{"id":"https://openalex.org/W2522192589","doi":"https://doi.org/10.1093/carcin/bgw100","title":"Prevention of DNA damage in Barrett\u2019s esophageal cells exposed to acidic bile salts","display_name":"Prevention of DNA damage in Barrett\u2019s esophageal cells exposed to acidic bile salts","publication_year":2016,"publication_date":"2016-09-21","ids":{"openalex":"https://openalex.org/W2522192589","doi":"https://doi.org/10.1093/carcin/bgw100","mag":"2522192589","pmid":"https://pubmed.ncbi.nlm.nih.gov/27655834","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5137263"},"language":"en","primary_location":{"id":"doi:10.1093/carcin/bgw100","doi":"https://doi.org/10.1093/carcin/bgw100","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/bgw100","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5137263","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045669863","display_name":"Vikas Bhardwaj","orcid":"https://orcid.org/0000-0003-3364-8711","observed_orcids":["https://orcid.org/0000-0003-3364-8711"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I4210101790","display_name":"VA Tennessee Valley Healthcare System","ror":"https://ror.org/01c9rqr26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210112672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikas Bhardwaj","raw_affiliation_strings":["Department of Surgery","Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37212, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery","institution_ids":[]},{"raw_affiliation_string":"Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37212, USA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210101790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067438060","display_name":"An\u0111ela Horvat","orcid":"https://orcid.org/0000-0002-5771-2434","observed_orcids":["https://orcid.org/0000-0002-5771-2434"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andela Horvat","raw_affiliation_strings":["Department of Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087691796","display_name":"Olga Korolkova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olga Korolkova","raw_affiliation_strings":["Department of Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088878363","display_name":"Mary K. Washington","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary K. Washington","raw_affiliation_strings":["Department of Cancer Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001099941","display_name":"Wael M. El-Rifai","orcid":"https://orcid.org/0000-0003-2101-6098","observed_orcids":["https://orcid.org/0000-0003-2101-6098"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wael El-Rifai","raw_affiliation_strings":["Department of Cancer Biology and","Department of Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology and","institution_ids":[]},{"raw_affiliation_string":"Department of Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086468930","display_name":"Sergey Dikalov","orcid":"https://orcid.org/0000-0003-2976-6184","observed_orcids":["https://orcid.org/0000-0003-2976-6184"]},"institutions":[{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergey I. Dikalov","raw_affiliation_strings":["Division of Clinical Pharmacology, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I4390039299","https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032514998","display_name":"Alexander I. Zaika","orcid":"https://orcid.org/0000-0001-6760-2020","observed_orcids":["https://orcid.org/0000-0001-6760-2020"]},"institutions":[{"id":"https://openalex.org/I4210101790","display_name":"VA Tennessee Valley Healthcare System","ror":"https://ror.org/01c9rqr26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210112672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander I. Zaika","raw_affiliation_strings":["Department of Cancer Biology and","Department of Surgery","Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37212, USA, alex.zaika@vanderbilt.edu","Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37212, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology and","institution_ids":[]},{"raw_affiliation_string":"Department of Surgery","institution_ids":[]},{"raw_affiliation_string":"Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37212, USA, alex.zaika@vanderbilt.edu","institution_ids":["https://openalex.org/I4210101790"]},{"raw_affiliation_string":"Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37212, USA,","institution_ids":["https://openalex.org/I4210101790"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4835,"currency":"USD","value_usd":4835},"apc_paid":null,"fwci":1.2154,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.768176,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"37","issue":"12","first_page":"bgw100","last_page":"bgw100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/barrett-s-esophagus","display_name":"Barrett's esophagus","score":0.925000011920929},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8489999771118164},{"id":"https://openalex.org/keywords/gastroesophageal-reflux-disease","display_name":"gastroesophageal reflux disease","score":0.925000011920929},{"id":"https://openalex.org/keywords/esophageal-adenocarcinoma","display_name":"esophageal adenocarcinoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9909999966621399},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apocynin","display_name":"apocynin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.718999981880188},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.9660000205039978},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/p73","display_name":"p73","score":0.9729999899864197}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5634279251098633},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5068641304969788},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.502110481262207},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.46491318941116333},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4150298833847046},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32808631658554077},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32593464851379395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3026428520679474}],"mesh":[{"descriptor_ui":"D000098","descriptor_name":"Acetophenones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000143","descriptor_name":"Acids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005744","descriptor_name":"Gastric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019313","descriptor_name":"BRCA1 Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/carcin/bgw100","doi":"https://doi.org/10.1093/carcin/bgw100","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/bgw100","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4621234","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5137263","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27655834","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27655834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5137263","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5137263/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Text"},{"id":"pmh:oai:open-archive.highwire.org:carcin:37/12/1161","doi":null,"is_oa":false,"landing_page_url":"http://carcin.oxfordjournals.org/cgi/content/short/37/12/1161","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4621234","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5137263","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G103793021","display_name":null,"funder_award_id":"RO1 138833","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1300984159","display_name":null,"funder_award_id":"P30 CA 68485","funder_id":"https://openalex.org/F4320309601","funder_display_name":"Vanderbilt-Ingram Cancer Center"},{"id":"https://openalex.org/G2065299061","display_name":null,"funder_award_id":"IK6 BX003787","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4317142111","display_name":"The Molecular Functions of APE1 in Barrett's Tumorigenesis","funder_award_id":"R01CA206563","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5396406744","display_name":"Mechanisms of Tumorigenic Transformation of Barretts Esophagus","funder_award_id":"R01CA206564","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8616801171","display_name":null,"funder_award_id":"I01 BX002115","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G9000862353","display_name":"Molecular and Cellular Basis for Digestive Diseases","funder_award_id":"P30DK058404","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000880732","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA068485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309601","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/05dq2gs74"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W157953822","https://openalex.org/W1523650995","https://openalex.org/W1573413333","https://openalex.org/W1575933290","https://openalex.org/W1661423779","https://openalex.org/W1967288092","https://openalex.org/W1971114351","https://openalex.org/W1979082790","https://openalex.org/W1994429206","https://openalex.org/W1999600314","https://openalex.org/W2010154445","https://openalex.org/W2013557200","https://openalex.org/W2018334671","https://openalex.org/W2024455739","https://openalex.org/W2026007913","https://openalex.org/W2026108627","https://openalex.org/W2026203131","https://openalex.org/W2027040596","https://openalex.org/W2028190494","https://openalex.org/W2036509107","https://openalex.org/W2040143851","https://openalex.org/W2047841249","https://openalex.org/W2048303910","https://openalex.org/W2051590898","https://openalex.org/W2053552746","https://openalex.org/W2075008048","https://openalex.org/W2090423996","https://openalex.org/W2092362354","https://openalex.org/W2098391097","https://openalex.org/W2101769279","https://openalex.org/W2106244991","https://openalex.org/W2107465292","https://openalex.org/W2116337984","https://openalex.org/W2121640545","https://openalex.org/W2129139391","https://openalex.org/W2131301097","https://openalex.org/W2133939796","https://openalex.org/W2137879603","https://openalex.org/W2142180745","https://openalex.org/W2149892509","https://openalex.org/W2155763924","https://openalex.org/W2161446270","https://openalex.org/W2168544170","https://openalex.org/W2170048907","https://openalex.org/W4237619634","https://openalex.org/W6636848357"],"related_works":["https://openalex.org/W2292142818","https://openalex.org/W1971933415","https://openalex.org/W145470261","https://openalex.org/W2107511253","https://openalex.org/W2747010944","https://openalex.org/W2027040596","https://openalex.org/W3003346578","https://openalex.org/W1427873138","https://openalex.org/W2090423996","https://openalex.org/W2349624428"],"abstract_inverted_index":{"Esophageal":[0],"adenocarcinoma":[1],"(EA)":[2],"is":[3,19],"one":[4],"of":[5,58,82,101,137,174,187,193,202,210],"the":[6,11,145,170,190],"fastest":[7],"rising":[8],"tumors":[9],"in":[10,67,95,116,148],"USA.":[12],"The":[13],"major":[14],"risk":[15],"factor":[16],"for":[17,77,208],"EA":[18],"gastroesophageal":[20],"reflux":[21],"disease":[22],"(GERD).":[23],"During":[24],"GERD,":[25],"esophageal":[26,150],"cells":[27,69,84,151],"are":[28,52],"exposed":[29,70],"to":[30,44,56,71,85,90,99,143],"refluxate":[31],"which":[32,94,122],"contains":[33],"gastric":[34],"acid":[35],"frequently":[36],"mixed":[37],"with":[38],"duodenal":[39],"bile.":[40],"This":[41],"may":[42],"lead":[43],"mucosal":[45],"injury":[46],"and":[47,75,119,130,168,180,214],"Barrett's":[48],"metaplasia":[49],"(BE)":[50],"that":[51,108,163],"important":[53],"factors":[54],"contributing":[55],"development":[57],"EA.":[59],"In":[60],"this":[61],"study,":[62],"we":[63,140],"investigated":[64],"DNA":[65,92,153,171,212],"damage":[66,154,213],"BE":[68,83,175],"acidic":[72,86,109,157],"bile":[73,87,110,158],"salts":[74,88,111],"explored":[76],"potential":[78,200],"protective":[79,191],"strategies.":[80],"Exposure":[81],"led":[89],"significant":[91],"damage,":[93],"turn,":[96],"was":[97],"due":[98],"generation":[100,167],"reactive":[102],"oxygen":[103],"species":[104],"(ROS).":[105],"We":[106,177],"found":[107],"induce":[112],"a":[113,135],"rapid":[114],"increase":[115],"superoxide":[117],"radicals":[118],"hydrogen":[120],"peroxide,":[121],"were":[123],"determined":[124],"using":[125],"electron":[126],"paramagnetic":[127],"resonance":[128],"spectroscopy":[129],"Amplex":[131],"Red":[132],"assay.":[133],"Analyzing":[134],"panel":[136],"natural":[138,203],"antioxidants,":[139],"identified":[141,178],"apocynin":[142,164,184,207],"be":[144],"most":[146],"effective":[147],"protecting":[149],"from":[152],"induced":[155],"by":[156],"salts.":[159],"Mechanistic":[160],"analyses":[161],"showed":[162],"inhibited":[165,189],"ROS":[166],"increases":[169],"repair":[172],"capacity":[173],"cells.":[176],"BRCA1":[179],"p73":[181,188],"proteins":[182],"as":[183,206],"targets.":[185],"Downregulation":[186],"effect":[192],"apocynin.":[194],"Taken":[195],"together,":[196],"our":[197],"results":[198],"suggest":[199],"application":[201],"compounds":[204],"such":[205],"prevention":[209],"reflux-induced":[211],"GERD-associated":[215],"tumorigenesis.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-09-30T00:00:00"}
