{"id":"https://openalex.org/W2519639841","doi":"https://doi.org/10.1200/jop.2016.016873","title":"Neoadjuvant Chemotherapy for Newly Diagnosed Advanced Ovarian Cancer: Society of Gynecologic Oncology and ASCO Clinical Practice Guideline Summary","display_name":"Neoadjuvant Chemotherapy for Newly Diagnosed Advanced Ovarian Cancer: Society of Gynecologic Oncology and ASCO Clinical Practice Guideline Summary","publication_year":2016,"publication_date":"2016-09-14","ids":{"openalex":"https://openalex.org/W2519639841","doi":"https://doi.org/10.1200/jop.2016.016873","mag":"2519639841"},"language":"en","primary_location":{"id":"doi:10.1200/jop.2016.016873","doi":"https://doi.org/10.1200/jop.2016.016873","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jop.2016.016873","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JOP.2016.016873","source":{"id":"https://openalex.org/S131102849","display_name":"Journal of Oncology Practice","issn_l":"1554-7477","issn":["1554-7477","1935-469X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320068","host_organization_name":"American Society of Clinical Oncology","host_organization_lineage":["https://openalex.org/P4310320068"],"host_organization_lineage_names":["American Society of Clinical Oncology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oncology Practice","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JOP.2016.016873","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032378308","display_name":"Alexi A. Wright","orcid":"https://orcid.org/0000-0002-9776-7114","observed_orcids":["https://orcid.org/0000-0002-9776-7114"]},"institutions":[{"id":"https://openalex.org/I1315885867","display_name":"American Society of Clinical Oncology","ror":"https://ror.org/04fy6j421","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315885867"]},{"id":"https://openalex.org/I2803030221","display_name":"Abington Memorial Hospital","ror":"https://ror.org/03jgh1p68","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2803030221"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexi A. Wright","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA; ASCO, Alexandria, VA; and Abington-Jefferson Health, Abington, PA","ASCO, 2318 Mill Rd, Ste 800, Alexandria, VA 22314;","Abington-Jefferson Health, Abington, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA; ASCO, Alexandria, VA; and Abington-Jefferson Health, Abington, PA","institution_ids":["https://openalex.org/I1315885867","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"ASCO, 2318 Mill Rd, Ste 800, Alexandria, VA 22314;","institution_ids":["https://openalex.org/I1315885867"]},{"raw_affiliation_string":"Abington-Jefferson Health, Abington, PA","institution_ids":["https://openalex.org/I2803030221"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007104720","display_name":"Kari Bohlke","orcid":"https://orcid.org/0000-0003-1529-7903","observed_orcids":["https://orcid.org/0000-0003-1529-7903"]},"institutions":[{"id":"https://openalex.org/I1315885867","display_name":"American Society of Clinical Oncology","ror":"https://ror.org/04fy6j421","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315885867"]},{"id":"https://openalex.org/I2803030221","display_name":"Abington Memorial Hospital","ror":"https://ror.org/03jgh1p68","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2803030221"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kari Bohlke","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA; ASCO, Alexandria, VA; and Abington-Jefferson Health, Abington, PA","ASCO, 2318 Mill Rd, Ste 800, Alexandria, VA 22314;","Abington-Jefferson Health, Abington, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA; ASCO, Alexandria, VA; and Abington-Jefferson Health, Abington, PA","institution_ids":["https://openalex.org/I1315885867","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"ASCO, 2318 Mill Rd, Ste 800, Alexandria, VA 22314;","institution_ids":["https://openalex.org/I1315885867"]},{"raw_affiliation_string":"Abington-Jefferson Health, Abington, PA","institution_ids":["https://openalex.org/I2803030221"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018927056","display_name":"Mitchell I. Edelson","orcid":"https://orcid.org/0000-0001-6708-7380","observed_orcids":["https://orcid.org/0000-0001-6708-7380"]},"institutions":[{"id":"https://openalex.org/I1315885867","display_name":"American Society of Clinical Oncology","ror":"https://ror.org/04fy6j421","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315885867"]},{"id":"https://openalex.org/I2803030221","display_name":"Abington Memorial Hospital","ror":"https://ror.org/03jgh1p68","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2803030221"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell I. Edelson","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA; ASCO, Alexandria, VA; and Abington-Jefferson Health, Abington, PA","ASCO, 2318 Mill Rd, Ste 800, Alexandria, VA 22314;","Abington-Jefferson Health, Abington, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA; ASCO, Alexandria, VA; and Abington-Jefferson Health, Abington, PA","institution_ids":["https://openalex.org/I1315885867","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"ASCO, 2318 Mill Rd, Ste 800, Alexandria, VA 22314;","institution_ids":["https://openalex.org/I1315885867"]},{"raw_affiliation_string":"Abington-Jefferson Health, Abington, PA","institution_ids":["https://openalex.org/I2803030221"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5032,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.69560084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"12","first_page":"1254","last_page":"1257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/advanced-epithelial-ovarian-cancer","display_name":"advanced epithelial ovarian cancer","score":0.8730000257492065},{"id":"https://openalex.org/keywords/primary-cytoreductive-surgery","display_name":"primary cytoreductive surgery","score":0.8600000143051147},{"id":"https://openalex.org/keywords/interval-cytoreductive-surgery","display_name":"interval cytoreductive surgery","score":0.9559999704360962},{"id":"https://openalex.org/keywords/postoperative-chemotherapy","display_name":"postoperative chemotherapy","score":0.7960000038146973},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6620000004768372},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.984000027179718},{"id":"https://openalex.org/keywords/treatment-related-morbidity","display_name":"treatment-related morbidity","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9307656288146973},{"id":"https://openalex.org/C2780435969","wikidata":"https://www.wikidata.org/wiki/Q5625186","display_name":"Gynecologic oncology","level":2,"score":0.8263416290283203},{"id":"https://openalex.org/C2776598537","wikidata":"https://www.wikidata.org/wiki/Q1812651","display_name":"Clinical Oncology","level":3,"score":0.7833613157272339},{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.7127972841262817},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6059648394584656},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5555569529533386},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5463595390319824},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5309457778930664},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.46577709913253784},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.4597506821155548},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.421661376953125},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28524285554885864},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.2792659401893616},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13475441932678223}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jop.2016.016873","doi":"https://doi.org/10.1200/jop.2016.016873","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jop.2016.016873","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JOP.2016.016873","source":{"id":"https://openalex.org/S131102849","display_name":"Journal of Oncology Practice","issn_l":"1554-7477","issn":["1554-7477","1935-469X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320068","host_organization_name":"American Society of Clinical Oncology","host_organization_lineage":["https://openalex.org/P4310320068"],"host_organization_lineage_names":["American Society of Clinical Oncology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oncology Practice","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1200/jop.2016.016873","doi":"https://doi.org/10.1200/jop.2016.016873","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jop.2016.016873","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JOP.2016.016873","source":{"id":"https://openalex.org/S131102849","display_name":"Journal of Oncology Practice","issn_l":"1554-7477","issn":["1554-7477","1935-469X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320068","host_organization_name":"American Society of Clinical Oncology","host_organization_lineage":["https://openalex.org/P4310320068"],"host_organization_lineage_names":["American Society of Clinical Oncology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oncology Practice","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2519639841.pdf","grobid_xml":"https://content.openalex.org/works/W2519639841.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W1852039702","https://openalex.org/W2106767659","https://openalex.org/W2168893449"],"related_works":["https://openalex.org/W2566099954","https://openalex.org/W2529983824","https://openalex.org/W2515729057","https://openalex.org/W2998625851","https://openalex.org/W2588122054","https://openalex.org/W2945673801","https://openalex.org/W4410812749","https://openalex.org/W4407649420","https://openalex.org/W2164307258","https://openalex.org/W4234792047"],"abstract_inverted_index":{"Nearly":[0],"75%":[1],"of":[2,9,26,76,96,119],"ovarian":[3,52,137],"cancers":[4],"are":[5],"diagnosed":[6],"intheadvancedstageofdisease(International":[7],"Federation":[8],"Gynecology":[10],"and":[11,34,45,67,70,79,94,107,121,127],"Obstetrics":[12],"IIIC":[13,133],"or":[14,134],"IV)":[15],"at":[16,142,147],"presentation.Treatment":[17],"with":[18,50,63,114,131],"primarycytoreductivesurgery(PCS)followed":[19],"by":[20,41],"chemotherapy":[21,35,38,47,128],"has":[22],"been":[23,84],"the":[24,87,117],"standard":[25],"care.However,":[27],"two":[28],"randomized":[29],"clinical":[30],"trials":[31,55,82],"compared":[32],"PCS":[33,62,106],"to":[36,61,65],"neoadjuvant":[37],"(NACT)":[39],"followed":[40],"interval":[42,122],"cytoreductive":[43],"surgery":[44],"postoperative":[46],"in":[48,72],"women":[49,130],"advanced":[51],"cancer.1,2":[53],"These":[54],"demonstrated":[56],"that":[57],"NACT":[58,108,120],"was":[59],"noninferior":[60],"respect":[64],"progression-free":[66],"overall":[68,89],"survival":[69],"resulted":[71],"a":[73],"lower":[74,100],"incidence":[75],"treatment-related":[77],"morbidity":[78],"mortality.However,":[80],"both":[81],"have":[83],"criticized":[85],"because":[86],"median":[88],"survival,":[90],"mean":[91],"operative":[92],"times,":[93],"rates":[95],"optimal":[97],"cytoreduction":[98,123,126],"were":[99],"than":[101],"expected.3":[102],"The":[103],"choice":[104],"between":[105],"remains":[109],"controversial.This":[110],"guideline":[111],"provides":[112],"clinicians":[113],"information":[115,139,144],"on":[116],"use":[118],"versus":[124],"primary":[125],"among":[129],"stage":[132],"IV":[135],"epithelial":[136],"cancer.Additional":[138],"is":[140,145],"available":[141,146],"www.asco.org/NACT-ovarian-guideline.Patient":[143],"www.":[148],"cancer.net.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3}],"updated_date":"2026-09-10T07:47:47.112893","created_date":"2016-09-23T00:00:00"}