{"id":"https://openalex.org/W2519939054","doi":"https://doi.org/10.1161/circulationaha.116.023648","title":"Could Modification of Titin Contribute to an Answer for Heart Failure With Preserved Ejection Fraction?","display_name":"Could Modification of Titin Contribute to an Answer for Heart Failure With Preserved Ejection Fraction?","publication_year":2016,"publication_date":"2016-09-15","ids":{"openalex":"https://openalex.org/W2519939054","doi":"https://doi.org/10.1161/circulationaha.116.023648","mag":"2519939054","pmid":"https://pubmed.ncbi.nlm.nih.gov/27630137","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5069174"},"language":"en","primary_location":{"id":"doi:10.1161/circulationaha.116.023648","doi":"https://doi.org/10.1161/circulationaha.116.023648","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.116.023648","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.116.023648","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.116.023648","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001770808","display_name":"Martin M. LeWinter","orcid":"https://orcid.org/0000-0003-3938-3531","observed_orcids":["https://orcid.org/0000-0003-3938-3531"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I2801980284","display_name":"University of Vermont Medical Center","ror":"https://ror.org/04cewr321","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801980284"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin M. LeWinter","raw_affiliation_strings":["From Cardiology Unit, University of Vermont College of Medicine, Burlington (M.M.L.); and RHJ Department of Veterans Affairs Medical Center and the Medical University of South Carolina, Charleston (M.R.Z.)","Martin M. LeWinter From Cardiology Unit, University of Vermont College of Medicine, Burlington (M.M.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Cardiology Unit, University of Vermont College of Medicine, Burlington (M.M.L.); and RHJ Department of Veterans Affairs Medical Center and the Medical University of South Carolina, Charleston (M.R.Z.)","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I153297377","https://openalex.org/I2801980284"]},{"raw_affiliation_string":"Martin M. LeWinter From Cardiology Unit, University of Vermont College of Medicine, Burlington (M.M.L.)","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I2801980284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047833899","display_name":"Michael R. Zile","orcid":"https://orcid.org/0000-0001-7076-221X","observed_orcids":["https://orcid.org/0000-0001-7076-221X"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I2801980284","display_name":"University of Vermont Medical Center","ror":"https://ror.org/04cewr321","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801980284"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Zile","raw_affiliation_strings":["From Cardiology Unit, University of Vermont College of Medicine, Burlington (M.M.L.); and RHJ Department of Veterans Affairs Medical Center and the Medical University of South Carolina, Charleston (M.R.Z.)","Michael R. Zile From Cardiology Unit, University of Vermont College of Medicine, Burlington (M.M.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Cardiology Unit, University of Vermont College of Medicine, Burlington (M.M.L.); and RHJ Department of Veterans Affairs Medical Center and the Medical University of South Carolina, Charleston (M.R.Z.)","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I153297377","https://openalex.org/I2801980284"]},{"raw_affiliation_string":"Michael R. Zile From Cardiology Unit, University of Vermont College of Medicine, Burlington (M.M.L.)","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I2801980284"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"134","issue":"15","first_page":"1100","last_page":"1104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.5439000129699707,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.5439000129699707,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.22200000286102295,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.07890000194311142,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/titin","display_name":"titin","score":0.968999981880188},{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.9110000133514404},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.5730000138282776},{"id":"https://openalex.org/keywords/sarcomere","display_name":"sarcomere","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9081674814224243},{"id":"https://openalex.org/C90671521","wikidata":"https://www.wikidata.org/wiki/Q74314","display_name":"Titin","level":4,"score":0.8827279806137085},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.7444224953651428},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6588233709335327},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6137134432792664},{"id":"https://openalex.org/C2777099384","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Heart failure with preserved ejection fraction","level":4,"score":0.5972216129302979},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5059499144554138},{"id":"https://openalex.org/C68731436","wikidata":"https://www.wikidata.org/wiki/Q1337087","display_name":"Sarcomere","level":3,"score":0.13372433185577393},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.12216520309448242}],"mesh":[{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064211","descriptor_name":"Connectin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1161/circulationaha.116.023648","doi":"https://doi.org/10.1161/circulationaha.116.023648","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.116.023648","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.116.023648","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:27630137","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27630137","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Editorial"},{"id":"pmh:oai:europepmc.org:4554200","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5069174","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5069174","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5069174","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circulation","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1161/circulationaha.116.023648","doi":"https://doi.org/10.1161/circulationaha.116.023648","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circulationaha.116.023648","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.116.023648","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1689525783","display_name":"New England, New York and Quebec Regional Clinical Center","funder_award_id":"U10HL110342","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1748238287","display_name":"Myofilament-based mechanisms of diastolic dysfunction in HFpEF","funder_award_id":"R01HL118524","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2111680132","display_name":"Advanced Glycation End-Products in Human Myocardium","funder_award_id":"R01HL089944","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4433622810","display_name":"Extracellular Matrix in Hypertensive Heart Disease & Transition to Heart Failure","funder_award_id":"R01HL123478","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4507660218","display_name":"Extracellular Matrix in Hypertensive Heart Disease & Transition to Heart Failure","funder_award_id":"R56HL123478","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2519939054.pdf","grobid_xml":"https://content.openalex.org/works/W2519939054.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1987902037","https://openalex.org/W2059060273","https://openalex.org/W2088776044","https://openalex.org/W2092557231","https://openalex.org/W2109289860","https://openalex.org/W2111216769","https://openalex.org/W2144214162","https://openalex.org/W2150274772","https://openalex.org/W2153195779","https://openalex.org/W2159549492","https://openalex.org/W2166481839","https://openalex.org/W2166504467","https://openalex.org/W2167989424","https://openalex.org/W2213926659","https://openalex.org/W2427094903","https://openalex.org/W2462116812","https://openalex.org/W2531279979","https://openalex.org/W4293860347"],"related_works":["https://openalex.org/W2811394663","https://openalex.org/W7161951426","https://openalex.org/W3120378324","https://openalex.org/W6893757047","https://openalex.org/W4399732645","https://openalex.org/W3035304264","https://openalex.org/W3081359270","https://openalex.org/W2013889037","https://openalex.org/W4410439175","https://openalex.org/W3046733242"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-09-23T00:00:00"}