{"id":"https://openalex.org/W2520433337","doi":null,"title":"Effect of Low (7.5 mg/day), Standard (15 mg/ day) and High (30 mg/day) Dose Pioglitazone Therapy on Glycemic Control and Weight Gain in Recently-Diagnosed Type 2 Diabetes Patients.","display_name":"Effect of Low (7.5 mg/day), Standard (15 mg/ day) and High (30 mg/day) Dose Pioglitazone Therapy on Glycemic Control and Weight Gain in Recently-Diagnosed Type 2 Diabetes Patients.","publication_year":2015,"publication_date":"2015-11-01","ids":{"openalex":"https://openalex.org/W2520433337","mag":"2520433337","pmid":"https://pubmed.ncbi.nlm.nih.gov/29900709"},"language":"en","primary_location":{"id":"pmid:29900709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29900709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Association of Physicians of India","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004890566","display_name":"Vijay Panikar","orcid":"https://orcid.org/0009-0007-7785-8311","observed_orcids":["https://orcid.org/0009-0007-7785-8311"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vijay Panikar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055035986","display_name":"Namdev J Kale","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Namdev J Kale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044094077","display_name":"Sumedh S. Hoskote","orcid":"https://orcid.org/0000-0002-0512-2600","observed_orcids":["https://orcid.org/0000-0002-0512-2600"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sumedh S Hoskote","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042241206","display_name":"Narayan Deogaonkar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Narayan Deogaonkar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033769407","display_name":"Shashank Joshi","orcid":"https://orcid.org/0000-0002-0990-5821","observed_orcids":["https://orcid.org/0000-0002-0990-5821","https://orcid.org/0000-0003-2741-5022"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shashank R Joshi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9335,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.74005123,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"63","issue":"11","first_page":"36","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pioglitazone","display_name":"pioglitazone","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9610000252723694},{"id":"https://openalex.org/keywords/newly-diagnosed-diabetes","display_name":"newly diagnosed diabetes","score":0.8230000138282776},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5360000133514404},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.8149999976158142},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.7910000085830688},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9039999842643738},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7940000295639038},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.902999997138977},{"id":"https://openalex.org/keywords/thiazolidinediones","display_name":"thiazolidinediones","score":0.8500000238418579},{"id":"https://openalex.org/keywords/oral-antidiabetic-therapy","display_name":"oral antidiabetic therapy","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9467489123344421},{"id":"https://openalex.org/C2778384471","wikidata":"https://www.wikidata.org/wiki/Q417765","display_name":"Pioglitazone","level":4,"score":0.932442307472229},{"id":"https://openalex.org/C2780320433","wikidata":"https://www.wikidata.org/wiki/Q3403879","display_name":"Weight gain","level":3,"score":0.7104839086532593},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.7018346190452576},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.636273205280304},{"id":"https://openalex.org/C2777538456","wikidata":"https://www.wikidata.org/wiki/Q311213","display_name":"Glycated hemoglobin","level":4,"score":0.5693349838256836},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5359654426574707},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5297856330871582},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.49591121077537537},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.4752357304096222},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3528284728527069},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35021692514419556},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.20441791415214539}],"mesh":[{"descriptor_ui":"D000077205","descriptor_name":"Pioglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007194","descriptor_name":"India","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015430","descriptor_name":"Weight Gain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D054795","descriptor_name":"Incretins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:29900709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29900709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Association of Physicians of India","raw_type":"Journal Article"},{"id":"mag:2520433337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29900709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1963852432","https://openalex.org/W1966435893","https://openalex.org/W1975674037","https://openalex.org/W2013300466","https://openalex.org/W2015279471","https://openalex.org/W2029520989","https://openalex.org/W2052862952","https://openalex.org/W2066708831","https://openalex.org/W2101667913","https://openalex.org/W2111184067","https://openalex.org/W2178920245"],"related_works":["https://openalex.org/W2338128803","https://openalex.org/W7221017668","https://openalex.org/W2151713218","https://openalex.org/W1977235023","https://openalex.org/W2101812928","https://openalex.org/W1999964621","https://openalex.org/W1997078930","https://openalex.org/W2054381014","https://openalex.org/W4415607321","https://openalex.org/W7221621265"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"study":[2],"the":[3,66,108,179,224,242,260],"effect":[4,214],"of":[5,9,33,85,110,215,262],"different":[6],"daily":[7],"doses":[8],"pioglitazone":[10,216,237],"on":[11,271],"glycemic":[12,213],"control":[13],"and":[14,27,94,102,141,157,159,162,169,204],"weight":[15,116,186,228],"gain":[16,117,125,187,229],"in":[17,118,128,135,143,178,250,259],"newly-diagnosed":[18],"type":[19,37,263],"2":[20,38,264],"diabetes":[21,265],"mellitus":[22,266],"(DM)":[23,267],"patients.":[24,252],"Research":[25],"Design":[26],"Methods:":[28],"Chart":[29],"reviews":[30],"were":[31,47,60,98],"performed":[32],"recently-diagnosed":[34,251],"(<24":[35],"months)":[36],"DM":[39],"patients":[40],"receiving":[41],"oral":[42],"therapy":[43,249],"including":[44,88],"pioglitazone.":[45,86],"Patients":[46,69],"excluded":[48],"if":[49],"they":[50],"had":[51,70],"heart":[52],"disease,":[53],"liver":[54],"dysfunction":[55],"or":[56,59,65,80],"renal":[57],"insufficiency;":[58],"being":[61],"treated":[62],"with":[63,185,192,231],"insulin":[64,273],"incretin":[67],"drugs.":[68],"received":[71],"7.5":[72],"mg/day":[73,77,82],"(Group":[74,78,83],"A),":[75],"15":[76],"B)":[79],"30":[81],"C)":[84],"Characteristics":[87],"demographics,":[89],"weight,":[90],"body":[91],"mass":[92],"index":[93],"glycated":[95],"hemoglobin":[96],"(HbA1c)":[97],"recorded":[99],"at":[100,103,220,245],"baseline":[101,122],"six":[104,111],"months.":[105],"Results:":[106],"At":[107],"end":[109],"months,":[112],"there":[113],"was":[114,126,151,172,198],"significant":[115,153],"all":[119],"groups":[120,181],"from":[121],"(P<0.01).":[123],"Weight":[124],"greatest":[127],"Group":[129,136,144],"C":[130],"(2.72":[131],"kg;":[132,139,147],"SD=2.97),":[133],"intermediate":[134],"B":[137,161],"(1.62":[138],"SD=2.91)":[140],"least":[142],"A":[145,156,168],"(0.88":[146],"SD=2.77).":[148],"The":[149,212],"difference":[150,174],"statistically":[152],"between":[154,166,175,201],"Groups":[155,160,167],"C;":[158,163],"but":[164,190],"not":[165,191],"B.":[170],"There":[171,197],"no":[173,199],"HbA1c":[176,193,202],"lowering":[177],"three":[180],"(P>0.05).":[182],"Dose":[183],"correlated":[184],"(r=0.254;":[188],"P<0.001)":[189],"reduction":[194,203],"(r=0.012;":[195],"P=0.85).":[196],"correlation":[200],"BMI":[205],"increase":[206],"(r":[207],"=":[208],"-0.024;":[209],"P=0.72).":[210],"Conclusions:":[211],"is":[217,254],"preserved":[218],"even":[219],"lower":[221],"doses,":[222],"while":[223],"propensity":[225],"to":[226,247],"cause":[227],"increases":[230],"dose.":[232],"We":[233],"suggest":[234],"that":[235],"low-dose":[236],"(7.5":[238],"mg/day)":[239],"should":[240],"be":[241],"preferred":[243],"dose":[244],"which":[246],"initiate":[248],"Pioglitazone":[253],"an":[255],"extremely":[256],"useful":[257],"agent":[258],"treatment":[261],"through":[268],"its":[269],"actions":[270],"alleviating":[272],"resistance.":[274]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-09-23T00:00:00"}