{"id":"https://openalex.org/W2521117217","doi":null,"title":"SUMO-1 mapping in the human genome and its implications for transcription control","display_name":"SUMO-1 mapping in the human genome and its implications for transcription control","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2521117217","mag":"2521117217"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:osu1397218712","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1397218712","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1397218712","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1397218712","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1397218712","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050938121","display_name":"Huiwen Liu","orcid":"https://orcid.org/0000-0001-5424-2628","observed_orcids":["https://orcid.org/0000-0001-5424-2628"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Huiwen Liu","raw_affiliation_strings":["the Ohio State University"],"raw_orcid":"https://orcid.org/0000-0001-5424-2628","affiliations":[{"raw_affiliation_string":"the Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050938121"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23709959,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.05820000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0272000003606081,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sumo1","display_name":"SUMO1","score":0.996999979019165},{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.847000002861023},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.527999997138977},{"id":"https://openalex.org/keywords/chromatin","display_name":"chromatin","score":0.5820000171661377},{"id":"https://openalex.org/keywords/proximal-promoter","display_name":"proximal promoter","score":0.7160000205039978},{"id":"https://openalex.org/keywords/housekeeping-genes","display_name":"housekeeping genes","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cajal-bodies","display_name":"Cajal bodies","score":0.9539999961853027},{"id":"https://openalex.org/keywords/transcription-initiation","display_name":"transcription initiation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/rna-processing","display_name":"RNA processing","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5399821400642395},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.5284613966941833},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5181766748428345},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49770453572273254},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4518328905105591},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4458782374858856},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3331753611564636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.296841561794281},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.10403767228126526},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:osu1397218712","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1397218712","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1397218712","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1397218712","raw_type":"text"},{"id":"mag:2521117217","doi":null,"is_oa":false,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1397218712","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:osu1397218712","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1397218712","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1397218712","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1397218712","raw_type":"text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2521117217.pdf","grobid_xml":"https://content.openalex.org/works/W2521117217.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2160955607","https://openalex.org/W7096185360","https://openalex.org/W2008260297","https://openalex.org/W1964675354","https://openalex.org/W2068342722","https://openalex.org/W2321166314","https://openalex.org/W3016501695","https://openalex.org/W2149065115","https://openalex.org/W2014530773","https://openalex.org/W2913922522"],"abstract_inverted_index":{"SUMOylation":[0],"is":[1,8],"a":[2,12,22],"post-translational":[3],"modification":[4,117],"in":[5,18,36],"which":[6,109],"SUMO":[7,69],"covalently":[9],"conjugated":[10],"to":[11,67,75],"variety":[13],"of":[14,21,24,32,51,53,101,106,118,129],"proteins":[15],"that":[16,42,85,99,131],"results":[17],"the":[19,37,47,54,72,79,88,91,104,119],"regulation":[20],"range":[23],"cellular":[25],"processes":[26],"including":[27],"cell":[28],"proliferation":[29],"and":[30,78,116,121,135],"maintenance":[31],"genome":[33],"stability.As":[34],"described":[35],"previous":[38],"chapter,":[39,62],"we":[40,63],"found":[41,84,98,125],"SUMO-1":[43,86],"marks":[44,87],"chromatin":[45,73],"at":[46],"proximal":[48],"promoter":[49],"regions":[50],"some":[52],"most":[55],"active":[56],"housekeeping":[57],"genes":[58],"during":[59],"interphase.In":[60],"this":[61],"show":[64],"our":[65],"work":[66],"identify":[68],"substrates":[70],"on":[71,81],"bound":[74],"these":[76],"promoters":[77,89],"effect":[80],"transcription":[82,133],"regulation.We":[83],"via":[90],"Scaffold":[92],"Associated":[93],"Factor":[94],"B":[95],"(SAFB)":[96],"protein.We":[97],"depletion":[100],"SAFB":[102,130],"disrupted":[103],"organization":[105],"Cajal":[107],"body,":[108],"plays":[110],"an":[111,126],"important":[112],"role":[113,128],"for":[114],"assembly":[115],"nuclear-transcription":[120],"RNA-processing":[122],"machinery.This":[123],"study":[124],"unexpected":[127],"coupling":[132],"initiation":[134],"RNA":[136],"processing":[137],"process.":[138]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2016-09-30T00:00:00"}