{"id":"https://openalex.org/W2518314263","doi":"https://doi.org/10.1074/jbc.m116.738807","title":"Reversal of Phospholamban Inhibition of the Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA) Using Short, Protein-interacting RNAs and Oligonucleotide Analogs","display_name":"Reversal of Phospholamban Inhibition of the Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA) Using Short, Protein-interacting RNAs and Oligonucleotide Analogs","publication_year":2016,"publication_date":"2016-08-17","ids":{"openalex":"https://openalex.org/W2518314263","doi":"https://doi.org/10.1074/jbc.m116.738807","mag":"2518314263","pmid":"https://pubmed.ncbi.nlm.nih.gov/27531746","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5076822"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m116.738807","doi":"https://doi.org/10.1074/jbc.m116.738807","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m116.738807","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m116.738807","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088273527","display_name":"Kailey J. Soller","orcid":"https://orcid.org/0000-0002-4675-1964","observed_orcids":["https://orcid.org/0000-0002-4675-1964"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kailey J. Soller","raw_affiliation_strings":["From the Departments of Chemistry and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Chemistry and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101789903","display_name":"Jing Yang","orcid":"https://orcid.org/0000-0003-3363-5515","observed_orcids":["https://orcid.org/0000-0003-3363-5515"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Yang","raw_affiliation_strings":["From the Departments of Chemistry and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Chemistry and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009664013","display_name":"Gianluigi Veglia","orcid":"https://orcid.org/0000-0002-2795-6964","observed_orcids":["https://orcid.org/0000-0002-2795-6964","https://orcid.org/0000-0001-8789-9546"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gianluigi Veglia","raw_affiliation_strings":["Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455","From the Departments of Chemistry and vegli001@umn.edu","From the Departments of Chemistry and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"From the Departments of Chemistry and vegli001@umn.edu","institution_ids":[]},{"raw_affiliation_string":"From the Departments of Chemistry and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019899850","display_name":"Michael T. Bowser","orcid":"https://orcid.org/0000-0002-1570-2414","observed_orcids":["https://orcid.org/0000-0002-1570-2414"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael T. Bowser","raw_affiliation_strings":["From the Departments of Chemistry and bowser@umn.edu","From the Departments of Chemistry and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Chemistry and bowser@umn.edu","institution_ids":[]},{"raw_affiliation_string":"From the Departments of Chemistry and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009664013","https://openalex.org/A5019899850"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.5151,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.90450675,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"291","issue":"41","first_page":"21510","last_page":"21518"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.2930000126361847,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.2930000126361847,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.26170000433921814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.1298000067472458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phospholamban","display_name":"phospholamban","score":0.9879999756813049},{"id":"https://openalex.org/keywords/serca","display_name":"SERCA","score":0.9549999833106995},{"id":"https://openalex.org/keywords/sarco-endoplasmic-reticulum-ca2-atpase","display_name":"sarco/endoplasmic reticulum Ca2+-ATPase","score":0.9549999833106995},{"id":"https://openalex.org/keywords/protein-rna-interactions","display_name":"RNA-protein interactions","score":0.5270000100135803},{"id":"https://openalex.org/keywords/xeno-nucleic-acids","display_name":"XNA","score":0.8320000171661377},{"id":"https://openalex.org/keywords/oligonucleotide-analogs","display_name":"oligonucleotide analogues","score":0.9010000228881836},{"id":"https://openalex.org/keywords/mir-1","display_name":"miR-1","score":0.8560000061988831},{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":0.9990000128746033},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.3100000023841858}],"concepts":[{"id":"https://openalex.org/C2781414619","wikidata":"https://www.wikidata.org/wiki/Q24785512","display_name":"SERCA","level":4,"score":0.9623489379882812},{"id":"https://openalex.org/C17137333","wikidata":"https://www.wikidata.org/wiki/Q410105","display_name":"Phospholamban","level":3,"score":0.9312152862548828},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5551121234893799},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.5250484943389893},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.48846903443336487},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4693986475467682},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46157822012901306},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4562959671020508},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3804601728916168},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3614974915981293},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32263684272766113},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08353552222251892}],"mesh":[{"descriptor_ui":"D000099211","descriptor_name":"Phospholamban","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053498","descriptor_name":"Sarcoplasmic Reticulum Calcium-Transporting ATPases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053498","descriptor_name":"Sarcoplasmic Reticulum Calcium-Transporting ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053498","descriptor_name":"Sarcoplasmic Reticulum Calcium-Transporting ATPases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m116.738807","doi":"https://doi.org/10.1074/jbc.m116.738807","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m116.738807","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5076822","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5076822","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:27531746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27531746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m116.738807","doi":"https://doi.org/10.1074/jbc.m116.738807","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m116.738807","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1965713349","display_name":"University of Minnesota Clinical and Translational Science Institute (UMN CTSI)","funder_award_id":"UL1TR000114","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4683644755","display_name":"Structural Basis Of Dilated Cardiomyopathy","funder_award_id":"R01GM072701","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5208120376","display_name":"Microfluidic Selection of Aptamers","funder_award_id":"R01GM063533","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5499460782","display_name":null,"funder_award_id":"13PRE16950023","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W58055601","https://openalex.org/W76973823","https://openalex.org/W123622833","https://openalex.org/W1499775870","https://openalex.org/W1520266592","https://openalex.org/W1696977597","https://openalex.org/W1980691914","https://openalex.org/W1997874930","https://openalex.org/W1998713271","https://openalex.org/W2003522806","https://openalex.org/W2006892972","https://openalex.org/W2014393752","https://openalex.org/W2022669496","https://openalex.org/W2023217871","https://openalex.org/W2026949272","https://openalex.org/W2027304858","https://openalex.org/W2029614054","https://openalex.org/W2036934832","https://openalex.org/W2039935249","https://openalex.org/W2043863942","https://openalex.org/W2050824263","https://openalex.org/W2054604628","https://openalex.org/W2054618173","https://openalex.org/W2060515857","https://openalex.org/W2067275294","https://openalex.org/W2072190764","https://openalex.org/W2085038746","https://openalex.org/W2088565678","https://openalex.org/W2092113020","https://openalex.org/W2098404009","https://openalex.org/W2098505754","https://openalex.org/W2107033535","https://openalex.org/W2109675385","https://openalex.org/W2110533096","https://openalex.org/W2114559045","https://openalex.org/W2115495932","https://openalex.org/W2123490348","https://openalex.org/W2126250632","https://openalex.org/W2130483595","https://openalex.org/W2130750499","https://openalex.org/W2134336691","https://openalex.org/W2137081126","https://openalex.org/W2139331439","https://openalex.org/W2144792857","https://openalex.org/W2146665756","https://openalex.org/W2149091556","https://openalex.org/W2153066829","https://openalex.org/W2156314083","https://openalex.org/W2159453909","https://openalex.org/W2167963746","https://openalex.org/W2171260596","https://openalex.org/W2188449804","https://openalex.org/W2397630349","https://openalex.org/W2475974849","https://openalex.org/W3145571634"],"related_works":["https://openalex.org/W2397630349","https://openalex.org/W2087386212","https://openalex.org/W2064615961","https://openalex.org/W1991160959","https://openalex.org/W2149091556","https://openalex.org/W2036934832","https://openalex.org/W2104021296","https://openalex.org/W1990886180","https://openalex.org/W2021059476","https://openalex.org/W1993988393"],"abstract_inverted_index":{"The":[0,124],"sarco(endo)plasmic":[1],"reticulum":[2],"Ca":[3,19],"2+":[4,20],"-ATPase":[5],"(SERCA)":[6],"and":[7,34,66,83,101,147,152,175],"phospholamban":[8],"(PLN)":[9],"complex":[10,26],"regulates":[11],"heart":[12,32],"relaxation":[13],"through":[14],"its":[15],"removal":[16],"of":[17,24,69,104,112,129,156],"cytosolic":[18],"during":[21],"diastole.":[22],"Dysfunction":[23],"this":[25],"has":[27,54],"been":[28,55],"related":[29],"to":[30,120,158,179],"many":[31],"disorders":[33],"is":[35,109,115],"therefore":[36],"a":[37,72,159,163],"key":[38],"pharmacological":[39,134],"target.":[40],"There":[41],"are":[42,185],"currently":[43],"no":[44],"therapeutics":[45],"that":[46,58,81,143,173,184],"directly":[47],"target":[48],"either":[49],"SERCA":[50,70,118,157],"or":[51,87,138],"PLN.":[52],"It":[53],"previously":[56],"reported":[57],"single-stranded":[59,84],"DNA":[60,137],"binds":[61],"PLN":[62,94,108,113,150,154,190],"with":[63],"strong":[64],"affinity":[65],"relieves":[67],"inhibition":[68,103,114,155,191],"in":[71,126],"length-dependent":[73],"manner.":[74],"In":[75],"the":[76],"current":[77],"article,":[78],"we":[79],"demonstrate":[80],"RNAs":[82],"oligonucleotide":[85],"analogs,":[86],"xeno":[88],"nucleic":[89],"acids":[90],"(XNAs),":[91],"also":[92,141],"bind":[93,149],"strongly":[95,151],"(":[96],"K":[97],"d":[98],"<10":[99],"nm)":[100],"relieve":[102,153],"SERCA.":[105],"Affinity":[106],"for":[107],"sequence-independent.":[110],"Relief":[111],"length-dependent,":[116],"allowing":[117],"activity":[119],"be":[121],"restored":[122],"incrementally.":[123],"improved":[125],"vivo":[127],"stability":[128],"XNAs":[130],"offers":[131],"more":[132,186],"realistic":[133],"potential":[135],"than":[136,162,192],"RNA.":[139],"We":[140],"found":[142],"microRNAs":[144],"(miRNAs)":[145],"1":[146],"21":[148],"greater":[160],"extent":[161],"similar":[164],"length":[165],"random":[166,193],"sequence":[167,182],"RNA":[168],"mixture.":[169],"This":[170],"may":[171],"suggest":[172],"miR-1":[174],"miR-21":[176],"have":[177],"evolved":[178],"contain":[180],"distinct":[181],"elements":[183],"effective":[187],"at":[188],"relieving":[189],"sequences.":[194]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-09-16T00:00:00"}