{"id":"https://openalex.org/W2515212862","doi":"https://doi.org/10.14882/jrds.105.0_1084","title":"Mitochondrial complex I modulation of cellular NAD+/NADH regulates mTOR, autophagy and breast cancer progression","display_name":"Mitochondrial complex I modulation of cellular NAD+/NADH regulates mTOR, autophagy and breast cancer progression","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2515212862","doi":"https://doi.org/10.14882/jrds.105.0_1084","mag":"2515212862"},"language":"en","primary_location":{"id":"mag:2515212862","doi":"https://doi.org/10.14882/jrds.105.0_1084","is_oa":false,"landing_page_url":"https://www.jstage.jst.go.jp/article/jrds/105/0/105_1084/_pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018615904","display_name":"Byoung Boo Seo","orcid":"https://orcid.org/0000-0002-1344-2145","observed_orcids":["https://orcid.org/0000-0002-1344-2145"]},"institutions":[{"id":"https://openalex.org/I9323808","display_name":"Daegu University","ror":"https://ror.org/01zqccq48","country_code":"KR","type":"education","lineage":["https://openalex.org/I9323808"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byoung Boo Seo","raw_affiliation_strings":["Dept. of Animal Resources, Daegu University, Korea"],"raw_orcid":"https://orcid.org/0000-0002-1344-2145","affiliations":[{"raw_affiliation_string":"Dept. of Animal Resources, Daegu University, Korea","institution_ids":["https://openalex.org/I9323808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085500429","display_name":"Hyae-Lee Do","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89004649","display_name":"Korea Institute of Industrial Technology","ror":"https://ror.org/04qfph657","country_code":"KR","type":"other","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I89004649"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyae-Lee Do","raw_affiliation_strings":["Korea Institute of Industrial Technology,,Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea Institute of Industrial Technology,,Korea","institution_ids":["https://openalex.org/I89004649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058865732","display_name":"Antonio F. Santidri\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio F. Santidri\u00e1n","raw_affiliation_strings":["Dept. of Molecular and Experimental Medicine, The Scripps Research Institute, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Molecular and Experimental Medicine, The Scripps Research Institute, U.S.A","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041068222","display_name":"Hum Dae Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9323808","display_name":"Daegu University","ror":"https://ror.org/01zqccq48","country_code":"KR","type":"education","lineage":["https://openalex.org/I9323808"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hum Dae Park","raw_affiliation_strings":["Dept. of Biotechnology, College of Engineering, Daegu University, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biotechnology, College of Engineering, Daegu University, Korea","institution_ids":["https://openalex.org/I9323808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017676398","display_name":"Zae Young Ryoo","orcid":"https://orcid.org/0000-0001-6993-3624","observed_orcids":["https://orcid.org/0000-0001-6993-3624","https://orcid.org/0000-0002-4675-5113"]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Zae Young Ryoo","raw_affiliation_strings":["School of Life Science and Biotechnology, Kyungpook National University, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Biotechnology, Kyungpook National University, Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039226657","display_name":"Brunhilde Felding\u2010Habermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brunhilde Felding\u2010Habermann","raw_affiliation_strings":["Dept. of Molecular and Experimental Medicine, The Scripps Research Institute, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Molecular and Experimental Medicine, The Scripps Research Institute, U.S.A","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070828621","display_name":"Dong-Mok Lee","orcid":"https://orcid.org/0000-0002-2423-3322","observed_orcids":["https://orcid.org/0000-0002-2423-3322"]},"institutions":[{"id":"https://openalex.org/I89004649","display_name":"Korea Institute of Industrial Technology","ror":"https://ror.org/04qfph657","country_code":"KR","type":"other","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I89004649"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Mok Lee","raw_affiliation_strings":["Korea Institute of Industrial Technology,,Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea Institute of Industrial Technology,,Korea","institution_ids":["https://openalex.org/I89004649"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1084","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.7484999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.7484999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.08330000191926956,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.04100000113248825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-complex-i","display_name":"mitochondrial complex I","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nad-nadh-ratio","display_name":"NAD+/NADH ratio","score":0.949999988079071},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.8740000128746033},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/breast-cancer-progression","display_name":"breast cancer progression","score":0.9539999961853027},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.3659999966621399},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7929511070251465},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.7067574262619019},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5216895937919617},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4996523857116699},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45744770765304565},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.43714383244514465},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4231742322444916},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3706664443016052},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36695122718811035},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35912707448005676},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3266642093658447},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3019155263900757},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2275761067867279},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2192331850528717},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.18557000160217285}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2515212862","doi":"https://doi.org/10.14882/jrds.105.0_1084","is_oa":false,"landing_page_url":"https://www.jstage.jst.go.jp/article/jrds/105/0/105_1084/_pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1964272650","https://openalex.org/W2124276356","https://openalex.org/W3191374320","https://openalex.org/W1967868873","https://openalex.org/W2195022070","https://openalex.org/W2888909823","https://openalex.org/W2791961925","https://openalex.org/W6925463401","https://openalex.org/W1777667114","https://openalex.org/W2007891991"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-09-16T00:00:00"}
