta":[206],"(DGKh)":[207],"positively":[208],"modulates":[209],"muscarinic":[213],"purinergic":[215],"GPCRs.":[216],"This":[217],"effect":[218,256],"DGKh":[220,229,231,255,262,277,287,302],"catalytic":[221],"only":[224],"minimal":[226],"level":[227],"expression.":[230],"expression":[232,275],"suppressed":[234],"signal-related":[236],"(ERK)":[238],"phosphorylation":[239],"protein":[242],"C":[244],"(PKC)":[245],"depletion":[250],"PKC":[252,268,296],"abolished":[253],"on":[257],"indicating":[260],"enhances":[263],"suppressing":[267],"activation,":[269],"likely":[270],"reducing":[271],"Enhanced":[274],"linked":[279],"bipolar":[281],"disorder":[282],"(BPD),":[283],"suggesting":[284],"increased":[286],"activity":[288],"contributes":[289],"dysregulation":[292],"BPD":[299],"inhibitors":[303],"have":[305],"therapeutic":[306],"potential":[307],"treatment":[310],"BPD.":[312],"Together,":[313],"my":[314],"work":[315],"expands":[316],"current":[318],"understanding":[319],"implies":[324],"enhanced":[326],"role":[327],"multiple":[329],"endogenous":[330],"ligands":[331],"functional":[333],"selectivity":[334],"highlights":[340],"GPCR-modulating":[341],"enzymes":[342],"as":[343],"targets":[344],"drug":[346],"discovery.":[347]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-09-30T00:00:00"}
