{"id":"https://openalex.org/W2519488246","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.10044","title":"Patterns of care, prognosis, and survival of patients with metastatic gastrointestinal stromal tumors (GIST) refractory to first-line imatinib and second-line sunitinib.","display_name":"Patterns of care, prognosis, and survival of patients with metastatic gastrointestinal stromal tumors (GIST) refractory to first-line imatinib and second-line sunitinib.","publication_year":2011,"publication_date":"2011-05-20","ids":{"openalex":"https://openalex.org/W2519488246","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.10044","mag":"2519488246"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2011.29.15_suppl.10044","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.10044","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.29.15_suppl.10044","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060949051","display_name":"Anto\u00eene Italiano","orcid":"https://orcid.org/0000-0002-8540-5351","observed_orcids":["https://orcid.org/0000-0002-8540-5351"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Italiano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012782858","display_name":"Angela Cioffi","orcid":"https://orcid.org/0000-0001-8290-6815","observed_orcids":["https://orcid.org/0000-0001-8290-6815"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Cioffi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068677359","display_name":"Robert G. Maki","orcid":"https://orcid.org/0000-0002-9853-2528","observed_orcids":["https://orcid.org/0000-0002-9853-2528"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. G. Maki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021550191","display_name":"Patrick Sch\u00f6ffski","orcid":"https://orcid.org/0000-0001-5980-030X","observed_orcids":["https://orcid.org/0000-0001-5980-030X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Schoffski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074975947","display_name":"Piotr Lukasz Rutkowski","orcid":"https://orcid.org/0000-0002-8920-5429","observed_orcids":["https://orcid.org/0000-0002-8920-5429"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Rutkowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090103193","display_name":"Axel Le Cesne","orcid":"https://orcid.org/0000-0002-8006-8659","observed_orcids":["https://orcid.org/0000-0002-8006-8659"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Le Cesne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065856111","display_name":"Florence Duffaud","orcid":"https://orcid.org/0000-0002-2057-3557","observed_orcids":["https://orcid.org/0000-0002-2057-3557"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Duffaud","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026512478","display_name":"Antoine Adenis","orcid":"https://orcid.org/0000-0003-3123-9746","observed_orcids":["https://orcid.org/0000-0003-3123-9746"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Adenis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082347575","display_name":"Nicol\u00e1s Isambert","orcid":"https://orcid.org/0000-0003-3596-2114","observed_orcids":["https://orcid.org/0000-0003-3596-2114"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Isambert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080620486","display_name":"Emmanuelle Bompas","orcid":"https://orcid.org/0000-0003-4414-7760","observed_orcids":["https://orcid.org/0000-0003-4414-7760"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Bompas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042202815","display_name":"Jean\u2010Yves Blay","orcid":"https://orcid.org/0000-0001-7190-120X","observed_orcids":["https://orcid.org/0000-0001-7190-120X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Blay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029415642","display_name":"Paolo Giovanni Casali","orcid":"https://orcid.org/0000-0003-4056-8023","observed_orcids":["https://orcid.org/0000-0003-4056-8023"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. G. Casali","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046905065","display_name":"Paola Coco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Coco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089853423","display_name":"David R. D\u2019Adamo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. R. D'Adamo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067158281","display_name":"Mary Louise Keohan","orcid":"https://orcid.org/0000-0002-8240-4900","observed_orcids":["https://orcid.org/0000-0002-8240-4900"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. L. Keohan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084836759","display_name":"Maud Toulmonde","orcid":"https://orcid.org/0000-0003-3896-9274","observed_orcids":["https://orcid.org/0000-0003-3896-9274"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Toulmonde","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112214030","display_name":"Christina Antonescu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Antonescu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015197719","display_name":"Maria D\u00eabiec\u2010Rychter","orcid":"https://orcid.org/0000-0001-8183-2105","observed_orcids":["https://orcid.org/0000-0001-8183-2105","https://orcid.org/0000-0002-0326-6766"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Debiec-Rychter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110492914","display_name":"J.M. Coindre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Coindre","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073741289","display_name":"Binh Bui Nguyen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Bui Nguyen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"15_suppl","first_page":"10044","last_page":"10044"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sunitinib","display_name":"sunitinib","score":0.9829999804496765},{"id":"https://openalex.org/keywords/imatinib-refractory-disease","display_name":"imatinib-refractory disease","score":0.8130000233650208},{"id":"https://openalex.org/keywords/sorafenib","display_name":"sorafenib","score":0.7369999885559082},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8650000095367432},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9340000152587891},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.6850000023841858},{"id":"https://openalex.org/keywords/pdgfra-mutation","display_name":"PDGFRA mutation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/kit-exon-11-mutation","display_name":"KIT exon 11 mutation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/kit-exon-9-mutation","display_name":"KIT exon 9 mutation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/patterns-of-care","display_name":"patterns of care","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2775922572","wikidata":"https://www.wikidata.org/wiki/Q83567","display_name":"GiST","level":3,"score":0.9250010251998901},{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.915773868560791},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8950569033622742},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.7794713973999023},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6085093021392822},{"id":"https://openalex.org/C2777007597","wikidata":"https://www.wikidata.org/wiki/Q16869243","display_name":"Stromal tumor","level":3,"score":0.5779034495353699},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5619865655899048},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5502861738204956},{"id":"https://openalex.org/C2993493390","wikidata":"https://www.wikidata.org/wiki/Q5453208","display_name":"First line","level":2,"score":0.5226255059242249},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.45663076639175415},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23541653156280518},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2011.29.15_suppl.10044","doi":"https://doi.org/10.1200/jco.2011.29.15_suppl.10044","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.29.15_suppl.10044","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1967431262","https://openalex.org/W2241935000","https://openalex.org/W2779296370","https://openalex.org/W3029641347","https://openalex.org/W4404168997","https://openalex.org/W2892053514","https://openalex.org/W2560394077","https://openalex.org/W2599392595","https://openalex.org/W2763849926","https://openalex.org/W4308952102"],"abstract_inverted_index":{"10044":[0],"Background:":[1],"Data":[2],"regarding":[3],"the":[4,38,58,177,189,194,216,238],"management":[5,195],"and":[6,19,76,87,135,166,196,204],"outcome":[7],"of":[8,181,198,244],"metastatic":[9],"GIST":[10,199],"patients":[11,200],"(pts)":[12],"refractory":[13,201],"to":[14,202,209,214,231],"1st":[15,73],"line":[16,74,78,102,121,317,362,372],"imatinib":[17],"(I)":[18,277],"2nd":[20,77],"sunitinib":[21],"(S)":[22],"are":[23],"limited.":[24],"Methods:":[25],"Eleven":[26],"institutions":[27,46],"participated":[28],"in":[29,44,49,113,119,242],"this":[30,50],"retrospective":[31],"study.":[32],"A":[33],"preliminary":[34],"analysis":[35,53],"based":[36],"on":[37,72,138,193],"data":[39],"from":[40],"176":[41],"pts":[42],"treated":[43,97],"9":[45,142],"is":[47,188,222],"presented":[48,56],"abstract.":[51],"Final":[52],"will":[54],"be":[55],"at":[57],"meeting.":[59],"Results:":[60],"Median":[61,68,255,261],"age":[62],"was":[63,117],"57":[64],"years":[65],"(range":[66],"18-84).":[67],"progression":[69],"free-survival":[70],"(PFS)":[71],"I":[75,203,221,287,326,336],"S":[79],"were":[80,96,148,176],"22.4":[81],"months":[82],"(mo)":[83],"(95%":[84,90],"CI:":[85,91],"19.2-26.2)":[86],"8.2":[88,356],"mo":[89],"6-10.4),":[92],"respectively.":[93],"Pts":[94,206],"who":[95],"with":[98,151,220,224],"3rd":[99],"or":[100,141,145],"4th":[101,120,316],"sorafenib":[103],"(vs":[104],"other":[105,289,338],"treatment)":[106],"had":[107],"significantly":[108,149],"higher":[109],"PFS,":[110],"although":[111],"improvement":[112],"overall":[114],"survival":[115,197],"(OS)":[116],"observed":[118],"only.":[122],"On":[123,154],"univariate":[124],"analysis,":[125,156],"age,":[126],"performance":[127],"status":[128,168],"\u22652,":[129],"haemoglobin":[130],"<10g/dl,":[131],"albumin":[132,157],"<":[133,285,334],"35g/l":[134],"primary":[136],"mutation":[137],"exon":[139],"11":[140],"(versus":[143],"wild-type":[144],"PDGFR\u03b1":[146],"mutation)":[147],"associated":[150,223],"inferior":[152],"OS.":[153,183],"multivariate":[155],"level":[158],"(HR=2.2,":[159],"95%":[160,170,257,263],"CI":[161,171,258,264],"1.1\u20134.4;":[162],"p":[163,173,280,284,329,333],"=":[164,174,281,330],"0.03)":[165],"mutational":[167],"(HR=4.1,":[169],"1.4\u201311.9;":[172],"0.01)":[175],"sole":[178],"independent":[179],"predictors":[180],"poor":[182],"Conclusions:":[184],"This":[185],"collaborative":[186],"study":[187],"largest":[190],"one":[191],"focusing":[192],"S.":[205],"more":[207],"likely":[208],"carry":[210],"secondary":[211],"mutations":[212],"seem":[213],"have":[215],"worst":[217],"outcome.":[218],"Rechallenge":[219],"limited":[225],"clinical":[226,245],"benefit,":[227],"but":[228],"appears":[229],"superior":[230],"best":[232,239],"supportive":[233,310],"care.":[234],"Sorafenib":[235,301,349],"may":[236],"provide":[237],"treatment":[240],"option":[241],"case":[243],"trial":[246],"ineligibility,":[247],"given":[248],"these":[249],"data.":[250],"Treatment":[251],"N":[252,345],"PFS":[253],"OS":[254],"(months)":[256,262],"P":[259,265],"value":[260,266],"3rd-line":[267],"setting":[268,318,363,373],"157":[269],"3.6":[270,279],"[3.0-4.2]":[271],"-":[272,275,322,325,367,370,377,380],"9.5":[273],"[7.7-11.4]":[274],"Imatinib":[276],"23":[278],"0.001":[282],"9.9":[283],"0.0001":[286,335],"+":[288,337],"agent":[290,339],"(not":[291,340],"\u201cib\u201d)":[292,341],"26":[293,298],"2.7":[294],"8.6":[295],"Nilotinib":[296],"(N)":[297],"3.9":[299],"13.6":[300],"54":[302],"6.1":[303],"11.3":[304],"Other":[305,353],"10":[306],"2.5":[307,320],"9.1":[308],"Best":[309],"care":[311],"(BSC)":[312],"18":[313,327,374],"2.1":[314],"2.3":[315],"104":[319],"[1.9-3.0]":[321],"5.1":[323],"[3.6-6.7]":[324],"4.9":[328],"0.008":[331],"7.4":[332],"13":[342],"1.9":[343],"5.5":[344],"14":[346,350],"3.8":[347],"5.4":[348],"7.5":[351],"11.5":[352],"20":[354],"1.8":[355],"BSC":[357],"25":[358],"1.6":[359,360],"5th":[361],"45":[364],"2.6":[365],"[1.7-3.6]":[366],"4.4":[368],"[2.7-6.0]":[369],"6th":[371],"1.4":[375],"[0.6-2.2]":[376],"2.8":[378],"[1.4-4.2]":[379]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-09-23T00:00:00"}