{"id":"https://openalex.org/W2519787291","doi":null,"title":"Inactivation of At1A Receptors Attenuate Lactate Accumulation and Improve Cardiac Performance and Acid-Base Homeostasis during Endurance Exercise","display_name":"Inactivation of At1A Receptors Attenuate Lactate Accumulation and Improve Cardiac Performance and Acid-Base Homeostasis during Endurance Exercise","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2519787291","mag":"2519787291"},"language":"en","primary_location":{"id":"pmh:oai:corescholar.libraries.wright.edu:etd_all-2318","doi":null,"is_oa":true,"landing_page_url":"https://corescholar.libraries.wright.edu/etd_all/1179","pdf_url":"https://corescholar.libraries.wright.edu/cgi/viewcontent.cgi?article=2318&context=etd_all","source":{"id":"https://openalex.org/S2737205702","display_name":"Journal of Bioresource Management","issn_l":"2309-3854","issn":["2309-3854"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","erih-plus"],"host_organization":"https://openalex.org/P4310316536","host_organization_name":"Bioresource Research Center (BRC), Islamabad","host_organization_lineage":["https://openalex.org/P4310316536"],"host_organization_lineage_names":["Bioresource Research Center (BRC), Islamabad"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Browse all Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://corescholar.libraries.wright.edu/cgi/viewcontent.cgi?article=2318&context=etd_all","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060192451","display_name":"Ahmad M. Alhajoj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19648265","display_name":"Wright State University","ror":"https://ror.org/04qk6pt94","country_code":"US","type":"education","lineage":["https://openalex.org/I19648265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ahmad M. Alhajoj","raw_affiliation_strings":["Wright State University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wright State University;","institution_ids":["https://openalex.org/I19648265"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5060192451"],"corresponding_institution_ids":["https://openalex.org/I19648265"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.029999999329447746,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.8399999737739563},{"id":"https://openalex.org/keywords/endurance-exercise","display_name":"endurance exercise","score":0.8690000176429749},{"id":"https://openalex.org/keywords/aerobic-exercise","display_name":"aerobic exercise","score":0.5789999961853027},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.6050000190734863},{"id":"https://openalex.org/keywords/ejection-fraction","display_name":"ejection fraction","score":0.8970000147819519},{"id":"https://openalex.org/keywords/blood-lactate-accumulation","display_name":"blood lactate accumulation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/acid-base-balance","display_name":"acid-base balance","score":0.9599999785423279},{"id":"https://openalex.org/keywords/exercise-tolerance","display_name":"exercise tolerance","score":0.4950000047683716},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cardiomyocyte-hypertrophy","display_name":"cardiomyocyte hypertrophy","score":0.7649999856948853},{"id":"https://openalex.org/keywords/heart-weight-to-body-weight-ratio","display_name":"heart-to-body weight ratio","score":0.6620000004768372},{"id":"https://openalex.org/keywords/echocardiography","display_name":"echocardiography","score":0.6100000143051147},{"id":"https://openalex.org/keywords/wheel-running","display_name":"wheel running","score":0.5419999957084656},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.6759999990463257},{"id":"https://openalex.org/keywords/angiotensin-ii-signaling","display_name":"angiotensin II signaling","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5976349115371704},{"id":"https://openalex.org/C99830354","wikidata":"https://www.wikidata.org/wiki/Q362854","display_name":"Endurance training","level":2,"score":0.5945749282836914},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5398210287094116},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4400516450405121},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43336641788482666},{"id":"https://openalex.org/C134746045","wikidata":"https://www.wikidata.org/wiki/Q3275718","display_name":"Acid\u2013base homeostasis","level":2,"score":0.43091896176338196},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4087277352809906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3377726674079895}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:corescholar.libraries.wright.edu:etd_all-2318","doi":null,"is_oa":true,"landing_page_url":"https://corescholar.libraries.wright.edu/etd_all/1179","pdf_url":"https://corescholar.libraries.wright.edu/cgi/viewcontent.cgi?article=2318&context=etd_all","source":{"id":"https://openalex.org/S2737205702","display_name":"Journal of Bioresource Management","issn_l":"2309-3854","issn":["2309-3854"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","erih-plus"],"host_organization":"https://openalex.org/P4310316536","host_organization_name":"Bioresource Research Center (BRC), Islamabad","host_organization_lineage":["https://openalex.org/P4310316536"],"host_organization_lineage_names":["Bioresource Research Center (BRC), Islamabad"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Browse all Theses and Dissertations","raw_type":"text"},{"id":"pmh:oai:etd.ohiolink.edu:wright1396018497","doi":null,"is_oa":false,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1396018497","pdf_url":null,"source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=wright1396018497","raw_type":"text"},{"id":"mag:2519787291","doi":null,"is_oa":false,"landing_page_url":"https://corescholar.libraries.wright.edu/etd_all/1179/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:corescholar.libraries.wright.edu:etd_all-2318","doi":null,"is_oa":true,"landing_page_url":"https://corescholar.libraries.wright.edu/etd_all/1179","pdf_url":"https://corescholar.libraries.wright.edu/cgi/viewcontent.cgi?article=2318&context=etd_all","source":{"id":"https://openalex.org/S2737205702","display_name":"Journal of Bioresource Management","issn_l":"2309-3854","issn":["2309-3854"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","erih-plus"],"host_organization":"https://openalex.org/P4310316536","host_organization_name":"Bioresource Research Center (BRC), Islamabad","host_organization_lineage":["https://openalex.org/P4310316536"],"host_organization_lineage_names":["Bioresource Research Center (BRC), Islamabad"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Browse all Theses and Dissertations","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2519787291.pdf","grobid_xml":"https://content.openalex.org/works/W2519787291.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W1512100404","https://openalex.org/W1649582880","https://openalex.org/W1760461988","https://openalex.org/W1901112539","https://openalex.org/W1965413914","https://openalex.org/W1968153656","https://openalex.org/W1976268968","https://openalex.org/W1980702134","https://openalex.org/W1982875778","https://openalex.org/W1989061343","https://openalex.org/W1989449749","https://openalex.org/W1991306589","https://openalex.org/W1997973024","https://openalex.org/W2000494300","https://openalex.org/W2010210915","https://openalex.org/W2017757794","https://openalex.org/W2018431713","https://openalex.org/W2021345753","https://openalex.org/W2022257696","https://openalex.org/W2032643935","https://openalex.org/W2033433176","https://openalex.org/W2041299165","https://openalex.org/W2045612170","https://openalex.org/W2045836006","https://openalex.org/W2050505383","https://openalex.org/W2052771787","https://openalex.org/W2054301807","https://openalex.org/W2059955360","https://openalex.org/W2060681710","https://openalex.org/W2064100845","https://openalex.org/W2068519950","https://openalex.org/W2069165194","https://openalex.org/W2070283725","https://openalex.org/W2070304234","https://openalex.org/W2071322533","https://openalex.org/W2079132293","https://openalex.org/W2084752040","https://openalex.org/W2086765278","https://openalex.org/W2087023069","https://openalex.org/W2089454189","https://openalex.org/W2089923812","https://openalex.org/W2093423582","https://openalex.org/W2093934591","https://openalex.org/W2096592800","https://openalex.org/W2102588555","https://openalex.org/W2104588665","https://openalex.org/W2105070149","https://openalex.org/W2107595729","https://openalex.org/W2108981107","https://openalex.org/W2111806565","https://openalex.org/W2118454692","https://openalex.org/W2118543302","https://openalex.org/W2121472737","https://openalex.org/W2122198440","https://openalex.org/W2123593871","https://openalex.org/W2125228577","https://openalex.org/W2128916765","https://openalex.org/W2132454291","https://openalex.org/W2134899427","https://openalex.org/W2136718708","https://openalex.org/W2139427670","https://openalex.org/W2153567878","https://openalex.org/W2154901469","https://openalex.org/W2164286305","https://openalex.org/W2166198581","https://openalex.org/W2167398654","https://openalex.org/W2168052680","https://openalex.org/W2168366921","https://openalex.org/W2168546845","https://openalex.org/W2171756298","https://openalex.org/W2252531331","https://openalex.org/W2313799193","https://openalex.org/W2315193906","https://openalex.org/W3022179669"],"related_works":["https://openalex.org/W2623448807","https://openalex.org/W2744223626","https://openalex.org/W2054505979","https://openalex.org/W3174414895","https://openalex.org/W2062211714","https://openalex.org/W2059955360","https://openalex.org/W3135757787","https://openalex.org/W2012406180","https://openalex.org/W2766483043","https://openalex.org/W1972263902"],"abstract_inverted_index":{"Angiotensin":[0],"Type":[1],"1":[2,113],"(AT1)":[3],"receptors":[4,41],"are":[5],"involved":[6],"in":[7,15,25,48,146,151,170,173,195,213,229,255,274,285,312],"cardiovascular":[8],"pathology.":[9],"Losartan,":[10],"the":[11,32,37,66,321],"AT1":[12],"receptor":[13,55,323],"blocker,":[14],"combination":[16],"with":[17],"exercise":[18,46,52,60,67,87,98,132,306,329,337],"has":[19],"been":[20],"shown":[21],"to":[22,35,50,80,104,176,198,206,233,288,314],"be":[23],"effective":[24],"improving":[26],"cardiac":[27,43,136,300,331],"performance.":[28],"The":[29],"goal":[30],"of":[31,39,109,252,328],"study":[33],"was":[34,63,120,128,193,210,283],"investigate":[36],"role":[38],"AT1a":[40,54,90,96,322],"on":[42],"function,":[44],"and":[45,74,95,124,135,156,160,236,249,258,264,308,333],"tolerance":[47],"response":[49,313],"aerobic":[51],"using":[53],"knockout":[56],"(AT1aKO)":[57],"mice.":[58],"An":[59],"wheel":[61,253],"system":[62],"used":[64],"for":[65,112,116],"paradigm.":[68],"Male":[69],"(C57BL/6)":[70],"wild":[71],"type":[72],"(WT)":[73],"AT1aKO":[75,296],"mice":[76,297],"were":[77,102,138,245],"randomly":[78],"assigned":[79],"four":[81],"groups:":[82],"WT":[83,86,177,234],"control":[84,93,158,178,235],"(n=6),":[85],"(WTEX,":[88],"n=8),":[89],"KO":[91,97,157],"(KO)":[92],"(n=5),":[94],"(KOEX,":[99],"n=8).":[100],"Mice":[101],"forced":[103],"run":[105],"at":[106,122,179,247],"a":[107,143,167],"velocity":[108,172],"8":[110],"m/min":[111],"hour,":[114],"3d/wk,":[115],"7":[117,125],"wks.":[118,126],"Echocardiography":[119],"conducted":[121],"baseline":[123,180],"Lactate":[127],"measured":[129],"during":[130,336],"several":[131],"sessions.":[133],"Electrolytes":[134],"histology":[137],"assessed":[139],"post-sacrifice.":[140],"Results":[141],"showed":[142],"significant":[144],"increase":[145],"ejection":[147],"fraction":[148],"(EF":[149],"%)":[150],"KOEX":[152,199,216,237,262,275,286],"(72.5\u00b11.5%)":[153],"vs.":[154,201,215,218,239,261,276,279,291],"WTEX":[155,174,196,214,230,256,277,289],"(63.4\u00b11.2%":[159],"63.2\u00b12.2%,":[161],"respectively).":[162],"Mitral":[163],"valve":[164],"assessment":[165],"revealed":[166,225,271],"marked":[168],"decrease":[169],"E-wave":[171],"compared":[175,197,232,287],"(74\u00b11.9":[181],"vs.90\u00b13.5":[182],"cm/s,":[183],"p<0.05),":[184],"while":[185],"E/A":[186],"wave":[187],"ratio":[188,209],"remained":[189],"unchanged.":[190],"Cardiomyocyte":[191],"diameter":[192],"larger":[194],"(29.5\u00b10.7":[200],"25.8\u00b10.5":[202],"\u03bcm,":[203],"p<0.05).":[204,293],"Heart":[205],"body":[207],"weight":[208],"significantly":[211],"higher":[212,226,272],"(5.5\u00b10.2":[217],"4.3\u00b10.1":[219],"mg/g,":[220],"p<0.001).":[221],"Masson's":[222],"Trichrome":[223],"staining":[224],"collagen":[227],"levels":[228],"myocardium":[231,303],"(16%":[238],"5%).":[240],"Blood":[241],"lactate":[242],"accumulation":[243],"values":[244],"greater":[246,305],"5":[248],"60":[250],"min":[251],"running":[254],"(4.2\u00b10.4":[257],"3.9\u00b10.5":[259],"mmol/l)":[260],"(3.0\u00b10.2":[263],"2.9\u00b10.2":[265],"mmol/l).":[266,281],"A":[267],"basic":[268],"metabolic":[269,310],"panel":[270],"[HCO3-]":[273],"(21.7\u00b10.6":[278],"13.7\u00b11.8":[280],"Cl-":[282],"lower":[284],"(102.5\u00b12.5":[290],"113.5\u00b12.7mmol/l,":[292],"In":[294],"conclusion,":[295],"exhibited":[298],"improved":[299],"performance":[301],"without":[302],"hypertrophy,":[304],"endurance,":[307],"enhanced":[309],"activity":[311],"chronic":[315],"exercise.":[316],"These":[317],"results":[318],"suggest":[319],"that":[320],"is":[324],"an":[325],"important":[326],"mediator":[327],"induced":[330],"dysfunction":[332],"acid-base":[334],"imbalance":[335],"training.":[338]},"counts_by_year":[],"updated_date":"2026-09-02T07:38:04.252551","created_date":"2016-09-23T00:00:00"}