{"id":"https://openalex.org/W2519786000","doi":"https://doi.org/10.4172/2165-7890.s1-009","title":"The BTBR T+tf/J (BTBR) Mouse Model of Autism","display_name":"The BTBR T+tf/J (BTBR) Mouse Model of Autism","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2519786000","doi":"https://doi.org/10.4172/2165-7890.s1-009","mag":"2519786000"},"language":"en","primary_location":{"id":"doi:10.4172/2165-7890.s1-009","doi":"https://doi.org/10.4172/2165-7890.s1-009","is_oa":false,"landing_page_url":"https://doi.org/10.4172/2165-7890.s1-009","pdf_url":null,"source":{"id":"https://openalex.org/S2764757173","display_name":"Autism - Open Access","issn_l":"2165-7890","issn":["2165-7890"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autism- Open Access","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008131329","display_name":"Kathryn K. Chadman","orcid":"https://orcid.org/0000-0002-2307-7225","observed_orcids":["https://orcid.org/0000-0002-2307-7225"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kathryn K. Chadman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5008131329"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8172,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.72489993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"01","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/btbr-t-tf-j-mice","display_name":"BTBR T+tf/J mice","score":0.9240000247955322},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mouse-models-of-autism","display_name":"mouse models of autism","score":0.8410000205039978},{"id":"https://openalex.org/keywords/face-validity","display_name":"face validity","score":0.9010000228881836},{"id":"https://openalex.org/keywords/construct-validity","display_name":"construct validity","score":0.996999979019165},{"id":"https://openalex.org/keywords/predictive-validity","display_name":"predictive validity","score":1.0},{"id":"https://openalex.org/keywords/social-interaction-deficits","display_name":"social interaction deficits","score":0.7820000052452087},{"id":"https://openalex.org/keywords/communication-difficulties","display_name":"communication difficulties","score":0.7770000100135803},{"id":"https://openalex.org/keywords/repetitive-behavior","display_name":"repetitive behavior","score":0.8050000071525574},{"id":"https://openalex.org/keywords/grooming","display_name":"grooming","score":0.8740000128746033},{"id":"https://openalex.org/keywords/inbred-mouse-strains","display_name":"inbred mouse strains","score":0.8080000281333923},{"id":"https://openalex.org/keywords/behavioral-phenotypes","display_name":"behavioral phenotypes","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.6545989513397217},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.45359107851982117},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3866458535194397},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.36653417348861694},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27083003520965576},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.20884358882904053}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4172/2165-7890.s1-009","doi":"https://doi.org/10.4172/2165-7890.s1-009","is_oa":false,"landing_page_url":"https://doi.org/10.4172/2165-7890.s1-009","pdf_url":null,"source":{"id":"https://openalex.org/S2764757173","display_name":"Autism - Open Access","issn_l":"2165-7890","issn":["2165-7890"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autism- Open Access","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1541506878","https://openalex.org/W1565550930","https://openalex.org/W1605805624","https://openalex.org/W1793725714","https://openalex.org/W1964614355","https://openalex.org/W1967249800","https://openalex.org/W1974237084","https://openalex.org/W1978783429","https://openalex.org/W1979041721","https://openalex.org/W1980625058","https://openalex.org/W1981091499","https://openalex.org/W1983121205","https://openalex.org/W1984005834","https://openalex.org/W1988372841","https://openalex.org/W1992887691","https://openalex.org/W1995632078","https://openalex.org/W2003863298","https://openalex.org/W2004777672","https://openalex.org/W2005479877","https://openalex.org/W2006032860","https://openalex.org/W2009443134","https://openalex.org/W2011001109","https://openalex.org/W2015172493","https://openalex.org/W2016411894","https://openalex.org/W2024552192","https://openalex.org/W2029887906","https://openalex.org/W2031765572","https://openalex.org/W2032163899","https://openalex.org/W2033844955","https://openalex.org/W2036441276","https://openalex.org/W2042885239","https://openalex.org/W2043402111","https://openalex.org/W2044009124","https://openalex.org/W2048377822","https://openalex.org/W2049785017","https://openalex.org/W2050550932","https://openalex.org/W2050597016","https://openalex.org/W2051464199","https://openalex.org/W2052072017","https://openalex.org/W2052424568","https://openalex.org/W2052477543","https://openalex.org/W2054445281","https://openalex.org/W2058342099","https://openalex.org/W2058476564","https://openalex.org/W2060003561","https://openalex.org/W2062235386","https://openalex.org/W2062496408","https://openalex.org/W2065827336","https://openalex.org/W2071797996","https://openalex.org/W2072319418","https://openalex.org/W2079648142","https://openalex.org/W2080326011","https://openalex.org/W2082109123","https://openalex.org/W2085202176","https://openalex.org/W2085542546","https://openalex.org/W2090460252","https://openalex.org/W2093081094","https://openalex.org/W2104220482","https://openalex.org/W2115555597","https://openalex.org/W2117928188","https://openalex.org/W2118384136","https://openalex.org/W2124502418","https://openalex.org/W2129179498","https://openalex.org/W2131568512","https://openalex.org/W2134845198","https://openalex.org/W2136328934","https://openalex.org/W2139399313","https://openalex.org/W2141910384","https://openalex.org/W2143163318","https://openalex.org/W2144774511","https://openalex.org/W2146597551","https://openalex.org/W2153617971","https://openalex.org/W2153976217","https://openalex.org/W2155055267","https://openalex.org/W2157619703","https://openalex.org/W2157818369","https://openalex.org/W2164432256","https://openalex.org/W2171189029","https://openalex.org/W2345098945","https://openalex.org/W2346906038"],"related_works":["https://openalex.org/W2343431741","https://openalex.org/W3029133454","https://openalex.org/W2013997760","https://openalex.org/W1978783429","https://openalex.org/W1998288248","https://openalex.org/W2585844730","https://openalex.org/W2071797996","https://openalex.org/W2072319418","https://openalex.org/W2581154846","https://openalex.org/W2055675844"],"abstract_inverted_index":{"Mouse":[0],"models":[1,28],"of":[2,29,66,71,83,122,134,169,181,186],"neuropsychiatric":[3],"disorders":[4],"are":[5,23,42,59,95],"validated":[6],"according":[7],"to":[8,148],"three":[9,37,69,114],"different":[10],"criteria:":[11],"face":[12,34,110],"validity,":[13,140],"construct":[14,139],"validity":[15,111],"and":[16,48,99,127,154,184],"predictive":[17],"validity.":[18,35],"Autism":[19],"Spectrum":[20],"Disorders":[21],"(ASDs)":[22],"diagnosed":[24],"behaviorally,":[25],"therefore,":[26],"mouse":[27],"ASDs":[30,41,158],"rely":[31],"primarily":[32],"on":[33],"The":[36,54,105],"diagnostic":[38],"criteria":[39,73],"for":[40,103,112,157,193],"impairments":[43],"in":[44,77,162],"social":[45,123],"interaction,":[46],"communication":[47,126],"repetitive":[49],"behavior,":[50,124],"and/or":[51],"restricted":[52],"interests.":[53],"BTBR":[55,79,90,106,136,142,164,188],"T+tf/J":[56],"(BTBR)":[57],"mice":[58,94,107,143,189],"an":[60,85],"inbred":[61,86],"strain":[62],"used":[63],"as":[64,89,190],"model":[65,192],"ASDs.":[67,119,151,194],"All":[68],"types":[70],"behavioral":[72,132,155],"have":[74,108,144,159],"been":[75,160],"evaluated":[76],"the":[78,93,113,131,135,141,163,182,187],"mice.":[80,137],"An":[81],"advantage":[82],"using":[84],"strain,":[87],"such":[88],"is":[91,171],"that,":[92],"considered":[96],"genetically":[97],"identical":[98],"offer":[100,178],"good":[101],"controls":[102],"experimentation.":[104],"demonstrated":[109],"core":[115],"behaviors":[116],"that":[117],"define":[118],"Low":[120],"levels":[121],"altered":[125],"spontaneous":[128],"grooming":[129],"comprise":[130],"phenotype":[133],"For":[138],"some":[145],"physiological\r\ncharacteristics":[146],"similar":[147],"humans":[149],"with":[150],"Several":[152],"drug":[153],"treatments":[156],"examined":[161],"mice;":[165],"however":[166],"this":[167],"area":[168],"research":[170],"still":[172],"being":[173],"developed.":[174],"This":[175],"review":[176],"will":[177],"a":[179,191],"description":[180],"behavior":[183],"physiology":[185]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-09-23T00:00:00"}
