{"id":"https://openalex.org/W2521995441","doi":"https://doi.org/10.1097/pcc.0000000000000955","title":"Antithrombin Concentrate Use in Pediatric Extracorporeal Membrane Oxygenation: A Multicenter Cohort Study*","display_name":"Antithrombin Concentrate Use in Pediatric Extracorporeal Membrane Oxygenation: A Multicenter Cohort Study*","publication_year":2016,"publication_date":"2016-09-23","ids":{"openalex":"https://openalex.org/W2521995441","doi":"https://doi.org/10.1097/pcc.0000000000000955","mag":"2521995441","pmid":"https://pubmed.ncbi.nlm.nih.gov/27662567"},"language":"en","primary_location":{"id":"doi:10.1097/pcc.0000000000000955","doi":"https://doi.org/10.1097/pcc.0000000000000955","is_oa":false,"landing_page_url":"https://doi.org/10.1097/pcc.0000000000000955","pdf_url":null,"source":{"id":"https://openalex.org/S180821644","display_name":"Pediatric Critical Care Medicine","issn_l":"1529-7535","issn":["1529-7535","1947-3893"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Critical Care Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027246053","display_name":"Trisha E. Wong","orcid":"https://orcid.org/0000-0002-5298-6217","observed_orcids":["https://orcid.org/0000-0002-5298-6217"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trisha E. Wong","raw_affiliation_strings":["Division of Hematology/Oncology, Departments of Pediatrics and Pathology, Oregon Health and Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Departments of Pediatrics and Pathology, Oregon Health and Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104036023","display_name":"Thuan Doan Nguyen","orcid":"https://orcid.org/0009-0003-2386-395X","observed_orcids":["https://orcid.org/0009-0003-2386-395X","https://orcid.org/0009-0005-6606-3690"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thuan Nguyen","raw_affiliation_strings":["Department of Public Health & Preventive Medicine, Biostatistics & Design Program, Oregon Health and Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health & Preventive Medicine, Biostatistics & Design Program, Oregon Health and Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027203858","display_name":"Samir S. Shah","orcid":"https://orcid.org/0000-0001-7902-7000","observed_orcids":["https://orcid.org/0000-0001-7902-7000"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samir S. Shah","raw_affiliation_strings":["Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045478368","display_name":"Thomas V. Brogan","orcid":"https://orcid.org/0000-0002-8424-0831","observed_orcids":["https://orcid.org/0000-0002-8424-0831","https://orcid.org/0000-0001-8315-8337"]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas V. Brogan","raw_affiliation_strings":["Division of Critical Care, Department of Pediatrics, Seattle Children\u2019s Hospital, University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Critical Care, Department of Pediatrics, Seattle Children\u2019s Hospital, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I1295499534","https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064630175","display_name":"Char M. Witmer","orcid":"https://orcid.org/0000-0002-9551-4068","observed_orcids":["https://orcid.org/0000-0002-9551-4068"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Char M. Witmer","raw_affiliation_strings":["Division of Hematology, Department of Pediatrics, The Children\u2019s Hospital of Philadelphia, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Pediatrics, The Children\u2019s Hospital of Philadelphia, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0478,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.91118501,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"17","issue":"12","first_page":"1170","last_page":"1178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antithrombin-concentrate","display_name":"antithrombin III concentrate","score":0.9919999837875366},{"id":"https://openalex.org/keywords/extracorporeal-membrane-oxygenation","display_name":"extracorporeal membrane oxygenation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/pediatric-ecmo","display_name":"pediatric ECMO","score":0.777999997138977},{"id":"https://openalex.org/keywords/thrombotic-complications","display_name":"thrombotic complications","score":0.8579999804496765},{"id":"https://openalex.org/keywords/bleeding-complications","display_name":"bleeding complications","score":0.9929999709129333},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.7229999899864197},{"id":"https://openalex.org/keywords/in-hospital-mortality","display_name":"in-hospital mortality","score":0.9729999899864197},{"id":"https://openalex.org/keywords/chronic-disease","display_name":"chronic disease","score":0.3059999942779541},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.5789999961853027},{"id":"https://openalex.org/keywords/pediatric-health-information-system","display_name":"Pediatric Health Information System","score":0.5479999780654907},{"id":"https://openalex.org/keywords/children-s-hospitals","display_name":"children's hospitals","score":0.5839999914169312},{"id":"https://openalex.org/keywords/ecmo-weaning","display_name":"ECMO weaning","score":0.335999995470047},{"id":"https://openalex.org/keywords/ecmo-weaning-failure","display_name":"ECMO weaning failure","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C2776858399","wikidata":"https://www.wikidata.org/wiki/Q1385195","display_name":"Extracorporeal membrane oxygenation","level":2,"score":0.9524347186088562},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9495092630386353},{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.7585864067077637},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6680737733840942},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6167519092559814},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4833216667175293},{"id":"https://openalex.org/C2780820407","wikidata":"https://www.wikidata.org/wiki/Q6815136","display_name":"Membrane oxygenator","level":3,"score":0.42332208156585693},{"id":"https://openalex.org/C2779915274","wikidata":"https://www.wikidata.org/wiki/Q1115882","display_name":"Extracorporeal","level":2,"score":0.4225511848926544},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4181179106235504},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.37678009271621704},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3739039897918701},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37329936027526855},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.2667480707168579}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000991","descriptor_name":"Antithrombins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000991","descriptor_name":"Antithrombins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006776","descriptor_name":"Hospitals, Pediatric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007902","descriptor_name":"Length of Stay","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015199","descriptor_name":"Extracorporeal Membrane Oxygenation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017052","descriptor_name":"Hospital Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/pcc.0000000000000955","doi":"https://doi.org/10.1097/pcc.0000000000000955","is_oa":false,"landing_page_url":"https://doi.org/10.1097/pcc.0000000000000955","pdf_url":null,"source":{"id":"https://openalex.org/S180821644","display_name":"Pediatric Critical Care Medicine","issn_l":"1529-7535","issn":["1529-7535","1947-3893"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Critical Care Medicine","raw_type":"journal-article"},{"id":"pmid:27662567","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27662567","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2044738848","display_name":"Career Development in Clinical Hematology","funder_award_id":"K12HL087165","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8228210758","display_name":"VWF Multimer Distribution a Phenotypic Modifier of Hemophilia A","funder_award_id":"K23HL107455","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W15974371","https://openalex.org/W92400338","https://openalex.org/W141661929","https://openalex.org/W208593668","https://openalex.org/W1536230526","https://openalex.org/W1755677376","https://openalex.org/W1921148719","https://openalex.org/W1968334582","https://openalex.org/W1970982032","https://openalex.org/W1973245840","https://openalex.org/W1997057722","https://openalex.org/W2014129146","https://openalex.org/W2014851914","https://openalex.org/W2022557563","https://openalex.org/W2023649470","https://openalex.org/W2025715713","https://openalex.org/W2037530815","https://openalex.org/W2039221725","https://openalex.org/W2039675428","https://openalex.org/W2073934951","https://openalex.org/W2077920169","https://openalex.org/W2079260184","https://openalex.org/W2079275927","https://openalex.org/W2082416969","https://openalex.org/W2085519728","https://openalex.org/W2095754613","https://openalex.org/W2112446953","https://openalex.org/W2112733348","https://openalex.org/W2129427821","https://openalex.org/W2136732402","https://openalex.org/W2151884845","https://openalex.org/W2165627064","https://openalex.org/W2324513058","https://openalex.org/W2333123664","https://openalex.org/W4385345748"],"related_works":["https://openalex.org/W3041695635","https://openalex.org/W2014129146","https://openalex.org/W2548312975","https://openalex.org/W6998647296","https://openalex.org/W2559830868","https://openalex.org/W2949290351","https://openalex.org/W4323533039","https://openalex.org/W2073934951","https://openalex.org/W2611899567","https://openalex.org/W7125392525"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"describe":[2],"antithrombin":[3,75,84,145,174,202,270,327],"concentrate":[4],"use":[5,153,203],"and":[6,10,67,109,127,192,229,281,287,304,334],"to":[7,55,106,122,161,339],"compare":[8],"thrombotic":[9,110,207,280],"hemorrhagic":[11,108,218,282],"outcomes":[12],"throughout":[13,284],"the":[14,167,285,311],"hospital":[15,194,231],"stay":[16,126],"in":[17,25,44,249,296],"pediatric":[18,318],"subjects":[19,137,267],"who":[20,60,172,268],"received":[21,78,139,173,269],"extracorporeal":[22,62,87,148,155,177,272,321],"membrane":[23,63,88,149,156,178,273,322],"oxygenation":[24,64,150,157,179,274,323],"a":[26,276,344],"Pediatric":[27,45,115],"Health":[28,46,116],"Information":[29,47,117],"System-participating":[30],"children's":[31,41],"hospital.":[32],"DESIGN:":[33],"Retrospective,":[34],"multi-center,":[35],"cohort":[36,265],"study.":[37],"SETTING:":[38],"Forty-three":[39],"free-standing":[40],"hospitals":[42],"participating":[43],"System.":[48],"SUBJECTS:":[49],"Children":[50],"older":[51],"than":[52],"or":[53],"equal":[54],"18":[56],"years":[57],"of":[58,83,96,125,132,134,144,233,279,290,317],"age":[59],"underwent":[61],"between":[65],"2003":[66],"2012.":[68],"INTERVENTIONS:":[69],"Subjects":[70,171],"were":[71,104,120,180],"classified":[72],"as":[73],"receiving":[74,326],"if":[76],"they":[77],"at":[79,140],"least":[80,141],"one":[81,142],"dose":[82,143],"while":[85,175],"on":[86,176,320],"oxygenation.":[89],"MEASUREMENTS":[90],"AND":[91],"MAIN":[92],"RESULTS:":[93],"International":[94],"Classification":[95],"Diseases,":[97],"Ninth":[98],"Revision,":[99],"Clinical":[100],"Modification":[101],"codes":[102,103],"used":[105],"identify":[107],"complications":[111],"during":[112,146,154,271],"their":[113,147],"hospitalization.":[114],"System":[118],"data":[119],"analyzed":[121],"determine":[123],"hospital-length":[124],"in-hospital":[128],"mortality.":[129,297],"A":[130],"total":[131],"1,931":[133],"8,601":[135],"eligible":[136],"(21.5%)":[138],"course.":[151],"Antithrombin":[152],"increased":[158],"from":[159],"2.4%":[160],"51.9%":[162],"(p":[163,182,189,196],"<":[164,190,197,216,227,243],"0.001)":[165],"over":[166,315],"10-year":[168],"study":[169],"period.":[170],"younger":[181],"=":[183,258],"0.02),":[184],"had":[185,275],"more":[186],"chronic":[187],"conditions":[188],"0.001),":[191,217,228],"longer":[193,230,288],"stays":[195,234,291],"0.001).":[198,244],"On":[199],"multivariate":[200],"analysis,":[201],"was":[204,247],"associated":[205,294],"with":[206,301,309,331],"events":[208,219,283],"(odds":[209,220,251],"ratio,":[210,221,252],"1.55;":[211],"95%":[212,223,239,254],"CI,":[213,224,240,255],"1.36-1.77;":[214],"p":[215,226,242,257],"1.27;":[222],"1.14-1.42;":[225],"length":[232,289],"(slope":[235],"coefficient,":[236],"1.05":[237],"d;":[238],"1.04-1.06;":[241],"No":[245],"difference":[246,295],"observed":[248],"mortality":[250],"0.99;":[253],"0.89-1.11;":[256],"0.90).":[259],"CONCLUSIONS:":[260],"In":[261],"this":[262,302],"multicenter":[263],"retrospective":[264],"study,":[266],"higher":[277],"number":[278],"hospitalization":[286],"without":[292,328],"an":[293],"While":[298],"limitations":[299],"exist":[300],"analysis":[303],"results":[305],"should":[306],"be":[307,340],"interpreted":[308],"caution,":[310],"fact":[312],"remains":[313],"that":[314],"half":[316],"patients":[319],"are":[324],"currently":[325],"clear":[329],"benefit,":[330],"extra":[332],"cost,":[333],"potential":[335],"harms,":[336],"there":[337],"needs":[338],"strong":[341],"consideration":[342],"for":[343],"clinical":[345],"trial.":[346]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-09-30T00:00:00"}