{"id":"https://openalex.org/W2516850583","doi":null,"title":"The Role of T Lymphocyte Subsets in The Pathogenesis of Multiple Sclerosis","display_name":"The Role of T Lymphocyte Subsets in The Pathogenesis of Multiple Sclerosis","publication_year":2016,"publication_date":"2016-06-10","ids":{"openalex":"https://openalex.org/W2516850583","mag":"2516850583"},"language":"en","primary_location":{"id":"mag:2516850583","doi":null,"is_oa":false,"landing_page_url":"http://eprints.rums.ac.ir/5591/","pdf_url":null,"source":{"id":"https://openalex.org/S5407051355","display_name":"Journal of Rafsanjan University of Medical Sciences","issn_l":"2305-0535","issn":["2305-0535"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Rafsanjan University of Medical Sciences","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060210014","display_name":"Zahra Etesam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I235686326","display_name":"Kerman University of Medical Sciences","ror":"https://ror.org/02kxbqc24","country_code":"IR","type":"education","lineage":["https://openalex.org/I235686326"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Zahra Etesam","raw_affiliation_strings":["Kerman Univ. of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kerman Univ. of Medical Sciences","institution_ids":["https://openalex.org/I235686326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085113824","display_name":"Maryam Nemati","orcid":"https://orcid.org/0000-0001-5861-1224","observed_orcids":["https://orcid.org/0000-0001-5861-1224"]},"institutions":[{"id":"https://openalex.org/I235686326","display_name":"Kerman University of Medical Sciences","ror":"https://ror.org/02kxbqc24","country_code":"IR","type":"education","lineage":["https://openalex.org/I235686326"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Maryam Nemati","raw_affiliation_strings":["Kerman Univ. of Medical Sciences"],"raw_orcid":"https://orcid.org/0000-0001-5861-1224","affiliations":[{"raw_affiliation_string":"Kerman Univ. of Medical Sciences","institution_ids":["https://openalex.org/I235686326"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049462917","display_name":"Abdollah Jafarzadeh","orcid":"https://orcid.org/0000-0002-8180-0602","observed_orcids":["https://orcid.org/0000-0002-8180-0602"]},"institutions":[{"id":"https://openalex.org/I86959772","display_name":"Rafsanjan University of Medical Sciences","ror":"https://ror.org/01v8x0f60","country_code":"IR","type":"education","lineage":["https://openalex.org/I86959772"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Abdollah Jafarzadeh","raw_affiliation_strings":["Rafsanjan University of Medical Sciences"],"raw_orcid":"https://orcid.org/0000-0002-8180-0602","affiliations":[{"raw_affiliation_string":"Rafsanjan University of Medical Sciences","institution_ids":["https://openalex.org/I86959772"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2211,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.54748144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"15","issue":"3","first_page":"257","last_page":"280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.9890000224113464},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.8920000195503235},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.9639999866485596},{"id":"https://openalex.org/keywords/th9-cells","display_name":"Th9 cells","score":0.9380000233650208},{"id":"https://openalex.org/keywords/th22-cells","display_name":"Th22 cells","score":1.0},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/autoreactive-t-cells","display_name":"autoreactive T cells","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.5680000185966492},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7080000042915344},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.7250000238418579},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7309619784355164},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7239996194839478},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.6606392860412598},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6292926073074341},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4372670352458954},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4159000515937805},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41082000732421875},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.38094067573547363}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2516850583","doi":null,"is_oa":false,"landing_page_url":"http://eprints.rums.ac.ir/5591/","pdf_url":null,"source":{"id":"https://openalex.org/S5407051355","display_name":"Journal of Rafsanjan University of Medical Sciences","issn_l":"2305-0535","issn":["2305-0535"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Rafsanjan University of Medical Sciences","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W18824594","https://openalex.org/W775956452","https://openalex.org/W1538907359","https://openalex.org/W1543753614","https://openalex.org/W1797422316","https://openalex.org/W1896163982","https://openalex.org/W1903439047","https://openalex.org/W1925756130","https://openalex.org/W1968863779","https://openalex.org/W1973311558","https://openalex.org/W1976266513","https://openalex.org/W1977213877","https://openalex.org/W1989805933","https://openalex.org/W2002436119","https://openalex.org/W2005451808","https://openalex.org/W2024140382","https://openalex.org/W2028935955","https://openalex.org/W2032222821","https://openalex.org/W2034698482","https://openalex.org/W2035679400","https://openalex.org/W2037734036","https://openalex.org/W2043573475","https://openalex.org/W2044321247","https://openalex.org/W2049329367","https://openalex.org/W2052325011","https://openalex.org/W2054539129","https://openalex.org/W2059656664","https://openalex.org/W2063628490","https://openalex.org/W2064949253","https://openalex.org/W2078827499","https://openalex.org/W2084388036","https://openalex.org/W2100645101","https://openalex.org/W2100758902","https://openalex.org/W2105132195","https://openalex.org/W2105491136","https://openalex.org/W2105663540","https://openalex.org/W2108613248","https://openalex.org/W2112334818","https://openalex.org/W2114062831","https://openalex.org/W2115285149","https://openalex.org/W2116686907","https://openalex.org/W2117647921","https://openalex.org/W2121395252","https://openalex.org/W2136423984","https://openalex.org/W2141841595","https://openalex.org/W2142808413","https://openalex.org/W2143479333","https://openalex.org/W2145164170","https://openalex.org/W2145521029","https://openalex.org/W2147180300","https://openalex.org/W2147335530","https://openalex.org/W2150722068","https://openalex.org/W2153509933","https://openalex.org/W2157837362","https://openalex.org/W2169024323","https://openalex.org/W2180696344","https://openalex.org/W2182060226","https://openalex.org/W2199588523","https://openalex.org/W2206873254","https://openalex.org/W2330920478"],"related_works":["https://openalex.org/W2038860593","https://openalex.org/W4234444124","https://openalex.org/W2333485330","https://openalex.org/W2502957500","https://openalex.org/W1763258797","https://openalex.org/W1494747905","https://openalex.org/W2941884783","https://openalex.org/W3031449146","https://openalex.org/W3008780596","https://openalex.org/W1550823327"],"abstract_inverted_index":{"Background":[0],"and":[1,35,82,110,139,154,159,170,180,184,189],"Objectives:":[2],"Multiple":[3,205,234],"sclerosis":[4],"(MS)":[5],"is":[6],"an":[7],"autoimmune":[8],"neurodegenerative":[9],"disease":[10],"of":[11,20,41,78,87,167,172,176,187,200,226,233],"the":[12,18,39,72,76,124,185],"central":[13,58],"nervous":[14],"system":[15],"(CNS).":[16],"Although,":[17],"contribution":[19],"various":[21],"cells":[22,37,55,94,100,114,129,133,151,156,182],"such":[23],"as":[24],"B":[26],"cells,":[27,30,33,127],"CD8+":[28],"T":[29,54,79,93,99,112,126,227],"microglia/macrophages,":[31],"dendritic":[32],"asterocytes":[34],"mast":[36],"in":[38,60,64,85,146,230],"pathogenesis":[40,86],"MS":[42,65,88,147,201],"have":[43,161],"been":[44,162],"demonstrated,":[45],"however,":[46],"it":[47],"seems":[48],"that":[49],"autoreactive":[50],"myelin":[51],"specific":[52],"CD4+":[53],"play":[56,143],"a":[57,165],"role":[59],"pathological":[61],"events":[62],"contributing":[63],"pathogenesis.":[66],"The":[67,174,224,231],"aim":[68],"was":[69],"to":[70,214],"evaluate":[71],"recent":[73],"findings":[74],"regarding":[75],"properties":[77],"lymphocyte":[80],"subsets":[81],"their":[83,120],"roles":[84,145],"disease.":[89,202],"Functionally,":[90],"distinct":[91],"effector":[92],"are":[95,116],"induced":[96],"from":[97],"naive":[98],"upon":[101],"antigenic":[102],"stimulation,":[103],"including":[104],"Th1,":[105,177,207],"Th2,":[106,208],"Th17,":[107,178,210],"Th22,":[108,211],"Th9,":[109,209],"regulatory":[111],"(Treg)":[113],"which":[115],"characterized":[117],"based":[118],"on":[119],"cytokine":[121],"patterns.":[122],"Of":[123],"activated":[125],"Th1":[128],"secreting":[130,141,157],"IFN-\u03b3,":[131],"Th17":[132],"producing":[134,152],"IL-17,":[135],"Th9":[136,179],"releasing":[137],"IL-9,":[138],"Th22":[140,181],"IL-22":[142],"major":[144],"development,":[148],"while":[149],"Th2":[150,188],"IL-4,":[153],"Treg":[155,190,212],"IL-10":[158],"TGF-\u03b2":[160],"associated":[163],"with":[164],"reduction":[166],"CNS":[168],"inflammation":[169],"improvement":[171],"MS.":[173],"modulation":[175],"activity":[183],"promotion":[186],"cell-related":[191],"responses":[192],"can":[193],"be":[194],"more":[195],"consider":[196],"for":[197],"immunological":[198],"treatment":[199],"Key":[203],"words:":[204],"sclerosis,":[206],"How":[213],"cite":[215],"this":[216],"article:":[217],"Etesam":[218],"Z,":[219],"Nemati":[220],"M,":[221],"Jafarzadeh":[222],"A.":[223],"Role":[225],"Lymphocyte":[228],"Subsets":[229],"Pathogenesis":[232],"Sclerosis":[235],"J":[236],"Rafsanjan":[237],"Univ":[238],"Med":[239],"Sci":[240],"2016;":[241],"15(3):":[242],"257-80.":[243],"[Farsi]":[244]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-07-28T07:46:37.118299","created_date":"2016-09-16T00:00:00"}