{"id":"https://openalex.org/W2518944765","doi":null,"title":"Characterization of novel extracellular matrix (ECM) proteins (MGP and Lumican) and their implications in vascular development, angiogenesis, and cancer","display_name":"Characterization of novel extracellular matrix (ECM) proteins (MGP and Lumican) and their implications in vascular development, angiogenesis, and cancer","publication_year":2013,"publication_date":"2013-01-30","ids":{"openalex":"https://openalex.org/W2518944765","mag":"2518944765"},"language":"en","primary_location":{"id":"pmh:oai:scholars.indstate.edu:10484/4751","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10484/4751","pdf_url":null,"source":{"id":"https://openalex.org/S4306400829","display_name":"Sycamore Scholars (Indiana State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86420138","host_organization_name":"Indiana State University","host_organization_lineage":["https://openalex.org/I86420138"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033993779","display_name":"Bikram Sharma","orcid":"https://orcid.org/0000-0003-0479-0823","observed_orcids":["https://orcid.org/0000-0003-0479-0823"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bikram Sharma","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0479-0823","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033993779"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.06539999693632126,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8960000276565552},{"id":"https://openalex.org/keywords/matrix-gla-protein","display_name":"matrix Gla protein","score":0.925000011920929},{"id":"https://openalex.org/keywords/lumican","display_name":"lumican","score":0.9879999756813049},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/vascular-development","display_name":"vascular development","score":0.871999979019165},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6389999985694885},{"id":"https://openalex.org/keywords/endothelial-sprouting","display_name":"endothelial sprouting","score":0.9340000152587891},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.7179999947547913},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.4000000059604645},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.6359999775886536},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.8111851215362549},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7492979764938354},{"id":"https://openalex.org/C2779457992","wikidata":"https://www.wikidata.org/wiki/Q18028707","display_name":"Lumican","level":5,"score":0.7245486974716187},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4353746771812439},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40029874444007874},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3702414035797119},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3445039689540863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31313520669937134},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.23783132433891296},{"id":"https://openalex.org/C2779794767","wikidata":"https://www.wikidata.org/wiki/Q18248676","display_name":"Decorin","level":4,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholars.indstate.edu:10484/4751","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10484/4751","pdf_url":null,"source":{"id":"https://openalex.org/S4306400829","display_name":"Sycamore Scholars (Indiana State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86420138","host_organization_name":"Indiana State University","host_organization_lineage":["https://openalex.org/I86420138"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2518944765","doi":null,"is_oa":false,"landing_page_url":"https://indstate.openrepository.com/handle/10484/4751","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":124,"referenced_works":["https://openalex.org/W67680274","https://openalex.org/W781291094","https://openalex.org/W1494416455","https://openalex.org/W1495287184","https://openalex.org/W1497716328","https://openalex.org/W1506057274","https://openalex.org/W1529465070","https://openalex.org/W1532097092","https://openalex.org/W1540826870","https://openalex.org/W1552389611","https://openalex.org/W1561751527","https://openalex.org/W1562645464","https://openalex.org/W1573363574","https://openalex.org/W1575586433","https://openalex.org/W1577210936","https://openalex.org/W1592973534","https://openalex.org/W1860315828","https://openalex.org/W1879493681","https://openalex.org/W1931127206","https://openalex.org/W1956254370","https://openalex.org/W1964054216","https://openalex.org/W1971162717","https://openalex.org/W1971951473","https://openalex.org/W1975910155","https://openalex.org/W1981844849","https://openalex.org/W1982639675","https://openalex.org/W1985712533","https://openalex.org/W1985760249","https://openalex.org/W1985804036","https://openalex.org/W1988403143","https://openalex.org/W1991362893","https://openalex.org/W1995562870","https://openalex.org/W1995857537","https://openalex.org/W1996015837","https://openalex.org/W2000292756","https://openalex.org/W2013322971","https://openalex.org/W2013471998","https://openalex.org/W2013818100","https://openalex.org/W2022717979","https://openalex.org/W2024818970","https://openalex.org/W2025036947","https://openalex.org/W2025854516","https://openalex.org/W2027388325","https://openalex.org/W2028796640","https://openalex.org/W2031856001","https://openalex.org/W2033829777","https://openalex.org/W2034458870","https://openalex.org/W2035023695","https://openalex.org/W2036050820","https://openalex.org/W2036341761","https://openalex.org/W2036751011","https://openalex.org/W2038690518","https://openalex.org/W2040129777","https://openalex.org/W2040574458","https://openalex.org/W2045247659","https://openalex.org/W2045570819","https://openalex.org/W2046044320","https://openalex.org/W2048990271","https://openalex.org/W2050790000","https://openalex.org/W2052950329","https://openalex.org/W2053958843","https://openalex.org/W2055622456","https://openalex.org/W2055724051","https://openalex.org/W2056916102","https://openalex.org/W2058579856","https://openalex.org/W2059039052","https://openalex.org/W2059069305","https://openalex.org/W2060072724","https://openalex.org/W2061922416","https://openalex.org/W2068362930","https://openalex.org/W2071184715","https://openalex.org/W2071236821","https://openalex.org/W2075773133","https://openalex.org/W2076274098","https://openalex.org/W2078875435","https://openalex.org/W2080720938","https://openalex.org/W2085775973","https://openalex.org/W2086140631","https://openalex.org/W2086918224","https://openalex.org/W2088502271","https://openalex.org/W2093498435","https://openalex.org/W2096251733","https://openalex.org/W2096353669","https://openalex.org/W2099681388","https://openalex.org/W2100025529","https://openalex.org/W2100427896","https://openalex.org/W2101180504","https://openalex.org/W2102618636","https://openalex.org/W2103046899","https://openalex.org/W2105210284","https://openalex.org/W2107105080","https://openalex.org/W2107109133","https://openalex.org/W2107141327","https://openalex.org/W2112846750","https://openalex.org/W2115128893","https://openalex.org/W2117692326","https://openalex.org/W2117748018","https://openalex.org/W2122180991","https://openalex.org/W2122680170","https://openalex.org/W2123684807","https://openalex.org/W2124364682","https://openalex.org/W2128231056","https://openalex.org/W2129737450","https://openalex.org/W2130835350","https://openalex.org/W2131393213","https://openalex.org/W2131765789","https://openalex.org/W2132566055","https://openalex.org/W2133943800","https://openalex.org/W2135916513","https://openalex.org/W2136022210","https://openalex.org/W2137825733","https://openalex.org/W2147797062","https://openalex.org/W2147834547","https://openalex.org/W2150750426","https://openalex.org/W2151967532","https://openalex.org/W2152777246","https://openalex.org/W2153839353","https://openalex.org/W2155991810","https://openalex.org/W2156121797","https://openalex.org/W2159087408","https://openalex.org/W2167629024","https://openalex.org/W2168125520","https://openalex.org/W2171244087","https://openalex.org/W4244208753"],"related_works":["https://openalex.org/W2605258604","https://openalex.org/W2013471998","https://openalex.org/W1995562870","https://openalex.org/W2031856001","https://openalex.org/W1967164561","https://openalex.org/W781291094","https://openalex.org/W7098356774","https://openalex.org/W2139386138","https://openalex.org/W4281728293","https://openalex.org/W2612947095"],"abstract_inverted_index":{"Extracellular":[0],"matrix":[1,32],"(ECM)":[2],"constitutes":[3],"a":[4,42,157,201],"large":[5],"component":[6],"of":[7,30,48,73,108,132],"our":[8,19,39,105,189],"tissue":[9],"structure.":[10],"Primarily,":[11],"ECM":[12,57,65,91,110,134,159],"provides":[13],"structural":[14],"and":[15,27,34,46,54,69,78,102,112,139,147,169,196],"adhesive":[16],"support":[17],"to":[18,62,82,85,98],"cells,":[20],"but":[21],"it":[22,103,116],"also":[23,177],"controls":[24],"cellular":[25,120],"signaling":[26],"behavior.":[28],"Homeostasis":[29],"extracellular":[31],"composition":[33],"function":[35],"is":[36,59,127,156],"maintained":[37],"by":[38,165,181],"body":[40],"through":[41],"balanced":[43],"synthesis,":[44,66],"degradation":[45],"remodeling":[47],"ECM.":[49,88],"However,":[50],"under":[51],"pathological":[52],"conditions":[53],"genetic":[55],"mutations,":[56],"homeostasis":[58],"disrupted":[60],"due":[61,84],"deregulation":[63],"in":[64,87,118,143,200],"assembly,":[67],"remodeling,":[68],"degradation.":[70],"A":[71],"number":[72],"diseases,":[74,101],"including":[75],"cardiovascular":[76],"diseases":[77],"cancer,":[79],"are":[80],"found":[81],"occur":[83],"alterations":[86],"Therefore,":[89],"targeting":[90],"can":[92],"be":[93],"an":[94],"attractive":[95],"therapeutic":[96],"approach":[97],"treat":[99],"these":[100],"requires":[104],"complete":[106],"understanding":[107],"the":[109,113,130,186],"molecules":[111],"molecular":[114],"mechanism":[115],"employs":[117],"controlling":[119],"functions.":[121],"To":[122],"this":[123,125,151],"end,":[124],"study":[126,152],"aimed":[128],"at":[129],"characterization":[131],"two":[133],"proteins\u2014Matrix":[135],"Gla":[136],"Protein":[137],"(MGP)":[138],"Lumican\u2014for":[140],"their":[141],"roles":[142],"vascular":[144,171],"development,":[145],"angiogenesis,":[146],"cancer.":[148],"Findings":[149],"from":[150],"show":[153,191],"that":[154,161],"MGP":[155,176],"critical":[158],"regulator":[160],"promotes":[162],"angiogenic":[163],"resolution":[164],"suppressing":[166],"endothelial":[167],"sprouting":[168],"stabilizing":[170],"lumen":[172],"formation.":[173],"In":[174],"addition,":[175],"inhibits":[178],"tumor":[179,183,194],"growth":[180,195],"inhibiting":[182],"angiogenesis.":[184],"On":[185],"other":[187],"hand,":[188],"findings":[190],"Lumican":[192],"suppresses":[193],"has":[197],"anti-angiogenic":[198],"activity":[199],"context":[202],"specific":[203],"manner.":[204]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-09-23T00:00:00"}