{"id":"https://openalex.org/W2522493071","doi":"https://doi.org/10.1038/ncomms12887","title":"Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways","display_name":"Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways","publication_year":2016,"publication_date":"2016-09-21","ids":{"openalex":"https://openalex.org/W2522493071","doi":"https://doi.org/10.1038/ncomms12887","mag":"2522493071","pmid":"https://pubmed.ncbi.nlm.nih.gov/27650679","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5036006"},"language":"en","primary_location":{"id":"doi:10.1038/ncomms12887","doi":"https://doi.org/10.1038/ncomms12887","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms12887","pdf_url":"https://www.nature.com/articles/ncomms12887.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/ncomms12887.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022975919","display_name":"Ippei Kikuchi","orcid":"https://orcid.org/0009-0002-4946-4511","observed_orcids":["https://orcid.org/0009-0002-4946-4511"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ippei Kikuchi","raw_affiliation_strings":["Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101744623","display_name":"Atsushi Takahashi\u2010Kanemitsu","orcid":"https://orcid.org/0000-0002-4156-9522","observed_orcids":["https://orcid.org/0000-0002-4156-9522"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Takahashi-Kanemitsu","raw_affiliation_strings":["Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075845318","display_name":"Natsuki Sakiyama","orcid":"https://orcid.org/0000-0002-5040-9467","observed_orcids":["https://orcid.org/0000-0002-5040-9467"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Natsuki Sakiyama","raw_affiliation_strings":["Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091124184","display_name":"Chao Tang","orcid":"https://orcid.org/0000-0002-5072-5849","observed_orcids":["https://orcid.org/0000-0002-5072-5849"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chao Tang","raw_affiliation_strings":["Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077779945","display_name":"Pei-Jung Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Pei-Jung Tang","raw_affiliation_strings":["Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021468077","display_name":"Saori Noda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Saori Noda","raw_affiliation_strings":["Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113627059","display_name":"Kazuki Nakao","orcid":"https://orcid.org/0009-0001-5407-0819","observed_orcids":["https://orcid.org/0009-0001-5407-0819"]},"institutions":[{"id":"https://openalex.org/I4405287628","display_name":"Center for Disease Biology and Integrative Medicine, The University of Tokyo","ror":"https://ror.org/05py8r856","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287628","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuki Nakao","raw_affiliation_strings":["Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I4405287628","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064546848","display_name":"Hidetoshi Kassai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287628","display_name":"Center for Disease Biology and Integrative Medicine, The University of Tokyo","ror":"https://ror.org/05py8r856","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287628","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidetoshi Kassai","raw_affiliation_strings":["Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I4405287628","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011906232","display_name":"Toshiro Sato","orcid":"https://orcid.org/0000-0001-8353-8137","observed_orcids":["https://orcid.org/0000-0001-8353-8137"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiro Sato","raw_affiliation_strings":["Division of Gastroenterology, Keio University School of Medicine, Tokyo 108-8345, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Keio University School of Medicine, Tokyo 108-8345, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026554804","display_name":"Atsu Aiba","orcid":"https://orcid.org/0000-0002-8192-0778","observed_orcids":["https://orcid.org/0000-0002-8192-0778"]},"institutions":[{"id":"https://openalex.org/I4405287628","display_name":"Center for Disease Biology and Integrative Medicine, The University of Tokyo","ror":"https://ror.org/05py8r856","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287628","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsu Aiba","raw_affiliation_strings":["Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I4405287628","https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061468745","display_name":"Masanori Hatakeyama","orcid":"https://orcid.org/0000-0001-7517-2649","observed_orcids":["https://orcid.org/0000-0001-7517-2649"]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masanori Hatakeyama","raw_affiliation_strings":["CREST, Japan Science and Technology Agency, Saitama 332-0012, Japan","Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","Max Planck-The University of Tokyo Center for Integrative Inflammology, Tokyo 113-0033, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CREST, Japan Science and Technology Agency, Saitama 332-0012, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Max Planck-The University of Tokyo Center for Integrative Inflammology, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5061468745"],"corresponding_institution_ids":["https://openalex.org/I4210086780","https://openalex.org/I74801974"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":2.47,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.90006575,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"7","issue":"1","first_page":"12887","last_page":"12887"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.021199999377131462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parafibromin","display_name":"parafibromin","score":1.0},{"id":"https://openalex.org/keywords/paf-complex","display_name":"PAF complex","score":0.859000027179718},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.7369999885559082},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":1.0},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.9290000200271606},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.8619999885559082},{"id":"https://openalex.org/keywords/gli1","display_name":"Gli1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/notch-intracellular-domain","display_name":"Notch intracellular domain","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tyrosine-dephosphorylation","display_name":"tyrosine dephosphorylation","score":0.972000002861023},{"id":"https://openalex.org/keywords/shp2","display_name":"SHP2","score":0.9570000171661377},{"id":"https://openalex.org/keywords/signal-integration","display_name":"signal integration","score":0.7620000243186951},{"id":"https://openalex.org/keywords/intestinal-epithelium","display_name":"intestinal epithelium","score":0.8140000104904175},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.7917931079864502},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.757825493812561},{"id":"https://openalex.org/C2778386714","wikidata":"https://www.wikidata.org/wiki/Q417084","display_name":"Morphogen","level":3,"score":0.7140239477157593},{"id":"https://openalex.org/C2779933373","wikidata":"https://www.wikidata.org/wiki/Q14886430","display_name":"GLI1","level":4,"score":0.7061177492141724},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6530839204788208},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.6168285608291626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.522809624671936},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.4954584836959839},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.48607853055000305},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4512525796890259},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.4510183334350586},{"id":"https://openalex.org/C2775928862","wikidata":"https://www.wikidata.org/wiki/Q5282208","display_name":"Dishevelled","level":5,"score":0.4165398180484772},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3203597366809845},{"id":"https://openalex.org/C107300179","wikidata":"https://www.wikidata.org/wiki/Q41797887","display_name":"Frizzled","level":4,"score":0.2887806296348572},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.21966886520385742},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18872913718223572},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13531798124313354}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/ncomms12887","doi":"https://doi.org/10.1038/ncomms12887","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms12887","pdf_url":"https://www.nature.com/articles/ncomms12887.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmid:27650679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27650679","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5036006","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5036006/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12887","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/ncomms12887","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:656e488c9d224fa48eaa402ec5de0911","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/656e488c9d224fa48eaa402ec5de0911","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/ncomms12887","doi":"https://doi.org/10.1038/ncomms12887","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms12887","pdf_url":"https://www.nature.com/articles/ncomms12887.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1755844858","display_name":null,"funder_award_id":"25115010","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2087955445","display_name":"Analysis of mTOR signaling in central nervous systems","funder_award_id":"15K06701","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4434465379","display_name":"Induction of cardiovascular lesions by Helicobacter pylori","funder_award_id":"16K15273","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5730893317","display_name":"Mechanism of Hit-and-Run oncogenesis by the Helicobacter pylori CagA oncoprotein","funder_award_id":"16H06373","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G611038408","display_name":"\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u5206\u5b50\uff50\uff41\uff52\uff41\uff46\uff49\uff42\uff52\uff4f\uff4d\uff49\uff4e\u304c\u53f8\u308b\u8178\u7ba1\u4e0a\u76ae\u306e\u30b7\u30b0\u30ca\u30eb\u7d71\u5408\u5236\u5fa1\u6a5f\u69cb","funder_award_id":"16J02902","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6945890855","display_name":"Investigation of the medical/biological roles of the parafibromin functions regulated by SHP2 oncoprotein","funder_award_id":"15K18399","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2522493071.pdf","grobid_xml":"https://content.openalex.org/works/W2522493071.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1483496013","https://openalex.org/W1720193968","https://openalex.org/W1880466029","https://openalex.org/W1965157206","https://openalex.org/W1966731849","https://openalex.org/W1973472733","https://openalex.org/W1989379296","https://openalex.org/W1995060691","https://openalex.org/W1995572284","https://openalex.org/W1995745247","https://openalex.org/W1997801717","https://openalex.org/W1999330214","https://openalex.org/W2001780798","https://openalex.org/W2002513358","https://openalex.org/W2004823255","https://openalex.org/W2006419043","https://openalex.org/W2014963011","https://openalex.org/W2022052326","https://openalex.org/W2022137333","https://openalex.org/W2034559511","https://openalex.org/W2036599709","https://openalex.org/W2040397331","https://openalex.org/W2042082068","https://openalex.org/W2042742511","https://openalex.org/W2043880988","https://openalex.org/W2044821216","https://openalex.org/W2050307267","https://openalex.org/W2064815984","https://openalex.org/W2081080915","https://openalex.org/W2082126164","https://openalex.org/W2086669296","https://openalex.org/W2088342479","https://openalex.org/W2097901077","https://openalex.org/W2103045139","https://openalex.org/W2104330134","https://openalex.org/W2105719222","https://openalex.org/W2110386568","https://openalex.org/W2115054276","https://openalex.org/W2117513049","https://openalex.org/W2117692326","https://openalex.org/W2123477328","https://openalex.org/W2131004933","https://openalex.org/W2140632813","https://openalex.org/W2147139266","https://openalex.org/W2151507328","https://openalex.org/W2154861644","https://openalex.org/W2156632504","https://openalex.org/W2157071182","https://openalex.org/W2163571202","https://openalex.org/W2170039745","https://openalex.org/W2170536750","https://openalex.org/W2232994113","https://openalex.org/W2302318537","https://openalex.org/W2345629930","https://openalex.org/W2413587310","https://openalex.org/W6929598005"],"related_works":["https://openalex.org/W2004823255","https://openalex.org/W7213444413","https://openalex.org/W2786352386","https://openalex.org/W2014963011","https://openalex.org/W2520499607","https://openalex.org/W2022995924","https://openalex.org/W2034559511","https://openalex.org/W4239750117","https://openalex.org/W2809946522","https://openalex.org/W2109104650"],"abstract_inverted_index":{"Evolutionally":[0],"conserved":[1],"Wnt,":[2,125],"Hedgehog":[3],"(Hh)":[4],"and":[5,16,47,54,76,132],"Notch":[6,67,128],"morphogen":[7,138],"pathways":[8,139],"play":[9],"essential":[10],"roles":[11],"in":[12,57,110,144],"the":[13,40,66,113,118],"development,":[14],"homeostasis":[15],"pathogenesis":[17],"of":[18,39,52,74,83,108,117,124],"multicellular":[19],"organisms.":[20],"Nevertheless,":[21],"mechanisms":[22],"that":[23,35],"intracellularly":[24],"coordinate":[25],"these":[26,137],"signal":[27],"inputs":[28],"remain":[29],"poorly":[30],"understood.":[31],"Here":[32],"we":[33],"found":[34],"parafibromin,":[36],"a":[37,58,145],"component":[38],"PAF":[41],"complex,":[42],"competitively":[43],"interacts":[44],"with":[45],"\u03b2-catenin":[46],"Gli1,":[48],"thereby":[49],"potentiating":[50],"transactivation":[51],"Wnt-":[53,75],"Hh-target":[55],"genes":[56],"mutually":[59],"exclusive":[60],"manner.":[61,148],"Parafibromin":[62,130],"also":[63],"binds":[64],"to":[65],"intracellular":[68],"domain":[69],"(NICD),":[70],"enabling":[71],"concerted":[72],"activation":[73],"Notch-target":[77],"genes.":[78],"The":[79],"transcriptional":[80,142],"platform":[81],"function":[82],"parafibromin":[84,109],"is":[85,96],"potentiated":[86],"by":[87,91,98,102,136],"tyrosine":[88,99,146],"dephosphorylation,":[89],"mediated":[90,101],"SHP2":[92],"phosphatase,":[93],"while":[94],"it":[95],"attenuated":[97],"phosphorylation,":[100],"PTK6":[103],"kinase.":[104],"Consequently,":[105],"acute":[106],"loss":[107],"mice":[111],"disorganizes":[112],"normal":[114],"epithelial":[115],"architecture":[116],"intestine,":[119],"which":[120],"requires":[121],"coordinated":[122],"activation/inactivation":[123],"Hh":[126],"and/or":[127],"signalling.":[129],"integrates":[131],"converts":[133],"signals":[134],"conveyed":[135],"into":[140],"appropriate":[141],"outputs":[143],"phosphorylation/dephosphorylation-regulated":[147]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-09-30T00:00:00"}
