{"id":"https://openalex.org/W2519203493","doi":null,"title":"Polyprenols isolated from Picea abies L.spruce needles influence atorvastatin-mediated muscle strength weakness in Wistar female rats","display_name":"Polyprenols isolated from Picea abies L.spruce needles influence atorvastatin-mediated muscle strength weakness in Wistar female rats","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2519203493","mag":"2519203493"},"language":"en","primary_location":{"id":"mag:2519203493","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/93652X/2015S1/89766683504849538349495550.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306542252","display_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u4e0e\u6bd2\u7406\u5b66\u6742\u5fd7","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u4e0e\u6bd2\u7406\u5b66\u6742\u5fd7","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056625262","display_name":"Baiba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Baiba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051975601","display_name":"Jansone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jansone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Zane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053089992","display_name":"Dzirkale","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dzirkale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066105572","display_name":"Kaspars","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaspars","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091749206","display_name":"Jekabsons","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jekabsons","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048700172","display_name":"Vladimirs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vladimirs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020106525","display_name":"Pilipenko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pilipenko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010695069","display_name":"Ulrika","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ulrika","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022966310","display_name":"Beitnere","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beitnere","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054663338","display_name":"Raimonds","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raimonds","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071774463","display_name":"Skumbins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Skumbins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077578138","display_name":"Zita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006244002","display_name":"Freiberga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Freiberga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Elga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022230785","display_name":"Poppela","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Poppela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086431217","display_name":"Ugis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ugis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059195400","display_name":"Kletnieks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kletnieks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024619907","display_name":"Ilona","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ilona","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5016476054","display_name":"Vanaga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vanaga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17953528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"113","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.3082999885082245,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.3082999885082245,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13651","display_name":"Medicinal Plants and Bioactive Compounds","score":0.17800000309944153,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.09000000357627869,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyprenols","display_name":"polyprenols","score":0.9980000257492065},{"id":"https://openalex.org/keywords/norway-spruce","display_name":"Norway spruce","score":0.9259999990463257},{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":0.875},{"id":"https://openalex.org/keywords/statin-induced-myopathy","display_name":"statin-induced myopathy","score":0.8230000138282776},{"id":"https://openalex.org/keywords/muscle-weakness","display_name":"muscle weakness","score":0.9309999942779541},{"id":"https://openalex.org/keywords/muscle-strength","display_name":"muscle strength","score":0.8119999766349792},{"id":"https://openalex.org/keywords/muscle-tone","display_name":"muscle tone","score":0.6570000052452087},{"id":"https://openalex.org/keywords/locomotor-coordination","display_name":"locomotor coordination","score":0.8019999861717224},{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.9169999957084656},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.9129999876022339},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.3720000088214874},{"id":"https://openalex.org/keywords/protective-effect","display_name":"protective effect","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.8997502326965332},{"id":"https://openalex.org/C2777433710","wikidata":"https://www.wikidata.org/wiki/Q5609571","display_name":"Grip strength","level":2,"score":0.5157483220100403},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.4869576394557953},{"id":"https://openalex.org/C2776418732","wikidata":"https://www.wikidata.org/wiki/Q270421","display_name":"Muscle weakness","level":2,"score":0.48297587037086487},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45341357588768005},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44684237241744995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43935737013816833},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.372139036655426},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3574063181877136},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.19752034544944763},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19429433345794678}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2519203493","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/93652X/2015S1/89766683504849538349495550.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306542252","display_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u4e0e\u6bd2\u7406\u5b66\u6742\u5fd7","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u4e0e\u6bd2\u7406\u5b66\u6742\u5fd7","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2322198581","https://openalex.org/W3083979820","https://openalex.org/W7011619665","https://openalex.org/W4410431489","https://openalex.org/W3042570948","https://openalex.org/W131871970","https://openalex.org/W7096248191","https://openalex.org/W2148880612","https://openalex.org/W2323540323","https://openalex.org/W4403503808"],"abstract_inverted_index":{"OBJECTIVE":[0],"To":[1],"assess":[2],"the":[3,215],"effects":[4,239],"of":[5,33,57,95,197,223,228],"polyprenols(isolated":[6],"from":[7],"Picea":[8],"abies":[9],"L.spruce":[10],"needles)on":[11],"muscle":[12,23,58,81,123,225],"strength/tone":[13,24],"and":[14,35,80,99,117,152,179,186],"coordination,and":[15],"to":[16,76,131,159],"investigate":[17],"whether":[18],"polyprenols":[19,219,229],"may":[20,232],"protect":[21],"atorvastatin-mediated":[22],"weakness":[25,124],"in":[26,51,89,114,125,144,172,184,195,200,240],"female":[27,53,201],"Wistar":[28,52,202],"rats.METHODS":[29],"Polyprenols":[30],"at":[31,150,164],"doses":[32],"1,10":[34],"20mg\u00b7kg-1,atorvastatin":[36],"80mg\u00b7kg-1":[37],"or":[38],"their":[39],"combination":[40,227],"were":[41,182],"administered":[42],"once":[43],"daily":[44],"per":[45,55,148],"os":[46],"for":[47,235],"16":[48],"consecutive":[49],"days":[50],"rats(n=9-10":[54],"group).Assessment":[56],"strength":[59,64,116,127],"was":[60,74,87,103,140,169,192,211],"performed":[61],"by":[62,142,214],"grip":[63,126],"test(on":[65,70,92],"day":[66,71,83,93,106],"15)and":[67],"wire":[68,145,173],"hang":[69,146,174],"16).Rotarod":[72],"test":[73],"used":[75],"measured":[77],"locomotor":[78,85],"coordination":[79],"tone(on":[82],"16).General":[84],"activity":[86,102,208],"evaluated":[88],"open":[90,187],"field":[91,188],"15).Assessment":[94],"plasma":[96,205],"cholesterol":[97,190],"level":[98,191],"creatine":[100,206],"kinase":[101,207],"done":[104],"on":[105],"17.RESULTS":[107],"Atorvastatin-treated":[108],"rats":[109],"exhibited":[110],"a":[111,243],"marked":[112],"decrease":[113],"grasping":[115],"hanging":[118,137],"time.PP(20mg\u00b7kg-1)significantly":[119],"protected":[120],"against":[121],"atorvastatin-induced":[122,224],"test,and":[128],"restored":[129],"it":[130,210],"control":[132,160,178],"values.At":[133],"all":[134],"doses,polyprenols":[135],"prolonged":[136,170],"time":[138,168],"which":[139],"decreased":[141],"atorvastatin":[143,231,245],"test.Polyprenols":[147],"se":[149],"1":[151],"10mg\u00b7kg-1":[153],"did":[154],"not":[155,193,212],"show":[156],"difference":[157],"compared":[158],"group":[161],"animals,while":[162],"only":[163],"20mg\u00b7kg-1":[165],"h":[166],"anging":[167],"vs.control":[171],"test.No":[175],"changes":[176],"between":[177],"tested":[180,198],"groups":[181,199],"observed":[183],"rotarod":[185],"tests.Blood":[189],"changed":[194],"any":[196],"rats.Polyprenols(20mg\u00b7kg-1)significantly(by":[203],"25%)increased":[204],"but":[209],"affected":[213],"combined":[216],"treatment.CONCLUSION":[217],"Since":[218],"acted":[220],"as":[221],"protectors":[222],"weakness,the":[226],"with":[230],"be":[233],"helpful":[234],"reducing":[236],"muscle-related":[237],"side":[238],"patients":[241],"receiving":[242],"long-term":[244],"therapy.":[246]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-09-23T00:00:00"}