{"id":"https://openalex.org/W2520537726","doi":"https://doi.org/10.1136/gutjnl-2016-312423","title":"Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling","display_name":"Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling","publication_year":2016,"publication_date":"2016-09-15","ids":{"openalex":"https://openalex.org/W2520537726","doi":"https://doi.org/10.1136/gutjnl-2016-312423","mag":"2520537726","pmid":"https://pubmed.ncbi.nlm.nih.gov/27633923"},"language":"en","primary_location":{"id":"doi:10.1136/gutjnl-2016-312423","doi":"https://doi.org/10.1136/gutjnl-2016-312423","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gutjnl-2016-312423","pdf_url":"https://gut.bmj.com/content/gutjnl/66/3/473.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://gut.bmj.com/content/gutjnl/66/3/473.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011815129","display_name":"Meike Hohwieler","orcid":"https://orcid.org/0000-0002-0640-0764","observed_orcids":["https://orcid.org/0000-0002-0640-0764"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Meike Hohwieler","raw_affiliation_strings":["Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035242045","display_name":"Anett Illing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anett Illing","raw_affiliation_strings":["Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056191434","display_name":"Patrick Christian Hermann","orcid":"https://orcid.org/0000-0003-0418-0478","observed_orcids":["https://orcid.org/0000-0003-0418-0478"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Patrick C Hermann","raw_affiliation_strings":["Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006412078","display_name":"Tobias Mayer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Mayer","raw_affiliation_strings":["Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042302434","display_name":"Marianne Stockmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marianne Stockmann","raw_affiliation_strings":["Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034891779","display_name":"Lukas Perkhofer","orcid":"https://orcid.org/0000-0003-0484-0974","observed_orcids":["https://orcid.org/0000-0003-0484-0974"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lukas Perkhofer","raw_affiliation_strings":["Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080401180","display_name":"Tim Eiseler","orcid":"https://orcid.org/0000-0001-7819-4659","observed_orcids":["https://orcid.org/0000-0001-7819-4659"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tim Eiseler","raw_affiliation_strings":["Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091877687","display_name":"Justin S. Antony","orcid":"https://orcid.org/0000-0003-1241-2013","observed_orcids":["https://orcid.org/0000-0003-1241-2013","https://orcid.org/0000-0001-6603-5853"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Justin S Antony","raw_affiliation_strings":["Department of Pediatrics I, Pediatric Infectiology and Immunology, Translational Genomics and Gene Therapy in Pediatrics, University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics I, Pediatric Infectiology and Immunology, Translational Genomics and Gene Therapy in Pediatrics, University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Martin M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin M\u00fcller","raw_affiliation_strings":["Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Susanne Renz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susanne Renz","raw_affiliation_strings":["Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081112159","display_name":"Chao\u2010Chung Kuo","orcid":"https://orcid.org/0000-0001-8879-4754","observed_orcids":["https://orcid.org/0000-0001-8879-4754"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Chao-Chung Kuo","raw_affiliation_strings":["Medical Faculty, IZKF Computational Biology Research Group, RWTH Aachen University, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty, IZKF Computational Biology Research Group, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066373718","display_name":"Qiong Lin","orcid":"https://orcid.org/0000-0002-7964-6191","observed_orcids":["https://orcid.org/0000-0002-7964-6191"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Qiong Lin","raw_affiliation_strings":["Medical Faculty, Department of Cell Biology, Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty, Department of Cell Biology, Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054632336","display_name":"Matthias Sendler","orcid":"https://orcid.org/0000-0003-3554-9426","observed_orcids":["https://orcid.org/0000-0003-3554-9426","https://orcid.org/0000-0001-9860-2007"]},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Sendler","raw_affiliation_strings":["Department of Medicine A, University Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine A, University Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany","institution_ids":["https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002756320","display_name":"Markus Breunig","orcid":"https://orcid.org/0000-0002-2817-1974","observed_orcids":["https://orcid.org/0000-0002-2817-1974"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Breunig","raw_affiliation_strings":["Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010250584","display_name":"Susanne Kleiderman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susanne M Kleiderman","raw_affiliation_strings":["Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086342180","display_name":"Andr\u00e9 Lechel","orcid":"https://orcid.org/0000-0003-0221-6959","observed_orcids":["https://orcid.org/0000-0003-0221-6959"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Lechel","raw_affiliation_strings":["Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019664227","display_name":"Martin Zenker","orcid":"https://orcid.org/0000-0003-1618-9269","observed_orcids":["https://orcid.org/0000-0003-1618-9269"]},"institutions":[{"id":"https://openalex.org/I4210138551","display_name":"University Hospital Magdeburg","ror":"https://ror.org/03m04df46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138551"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Zenker","raw_affiliation_strings":["Institute of Human Genetics, University Hospital, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Genetics, University Hospital, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210138551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086605508","display_name":"Michael Leichsenring","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Leichsenring","raw_affiliation_strings":["Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056862255","display_name":"Jonas Rosendahl","orcid":"https://orcid.org/0000-0003-4513-0506","observed_orcids":["https://orcid.org/0000-0003-4513-0506"]},"institutions":[{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jonas Rosendahl","raw_affiliation_strings":["Department of Internal Medicine I, Division of Medicine, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, Division of Medicine, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany","institution_ids":["https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004290451","display_name":"Martin Zenke","orcid":"https://orcid.org/0000-0002-1107-3251","observed_orcids":["https://orcid.org/0000-0002-1107-3251"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Zenke","raw_affiliation_strings":["Medical Faculty, Department of Cell Biology, Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty, Department of Cell Biology, Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031406092","display_name":"Bruno S\u00e1inz","orcid":"https://orcid.org/0000-0003-4829-7651","observed_orcids":["https://orcid.org/0000-0003-4829-7651"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210091816","display_name":"Instituto de Investigaciones Biom\u00e9dicas Sols-Morreale","ror":"https://ror.org/00ha1f767","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210091816","https://openalex.org/I63634437"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Bruno Sainz","raw_affiliation_strings":["Department of Biochemistry, Universidad Aut\u00f3noma de Madrid, Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols\u201d CSIC-UAM, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Universidad Aut\u00f3noma de Madrid, Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols\u201d CSIC-UAM, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210091816","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008677072","display_name":"Julia V. Mayerle","orcid":"https://orcid.org/0000-0002-3666-6459","observed_orcids":["https://orcid.org/0000-0002-3666-6459"]},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Mayerle","raw_affiliation_strings":["Department of Medicine A, University Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine A, University Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany","institution_ids":["https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057250270","display_name":"Ivan G. Costa","orcid":"https://orcid.org/0000-0003-2890-8697","observed_orcids":["https://orcid.org/0000-0003-2890-8697"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ivan G Costa","raw_affiliation_strings":["Medical Faculty, IZKF Computational Biology Research Group, RWTH Aachen University, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty, IZKF Computational Biology Research Group, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062163674","display_name":"Thomas Theodor Werner Seufferlein","orcid":"https://orcid.org/0000-0003-3259-0810","observed_orcids":["https://orcid.org/0000-0003-3259-0810"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Seufferlein","raw_affiliation_strings":["Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051594346","display_name":"Michael Kormann","orcid":"https://orcid.org/0000-0003-3492-0393","observed_orcids":["https://orcid.org/0000-0003-3492-0393"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Kormann","raw_affiliation_strings":["Department of Pediatrics I, Pediatric Infectiology and Immunology, Translational Genomics and Gene Therapy in Pediatrics, University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics I, Pediatric Infectiology and Immunology, Translational Genomics and Gene Therapy in Pediatrics, University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101584177","display_name":"Martin Wagner","orcid":"https://orcid.org/0000-0001-5735-3462","observed_orcids":["https://orcid.org/0000-0001-5735-3462"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Wagner","raw_affiliation_strings":["Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034264196","display_name":"Stefan Liebau","orcid":"https://orcid.org/0000-0003-0721-8187","observed_orcids":["https://orcid.org/0000-0003-0721-8187"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Liebau","raw_affiliation_strings":["Institute of Neuroanatomy, Eberhard Karls University Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroanatomy, Eberhard Karls University Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055082801","display_name":"Alexander Kleger","orcid":"https://orcid.org/0000-0003-0592-5232","observed_orcids":["https://orcid.org/0000-0003-0592-5232"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Alexander Kleger","raw_affiliation_strings":["Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany","Department of Internal Medicine I, University Medical Center Ulm, Albert-Einstein-Allee 23, Ulm 89081, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]},{"raw_affiliation_string":"Department of Internal Medicine I, University Medical Center Ulm, Albert-Einstein-Allee 23, Ulm 89081, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5055082801"],"corresponding_institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"],"apc_list":null,"apc_paid":null,"fwci":18.9186,"has_fulltext":true,"cited_by_count":210,"citation_normalized_percentile":{"value":0.99571095,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"66","issue":"3","first_page":"473","last_page":"486"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.6571999788284302,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.6571999788284302,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.29589998722076416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-pluripotent-stem-cells","display_name":"human pluripotent stem cells","score":0.9110000133514404},{"id":"https://openalex.org/keywords/pancreatic-organoids","display_name":"pancreatic organoids","score":0.9629999995231628},{"id":"https://openalex.org/keywords/acinar-cells","display_name":"acinar cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/ductal-cells","display_name":"ductal cells","score":0.8690000176429749},{"id":"https://openalex.org/keywords/orthotopic-transplantation","display_name":"orthotopic transplantation","score":0.890999972820282},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.9610000252723694},{"id":"https://openalex.org/keywords/disease-modeling","display_name":"disease modeling","score":0.8429999947547913},{"id":"https://openalex.org/keywords/pancreas-development","display_name":"pancreatic development","score":0.6970000267028809},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.8427978754043579},{"id":"https://openalex.org/C2778148616","wikidata":"https://www.wikidata.org/wiki/Q5311600","display_name":"Ductal cells","level":3,"score":0.7520588636398315},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.7028191685676575},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.6401498317718506},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.635890007019043},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.6148688197135925},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5407367944717407},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5315605998039246},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42707371711730957},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3987799882888794},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38935989141464233},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3059360384941101},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.2646448314189911},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2338595986366272},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1954813003540039},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11617165803909302},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06685402989387512}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010183","descriptor_name":"Pancreatic Ducts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010183","descriptor_name":"Pancreatic Ducts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010183","descriptor_name":"Pancreatic Ducts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061354","descriptor_name":"Acinar Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D061354","descriptor_name":"Acinar Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D061354","descriptor_name":"Acinar Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1136/gutjnl-2016-312423","doi":"https://doi.org/10.1136/gutjnl-2016-312423","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gutjnl-2016-312423","pdf_url":"https://gut.bmj.com/content/gutjnl/66/3/473.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},{"id":"pmid:27633923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27633923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Journal Article"},{"id":"pmh:oai:dnet:biblosearchi::7bd300ba92058c670f89f5e13ca20b92","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10486/678024","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.tdx.cat:10486/678024","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10486/678024","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5534761","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5534761","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gut","raw_type":"Text"},{"id":"pmh:oai:digital.csic.es:10261/150796","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/150796","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:hispana.mcu.es:59505339","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10486/678024","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"},{"id":"pmh:oai:open-archive.highwire.org:gutjnl:66/3/473","doi":null,"is_oa":false,"landing_page_url":"http://gut.bmj.com/cgi/content/short/66/3/473","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:publications.rwth-aachen.de:684845","doi":null,"is_oa":true,"landing_page_url":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-212309%22","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gut : an international journal of gastroenterology and hepatology 66(3), 473-486 (2016). doi:10.1136/gutjnl-2016-312423","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositorio.uam.es:10486/678024","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10486/678024","pdf_url":null,"source":{"id":"https://openalex.org/S4306400964","display_name":"Biblos-e Archivo (Universidad Aut\u00f3noma de Madrid)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63634437","host_organization_name":"Universidad Aut\u00f3noma de Madrid","host_organization_lineage":["https://openalex.org/I63634437"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"doi:10.1136/gutjnl-2016-312423","doi":"https://doi.org/10.1136/gutjnl-2016-312423","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gutjnl-2016-312423","pdf_url":"https://gut.bmj.com/content/gutjnl/66/3/473.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1520029538","display_name":null,"funder_award_id":"2544/1-1 and 1-2","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G1799387967","display_name":null,"funder_award_id":"111879","funder_id":"https://openalex.org/F4320323556","funder_display_name":"Deutsche Krebshilfe"},{"id":"https://openalex.org/G236229821","display_name":null,"funder_award_id":"2011 A200","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6447807051","display_name":null,"funder_award_id":"KL2544/1\u20101","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6618831505","display_name":null,"funder_award_id":"2011_A200","funder_id":"https://openalex.org/F4320310414","funder_display_name":"Baden-W\u00fcrttemberg Stiftung"},{"id":"https://openalex.org/G7105171327","display_name":null,"funder_award_id":"2544/1\u20101","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320310414","display_name":"Baden-W\u00fcrttemberg Stiftung","ror":"https://ror.org/031h5fa94"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"},{"id":"https://openalex.org/F4320324232","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34"},{"id":"https://openalex.org/F4320325530","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02"},{"id":"https://openalex.org/F4320327571","display_name":"United European Gastroenterology","ror":"https://ror.org/005hr7v68"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2520537726.pdf","grobid_xml":"https://content.openalex.org/works/W2520537726.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1483496013","https://openalex.org/W1496521029","https://openalex.org/W1965157206","https://openalex.org/W1979959112","https://openalex.org/W1980215804","https://openalex.org/W1980888760","https://openalex.org/W1984477435","https://openalex.org/W1986404310","https://openalex.org/W1990036449","https://openalex.org/W2010916968","https://openalex.org/W2016236221","https://openalex.org/W2023076580","https://openalex.org/W2026124993","https://openalex.org/W2027310534","https://openalex.org/W2031522785","https://openalex.org/W2032472678","https://openalex.org/W2034460442","https://openalex.org/W2038087283","https://openalex.org/W2040207288","https://openalex.org/W2043400880","https://openalex.org/W2054361177","https://openalex.org/W2057980261","https://openalex.org/W2062305588","https://openalex.org/W2064412199","https://openalex.org/W2065143344","https://openalex.org/W2066320259","https://openalex.org/W2071302752","https://openalex.org/W2075809760","https://openalex.org/W2086293424","https://openalex.org/W2087895503","https://openalex.org/W2088924928","https://openalex.org/W2089766172","https://openalex.org/W2105031631","https://openalex.org/W2106219965","https://openalex.org/W2110982118","https://openalex.org/W2116429223","https://openalex.org/W2116475082","https://openalex.org/W2125445020","https://openalex.org/W2130410032","https://openalex.org/W2133271464","https://openalex.org/W2134596927","https://openalex.org/W2135020982","https://openalex.org/W2137935662","https://openalex.org/W2141915435","https://openalex.org/W2144155263","https://openalex.org/W2146177965","https://openalex.org/W2151829259","https://openalex.org/W2169191544","https://openalex.org/W2176166968","https://openalex.org/W2192723508","https://openalex.org/W2201543151","https://openalex.org/W2337762305","https://openalex.org/W2339075713","https://openalex.org/W2343369957","https://openalex.org/W2465114161"],"related_works":["https://openalex.org/W4386439204","https://openalex.org/W3048825385","https://openalex.org/W3033121461","https://openalex.org/W3094248195","https://openalex.org/W3215034816","https://openalex.org/W3047590429","https://openalex.org/W1985346628","https://openalex.org/W2197830452","https://openalex.org/W2905495085","https://openalex.org/W2169593856"],"abstract_inverted_index":{"Objective":[0],"The":[1],"generation":[2],"of":[3,47,66,94,114,185],"acinar":[4,40,86],"and":[5,41,63,85,188,190,212,218],"ductal":[6,42],"cells":[7,12],"from":[8,23],"human":[9,34,68,90],"pluripotent":[10],"stem":[11],"(PSCs)":[13],"is":[14],"a":[15,29,107,167,174,183],"poorly":[16],"studied":[17],"process,":[18],"although":[19],"various":[20],"diseases":[21],"arise":[22],"this":[24,102],"compartment.":[25],"Design":[26],"We":[27,171],"designed":[28],"straightforward":[30],"approach":[31,196],"to":[32,109,208,219],"direct":[33],"PSCs":[35],"towards":[36],"pancreatic":[37,83,112,136,153,180,210],"organoids":[38,49,80,154,181],"resembling":[39,88],"progeny.":[43],"Results":[44],"Extensive":[45],"phenotyping":[46,104],"the":[48,53,67,71,111,119,158],"not":[50,155],"only":[51,156],"shows":[52],"appropriate":[54],"marker":[55],"profile":[56],"but":[57,129,164],"also":[58,130,165,172],"ultrastructural,":[59],"global":[60,168],"gene":[61,194],"expression":[62,169],"functional":[64,162],"hallmarks":[65],"pancreas":[69,91],"in":[70,126,131,141,151,161,178,197],"dish.":[72],"Upon":[73],"orthotopic":[74],"transplantation":[75,134],"into":[76],"immunodeficient":[77],"mice,":[78],"these":[79],"form":[81],"normal":[82],"ducts":[84],"tissue":[87],"fetal":[89],"without":[92],"evidence":[93,124],"tumour":[95],"formation":[96],"or":[97],"transformation.":[98],"Finally,":[99],"we":[100,122],"implemented":[101],"unique":[103],"tool":[105],"as":[106],"model":[108,209],"study":[110],"facets":[113],"cystic":[115,144],"fibrosis":[116,145],"(CF).":[117],"For":[118],"first":[120],"time,":[121],"provide":[123],"that":[125],"vitro":[127],",":[128],"our":[132,203],"xenograft":[133],"assay,":[135],"commitment":[137],"occurs":[138],"generally":[139],"unhindered":[140],"CF.":[142],"Importantly,":[143],"transmembrane":[146],"conductance":[147],"regulator":[148],"(CFTR)":[149],"activation":[150],"mutated":[152],"mirrors":[157],"CF":[159,179,198],"phenotype":[160],"assays":[163],"at":[166],"level.":[170],"conducted":[173],"scalable":[175],"proof-of-concept":[176],"screen":[177,214],"using":[182],"set":[184],"CFTR":[186],"correctors":[187],"activators,":[189],"established":[191],"an":[192],"mRNA-mediated":[193],"therapy":[195],"organoids.":[199],"Conclusions":[200],"Taken":[201],"together,":[202],"platform":[204],"provides":[205],"novel":[206],"opportunities":[207],"disease":[211],"development,":[213],"for":[215],"disease-rescuing":[216],"agents":[217],"test":[220],"therapeutic":[221],"procedures.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":37},{"year":2020,"cited_by_count":27},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":4}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
