{"id":"https://openalex.org/W25227422","doi":null,"title":"HCC, diet and metabolic factors: Diet and HCC.","display_name":"HCC, diet and metabolic factors: Diet and HCC.","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W25227422","mag":"25227422","pmid":"https://pubmed.ncbi.nlm.nih.gov/22087137","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3206690"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2217423","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3206690","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3206690","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091319902","display_name":"Maurizio Montella","orcid":"https://orcid.org/0000-0002-0529-2984","observed_orcids":["https://orcid.org/0000-0002-0529-2984"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maurizio Montella","raw_affiliation_strings":["Epidemiology Unit, National Cancer Institute, Napoli, Italy","Epidemiology Unit, National Cancer Institute, epidemiologia.int@alice.it, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology Unit, National Cancer Institute, Napoli, Italy","institution_ids":[]},{"raw_affiliation_string":"Epidemiology Unit, National Cancer Institute, epidemiologia.int@alice.it, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049048856","display_name":"Anna Crispo","orcid":"https://orcid.org/0000-0002-8455-3328","observed_orcids":["https://orcid.org/0000-0002-8455-3328"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Crispo","raw_affiliation_strings":["Epidemiology Unit, National Cancer Institute, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology Unit, National Cancer Institute, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110263495","display_name":"Aldo Giudice","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aldo Giudice","raw_affiliation_strings":["Epidemiology Unit, National Cancer Institute, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology Unit, National Cancer Institute, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6054,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.89520592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"3","first_page":"159","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.5990999937057495,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.5990999937057495,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.2671000063419342,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/diet","display_name":"diet","score":0.8169999718666077},{"id":"https://openalex.org/keywords/lifestyle-risk-factors","display_name":"lifestyle risk factors","score":0.8259999752044678},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7289999723434448},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9350000023841858},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9269999861717224},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.8109999895095825},{"id":"https://openalex.org/keywords/aflatoxins","display_name":"aflatoxins","score":0.906000018119812},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.7720000147819519},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/coffee-consumption","display_name":"coffee consumption","score":0.9739999771118164},{"id":"https://openalex.org/keywords/gamma-glutamyl-transferase","display_name":"gamma-glutamyl transferase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.7820000052452087},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.9890000224113464},{"id":"https://openalex.org/keywords/beta-carotene","display_name":"beta-carotene","score":0.9369999766349792},{"id":"https://openalex.org/keywords/dietary-glycemic-index","display_name":"dietary glycemic index","score":0.5709999799728394},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9032456874847412},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8429789543151855},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6911332607269287},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6414166688919067},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6066509485244751},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.5916409492492676},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5880526304244995},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.5429285764694214},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.4732276201248169},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.46745285391807556},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.46521759033203125},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.45931604504585266},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.4580039978027344},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4397229254245758},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4306362271308899},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4246661961078644},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.38959622383117676},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20079737901687622},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17466682195663452},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.1300199031829834},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:2217423","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3206690","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22087137","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22087137","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatitis monthly","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3206690","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3206690/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepat Mon","raw_type":"Text"},{"id":"mag:25227422","doi":null,"is_oa":false,"landing_page_url":"http://hepatmon.com/7774.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S151854748","display_name":"Hepatitis Monthly","issn_l":"1735-143X","issn":["1735-143X","1735-3408"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318596","host_organization_name":"Kowsar Publishing","host_organization_lineage":["https://openalex.org/P4310318596"],"host_organization_lineage_names":["Kowsar Publishing"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Hepatitis Monthly","raw_type":null},{"id":"mag:2993566130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22087137","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2217423","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3206690","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1966448677","https://openalex.org/W1969384099","https://openalex.org/W1982307785","https://openalex.org/W1995501999","https://openalex.org/W1996857574","https://openalex.org/W2002034811","https://openalex.org/W2017921235","https://openalex.org/W2029691295","https://openalex.org/W2029776483","https://openalex.org/W2031002674","https://openalex.org/W2035794058","https://openalex.org/W2037466891","https://openalex.org/W2059861068","https://openalex.org/W2064057901","https://openalex.org/W2067273401","https://openalex.org/W2073436773","https://openalex.org/W2074850478","https://openalex.org/W2080457679","https://openalex.org/W2085834652","https://openalex.org/W2088755464","https://openalex.org/W2096098978","https://openalex.org/W2097494822","https://openalex.org/W2103878518","https://openalex.org/W2112182413","https://openalex.org/W2114375358","https://openalex.org/W2119257963","https://openalex.org/W2120970673","https://openalex.org/W2127550752","https://openalex.org/W2131965674","https://openalex.org/W2133713937","https://openalex.org/W2139252765","https://openalex.org/W2142137274","https://openalex.org/W2142684885","https://openalex.org/W2149575448","https://openalex.org/W2152473190","https://openalex.org/W2168374843","https://openalex.org/W2169681036","https://openalex.org/W2170588255","https://openalex.org/W2171255319","https://openalex.org/W2317146091","https://openalex.org/W2338611861","https://openalex.org/W2402020281","https://openalex.org/W2513967314","https://openalex.org/W2797870555"],"related_works":["https://openalex.org/W2993566130","https://openalex.org/W7099745004","https://openalex.org/W2037700816","https://openalex.org/W4252424421","https://openalex.org/W2343062955","https://openalex.org/W4412490867","https://openalex.org/W4210385954","https://openalex.org/W4296165041","https://openalex.org/W2515617571","https://openalex.org/W2901956014"],"abstract_inverted_index":{"Hepatocellular":[0],"carcinoma":[1],"is":[2,10,33,145,154,173,181,202,220],"the":[3,19,56,68,85,101,125,192,212],"most":[4,20,86],"common":[5],"primary":[6],"liver":[7,90,108,128],"malignancy":[8],"and":[9,29,67,74,105,117,216],"an":[11,223],"international":[12,57],"public":[13],"health":[14],"concern,":[15],"constituting":[16],"one":[17],"of":[18,59,70,89,127,141,151,160,187,194,214,227],"deadly":[21],"cancers":[22],"worldwide.":[23],"Infection":[24],"with":[25,147,222],"hepatitis":[26,30],"B":[27],"virus":[28,32],"C":[31],"a":[34,121,148],"major":[35],"risk":[36,81,99,193,213,225],"factor":[37],"for":[38,83],"HCC":[39,161],"in":[40,203],"developed":[41],"countries.":[42],"Emerging":[43],"evidence":[44],"indicates":[45],"that":[46,53,135,156,169,201],"there":[47],"are":[48,76,163,170],"other":[49],"important":[50],"lifestyle":[51],"factors":[52,82],"contribute":[54],"to":[55,79,119,165,175],"burden":[58],"HCC,":[60,84,215],"such":[61],"as":[62],"alcohol":[63],"consumption,":[64],"diabetes,":[65],"obesity,":[66],"intake":[69,137],"aflotoxin-contaminated":[71],"food.":[72],"Obesity":[73],"diabetes":[75],"also":[77],"likely":[78],"be":[80],"frequent":[87],"subtype":[88],"cancer.":[91],"The":[92],"chief":[93],"pathway":[94],"by":[95],"which":[96,144],"obesity":[97,104],"increases":[98],"involves":[100],"association":[102],"between":[103],"nonalcoholic":[106],"fatty":[107,205],"disease":[109],"(NAFLD).":[110],"Coffee":[111],"consumption":[112],"has":[113],"been":[114],"studied":[115],"extensively":[116],"appears":[118],"have":[120],"favorable":[122],"effect":[123],"on":[124],"prevention":[126],"diseases,":[129],"including":[130],"HCC.":[131,152],"One":[132],"hypothesis":[133],"suggests":[134],"coffee":[136],"lowers":[138],"serum":[139],"levels":[140],"gamma-glutamyltransferase":[142],"(GGT),":[143],"associated":[146,221],"lower":[149],"incidence":[150],"It":[153,172],"estimated":[155],"more":[157],"than":[158],"80%":[159],"cases":[162],"attributable":[164],"four":[166],"principal":[167],"causes":[168],"avoidable.":[171],"difficult":[174],"make":[176],"dietary":[177,218],"recommendations,":[178],"because":[179],"it":[180],"unknown":[182],"whether":[183],"consuming":[184],"higher":[185],"amounts":[186],"specific":[188],"antioxidants":[189],"will":[190],"decrease":[191],"developing":[195],"hepatocellular":[196],"carcinoma.":[197],"A":[198],"diet":[199],"rich":[200],"polyunsaturated":[204],"acids":[206],"and,":[207],"possibly,":[208],"B-carotene":[209],"could":[210],"reduce":[211],"high":[217],"GL":[219],"increased":[224],"independently":[226],"cirrhosis":[228],"or":[229],"diabetes.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}