{"id":"https://openalex.org/W25226527","doi":"https://doi.org/10.21236/ada501177","title":"Aurora-A as a Modifier of Breast Cancer Risk in BRCA1/2 Mutation Carriers. Addendum","display_name":"Aurora-A as a Modifier of Breast Cancer Risk in BRCA1/2 Mutation Carriers. Addendum","publication_year":2008,"publication_date":"2008-06-01","ids":{"openalex":"https://openalex.org/W25226527","doi":"https://doi.org/10.21236/ada501177","mag":"25226527"},"language":"en","primary_location":{"id":"doi:10.21236/ada501177","doi":"https://doi.org/10.21236/ada501177","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada501177","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016908886","display_name":"Fergus J. Couch","orcid":"https://orcid.org/0000-0001-9417-9985","observed_orcids":["https://orcid.org/0000-0001-9417-9985"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fergus J. Couch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5016908886"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aurora-a-kinase","display_name":"AURKA","score":0.7990000247955322},{"id":"https://openalex.org/keywords/stk15","display_name":"STK15","score":0.9739999771118164},{"id":"https://openalex.org/keywords/brca1-mutation-carriers","display_name":"BRCA1 mutation carriers","score":0.9369999766349792},{"id":"https://openalex.org/keywords/brca2-mutation-carriers","display_name":"BRCA2 mutation carriers","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.972000002861023},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7049999833106995},{"id":"https://openalex.org/keywords/centrosome-amplification","display_name":"centrosome amplification","score":0.7960000038146973},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C2778945725","wikidata":"https://www.wikidata.org/wiki/Q352858","display_name":"Addendum","level":2,"score":0.950332760810852},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5899996757507324},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.481440007686615},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3823125958442688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3432426452636719},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34226831793785095},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2823934555053711},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22273188829421997},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.16891399025917053},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07763028144836426},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21236/ada501177","doi":"https://doi.org/10.21236/ada501177","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada501177","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W68280692","https://openalex.org/W2009759832","https://openalex.org/W1969592309","https://openalex.org/W1982140153","https://openalex.org/W2170345058","https://openalex.org/W7097149454","https://openalex.org/W7095883013","https://openalex.org/W2016722503","https://openalex.org/W2133218898","https://openalex.org/W2999761807"],"abstract_inverted_index":{"Abstract":[0],":":[1],"The":[2],"AURORA-A/BTAK/STK15":[3],"gene":[4,28],"encodes":[5],"a":[6],"centrosome-associated":[7],"kinase":[8],"that":[9,40,52,82],"causes":[10],"centrosome":[11],"amplification,":[12],"failure":[13],"of":[14,27,48,61,74,98,122,124,162],"cytokinesis,":[15],"and":[16,36,66,76,112,150],"aneuploidy":[17],"when":[18],"amplified":[19],"and/or":[20],"overexpressed":[21],"in":[22,44,64,101,107,146,165],"breast":[23,33,62,88,109,135,143,163],"tumors.":[24],"A":[25,120],"number":[26],"association":[29,96],"studies":[30],"using":[31],"matching":[32],"cancer":[34,63,89,110,136,144,164],"cases":[35,111],"controls":[37,114],"have":[38],"shown":[39],"the":[41,53,117],"F31I":[42,54,83],"polymorphism":[43,55],"STK15":[45],"increases":[46],"risk":[47,60,137,145,161],"breast.":[49],"We":[50],"hypothesized":[51],"is":[56],"associated":[57],"with":[58,128,134,142,160],"increased":[59],"BRCA1":[65,75,149],"BRCA2":[67,77,151,166],"mutation":[68,152,167],"carriers.":[69,153],"Using":[70],"over":[71],"7,000":[72],"carriers":[73,168],"deleterious":[78],"mutations":[79],"we":[80,93],"showed":[81],"has":[84],"no":[85],"influence":[86],"on":[87],"risk.":[90],"In":[91],"parallel,":[92],"completed":[94],"an":[95],"study":[97],"2400":[99],"polymorphisms":[100,126,131,155],"other":[102,130],"cell":[103],"division":[104],"regulatory":[105],"genes":[106],"800":[108,113],"collected":[115],"at":[116],"Mayo":[118],"Clinic.":[119],"total":[121],"52":[123],"these":[125],"along":[127],"332":[129],"displaying":[132,156],"associations":[133,141,158],"were":[138,169],"evaluated":[139],"for":[140],"approximately":[147],"5,400":[148],"Several":[154],"significant":[157],"(p<10-4)":[159],"observed.":[170]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
