{"id":"https://openalex.org/W2514101000","doi":"https://doi.org/10.5301/ijao.5000516","title":"Poly (L-Lactic Acid) Porous Scaffold-Supported Alginate Hydrogel with Improved Mechanical Properties and Biocompatibility","display_name":"Poly (L-Lactic Acid) Porous Scaffold-Supported Alginate Hydrogel with Improved Mechanical Properties and Biocompatibility","publication_year":2016,"publication_date":"2016-03-09","ids":{"openalex":"https://openalex.org/W2514101000","doi":"https://doi.org/10.5301/ijao.5000516","mag":"2514101000","pmid":"https://pubmed.ncbi.nlm.nih.gov/27646631"},"language":"en","primary_location":{"id":"doi:10.5301/ijao.5000516","doi":"https://doi.org/10.5301/ijao.5000516","is_oa":false,"landing_page_url":"https://doi.org/10.5301/ijao.5000516","pdf_url":null,"source":{"id":"https://openalex.org/S10751480","display_name":"The International Journal of Artificial Organs","issn_l":"0391-3988","issn":["0391-3988","1724-6040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Artificial Organs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015549444","display_name":"Jiaqi Chu","orcid":"https://orcid.org/0000-0002-2306-1805","observed_orcids":["https://orcid.org/0000-0002-2306-1805"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaqi Chu","raw_affiliation_strings":["Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang - China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang - China","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108873635","display_name":"Shaodong Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107851509","display_name":"Chinese Academy of Tropical Agricultural Sciences","ror":"https://ror.org/003qeh975","country_code":"CN","type":"government","lineage":["https://openalex.org/I107851509","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210098646","display_name":"Agricultural Product Processing Research Institute","ror":"https://ror.org/00g46p143","country_code":"CN","type":"facility","lineage":["https://openalex.org/I107851509","https://openalex.org/I4210098646","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaodong Zeng","raw_affiliation_strings":["Agricultural Product Processing Research Institute, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang- China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agricultural Product Processing Research Institute, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang- China","institution_ids":["https://openalex.org/I107851509","https://openalex.org/I4210098646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061084232","display_name":"Liyang Gao","orcid":"https://orcid.org/0000-0002-1362-6403","observed_orcids":["https://orcid.org/0000-0002-1362-6403"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyang Gao","raw_affiliation_strings":["Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang - China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang - China","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019916978","display_name":"Thomas Groth","orcid":"https://orcid.org/0000-0001-6647-9657","observed_orcids":["https://orcid.org/0000-0001-6647-9657"]},"institutions":[{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Groth","raw_affiliation_strings":["Biomedical Materials Group, Martin Luther University Halle-Wittenberg, Halle - Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Materials Group, Martin Luther University Halle-Wittenberg, Halle - Germany","institution_ids":["https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100770542","display_name":"Zhiwen Li","orcid":"https://orcid.org/0000-0003-2116-9916","observed_orcids":["https://orcid.org/0000-0003-2116-9916"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiwen Li","raw_affiliation_strings":["Department of Materials Science and Engineering, Jinan University, Guangzhou - China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, Jinan University, Guangzhou - China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088559915","display_name":"Junchao Kong","orcid":"https://orcid.org/0000-0001-8555-371X","observed_orcids":["https://orcid.org/0000-0001-8555-371X"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junchao Kong","raw_affiliation_strings":["Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang - China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang - China","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052304915","display_name":"Mingyan Zhao","orcid":"https://orcid.org/0000-0003-4063-8351","observed_orcids":["https://orcid.org/0000-0003-4063-8351"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingyan Zhao","raw_affiliation_strings":["Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang - China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang - China","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100440640","display_name":"Lihua Li","orcid":"https://orcid.org/0000-0001-9393-5961","observed_orcids":["https://orcid.org/0000-0001-9393-5961","https://orcid.org/0009-0006-3802-3090"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lihua Li","raw_affiliation_strings":["Department of Materials Science and Engineering, Jinan University, Guangzhou - China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, Jinan University, Guangzhou - China","institution_ids":["https://openalex.org/I159948400"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5052304915","https://openalex.org/A5100440640"],"corresponding_institution_ids":["https://openalex.org/I159948400","https://openalex.org/I176834541"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.0477,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.68358471,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"39","issue":"8","first_page":"435","last_page":"443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.24279999732971191,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.03500000014901161,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/poly-l-lactic-acid-scaffolds","display_name":"poly(L-lactic acid) scaffolds","score":0.9089999794960022},{"id":"https://openalex.org/keywords/alginate-hydrogel","display_name":"alginate hydrogel","score":0.9990000128746033},{"id":"https://openalex.org/keywords/composite-scaffolds","display_name":"composite scaffolds","score":0.9179999828338623},{"id":"https://openalex.org/keywords/porous-scaffolds","display_name":"porous scaffolds","score":0.9020000100135803},{"id":"https://openalex.org/keywords/hierarchical-porosity","display_name":"hierarchical porosity","score":0.5239999890327454},{"id":"https://openalex.org/keywords/mechanical-properties","display_name":"mechanical properties","score":0.7429999709129333},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.9179999828338623},{"id":"https://openalex.org/keywords/chondrocyte-encapsulation","display_name":"chondrocyte encapsulation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cartilage-repair","display_name":"cartilage repair","score":0.8569999933242798},{"id":"https://openalex.org/keywords/spinal-defects","display_name":"spinal defects","score":0.6309999823570251},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.597000002861023},{"id":"https://openalex.org/keywords/extracellular-matrix-mimicry","display_name":"extracellular matrix mimicry","score":0.6930000185966492},{"id":"https://openalex.org/keywords/cell-adhesion-and-proliferation","display_name":"cell adhesion and proliferation","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.8801795244216919},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.848885178565979},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7036914229393005},{"id":"https://openalex.org/C104779481","wikidata":"https://www.wikidata.org/wiki/Q50707","display_name":"Composite number","level":2,"score":0.606723964214325},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5910161733627319},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5564440488815308},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.5340691208839417},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.5150420665740967},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.483248770236969},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.47542765736579895},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.45113784074783325},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.43173953890800476},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.29744046926498413},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2448585331439972},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.21444392204284668},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.1208803653717041},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.11128076910972595},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.11118701100349426},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006603","descriptor_name":"Hexuronic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008422","descriptor_name":"Materials Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016062","descriptor_name":"Porosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020723","descriptor_name":"Glucuronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.5301/ijao.5000516","doi":"https://doi.org/10.5301/ijao.5000516","is_oa":false,"landing_page_url":"https://doi.org/10.5301/ijao.5000516","pdf_url":null,"source":{"id":"https://openalex.org/S10751480","display_name":"The International Journal of Artificial Organs","issn_l":"0391-3988","issn":["0391-3988","1724-6040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Artificial Organs","raw_type":"journal-article"},{"id":"pmid:27646631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27646631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International journal of artificial organs","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322292","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W311253392","https://openalex.org/W968705621","https://openalex.org/W1759779443","https://openalex.org/W1967485820","https://openalex.org/W1971339046","https://openalex.org/W1971561276","https://openalex.org/W1972929082","https://openalex.org/W1975846168","https://openalex.org/W1984845073","https://openalex.org/W1986520410","https://openalex.org/W1992726056","https://openalex.org/W1997651801","https://openalex.org/W1998985182","https://openalex.org/W2000209705","https://openalex.org/W2008861581","https://openalex.org/W2023962609","https://openalex.org/W2028065902","https://openalex.org/W2029735255","https://openalex.org/W2043330108","https://openalex.org/W2045896691","https://openalex.org/W2047834009","https://openalex.org/W2065610488","https://openalex.org/W2066282438","https://openalex.org/W2068840280","https://openalex.org/W2071522072","https://openalex.org/W2073065089","https://openalex.org/W2074395247","https://openalex.org/W2084610464","https://openalex.org/W2141425377","https://openalex.org/W2164480016","https://openalex.org/W2164803358","https://openalex.org/W2167304759","https://openalex.org/W2187684329","https://openalex.org/W2313636534","https://openalex.org/W2317969985","https://openalex.org/W3158396516","https://openalex.org/W4293859006"],"related_works":["https://openalex.org/W2060670644","https://openalex.org/W2028140088","https://openalex.org/W2048643283","https://openalex.org/W1996057099","https://openalex.org/W2069233781","https://openalex.org/W3155919470","https://openalex.org/W1984958581","https://openalex.org/W4309848446","https://openalex.org/W1982890092","https://openalex.org/W1995120074"],"abstract_inverted_index":{"PURPOSE:":[0],"Polymer":[1],"porous":[2,57,146],"scaffolds":[3],"and":[4,10,23,39,106,144,173,198,220],"hydrogels":[5],"have":[6],"been":[7],"separately":[8],"employed":[9],"explored":[11],"for":[12,69,130,210],"a":[13,30,74,115,160,194,207],"wide":[14],"range":[15],"of":[16,64,71,76,82,113],"applications":[17],"including":[18],"cell":[19],"encapsulation,":[20],"drug":[21],"delivery,":[22],"tissue":[24,191,200],"engineering.":[25],"METHODS:":[26],"In":[27],"this":[28],"study,":[29],"three-dimensional":[31],"poly":[32],"(L-lactic":[33],"acid)":[34],"(PLLA)":[35],"scaffold":[36,85,96,117,139,167,183,211],"with":[37,170,193],"interconnected":[38],"homogeneously":[40],"distributed":[41],"pores":[42],"was":[43,86,97,118],"fabricated":[44],"to":[45,150],"support":[46,75],"the":[47,56,83,95,137,157,165,181,189],"alginate":[48],"hydrogel":[49],"(Alg).":[50],"The":[51,79,91,110,176,203],"gels":[52],"were":[53],"filled":[54],"into":[55],"scaffold,":[58],"which":[59],"acted":[60],"as":[61],"an":[62],"analogue":[63],"native":[65],"extracellular":[66],"matrix":[67],"(ECM)":[68],"entrapment":[70],"cells":[72,158],"within":[73],"predefined":[77],"shape.":[78],"mechanical":[80,142,218],"strength":[81],"composite":[84,116,138,166,182],"characterized":[87],"by":[88,99,125],"compression":[89],"testing.":[90],"chondrocyte":[92],"behavior":[93],"in":[94,121,148,164,168,188],"determined":[98],"inverted":[100],"microscopy,":[101],"scanning":[102],"electron":[103],"microscopy":[104],"(SEM)":[105],"MTT":[107],"viability":[108],"assay.":[109],"repair":[111],"efficiency":[112],"such":[114],"further":[119],"investigated":[120],"dog":[122],"spinal":[123],"defects":[124],"histological":[126,177],"evaluation":[127],"after":[128],"implantation":[129],"4":[131],"weeks.":[132],"RESULTS:":[133],"Results":[134],"showed":[135],"that":[136,156,180,213],"possessed":[140],"superior":[141],"properties":[143,219],"hierarchical":[145],"structure":[147],"comparison":[149],"pure":[151],"Alg.":[152],"Cell":[153],"culture":[154],"revealed":[155],"presented":[159],"specific":[161],"cartilage":[162],"status":[163],"line":[169],"higher":[171],"adherence":[172],"proliferation":[174],"ratio.":[175],"analyses":[178],"suggested":[179],"substantially":[184],"promotes":[185],"its":[186],"integration":[187],"host":[190],"accompanied":[192],"low":[195],"inflammatory":[196],"reaction":[197],"new":[199],"formation.":[201],"CONCLUSIONS:":[202],"method":[204],"thus":[205],"provides":[206],"useful":[208],"pathway":[209],"preparation":[212],"can":[214],"simultaneously":[215],"achieve":[216],"suitable":[217],"good":[221],"biocompatibility.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-09-16T00:00:00"}