{"id":"https://openalex.org/W2521555893","doi":"https://doi.org/10.1177/1535370216670541","title":"Tissue transglutaminase-1 promotes stemness and chemoresistance in gastric cancer cells by regulating Wnt/\u03b2-catenin signaling","display_name":"Tissue transglutaminase-1 promotes stemness and chemoresistance in gastric cancer cells by regulating Wnt/\u03b2-catenin signaling","publication_year":2016,"publication_date":"2016-09-22","ids":{"openalex":"https://openalex.org/W2521555893","doi":"https://doi.org/10.1177/1535370216670541","mag":"2521555893","pmid":"https://pubmed.ncbi.nlm.nih.gov/27660242","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5167122"},"language":"en","primary_location":{"id":"doi:10.1177/1535370216670541","doi":"https://doi.org/10.1177/1535370216670541","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1535370216670541","pdf_url":null,"source":{"id":"https://openalex.org/S67514239","display_name":"Experimental Biology and Medicine","issn_l":"0071-3384","issn":["0071-3384","1535-3699","1535-3702"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5167122","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004720105","display_name":"Haitao Huang","orcid":"https://orcid.org/0000-0002-2396-4959","observed_orcids":["https://orcid.org/0000-0002-2396-4959"]},"institutions":[{"id":"https://openalex.org/I4210105529","display_name":"Daqing Oilfield General Hospital","ror":"https://ror.org/01ey7we33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105529"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haitao Huang","raw_affiliation_strings":["Department of General Surgery, Oilfield General Hospital of Daqing, Daqing 163001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Oilfield General Hospital of Daqing, Daqing 163001, China","institution_ids":["https://openalex.org/I4210105529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101784639","display_name":"Zhiqi Chen","orcid":"https://orcid.org/0000-0002-8322-9913","observed_orcids":["https://orcid.org/0000-0002-8322-9913"]},"institutions":[{"id":"https://openalex.org/I4210105529","display_name":"Daqing Oilfield General Hospital","ror":"https://ror.org/01ey7we33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105529"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiqi Chen","raw_affiliation_strings":["Department of General Surgery, Oilfield General Hospital of Daqing, Daqing 163001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Oilfield General Hospital of Daqing, Daqing 163001, China","institution_ids":["https://openalex.org/I4210105529"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034094327","display_name":"Xiuqin Ni","orcid":"https://orcid.org/0000-0003-4143-7711","observed_orcids":["https://orcid.org/0000-0003-4143-7711"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiuqin Ni","raw_affiliation_strings":["Department of Anatomy, Harbin Medical University-Daqing, Daqing 163319, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Harbin Medical University-Daqing, Daqing 163319, China","institution_ids":["https://openalex.org/I156144747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034094327"],"corresponding_institution_ids":["https://openalex.org/I156144747"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":null,"fwci":0.9966,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.75129908,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"242","issue":"2","first_page":"194","last_page":"202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.43140000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.43140000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.3296000063419342,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.1949000060558319,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.8199999928474426},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9929999709129333},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.6959999799728394},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8449169397354126},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.7683607935905457},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6773942112922668},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5866585969924927},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5477830171585083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49654561281204224},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4449630081653595},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4376756250858307},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.437367707490921},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34403592348098755},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32444900274276733},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30043041706085205},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19384923577308655},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11939546465873718}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011503","descriptor_name":"Transglutaminases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011503","descriptor_name":"Transglutaminases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1177/1535370216670541","doi":"https://doi.org/10.1177/1535370216670541","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1535370216670541","pdf_url":null,"source":{"id":"https://openalex.org/S67514239","display_name":"Experimental Biology and Medicine","issn_l":"0071-3384","issn":["0071-3384","1535-3699","1535-3702"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Biology and Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5167122","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5167122","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Biol Med (Maywood)","raw_type":"Text"},{"id":"pmid:27660242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27660242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental biology and medicine (Maywood, N.J.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5167122","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5167122","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Biol Med (Maywood)","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W28799811","https://openalex.org/W1003261060","https://openalex.org/W1067939983","https://openalex.org/W1135170528","https://openalex.org/W1868060543","https://openalex.org/W1928455777","https://openalex.org/W1975988029","https://openalex.org/W1976629146","https://openalex.org/W1976681308","https://openalex.org/W1980175613","https://openalex.org/W1989768508","https://openalex.org/W2002120623","https://openalex.org/W2006239354","https://openalex.org/W2007796044","https://openalex.org/W2015779044","https://openalex.org/W2029657029","https://openalex.org/W2050325712","https://openalex.org/W2062111689","https://openalex.org/W2064044053","https://openalex.org/W2071018297","https://openalex.org/W2078531409","https://openalex.org/W2092125592","https://openalex.org/W2093531978","https://openalex.org/W2095512379","https://openalex.org/W2095643532","https://openalex.org/W2100545793","https://openalex.org/W2104287126","https://openalex.org/W2106787323","https://openalex.org/W2119028086","https://openalex.org/W2126351542","https://openalex.org/W2138933179","https://openalex.org/W2143202717","https://openalex.org/W2154473845","https://openalex.org/W2171313654","https://openalex.org/W2289523148","https://openalex.org/W2294359435","https://openalex.org/W2306507104","https://openalex.org/W2317477512","https://openalex.org/W2917837889","https://openalex.org/W4211113621"],"related_works":["https://openalex.org/W4308678736","https://openalex.org/W4293375802","https://openalex.org/W4379011664","https://openalex.org/W2804223208","https://openalex.org/W2044821216","https://openalex.org/W2053363358","https://openalex.org/W4416061155","https://openalex.org/W2119540244","https://openalex.org/W6958716552","https://openalex.org/W2356227542"],"abstract_inverted_index":{"Gastric":[0],"cancer":[1,15,44,76,81,96,112,134,151,166],"is":[2,7],"a":[3,170],"common":[4],"malignancy,":[5],"and":[6,33,78,83,105,118],"one":[8],"of":[9,14,20,36,41,57,61,69,99,127,132,144,146,161,173],"the":[10,21,31,39,55,125,130,142,155],"most":[11],"frequent":[12],"causes":[13],"deaths":[16],"worldwide.":[17],"Recently,":[18],"members":[19],"transglutaminases":[22],"(TGM)":[23],"family,":[24],"especially":[25],"TGM2,":[26],"have":[27],"been":[28,47],"implicated":[29],"in":[30,43,59,73,129,148,164],"progression":[32],"drug":[34],"resistance":[35],"cancers,":[37],"but":[38],"function":[40],"TGM1":[42,58,70,85,100,128,147,162],"development":[45,60],"has":[46],"largely":[48],"overlooked.":[49],"In":[50,93,136],"this":[51],"study,":[52],"we":[53,138],"demonstrate":[54],"roles":[56],"gastric":[62,75,80,95,111,133,150,165],"cancer.":[63],"We":[64],"found":[65,139],"that":[66,84,141],"expression":[67,86,101,163],"levels":[68,87],"were":[71,88],"upregulated":[72],"both":[74],"tissues":[77],"cultured":[79,94],"cells,":[82,97],"correlated":[89],"with":[90],"patient":[91],"survival.":[92],"loss":[98,160],"inhibited":[102],"cell":[103,113,152],"proliferation":[104],"promoted":[106],"apoptosis,":[107],"as":[108,159],"well":[109],"increased":[110],"sensitivity":[114],"to":[115,169],"chemotherapeutic":[116],"drugs":[117],"reducing":[119],"stemness.":[120],"These":[121],"results":[122],"strongly":[123],"supported":[124],"participation":[126],"regulation":[131],"development.":[135],"addition,":[137],"evidence":[140],"mechanism":[143],"action":[145],"regulating":[149],"might":[153],"involve":[154],"Wnt":[156,174],"signaling":[157,175],"pathway,":[158],"cells":[167],"led":[168],"significant":[171],"suppression":[172],"activities.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-09-30T00:00:00"}
