{"id":"https://openalex.org/W2520490372","doi":"https://doi.org/10.1182/blood.v116.21.2351.2351","title":"A Novel Reduced Intensity Conditioning Can Induce a High Incidence of Sustained Donor Engraftment After Double Unit Cord Blood Transplantation (CBT) without Anti-Thymocyte Globulin","display_name":"A Novel Reduced Intensity Conditioning Can Induce a High Incidence of Sustained Donor Engraftment After Double Unit Cord Blood Transplantation (CBT) without Anti-Thymocyte Globulin","publication_year":2010,"publication_date":"2010-11-19","ids":{"openalex":"https://openalex.org/W2520490372","doi":"https://doi.org/10.1182/blood.v116.21.2351.2351","mag":"2520490372"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v116.21.2351.2351","doi":"https://doi.org/10.1182/blood.v116.21.2351.2351","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v116.21.2351.2351","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066163702","display_name":"Doris M. Ponce","orcid":"https://orcid.org/0000-0002-9422-5766","observed_orcids":["https://orcid.org/0000-0002-9422-5766"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Doris M Ponce","raw_affiliation_strings":["Department of Medicine, Adult Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Adult Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034628611","display_name":"Craig Steven Sauter","orcid":"https://orcid.org/0000-0002-5316-8785","observed_orcids":["https://orcid.org/0000-0002-5316-8785"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Craig Sauter","raw_affiliation_strings":["Department of Medicine, Adult Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Adult Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089293529","display_name":"Marissa N. Lubin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marissa Lubin","raw_affiliation_strings":["Department of Medicine, Adult Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Adult Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112764808","display_name":"Anne Marie Gonzales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne Marie Gonzales","raw_affiliation_strings":["Department of Medicine, Adult Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Adult Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031035765","display_name":"Glenn Heller","orcid":"https://orcid.org/0000-0001-9217-8348","observed_orcids":["https://orcid.org/0000-0001-9217-8348"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Glenn Heller","raw_affiliation_strings":["Department of Epidemiology-Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology-Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043966208","display_name":"Hugo R Castro-Malaspina","orcid":"https://orcid.org/0000-0002-9956-904X","observed_orcids":["https://orcid.org/0000-0002-9956-904X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hugo Castro-Malaspina","raw_affiliation_strings":["Department of Medicine, Adult Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Adult Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070096873","display_name":"Sergio Giralt","orcid":"https://orcid.org/0000-0003-1944-5053","observed_orcids":["https://orcid.org/0000-0003-1944-5053"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergio Giralt","raw_affiliation_strings":["Department of Medicine, Adult Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Adult Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079103223","display_name":"Nancy A. Kernan","orcid":"https://orcid.org/0000-0003-1417-1823","observed_orcids":["https://orcid.org/0000-0003-1417-1823"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nancy A. Kernan","raw_affiliation_strings":["Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058746837","display_name":"Esperanza Bouza Papadopoulos","orcid":"https://orcid.org/0000-0001-6066-1861","observed_orcids":["https://orcid.org/0000-0001-6066-1861"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Esperanza B. Papadopoulos","raw_affiliation_strings":["Department of Medicine, Adult Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Adult Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085595407","display_name":"Andromachi Scaradavou","orcid":"https://orcid.org/0000-0003-2425-1069","observed_orcids":["https://orcid.org/0000-0003-2425-1069"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andromachi Scaradavou","raw_affiliation_strings":["Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071626276","display_name":"Juliet N. Barker","orcid":"https://orcid.org/0000-0002-9030-183X","observed_orcids":["https://orcid.org/0000-0002-9030-183X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juliet N. Barker","raw_affiliation_strings":["Department of Medicine, Adult Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Adult Bone Marrow Transplantation, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031035765","https://openalex.org/A5034628611","https://openalex.org/A5043966208","https://openalex.org/A5058746837","https://openalex.org/A5079103223","https://openalex.org/A5085595407","https://openalex.org/A5089293529"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33864956,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"21","first_page":"2351","last_page":"2351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reduced-intensity-conditioning","display_name":"reduced-intensity conditioning","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cord-blood-transplantation","display_name":"cord blood transplantation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/donor-engraftment","display_name":"donor engraftment","score":0.9509999752044678},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8119999766349792},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9559999704360962},{"id":"https://openalex.org/keywords/fludarabine","display_name":"fludarabine","score":0.8080000281333923},{"id":"https://openalex.org/keywords/thiotepa","display_name":"thiotepa","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9120000004768372},{"id":"https://openalex.org/keywords/total-body-irradiation","display_name":"total body irradiation","score":0.984000027179718},{"id":"https://openalex.org/keywords/graft-versus-host-disease-prophylaxis","display_name":"graft-versus-host disease prophylaxis","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8096228837966919},{"id":"https://openalex.org/C2779263901","wikidata":"https://www.wikidata.org/wiki/Q185916","display_name":"Fludarabine","level":4,"score":0.7843682765960693},{"id":"https://openalex.org/C2779968505","wikidata":"https://www.wikidata.org/wiki/Q416507","display_name":"ThioTEPA","level":4,"score":0.6734551191329956},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5650078654289246},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5511972308158875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.537581205368042},{"id":"https://openalex.org/C2780882860","wikidata":"https://www.wikidata.org/wiki/Q584065","display_name":"Anti-thymocyte globulin","level":3,"score":0.5367734432220459},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.5359058976173401},{"id":"https://openalex.org/C2778880498","wikidata":"https://www.wikidata.org/wiki/Q1986672","display_name":"Total body irradiation","level":4,"score":0.5326658487319946},{"id":"https://openalex.org/C88879693","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative incidence","level":3,"score":0.5000636577606201},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.48596227169036865},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.47025835514068604},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4673699736595154},{"id":"https://openalex.org/C2777630719","wikidata":"https://www.wikidata.org/wiki/Q21006907","display_name":"Thymoglobulin","level":4,"score":0.4554164409637451},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.41461992263793945},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.25994545221328735},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.21402281522750854},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.19841262698173523},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v116.21.2351.2351","doi":"https://doi.org/10.1182/blood.v116.21.2351.2351","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v116.21.2351.2351","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2556480163","https://openalex.org/W2084757730","https://openalex.org/W1968205826","https://openalex.org/W1965556281","https://openalex.org/W2979305352","https://openalex.org/W2322815084","https://openalex.org/W2556217351","https://openalex.org/W2471154299","https://openalex.org/W2589967004","https://openalex.org/W2588379159"],"abstract_inverted_index":{"Abstract":[0,1],"2351":[2],"CBT":[3,115],"can":[4,129],"be":[5,581],"curative":[6],"for":[7,183,236,243,333,414],"patients":[8,14,47,51,117,177,191,262,441,472,486,502,547],"with":[9,19,48,52,118,123,247,355,473,487,534,571],"high-risk":[10,233],"hematologic":[11],"malignancies.":[12],"However,":[13,50],"of":[15,63,72,82,96,105,134,140,250,266,295,341,371,424,440,457,469,479,492,504,510,538,599],"older":[16,546],"age,":[17],"those":[18],"extensive":[20,56,255,605],"prior":[21,57,111,256,606],"therapy,":[22,257,607],"or":[23,35,450],"significant":[24,259,608],"co-morbidities":[25],"may":[26,579],"not":[27,566],"tolerate":[28],"high-dose":[29,248,586],"myeloablative":[30],"conditioning.":[31],"Reduced":[32],"intensity":[33],"(RI)":[34],"non-myeloablative":[36],"(NMA)":[37],"conditioning":[38,110,238,249,531,569,587],"has":[39],"been":[40],"successfully":[41],"used":[42],"in":[43,46,116,361,396,418,545,588],"CBT,":[44],"especially":[45],"lymphomas.":[49],"myeloid":[53],"malignancies":[54],"without":[55,374,548],"therapy":[58,449],"have":[59,442],"an":[60],"increased":[61],"risk":[62,81,95,241,268,274,476,489,550,563,600],"graft":[64,356],"rejection":[65],"following":[66],"NMA":[67],"CBT.":[68],"Further,":[69],"the":[70,80,94,101,124,240,282,296,334,362,397,470],"addition":[71],"anti-thymocyte":[73],"globulin":[74],"(ATG)":[75],"to":[76,112,153,281,380,453,585,597],"enhance":[77],"engraftment":[78,344,411],"increases":[79],"serious":[83],"infections":[84],"and":[85,91,103,121,162,164,174,180,218,308,316,325,409,436,542,578],"Epstein-Barr":[86],"virus":[87],"post-transplant":[88,370],"lymphoproliferative":[89],"disease,":[90],"could":[92],"increase":[93],"relapse.":[97,505],"Therefore,":[98],"we":[99],"investigated":[100],"efficacy":[102],"safety":[104],"a":[106,131,507,535,582],"novel":[107],"ATG-free":[108,529],"RI":[109,237,530],"double":[113,572],"unit":[114,417,573],"acute":[119,427,445],"leukemias":[120],"myelodysplasia":[122],"hypothesis":[125],"that":[126,527],"this":[127,528],"regimen":[128],"induce":[130],"high":[132,536],"incidence":[133,340,423,456,537],"sustained":[135,342,410,539],"donor":[136,343,360,394,540],"engraftment.":[137],"Conditioning":[138],"consisted":[139],"cyclophosphamide":[141],"50":[142],"mg/kg":[143],"(day":[144],"-6),":[145],"fludarabine":[146],"30":[147],"mg/m2/day":[148],"\u00d7":[149,158,170,301,310,318,327,384],"5":[150,156],"(days":[151,160,172],"-6":[152],"-2),":[154],"thiotepa":[155],"mg/kg/day":[157],"2":[159,171],"-5":[161],"-4),":[163],"total":[165,303,320,393],"body":[166],"irradiation":[167],"200":[168],"cGy":[169],"-2":[173],"-1).":[175],"All":[176],"received":[178],"cyclosporine-A":[179],"mycophenolate":[181],"mofetil":[182],"graft-versus-host":[184],"disease":[185],"(GVHD)":[186],"prophylaxis.":[187],"Between":[188],"10/01/07-04/30/10,":[189],"20":[190],"were":[192,239,277,299],"transplanted.":[193],"The":[194,230,290,338,352,377,391,422,455],"median":[195,291,378,392,508],"age":[196,251],"was":[197,348,358,386,402,412,432,463],"56":[198],"years":[199],"(range":[200,306,314,323,331,389,513],"18\u201369).":[201],"Thirteen":[202,261],"(65%)":[203],"had":[204,212,221,232,263,272,443],"AML":[205],"(9":[206],"CR1,":[207,215],"4":[208,210],"CR2),":[209],"(20%)":[211],"ALL":[213],"(3":[214],"1":[216,265,515,617,635,642],"CR3),":[217],"3":[219],"(15%)":[220],"MDS":[222],"(with":[223],"one":[224,416,475],"patient":[225,354],"also":[226,580],"having":[227],"follicular":[228],"lymphoma).":[229],"majority":[231],"disease.":[234],"Indications":[235],"factors":[242,490,564,601],"transplant-related":[244,460,480],"mortality":[245,461],"(TRM)":[246,462],"\u226550":[252,603],"years,":[253,604],"and/or":[254,258],"co-morbidities.":[260],"only":[264,474],"these":[267],"factors,":[269],"whereas":[270],"7":[271],"\u22652":[273,488,624],"factors.":[275,551],"Units":[276],"predominantly":[278],"4\u20135/6":[279],"HLA-matched":[280],"recipient":[283],"(one":[284],"6/6,":[285],"twenty-four":[286],"5/6,":[287],"fifteen":[288],"4/6).":[289],"infused":[292],"cell":[293],"doses":[294],"larger":[297],"units":[298,405],"2.7":[300],"107":[302],"nucleated":[304,321],"cells/kg":[305,313,322,330],"1.46\u20135.56)":[307],"0.95":[309],"105":[311],"CD34+":[312,329],"0.35\u20133.32),":[315],"1.89":[317],"107/kg":[319],"1.42\u20132.47)":[324],"0.59":[326],"105/kg":[328],"0.18\u20131.52)":[332],"smaller":[335],"units,":[336],"respectively.":[337],"cumulative":[339],"at":[345,429],"day":[346,363,398,430,458,495],"45":[347],"95%":[349],"(95%CI:":[350,434,438,465,521],"81\u2013100).":[351],"single":[353],"failure":[357,373],"100%":[359],"21":[364,399],"bone":[365,400],"marrow,":[366],"but":[367],"died":[368,478,491,503],"early":[369],"multi-organ":[372],"count":[375],"recovery.":[376],"time":[379],"neutrophil":[381],"recovery":[382],"\u22650.5":[383],"109/l":[385],"25":[387],"days":[388],"13\u201343).":[390],"chimerism":[395],"marrow":[401],"94%":[403],"(both":[404],"combined,":[406],"range":[407],"71\u2013100),":[408],"accounted":[413],"by":[415,494],"18/19":[419],"engrafting":[420],"patients.":[421,590],"grade":[425],"II-IV":[426],"GVHD":[428,446,452],"100":[431,459,496,594,613],"55%":[433],"32\u201378),":[435],"46%":[437],"21\u201371)":[439],"late":[444],"requiring":[447],"ongoing":[448],"chronic":[451],"date.":[454],"20%":[464],"2\u201338).":[466],"Notably,":[467],"none":[468],"13":[471,511],"factor":[477],"causes.":[481],"By":[482],"contrast,":[483],"5/7":[484,628],"(71%)":[485,629],"TRM":[493,595,614],"(p=0.03,":[497],"Table":[498,591],"1).":[499,524],"Two":[500],"additional":[501],"With":[506],"follow-up":[509,554],"months":[512],"3\u201331),":[514],"year":[516],"progression-free":[517,557],"survival":[518,558],"is":[519,532,555,559],"74%":[520],"55\u201394)":[522],"(Figure":[523],"We":[525],"demonstrate":[526],"associated":[533],"engraftment,":[541],"acceptable":[543],"toxicities":[544],"other":[549],"While":[552],"longer":[553],"needed,":[556],"encouraging":[560],"provided":[561],"multiple":[562],"are":[565],"present.":[567],"This":[568],"combined":[570],"grafts":[574],"warrants":[575],"further":[576],"investigation,":[577],"promising":[583],"alternative":[584],"younger":[589],"1.":[592,631,638],"Day":[593,612],"according":[596],"number":[598],"(age":[602],"co-morbidities).":[609],"Risk":[610],"Factors":[611],"P":[615],"Value":[616],"(N":[618,625],"=":[619,626],"13)":[620],"0/13":[621],"(0%)":[622],"0.03":[623],"7)":[627],"Figure":[630,637],"Progression-Free":[632,639],"Survival":[633,640],"At":[634,641],"Year":[636,643],"Disclosures:":[644],"Giralt:":[645],"Celgene:":[646],"Honoraria,":[647,651],"Speakers":[648,652],"Bureau;":[649],"Millenium:":[650],"Bureau.":[653]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-09-23T00:00:00"}