{"id":"https://openalex.org/W2516630800","doi":"https://doi.org/10.1038/cddis.2016.255","title":"Kinsenoside screening with a microfluidic chip attenuates gouty arthritis through inactivating NF-\u03baB signaling in macrophages and protecting endothelial cells","display_name":"Kinsenoside screening with a microfluidic chip attenuates gouty arthritis through inactivating NF-\u03baB signaling in macrophages and protecting endothelial cells","publication_year":2016,"publication_date":"2016-09-01","ids":{"openalex":"https://openalex.org/W2516630800","doi":"https://doi.org/10.1038/cddis.2016.255","mag":"2516630800","pmid":"https://pubmed.ncbi.nlm.nih.gov/27584788","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5059859"},"language":"en","primary_location":{"id":"doi:10.1038/cddis.2016.255","doi":"https://doi.org/10.1038/cddis.2016.255","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2016.255","pdf_url":"https://www.nature.com/articles/cddis2016255.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/cddis2016255.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Qiao Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiao Han","raw_affiliation_strings":["Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","Department of Orthopaedic Surgery, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wang Bing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wang Bing","raw_affiliation_strings":["Department of Orthopaedic Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China","institution_ids":["https://openalex.org/I4210120169"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yin Di","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yin Di","raw_affiliation_strings":["Complex and Intelligent Research Center, School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex and Intelligent Research Center, School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li Hua","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Hua","raw_affiliation_strings":["Department of Orthopaedic Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China","institution_ids":["https://openalex.org/I4210120169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034929089","display_name":"Shihe Li","orcid":"https://orcid.org/0000-0001-9425-8595","observed_orcids":["https://orcid.org/0000-0001-9425-8595"]},"institutions":[{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Shi-he","raw_affiliation_strings":["Department of Orthopaedic Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China","institution_ids":["https://openalex.org/I4210120169"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zheng Yu-hua","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zheng Yu-hua","raw_affiliation_strings":["Wenshan Zhengbao Orthopaedic Hospital of Yunnan Province, Wenshan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenshan Zhengbao Orthopaedic Hospital of Yunnan Province, Wenshan, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100614078","display_name":"Xiuguo Han","orcid":"https://orcid.org/0000-0001-5787-5332","observed_orcids":["https://orcid.org/0000-0001-5787-5332"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Xiu-guo","raw_affiliation_strings":["Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","Department of Orthopaedic Surgery, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101520197","display_name":"Yugang Wang","orcid":"https://orcid.org/0000-0001-5675-2509","observed_orcids":["https://orcid.org/0000-0001-5675-2509"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wang Yu-gang","raw_affiliation_strings":["Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","Department of Orthopaedic Surgery, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111498972","display_name":"Qi\u2010Ming Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Qi-ming","raw_affiliation_strings":["Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","Department of Orthopaedic Surgery, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yang Shih-mo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yang Shih-mo","raw_affiliation_strings":["Complex and Intelligent Research Center, School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex and Intelligent Research Center, School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062413297","display_name":"Tingting Tang","orcid":"https://orcid.org/0000-0002-1670-7452","observed_orcids":["https://orcid.org/0000-0002-1670-7452"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tang Ting-ting","raw_affiliation_strings":["Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","Department of Orthopaedic Surgery, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5062413297"],"corresponding_institution_ids":["https://openalex.org/I143593769","https://openalex.org/I183067930","https://openalex.org/I4210097066"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":3.9122,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.93265896,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"9","first_page":"e2350","last_page":"e2350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinsenoside","display_name":"kinsenoside","score":0.8799999952316284},{"id":"https://openalex.org/keywords/gout","display_name":"gout","score":0.8989999890327454},{"id":"https://openalex.org/keywords/monosodium-urate-crystals","display_name":"monosodium urate crystals","score":0.8989999890327454},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8899999856948853},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7929999828338623},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9139999747276306},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.8330000042915344},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cd14","display_name":"CD14","score":0.8970000147819519},{"id":"https://openalex.org/keywords/ikkalpha","display_name":"IKK\u03b1","score":0.7089999914169312},{"id":"https://openalex.org/keywords/ikkbeta","display_name":"IKK\u03b2","score":0.9129999876022339},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8090000152587891},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.8999999761581421},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.4129999876022339},{"id":"https://openalex.org/keywords/chinese-herbal-medicine","display_name":"Chinese herbal medicine","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.591706395149231},{"id":"https://openalex.org/C100175707","wikidata":"https://www.wikidata.org/wiki/Q6103519","display_name":"I\u03baB kinase","level":4,"score":0.5325177311897278},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4917042851448059},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.4642198085784912},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4641294479370117},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4510967433452606},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43103307485580444},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42816755175590515},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.3966977000236511},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3872383236885071},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38221487402915955},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36891669034957886},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3656427264213562},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23031333088874817}],"mesh":[{"descriptor_ui":"D000067996","descriptor_name":"RAW 264.7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005121","descriptor_name":"Extremities","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009005","descriptor_name":"Monosaccharides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009005","descriptor_name":"Monosaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009005","descriptor_name":"Monosaccharides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015107","descriptor_name":"4-Butyrolactone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015107","descriptor_name":"4-Butyrolactone","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015107","descriptor_name":"4-Butyrolactone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015107","descriptor_name":"4-Butyrolactone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015210","descriptor_name":"Arthritis, Gouty","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015210","descriptor_name":"Arthritis, Gouty","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015210","descriptor_name":"Arthritis, Gouty","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018950","descriptor_name":"Lipopolysaccharide Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/cddis.2016.255","doi":"https://doi.org/10.1038/cddis.2016.255","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2016.255","pdf_url":"https://www.nature.com/articles/cddis2016255.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4026446","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5059859","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5059859","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5059859","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Dis","raw_type":"Text"},{"id":"pmid:27584788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27584788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/cddis.2016.255","doi":"https://doi.org/10.1038/cddis.2016.255","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2016.255","pdf_url":"https://www.nature.com/articles/cddis2016255.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2715546332","display_name":null,"funder_award_id":"81672205","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3225946490","display_name":null,"funder_award_id":"81172549","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2516630800.pdf","grobid_xml":"https://content.openalex.org/works/W2516630800.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W614733133","https://openalex.org/W1484083850","https://openalex.org/W1551051666","https://openalex.org/W1913497650","https://openalex.org/W1929515229","https://openalex.org/W1936929899","https://openalex.org/W1963897953","https://openalex.org/W1965742680","https://openalex.org/W1972483153","https://openalex.org/W1976382352","https://openalex.org/W1978197109","https://openalex.org/W1978496495","https://openalex.org/W1985236996","https://openalex.org/W1988449196","https://openalex.org/W1990067598","https://openalex.org/W1990196604","https://openalex.org/W1997221332","https://openalex.org/W1999421483","https://openalex.org/W2003112634","https://openalex.org/W2009800174","https://openalex.org/W2010158955","https://openalex.org/W2012690514","https://openalex.org/W2014375773","https://openalex.org/W2016207805","https://openalex.org/W2016745207","https://openalex.org/W2021737033","https://openalex.org/W2021818882","https://openalex.org/W2026908430","https://openalex.org/W2030059329","https://openalex.org/W2033474014","https://openalex.org/W2045532799","https://openalex.org/W2048466758","https://openalex.org/W2050283646","https://openalex.org/W2060405139","https://openalex.org/W2073515400","https://openalex.org/W2076305091","https://openalex.org/W2078402539","https://openalex.org/W2079057795","https://openalex.org/W2079146178","https://openalex.org/W2082486260","https://openalex.org/W2082878502","https://openalex.org/W2085348840","https://openalex.org/W2085635063","https://openalex.org/W2090098587","https://openalex.org/W2093252878","https://openalex.org/W2095326585","https://openalex.org/W2101918793","https://openalex.org/W2104475738","https://openalex.org/W2107495112","https://openalex.org/W2114420064","https://openalex.org/W2124738515","https://openalex.org/W2126853519","https://openalex.org/W2132895884","https://openalex.org/W2134967712","https://openalex.org/W2141465922","https://openalex.org/W2151457918","https://openalex.org/W2165316896","https://openalex.org/W2166205537","https://openalex.org/W2167875991","https://openalex.org/W2169346791","https://openalex.org/W2174913332","https://openalex.org/W2183655789","https://openalex.org/W2254510206","https://openalex.org/W2275520397","https://openalex.org/W2275965337","https://openalex.org/W2290325168","https://openalex.org/W2291205197","https://openalex.org/W2306994132","https://openalex.org/W2307082067","https://openalex.org/W2310075126","https://openalex.org/W2320353392"],"related_works":["https://openalex.org/W4410244711","https://openalex.org/W4399300296","https://openalex.org/W2807042775","https://openalex.org/W2868321271","https://openalex.org/W2155299920","https://openalex.org/W4409463146","https://openalex.org/W4416968331","https://openalex.org/W7212475749","https://openalex.org/W4389065482","https://openalex.org/W4406873725"],"abstract_inverted_index":{"Gouty":[0],"arthritis":[1,74,212],"is":[2,7],"a":[3,28],"rheumatic":[4],"disease":[5],"that":[6,85,199],"characterized":[8],"by":[9,20],"the":[10,21,36,54,63,70,128,173,202],"deposition":[11],"of":[12,58,62,72,80,106,110,124,130,176,185],"monosodium":[13],"urate":[14],"(MSU)":[15],"in":[16,69,162],"synovial":[17],"joints":[18,170],"cause":[19],"increased":[22],"serum":[23],"hyperuricemia.":[24],"This":[25],"study":[26,166],"used":[27,68],"three-dimensional":[29],"(3D)":[30],"flowing":[31],"microfluidic":[32],"chip":[33],"to":[34,52,209],"screen":[35],"effective":[37,204],"candidate":[38,205],"against":[39],"MSU-stimulated":[40],"human":[41],"umbilical":[42],"vein":[43],"endothelial":[44],"cell":[45],"(HUVEC)":[46],"damage,":[47],"and":[48,78,89,121,126,134,144,179,188],"found":[49],"kinsenoside":[50],"(Kin)":[51],"be":[53],"leading":[55],"active":[56],"component":[57],"Anoectochilus":[59,207],"roxburghi,":[60],"one":[61],"Chinese":[64],"medicinal":[65],"plant":[66],"widely":[67],"treatment":[71],"gouty":[73,211],"clinically.":[75,213],"Cell":[76],"viability":[77],"apoptosis":[79],"HUVECs":[81],"were":[82,149],"evaluated,":[83],"indicating":[84],"direct":[86],"Kin":[87,103,153,156,192,200],"stimulation":[88],"conditioned":[90],"medium":[91],"(CM)":[92],"from":[93,206],"Kin-treated":[94],"macrophages":[95,125],"both":[96],"negatively":[97],"modulated":[98],"with":[99,167,183],"MSU":[100,159],"crystals.":[101],"Additionally,":[102],"was":[104,201],"capable":[105],"attenuating":[107],"MSU-induced":[108],"activation":[109],"nuclear":[111],"factor-\u03baB/mitogen-activated":[112],"protein":[113],"kinase":[114],"(NF-\u03baB/MAPK)":[115],"signaling,":[116],"targeting":[117],"I\u03baB":[118],"kinase-\u03b1":[119],"(IKK\u03b1)":[120],"IKK\u03b2":[122],"kinases":[123],"influencing":[127],"expressions":[129],"NF-\u03baB":[131],"downstream":[132],"cytokines":[133],"subsequent":[135],"HUVEC":[136],"bioactivity.":[137],"Inflammasome":[138],"NLR":[139],"pyrin":[140],"domain-containing":[141],"3":[142],"(NALP3)":[143],"toll-like":[145],"receptor":[146],"2":[147],"(TLR2)":[148],"also":[150],"inhibited":[151],"after":[152],"treatment.":[154],"Also,":[155],"downregulated":[157],"CD14-mediated":[158],"crystals":[160],"uptake":[161],"macrophages.":[163],"In":[164],"vivo":[165],"MSU-injected":[168],"ankle":[169,186],"further":[171],"revealed":[172],"significant":[174],"suppression":[175],"inflammatory":[177],"infiltration":[178],"endothelia":[180],"impairment":[181],"coupled":[182],"alleviation":[184],"swelling":[187],"nociceptive":[189],"response":[190],"via":[191],"treatments.":[193],"Taken":[194],"together,":[195],"these":[196],"data":[197],"implicated":[198],"most":[203],"roxburghi":[208],"treat":[210]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-09-16T00:00:00"}
