{"id":"https://openalex.org/W251514531","doi":null,"title":"Influence of nitric oxide synthase and cyclooxygenase blockade on expression of cyclooxygenase and hemodynamics in rats with portal hypertension.","display_name":"Influence of nitric oxide synthase and cyclooxygenase blockade on expression of cyclooxygenase and hemodynamics in rats with portal hypertension.","publication_year":2006,"publication_date":"2006-11-01","ids":{"openalex":"https://openalex.org/W251514531","mag":"251514531","pmid":"https://pubmed.ncbi.nlm.nih.gov/17085343"},"language":"en","primary_location":{"id":"pmid:17085343","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17085343","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatobiliary & pancreatic diseases international : HBPD INT","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102754508","display_name":"Hui Cao","orcid":"https://orcid.org/0009-0004-7861-1829","observed_orcids":["https://orcid.org/0009-0004-7861-1829"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Cao","raw_affiliation_strings":["Department of Surgery, Renji Hospital, College of Medicine, Shanghai Jiaotong University, Shanghai 200127, China. xujia201800@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Renji Hospital, College of Medicine, Shanghai Jiaotong University, Shanghai 200127, China. xujia201800@126.com","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075706135","display_name":"Jia Yin Xu","orcid":"https://orcid.org/0000-0002-3341-7668","observed_orcids":["https://orcid.org/0000-0002-3341-7668"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jia Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084338059","display_name":"Hua Liu","orcid":"https://orcid.org/0000-0001-7950-1227","observed_orcids":["https://orcid.org/0000-0001-7950-1227","https://orcid.org/0000-0002-8994-2808"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065908756","display_name":"Fang-Bin Meng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fang-Bin Meng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061051302","display_name":"Jiangfeng Qiu","orcid":"https://orcid.org/0000-0003-1220-5727","observed_orcids":["https://orcid.org/0000-0003-1220-5727"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiang-Feng Qiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100955324","display_name":"Zhiyong Wu","orcid":"https://orcid.org/0009-0006-0034-4788","observed_orcids":["https://orcid.org/0009-0006-0034-4788"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhi-Yong Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7563,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.84032799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"5","issue":"4","first_page":"564","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/portal-hypertension","display_name":"portal hypertension","score":0.7990000247955322},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cox-1","display_name":"cyclooxygenase-1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.949999988079071},{"id":"https://openalex.org/keywords/ng-nitro-l-arginine","display_name":"L-NNA","score":0.7789999842643738},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":1.0},{"id":"https://openalex.org/keywords/hyperdynamic-circulation","display_name":"hyperdynamic circulation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/splanchnic-hemodynamics","display_name":"splanchnic hemodynamics","score":0.9629999995231628},{"id":"https://openalex.org/keywords/splanchnic-vascular-resistance","display_name":"splanchnic vascular resistance","score":0.8320000171661377},{"id":"https://openalex.org/keywords/portal-venous-inflow","display_name":"portal venous inflow","score":0.8190000057220459},{"id":"https://openalex.org/keywords/superior-mesenteric-artery","display_name":"superior mesenteric artery","score":0.7480000257492065},{"id":"https://openalex.org/keywords/small-intestine","display_name":"small intestine","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8442519307136536},{"id":"https://openalex.org/C2778808290","wikidata":"https://www.wikidata.org/wiki/Q124604","display_name":"Portal hypertension","level":3,"score":0.7881096005439758},{"id":"https://openalex.org/C2779065481","wikidata":"https://www.wikidata.org/wiki/Q8578745","display_name":"Hyperdynamic circulation","level":4,"score":0.7219932675361633},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7156010270118713},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.6879633665084839},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.6520211696624756},{"id":"https://openalex.org/C2775849017","wikidata":"https://www.wikidata.org/wiki/Q4121920","display_name":"Splanchnic","level":3,"score":0.6517426371574402},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.607218325138092},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5994842052459717},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4968004524707794},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43931931257247925},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3548733592033386},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.33052247762680054},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.3087077736854553},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15804654359817505},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1342129409313202},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.11393272876739502},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.10452640056610107}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006975","descriptor_name":"Hypertension, Portal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013152","descriptor_name":"Splanchnic Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019335","descriptor_name":"Nitroarginine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051545","descriptor_name":"Cyclooxygenase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17085343","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17085343","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatobiliary & pancreatic diseases international : HBPD INT","raw_type":"Journal Article"},{"id":"mag:251514531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17085343","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W39585415","https://openalex.org/W280493037","https://openalex.org/W1797076168","https://openalex.org/W1971857999","https://openalex.org/W1978114274","https://openalex.org/W1988812417","https://openalex.org/W1990645532","https://openalex.org/W1995234023","https://openalex.org/W2009149270","https://openalex.org/W2030720197","https://openalex.org/W2051121657","https://openalex.org/W2062818431","https://openalex.org/W2069050090","https://openalex.org/W2097389213","https://openalex.org/W2120622445","https://openalex.org/W2161538539","https://openalex.org/W2395211444","https://openalex.org/W2410938972","https://openalex.org/W2435163580","https://openalex.org/W2463327555"],"related_works":["https://openalex.org/W2367096172","https://openalex.org/W328470957","https://openalex.org/W2009149270","https://openalex.org/W2070896270","https://openalex.org/W2081620434","https://openalex.org/W2395891224","https://openalex.org/W7096719777","https://openalex.org/W2376844464","https://openalex.org/W2410938972","https://openalex.org/W2048668931"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,41,166,201,360,387],"importance":[2],"of":[3,10,31,63,77,88,121,131,140,168,187,209,222,236,267,289,325,362,400,415,428],"nitric":[4,55],"oxide":[5,56],"(NO)":[6,57],"in":[7,27,35,58,81,95,170,212,244,274,286,295,391,412,423,433],"the":[8,48,59,72,96,132,162,175,207,213,234,278,287,302,318,323,344,398,413,421,424,429],"pathogenesis":[9],"portal":[11,67,115,124,133,256],"hypertension":[12,68,116,125],"(PHT)":[13],"has":[14,37],"been":[15,39],"extensively":[16],"studied,":[17],"but":[18,255,307],"whether":[19],"or":[20,91,100,145,150,264],"not":[21,38,371,420],"prostacyclin":[22,52],"(PGI(2))":[23,53],"plays":[24],"a":[25,182,283,405],"role":[26],"formation":[28,425],"and":[29,54,75,83,135,185,219,233,239,247,277,292,297,315,322,380,410,426],"development":[30,427],"hyperdynamic":[32,60,345,383,388,430],"circutatory":[33],"state":[34,62,347,390,432],"PHT":[36,394],"verified.":[40],"present":[42],"study":[43],"was":[44,159,172,189,348,370],"undertaken":[45],"to":[46],"investigate":[47],"possible":[49,406],"interaction":[50,407],"between":[51,408],"circulatory":[61,346,384,389,431],"rats":[64,108,299,392,434],"with":[65,153,227,282,357,393,397,435],"chronic":[66,436],"(PHT),":[69],"by":[70,119,128,161,181,191,365],"measuring":[71],"hemodynamic":[73],"changes":[74],"expression":[76,232,273,321],"cyclooxygenase":[78],"(COX)":[79],"mRNA":[80,211,231,272,320],"vessels":[82,276],"small":[84,220,279],"intestine":[85,221],"after":[86,328,350,376],"administration":[87],"N(omega)-nitro-L-arginine":[89],"(L-NNA)":[90],"indomethacin":[92],"(INDO)":[93],"either":[94,147],"short-term":[97],"(7":[98],"days)":[99],"long-term":[101],"(15":[102],"days).":[103],"METHODS:":[104],"Ninety-seven":[105],"male":[106],"Sprague-Dawley":[107],"were":[109,242,336],"divided":[110],"into":[111],"three":[112],"groups:":[113],"intrahepatic":[114],"(IHPH)":[117],"induced":[118,127],"injection":[120],"CCl(4),":[122],"prehepatic":[123],"(PHPH)":[126],"partial":[129],"stenosis":[130],"vein,":[134],"sham-operated":[136],"controls":[137],"(SO).":[138],"Animals":[139],"each":[141],"group":[142],"received":[143],"L-NNA":[144,268],"INDO":[146,366],"for":[148,194,333,340,353,367],"7":[149,341,358],"15":[151,265,334,354,368],"days,":[152,342],"saline":[154],"as":[155,174],"control.":[156],"Splanchnic":[157],"hemodynamics":[158,381],"measured":[160,190,206],"radioactive":[163],"microsphere":[164],"technique.":[165],"concentration":[167,288,324,361,399],"NO":[169,294,411],"serum":[171,240,293,401],"determined":[173],"nitrate;":[176],"nitrite":[177],"ratio":[178],"(NO(2)(-)/NO(3)(-),":[179],"micromol/L)":[180],"colorometric":[183],"method,":[184],"that":[186,375],"PGI(2)":[188,291,327,363,409,417],"specific":[192],"radioimmunoassay":[193],"its":[195],"stable":[196],"hydrolysis":[197],"product":[198],"6-keto-PGF(1alpha)":[199,238],"(pg/ml).":[200],"reverse":[202],"transcription-polymerase":[203],"chain":[204],"reaction":[205],"levels":[208],"COX-1":[210,230,271,319],"superior":[214],"mesenteric":[215],"artery,":[216],"thoracic":[217],"aorta,":[218],"these":[223,275],"rats.":[224],"RESULTS:":[225],"Compared":[226],"SO":[228],"rats,":[229,317],"concentrations":[235],"plasma":[237,290,326],"NO(2)(-)/NO(3)(-)":[241],"enhanced":[243],"both":[245,313],"IHPH":[246,296,314],"PHPH":[248,298,316],"rats;":[249],"splanchnic":[250],"vascular":[251],"resistance":[252],"(SVR)":[253],"decreased,":[254],"venous":[257],"inflow":[258],"(PVI)":[259],"markedly":[260],"increased":[261,309],"(P<0.05).":[262,300,311],"Seven":[263],"days":[266,335,355,369],"treatment":[269],"reduced":[270],"intestine,":[280],"concomitant":[281],"significant":[284],"decrease":[285],"At":[301],"same":[303],"time,":[304],"PVI":[305],"decreased":[306],"SVR":[308],"significantly":[310,372],"In":[312],"No":[329],"synthase":[330],"(NOS)":[331],"blockade":[332,352],"higher":[337],"than":[338],"those":[339],"whereas":[343],"improved":[349],"NOS":[351],"compared":[356],"days.":[359],"treated":[364],"different":[373],"from":[374],"7-day":[377],"COX":[378],"blockade,":[379],"restored":[382],"state.":[385],"CONCLUSIONS:":[386],"is":[395,404,418],"correlated":[396],"NO.":[402],"There":[403],"hyperhemodynamics":[414],"PHT.":[416,437],"probably":[419],"mediator":[422]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
