{"id":"https://openalex.org/W2515768560","doi":"https://doi.org/10.1182/blood.v116.21.31.31","title":"A Novel High Dose Chemotherapy Strategy with Bendamustine In Adjunct to Etoposide, Cytarabine and Melphalan (BeEAM) Followed by Autologous Stem Cell Rescue Is Safe and Highly Effective for the Treatment of Resistant/Relapsed Lymphoma Patients: a Phase I-II Study on 44 Patients","display_name":"A Novel High Dose Chemotherapy Strategy with Bendamustine In Adjunct to Etoposide, Cytarabine and Melphalan (BeEAM) Followed by Autologous Stem Cell Rescue Is Safe and Highly Effective for the Treatment of Resistant/Relapsed Lymphoma Patients: a Phase I-II Study on 44 Patients","publication_year":2010,"publication_date":"2010-11-19","ids":{"openalex":"https://openalex.org/W2515768560","doi":"https://doi.org/10.1182/blood.v116.21.31.31","mag":"2515768560"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v116.21.31.31","doi":"https://doi.org/10.1182/blood.v116.21.31.31","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v116.21.31.31","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028913158","display_name":"Giuseppe Visani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Giuseppe Visani","raw_affiliation_strings":["Hematology and Stem Cell Transplant Center, Pesaro, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Stem Cell Transplant Center, Pesaro, Italy,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108929952","display_name":"Lara Malerba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lara Malerba","raw_affiliation_strings":["Hematology and Stem Cell Transplant Center, Pesaro, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Stem Cell Transplant Center, Pesaro, Italy,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073971614","display_name":"Piero Maria Stefani","orcid":"https://orcid.org/0000-0003-2937-851X","observed_orcids":["https://orcid.org/0000-0003-2937-851X"]},"institutions":[{"id":"https://openalex.org/I4210146018","display_name":"Ca' Foncello Hospital","ror":"https://ror.org/04cb4je22","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146018"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Pietro Maria Stefani","raw_affiliation_strings":["Hematology, Ca\u2019Foncello Hospital, Treviso, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Ca\u2019Foncello Hospital, Treviso, Italy,","institution_ids":["https://openalex.org/I4210146018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103215545","display_name":"Saveria Capria","orcid":"https://orcid.org/0000-0002-3064-9332","observed_orcids":["https://orcid.org/0000-0002-3064-9332"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Saveria Capria","raw_affiliation_strings":["Hematology, La Sapienza University, Roma, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, La Sapienza University, Roma, Italy,","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068687462","display_name":"Piero Galieni","orcid":"https://orcid.org/0000-0002-0793-264X","observed_orcids":["https://orcid.org/0000-0002-0793-264X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Piero Galieni","raw_affiliation_strings":["Division of Hematology, Ospedale C. G. Mazzoni, Ascoli piceno, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Ospedale C. G. Mazzoni, Ascoli piceno, Italy,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022200573","display_name":"Francesco Gaudio","orcid":"https://orcid.org/0000-0002-7817-1665","observed_orcids":["https://orcid.org/0000-0002-7817-1665"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francesco Gaudio","raw_affiliation_strings":["University of Bari, Bari, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bari, Bari, Italy,","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057593886","display_name":"Giorgina Specchia","orcid":"https://orcid.org/0000-0002-2479-9529","observed_orcids":["https://orcid.org/0000-0002-2479-9529"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giorgina Specchia","raw_affiliation_strings":["Hematology, University of Bari, Bari, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, University of Bari, Bari, Italy,","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070417705","display_name":"Giovanna Meloni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giovanna Meloni","raw_affiliation_strings":["Hematology, La Sapienza University, Roma, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, La Sapienza University, Roma, Italy,","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008693201","display_name":"Fil\u00edppo Gherlinzoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146018","display_name":"Ca' Foncello Hospital","ror":"https://ror.org/04cb4je22","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146018"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo Gherlinzoni","raw_affiliation_strings":["Hematology, Ca\u2019Foncello Hospital, Treviso, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Ca\u2019Foncello Hospital, Treviso, Italy,","institution_ids":["https://openalex.org/I4210146018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030759518","display_name":"Claudio Giardini","orcid":"https://orcid.org/0000-0001-5216-7951","observed_orcids":["https://orcid.org/0000-0001-5216-7951"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Claudio Giardini","raw_affiliation_strings":["Hematology and Stem Cell Transplant Center, Pesaro, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Stem Cell Transplant Center, Pesaro, Italy,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081703894","display_name":"Sadia Falcioni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sadia Falcioni","raw_affiliation_strings":["Division of Hematology, Ospedale C. G. Mazzoni, Ascoli piceno, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Ospedale C. G. Mazzoni, Ascoli piceno, Italy,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013191501","display_name":"Federica Loscocco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Federica Loscocco","raw_affiliation_strings":["Hematology and Stem Cell Transplant Center, Pesaro, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Stem Cell Transplant Center, Pesaro, Italy,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045852022","display_name":"Francesca Cuberli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francesca Cuberli","raw_affiliation_strings":["Chair of Haematology, University of Genova, Genova,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Haematology, University of Genova, Genova,","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078922292","display_name":"Marco Gobbi","orcid":"https://orcid.org/0000-0003-0756-109X","observed_orcids":["https://orcid.org/0000-0003-0756-109X"]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Marco Gobbi","raw_affiliation_strings":["Chair of Haematology, University of Genova, Genova,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Haematology, University of Genova, Genova,","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100766578","display_name":"Armando Santoro","orcid":"https://orcid.org/0000-0003-1709-9492","observed_orcids":["https://orcid.org/0000-0003-1709-9492"]},"institutions":[{"id":"https://openalex.org/I4210152645","display_name":"Fondazione Humanitas per la Ricerca","ror":"https://ror.org/05fa04208","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210152645"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Armando Santoro","raw_affiliation_strings":["Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Rozzano,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Rozzano,","institution_ids":["https://openalex.org/I4210152645","https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080298171","display_name":"Barbara Sarina","orcid":"https://orcid.org/0000-0001-8138-7988","observed_orcids":["https://orcid.org/0000-0001-8138-7988"]},"institutions":[{"id":"https://openalex.org/I4210152645","display_name":"Fondazione Humanitas per la Ricerca","ror":"https://ror.org/05fa04208","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210152645"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Barbara Sarina","raw_affiliation_strings":["Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Rozzano,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Rozzano,","institution_ids":["https://openalex.org/I4210152645","https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041284036","display_name":"Marco Rocchi","orcid":"https://orcid.org/0000-0002-0056-5795","observed_orcids":["https://orcid.org/0000-0002-0056-5795"]},"institutions":[{"id":"https://openalex.org/I190397597","display_name":"University of Urbino","ror":"https://ror.org/04q4kt073","country_code":"IT","type":"education","lineage":["https://openalex.org/I190397597"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Marco Rocchi","raw_affiliation_strings":["University of Urbino, Urbino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Urbino, Urbino, Italy","institution_ids":["https://openalex.org/I190397597"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066257986","display_name":"Alessandro Isidori","orcid":"https://orcid.org/0000-0002-5723-9229","observed_orcids":["https://orcid.org/0000-0002-5723-9229"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessandro Isidori","raw_affiliation_strings":["Hematology and Stem Cell Transplant Center, Pesaro, Italy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Stem Cell Transplant Center, Pesaro, Italy,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5013191501","https://openalex.org/A5022200573","https://openalex.org/A5028913158","https://openalex.org/A5030759518","https://openalex.org/A5041284036","https://openalex.org/A5045852022","https://openalex.org/A5057593886","https://openalex.org/A5068687462","https://openalex.org/A5070417705","https://openalex.org/A5073971614","https://openalex.org/A5078922292","https://openalex.org/A5080298171","https://openalex.org/A5081703894","https://openalex.org/A5100766578","https://openalex.org/A5103215545","https://openalex.org/A5108929952"],"corresponding_institution_ids":["https://openalex.org/I190397597","https://openalex.org/I4210146018","https://openalex.org/I4210152645","https://openalex.org/I4210163047","https://openalex.org/I5561750","https://openalex.org/I83816512","https://openalex.org/I861853513"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":3.8539,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.93754948,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"116","issue":"21","first_page":"31","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.056699998676776886,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bendamustine","display_name":"bendamustine","score":0.968999981880188},{"id":"https://openalex.org/keywords/high-dose-chemotherapy","display_name":"high-dose chemotherapy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.972000002861023},{"id":"https://openalex.org/keywords/relapsed-lymphoma","display_name":"relapsed lymphoma","score":0.8939999938011169},{"id":"https://openalex.org/keywords/refractory-lymphoma","display_name":"refractory lymphoma","score":0.8429999947547913},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/hodgkin-lymphoma","display_name":"Hodgkin's disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cytarabine","display_name":"cytarabine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/melphalan","display_name":"melphalan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.7039999961853027},{"id":"https://openalex.org/keywords/oral-mucositis","display_name":"oral mucositis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.7960000038146973},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.36500000953674316}],"concepts":[{"id":"https://openalex.org/C2781442060","wikidata":"https://www.wikidata.org/wiki/Q425745","display_name":"Bendamustine","level":4,"score":0.7819455862045288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7318236231803894},{"id":"https://openalex.org/C2778684742","wikidata":"https://www.wikidata.org/wiki/Q2298283","display_name":"Melphalan","level":3,"score":0.7311882972717285},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.6950377225875854},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6694097518920898},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.6432275176048279},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5269642472267151},{"id":"https://openalex.org/C2780147359","wikidata":"https://www.wikidata.org/wiki/Q415869","display_name":"Carmustine","level":4,"score":0.49955272674560547},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4367362856864929},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.43191853165626526},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41520261764526367},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3701406717300415},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.23627609014511108},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v116.21.31.31","doi":"https://doi.org/10.1182/blood.v116.21.31.31","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v116.21.31.31","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2491989573","https://openalex.org/W2006996657","https://openalex.org/W4381659292","https://openalex.org/W2803950238","https://openalex.org/W1976641397","https://openalex.org/W7011847321","https://openalex.org/W2522094600","https://openalex.org/W2952045994","https://openalex.org/W7172494779","https://openalex.org/W2582012921"],"abstract_inverted_index":{"Abstract":[0,1],"31":[2],"Background:":[3],"BEAM":[4,29,63],"(Carmustine,":[5],"etoposide,":[6],"cytarabine,":[7],"and":[8,37,55,78,148,174,268,311,315,466],"melphalan)":[9],"regimen":[10,16,89,122,463],"is":[11,42,438,464],"the":[12,76,79,87,117,185,190,197,200,223,236,260,271,393,445,451],"most":[13],"used":[14],"conditioning":[15,88,121,487],"before":[17],"autologous":[18,455],"stem":[19,456],"cell":[20,457],"transplant":[21,41,359],"(ASCT)":[22],"in":[23,60,116,234,404,410,473,486,490,503],"lymphoma":[24,94,112,476,491],"patients.":[25,95,240,290,477],"However,":[26],"patients":[27,98,161,254,292,323,355,370,386,399,426,443,492],"receiving":[28,450],"show":[30],"a":[31,44,52,56,70,246,295,307,325,343,361,372,414,429,470],"significant":[32],"number":[33,277,333,345],"of":[34,46,81,84,124,127,133,159,178,192,199,230,239,262,278,300,321,327,334,346,349,364,384,417,424,432,439],"side":[35,243],"effects,":[36],"relapse":[38],"rate":[39],"after":[40,358,380,413,428,449],"still":[43],"matter":[45],"concern.":[47],"Therefore,":[48],"new":[49,120,461],"regimens":[50,488],"with":[51,105,130,166,222,294,336,342,454],"higher":[53,205],"efficacy":[54,80,472],"better":[57],"toxicity":[58],"profile":[59],"comparison":[61],"to":[62,74,90,139,146,184,289,298,305,390,395,468],"are":[64,387,400,403,409],"highly":[65],"needed.":[66],"Aims:":[67],"We":[68,257],"designed":[69],"phase":[71],"I-II":[72],"study":[73,217],"evaluate":[75],"safety":[77],"increasing":[82,125],"doses":[83,126,132],"Bendamustine":[85,128,167,179,231,263,485,495],"for":[86,92,213,270,360,392],"ASCT":[91],"resistant/relapsed":[93,106],"Methods:":[96],"Forty-four":[97],"(median":[99],"age":[100],"47":[101],"years,":[102],"range":[103],"18\u201370)":[104],"non-Hodgkin":[107],"(29)":[108],"or":[109],"Hodgkin":[110],"(15)":[111],"were":[113,163,210,313],"consecutively":[114],"enrolled":[115],"study.":[118,274],"The":[119,176,216,228,241,331,460],"consisted":[123],"coupled":[129],"fixed":[131,259],"Etoposide":[134],"(200mg/m2/day":[135],"on":[136,143,152,171,479],"days":[137,144,172,317,335,348,366],"-5":[138,145],"-2),":[140],"Cytarabine":[141],"(400mg/m2":[142],"-2)":[147],"Melphalan":[149],"(140":[150],"mg/m2":[151,265],"day":[153],"-1)":[154],"(BeEAM":[155],"regimen).":[156],"Three":[157,422],"cohorts":[158,238],"3":[160,237,433],"each":[162],"treated":[164],"starting":[165],"160":[168],"mg/m2/daily":[169],"given":[170],"-7":[173],"-6.":[175],"dose":[177,261],"was":[180,218,232,245,287,338],"then":[181,258],"escalated":[182],"according":[183],"Fibonacci's":[186],"increment":[187],"rule":[188],"until":[189],"onset":[191],"severe":[193],"adverse":[194,214],"events":[195],"and/or":[196],"attainment":[198],"expected":[201],"MTD,":[202],"but":[203],"not":[204],"than":[206],"200":[207,264,496],"mg/m2.":[208],"Patients":[209],"carefully":[211],"monitored":[212],"events.":[215],"registered":[219],"at":[220],"EMEA":[221],"EUDRACT":[224],"no":[225],"2008\u2013002736-15.":[226],"Results:":[227],"administration":[229],"safe":[233,267,465],"all":[235],"major":[242],"effect":[244],"grade":[247],"III-IV":[248],"oral":[249],"mucositis":[250],"developed":[251,371],"by":[252,505],"9":[253,347,365],"during":[255],"neutropenia.":[256],"as":[266],"effective":[269],"Phase":[272],"II":[273],"A":[275],"median":[276,296,332,344,362,415,430],"5.68\u00d7106CD34+/kg":[279],"cells":[280],"(range":[281],"2.4\u201315.5)":[282],"collected":[283],"from":[284,420,435],"peripheral":[285],"blood":[286],"reinfused":[288],"All":[291,354,397],"engrafted,":[293],"time":[297,363,431],"ANC>0.5\u00d7109/l":[299],"10":[301],"days.":[302,500],"Median":[303],"times":[304],"achieve":[306],"platelet":[308],"count":[309],">20\u00d7109/l":[310],">50\u00d7109/l":[312],"13":[314],"16":[316],"respectively.":[318],"Twenty-two":[319],"out":[320,383,423],"44":[322,385],"presented":[324],"fever":[326,337],"unknown":[328],"origin":[329],"(50%).":[330],"2":[339,499],"(range:":[340,352,367],"0\u20137),":[341],"intravenous":[350],"antibiotics":[351],"3\u201322).":[353],"received":[356],"G-CSF":[357],"8\u201325).":[368],"Two":[369],"viral":[373],"infection":[374],"(1":[375],"HSV-6,":[376],"1":[377],"CMV)":[378],"early":[379],"transplant.":[381,421,436],"Thirty-nine":[382],"evaluable":[388,398],"up":[389],"now":[391],"response":[394],"treatment.":[396],"alive.":[401],"32/39":[402],"complete":[405,447],"remission":[406,448],"whereas":[407],"4/39":[408,442],"partial":[411],"response,":[412],"follow-up":[416],"11":[418],"months":[419,434],"39":[425],"relapsed":[427],"It":[437],"note":[440],"that":[441],"achieved":[444],"first":[446],"high-dose":[452],"therapy":[453],"rescue.":[458],"Conclusions:":[459],"BeEAM":[462],"seems":[467],"have":[469],"high":[471],"heavily":[474],"pretreated":[475],"Basing":[478],"this":[480],"experience,":[481],"future":[482],"studies":[483],"incorporating":[484],"pre-ASCT":[489],"should":[493],"use":[494],"mg/m2/day":[497],"over":[498],"Acknowledgments:":[501],"supported":[502],"part":[504],"AIL":[506],"Pesaro":[507],"Onlus.":[508],"Disclosures:":[509],"Malerba:":[510],"celgene,":[511],"Janssen-Cilag:":[512],"Honoraria.":[513]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-09-16T00:00:00"}
