{"id":"https://openalex.org/W2515564255","doi":"https://doi.org/10.18632/oncotarget.11676","title":"Cancer stem cells from human glioblastoma resemble but do not mimic original tumors after in vitro passaging in serum-free media","display_name":"Cancer stem cells from human glioblastoma resemble but do not mimic original tumors after in vitro passaging in serum-free media","publication_year":2016,"publication_date":"2016-08-29","ids":{"openalex":"https://openalex.org/W2515564255","doi":"https://doi.org/10.18632/oncotarget.11676","mag":"2515564255","pmid":"https://pubmed.ncbi.nlm.nih.gov/27589567","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5323200"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.11676","doi":"https://doi.org/10.18632/oncotarget.11676","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.11676","pdf_url":null,"source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.18632/oncotarget.11676","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056610775","display_name":"Noem\u00ed Garcia\u2010Romero","orcid":"https://orcid.org/0000-0001-7744-8848","observed_orcids":["https://orcid.org/0000-0001-7744-8848"]},"institutions":[{"id":"https://openalex.org/I105140100","display_name":"Madrid Institute for Advanced Studies","ror":"https://ror.org/027pk6j83","country_code":"ES","type":"education","lineage":["https://openalex.org/I105140100"]},{"id":"https://openalex.org/I2802543619","display_name":"IMDEA Nanoscience","ror":"https://ror.org/02skytd81","country_code":"ES","type":"facility","lineage":["https://openalex.org/I105140100","https://openalex.org/I2802543619"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Noem\u00ed Garc\u00eda-Romero","raw_affiliation_strings":["Instituto Madrile\u00f1o de Estudios Avanzados, IMDEA Nanociencia, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Madrile\u00f1o de Estudios Avanzados, IMDEA Nanociencia, Madrid, Spain","institution_ids":["https://openalex.org/I105140100","https://openalex.org/I2802543619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002489906","display_name":"Carmen Gonz\u00e1lez-Tejedo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104776","display_name":"Centro Nacional de Biotecnolog\u00eda","ror":"https://ror.org/015w4v032","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210104776"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carmen Gonz\u00e1lez-Tejedo","raw_affiliation_strings":["Centro Nacional de Biotecnolog\u00eda (CNB-CSIC), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de Biotecnolog\u00eda (CNB-CSIC), Madrid, Spain","institution_ids":["https://openalex.org/I4210104776"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079254239","display_name":"Josefa Carri\u00f3n-Navarro","orcid":"https://orcid.org/0000-0001-6661-1240","observed_orcids":["https://orcid.org/0000-0001-6661-1240"]},"institutions":[{"id":"https://openalex.org/I4405267946","display_name":"Fundaci\u00f3n de Investigaci\u00f3n HM Hospitales","ror":"https://ror.org/0543ma965","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4405267946"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Josefa Carri\u00f3n-Navarro","raw_affiliation_strings":["Fundaci\u00f3n de Investigaci\u00f3n HM Hospitales, HM Hospitales, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundaci\u00f3n de Investigaci\u00f3n HM Hospitales, HM Hospitales, Madrid, Spain","institution_ids":["https://openalex.org/I4405267946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002450244","display_name":"Susana Esteban-Rubio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Susana Esteban-Rubio","raw_affiliation_strings":["Instituto de Medicina Molecular Aplicada (IMMA), School of Medicine, San Pablo-CEU University, Campus de Montepr\u00edncipe, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Medicina Molecular Aplicada (IMMA), School of Medicine, San Pablo-CEU University, Campus de Montepr\u00edncipe, Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077557296","display_name":"Gorjana Rackov","orcid":"https://orcid.org/0000-0001-6561-6357","observed_orcids":["https://orcid.org/0000-0001-6561-6357"]},"institutions":[{"id":"https://openalex.org/I105140100","display_name":"Madrid Institute for Advanced Studies","ror":"https://ror.org/027pk6j83","country_code":"ES","type":"education","lineage":["https://openalex.org/I105140100"]},{"id":"https://openalex.org/I2802543619","display_name":"IMDEA Nanoscience","ror":"https://ror.org/02skytd81","country_code":"ES","type":"facility","lineage":["https://openalex.org/I105140100","https://openalex.org/I2802543619"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gorjana Rackov","raw_affiliation_strings":["Instituto Madrile\u00f1o de Estudios Avanzados, IMDEA Nanociencia, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Madrile\u00f1o de Estudios Avanzados, IMDEA Nanociencia, Madrid, Spain","institution_ids":["https://openalex.org/I105140100","https://openalex.org/I2802543619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018597732","display_name":"Vanessa Rodr\u00edguez\u2010Fanjul","orcid":"https://orcid.org/0000-0002-3386-5874","observed_orcids":["https://orcid.org/0000-0002-3386-5874"]},"institutions":[{"id":"https://openalex.org/I105140100","display_name":"Madrid Institute for Advanced Studies","ror":"https://ror.org/027pk6j83","country_code":"ES","type":"education","lineage":["https://openalex.org/I105140100"]},{"id":"https://openalex.org/I2802543619","display_name":"IMDEA Nanoscience","ror":"https://ror.org/02skytd81","country_code":"ES","type":"facility","lineage":["https://openalex.org/I105140100","https://openalex.org/I2802543619"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Vanessa Rodr\u00edguez-Fanjul","raw_affiliation_strings":["Instituto Madrile\u00f1o de Estudios Avanzados, IMDEA Nanociencia, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Madrile\u00f1o de Estudios Avanzados, IMDEA Nanociencia, Madrid, Spain","institution_ids":["https://openalex.org/I105140100","https://openalex.org/I2802543619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037391338","display_name":"Jorge Oliver\u2010De La Cruz","orcid":"https://orcid.org/0000-0002-7536-8067","observed_orcids":["https://orcid.org/0000-0002-7536-8067"]},"institutions":[{"id":"https://openalex.org/I4210114565","display_name":"International Clinical Research Center, St. Anne's University Hospital Brno","ror":"https://ror.org/027v97282","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210114565","https://openalex.org/I4210136987"]},{"id":"https://openalex.org/I4210136987","display_name":"St. Anne's University Hospital Brno","ror":"https://ror.org/049bjee35","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210136987"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jorge Oliver-De La Cruz","raw_affiliation_strings":["International Clinical Research Center, Center for Translational Medicine, St. Anne's University Hospital, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Clinical Research Center, Center for Translational Medicine, St. Anne's University Hospital, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210114565","https://openalex.org/I4210136987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001057747","display_name":"Ricardo Prat-Ac\u00edn","orcid":"https://orcid.org/0000-0002-5173-8879","observed_orcids":["https://orcid.org/0000-0002-5173-8879"]},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ricardo Prat-Ac\u00edn","raw_affiliation_strings":["Neurosurgery Department, Hospital Universitario la Fe de Valencia, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosurgery Department, Hospital Universitario la Fe de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I3019010403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030153573","display_name":"Maria Peris\u2010Celda","orcid":"https://orcid.org/0000-0002-9189-303X","observed_orcids":["https://orcid.org/0000-0002-9189-303X"]},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Peris-Celda","raw_affiliation_strings":["Neurosurgery Department, Hospital Universitario la Fe de Valencia, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosurgery Department, Hospital Universitario la Fe de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I3019010403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088084893","display_name":"David Blesa","orcid":"https://orcid.org/0000-0002-1762-7833","observed_orcids":["https://orcid.org/0000-0002-1762-7833"]},"institutions":[{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"David Blesa","raw_affiliation_strings":["Genetic and Genomic Unit, Fundaci\u00f3n Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic and Genomic Unit, Fundaci\u00f3n Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035152732","display_name":"Laura Ram\u00edrez\u2010Jim\u00e9nez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura Ram\u00edrez-Jim\u00e9nez","raw_affiliation_strings":["Genetic and Genomic Unit, Fundaci\u00f3n Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic and Genomic Unit, Fundaci\u00f3n Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076482262","display_name":"Pilar S\u00e1nchez\u2010G\u00f3mez","orcid":"https://orcid.org/0000-0002-0709-4973","observed_orcids":["https://orcid.org/0000-0002-0709-4973"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210150178","display_name":"Unidad Funcional de Investigaci\u00f3n de Enfermedades Cr\u00f3nicas","ror":"https://ror.org/04hpbsh69","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210150178","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pilar S\u00e1nchez-G\u00f3mez","raw_affiliation_strings":["Neuro-oncology Unit, Instituto de Salud Carlos III-UFIEC, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuro-oncology Unit, Instituto de Salud Carlos III-UFIEC, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210150178"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028089976","display_name":"Rosario Perona","orcid":"https://orcid.org/0000-0002-2973-5153","observed_orcids":["https://orcid.org/0000-0002-2973-5153"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rosario Perona","raw_affiliation_strings":["Instituto de Investigaciones Biom\u00e9dicas, CIBERER, CSIC/UAM, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biom\u00e9dicas, CIBERER, CSIC/UAM, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210111366","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061751447","display_name":"Carmen Escobedo\u2010Lucea","orcid":"https://orcid.org/0000-0002-5642-0536","observed_orcids":["https://orcid.org/0000-0002-5642-0536"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Carmen Escobedo-Lucea","raw_affiliation_strings":["Division of Biopharmaceutics and Pharmacokinetics, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biopharmaceutics and Pharmacokinetics, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026127785","display_name":"Crist\u00f3bal Belda-Iniesta","orcid":"https://orcid.org/0000-0003-3254-7492","observed_orcids":["https://orcid.org/0000-0003-3254-7492"]},"institutions":[{"id":"https://openalex.org/I4405267946","display_name":"Fundaci\u00f3n de Investigaci\u00f3n HM Hospitales","ror":"https://ror.org/0543ma965","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4405267946"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristobal Belda-Iniesta","raw_affiliation_strings":["Fundaci\u00f3n de Investigaci\u00f3n HM Hospitales, HM Hospitales, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundaci\u00f3n de Investigaci\u00f3n HM Hospitales, HM Hospitales, Madrid, Spain","institution_ids":["https://openalex.org/I4405267946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019296073","display_name":"\u00c1ngel Ayuso\u2010Sacido","orcid":"https://orcid.org/0000-0003-3919-5880","observed_orcids":["https://orcid.org/0000-0003-3919-5880"]},"institutions":[{"id":"https://openalex.org/I105140100","display_name":"Madrid Institute for Advanced Studies","ror":"https://ror.org/027pk6j83","country_code":"ES","type":"education","lineage":["https://openalex.org/I105140100"]},{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]},{"id":"https://openalex.org/I2802543619","display_name":"IMDEA Nanoscience","ror":"https://ror.org/02skytd81","country_code":"ES","type":"facility","lineage":["https://openalex.org/I105140100","https://openalex.org/I2802543619"]},{"id":"https://openalex.org/I4405267946","display_name":"Fundaci\u00f3n de Investigaci\u00f3n HM Hospitales","ror":"https://ror.org/0543ma965","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4405267946"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Angel Ayuso-Sacido","raw_affiliation_strings":["Fundaci\u00f3n de Investigaci\u00f3n HM Hospitales, HM Hospitales, Madrid, Spain","Instituto Madrile\u00f1o de Estudios Avanzados, IMDEA Nanociencia, Madrid, Spain","Instituto de Medicina Molecular Aplicada (IMMA), School of Medicine, San Pablo-CEU University, Campus de Montepr\u00edncipe, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundaci\u00f3n de Investigaci\u00f3n HM Hospitales, HM Hospitales, Madrid, Spain","institution_ids":["https://openalex.org/I4405267946"]},{"raw_affiliation_string":"Instituto Madrile\u00f1o de Estudios Avanzados, IMDEA Nanociencia, Madrid, Spain","institution_ids":["https://openalex.org/I105140100","https://openalex.org/I2802543619"]},{"raw_affiliation_string":"Instituto de Medicina Molecular Aplicada (IMMA), School of Medicine, San Pablo-CEU University, Campus de Montepr\u00edncipe, Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":15,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5387,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.83279277,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"7","issue":"40","first_page":"65888","last_page":"65901"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7958999872207642,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.18709999322891235,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.7149999737739563},{"id":"https://openalex.org/keywords/serum-free-medium","display_name":"serum-free medium","score":0.7670000195503235},{"id":"https://openalex.org/keywords/genetic-alterations","display_name":"genetic alterations","score":0.5569999814033508},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.4880000054836273},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.7179999947547913},{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"tumor evolution","score":0.44600000977516174},{"id":"https://openalex.org/keywords/primary-culture","display_name":"primary cell culture","score":0.39100000262260437},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.5820000171661377},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.414000004529953},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.4749999940395355},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.46299999952316284},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5783142447471619},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.49049919843673706},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.3605455756187439},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34078896045684814},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.23128852248191833},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1769333779811859},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016895","descriptor_name":"Culture Media, Serum-Free","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.18632/oncotarget.11676","doi":"https://doi.org/10.18632/oncotarget.11676","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.11676","pdf_url":null,"source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5323200","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5323200/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5323200/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:4211151","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5323200","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27589567","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27589567","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/151200","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/151200","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:dnet:repisalud___::765c6ea55e91385a9935d329ed7637e9","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12105/7892","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:helda.helsinki.fi:10138/233904","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/233904","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.11676","doi":"https://doi.org/10.18632/oncotarget.11676","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.11676","pdf_url":null,"source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1609565072","display_name":null,"funder_award_id":"00077","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G2048222533","display_name":null,"funder_award_id":"RD12/0036/0027","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G2377181310","display_name":null,"funder_award_id":"PI14/","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G5893827543","display_name":null,"funder_award_id":"PI12/","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G5900765945","display_name":null,"funder_award_id":"CP11/00147","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G909064757","display_name":"Utilizaci\u00f3n del contenido de microves\u00edculas extracelulares circulantes en sangre perif\u00e9rica para el diagn\u00f3stico, estratificaci\u00f3n y seguimiento de pacientes con gliomas de alto grado","funder_award_id":"PI14/00077","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2515564255.pdf","grobid_xml":"https://content.openalex.org/works/W2515564255.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1560814177","https://openalex.org/W1893588436","https://openalex.org/W1972700706","https://openalex.org/W1989958716","https://openalex.org/W1997078049","https://openalex.org/W1997099893","https://openalex.org/W2001544973","https://openalex.org/W2011728195","https://openalex.org/W2015610520","https://openalex.org/W2017883800","https://openalex.org/W2018671779","https://openalex.org/W2021916242","https://openalex.org/W2040458067","https://openalex.org/W2041069305","https://openalex.org/W2042647718","https://openalex.org/W2047710431","https://openalex.org/W2079179944","https://openalex.org/W2096287682","https://openalex.org/W2109816625","https://openalex.org/W2113942802","https://openalex.org/W2123369892","https://openalex.org/W2124078079","https://openalex.org/W2128066516","https://openalex.org/W2135465849","https://openalex.org/W2148977460","https://openalex.org/W2157247642","https://openalex.org/W2161289668","https://openalex.org/W2167650288","https://openalex.org/W2419025306"],"related_works":["https://openalex.org/W2385278989","https://openalex.org/W2019471510","https://openalex.org/W2370115948","https://openalex.org/W111828346","https://openalex.org/W2018671779","https://openalex.org/W2017883800","https://openalex.org/W2064961349","https://openalex.org/W2100093425","https://openalex.org/W2410946291","https://openalex.org/W2158228067"],"abstract_inverted_index":{"//":[0],"Noem\u00ed":[1],"Garc\u00eda-Romero":[2],"1,":[3,68],"*":[4,9,14,187],",":[5,10,15,19,23,27,33,37,41,45,49,53,57,61,65],"Carmen":[6,58],"Gonz\u00e1lez-Tejedo":[7],"2,":[8],"Josefa":[11],"Carri\u00f3n-Navarro":[12],"3,":[13,69],"Susana":[16],"Esteban-Rubio":[17],"4":[18,70,99],"Gorjana":[20],"Rackov":[21],"1":[22,26,71],"Vanessa":[24],"Rodr\u00edguez-Fanjul":[25],"Jorge":[28],"Oliver-De":[29],"La":[30],"Cruz":[31],"5":[32,117],"Ricardo":[34],"Prat-Ac\u00edn":[35],"6":[36,40,133],"Mar\u00eda":[38],"Peris-Celda":[39],"David":[42],"Blesa":[43],"7":[44,48,144],"Laura":[46],"Ram\u00edrez-Jim\u00e9nez":[47],"Pilar":[50],"S\u00e1nchez-G\u00f3mez":[51],"8":[52,157],"Rosario":[54],"Perona":[55],"9":[56,167],"Escobedo-Lucea":[59],"10":[60,176],"Cristobal":[62],"Belda-Iniesta":[63],"3":[64,89],"Angel":[66,198],"Ayuso-Sacido":[67],"Instituto":[72,100,160,168],"Madrile\u00f1o":[73],"de":[74,84,91,101,113,140,151,161,169],"Estudios":[75],"Avanzados,":[76],"IMDEA":[77],"Nanociencia,":[78],"Madrid,":[79,87,97,115,165,174],"Spain":[80,88,98,116,143,156,166,175],"2":[81],"Centro":[82,150],"Nacional":[83],"Biotecnolog\u00eda":[85],"(CNB-CSIC),":[86],"Fundaci\u00f3n":[90,149],"Investigaci\u00f3n":[92,152],"HM":[93,95],"Hospitales,":[94,96],"Medicina":[102],"Molecular":[103],"Aplicada":[104],"(IMMA),":[105],"School":[106],"of":[107,178,183,239,359,365,384,390,418],"Medicine,":[108,125],"San":[109],"Pablo-CEU":[110],"University,":[111],"Campus":[112],"Montepr\u00edncipe,":[114],"International":[118],"Clinical":[119],"Research":[120],"Center,":[121],"Center":[122],"for":[123,281,381],"Translational":[124],"St.":[126],"Anne\u2019s":[127],"University":[128,182],"Hospital,":[129],"Brno,":[130],"Czech":[131],"Republic":[132],"Neurosurgery":[134],"Department,":[135],"Hospital":[136],"Universitario":[137],"la":[138],"Fe":[139],"Valencia,":[141,142,155],"Genetic":[145],"and":[146,180,255,263,297,369,413],"Genomic":[147],"Unit,":[148,159],"Pr\u00edncipe":[153],"Felipe,":[154],"Neuro-oncology":[158],"Salud":[162],"Carlos":[163],"III-UFIEC,":[164],"Investigaciones":[170],"Biom\u00e9dicas,":[171],"CIBERER,":[172],"CSIC/UAM,":[173],"Division":[177],"Biopharmaceutics":[179],"Pharmacokinetics,":[181],"Helsinki,":[184,185],"Finland":[186],"These":[188,250],"authors":[189],"have":[190],"contributed":[191],"equally":[192],"to":[193,257,259,265,292,320,373,397],"this":[194],"work":[195],"Correspondence":[196],"to:":[197],"Ayuso-Sacido,":[199],"email:":[200],"ayusosacido@gmail.com":[201],"Keywords:":[202],"cancer":[203,230],"stem":[204,231,360],"cells,":[205],"glioblastoma,":[206],"genetic":[207],"alterations,":[208],"drug":[209,374],"discovery,":[210],"primary":[211,282],"cell":[212,361],"culture":[213,308],"Received:":[214],"May":[215],"30,":[216],"2016":[217,221,225],"Accepted:":[218],"August":[219,223],"17,":[220],"Published:":[222],"29,":[224],"ABSTRACT":[226],"Human":[227],"gliomas":[228],"harbour":[229],"cells":[232,251,335],"(CSCs)":[233],"that":[234,313,338],"evolve":[235],"along":[236],"the":[237,240,247,275,306,325,351,379,388,406],"course":[238],"disease,":[241],"forming":[242],"highly":[243],"heterogeneous":[244],"subpopulations":[245],"within":[246],"tumour":[248,260],"mass.":[249],"possess":[252],"self-renewal":[253],"properties":[254,299],"appear":[256],"contribute":[258],"initiation,":[261],"metastasis":[262],"resistance":[264],"therapy.":[266],"CSC":[267,322],"cultures":[268,316,386],"isolated":[269],"from":[270,318,324],"surgical":[271],"samples":[272],"are":[273],"considered":[274],"best":[276],"preclinical":[277,403],"in":[278,302,305,347,353,387,393,395,405],"vitro":[279,303],"model":[280],"human":[283,326,419],"gliomas.":[284,420],"However,":[285],"it":[286],"is":[287],"not":[288],"yet":[289],"well":[290],"characterized":[291],"which":[293],"extent":[294],"their":[295,391,399],"biological":[296],"functional":[298],"change":[300],"during":[301],"passaging":[304],"serum-free":[307],"conditions.":[309],"Here,":[310],"we":[311],"demonstrate":[312],"our":[314],"CSC-enriched":[315,385],"harboured":[317],"one":[319],"several":[321],"clones":[323],"glioma":[327],"sample.":[328],"When":[329],"xenotransplanted":[330],"into":[331],"mouse":[332],"brain,":[333],"these":[334],"generated":[336],"tumours":[337],"reproduced":[339],"at":[340,409],"least":[341],"three":[342],"different":[343,363],"dissemination":[344],"patterns":[345],"found":[346],"original":[348],"tumours.":[349],"Along":[350],"passages":[352],"culture,":[354],"CSCs":[355],"displayed":[356],"increased":[357],"expression":[358],"markers,":[362],"ratios":[364],"chromosomal":[366],"instability":[367],"events,":[368],"a":[370],"varied":[371],"response":[372],"treatment.":[375],"Our":[376],"findings":[377],"highlight":[378],"need":[380],"better":[382],"characterization":[383],"context":[389],"evolution":[392],"vitro,":[394],"order":[396],"uncover":[398],"full":[400],"potential":[401],"as":[402],"models":[404],"studies":[407],"aimed":[408],"identifying":[410],"molecular":[411],"biomarkers":[412],"developing":[414],"new":[415],"therapeutic":[416],"approaches":[417]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-09-16T00:00:00"}