{"id":"https://openalex.org/W2513675909","doi":"https://doi.org/10.20517/2394-5079.2015.58","title":"Physiological potential of cytokines and liver damages","display_name":"Physiological potential of cytokines and liver damages","publication_year":2016,"publication_date":"2016-06-01","ids":{"openalex":"https://openalex.org/W2513675909","doi":"https://doi.org/10.20517/2394-5079.2015.58","mag":"2513675909"},"language":"en","primary_location":{"id":"doi:10.20517/2394-5079.2015.58","doi":"https://doi.org/10.20517/2394-5079.2015.58","is_oa":true,"landing_page_url":"https://doi.org/10.20517/2394-5079.2015.58","pdf_url":"https://hrjournal.net/article/download/1516","source":{"id":"https://openalex.org/S4210208932","display_name":"Hepatoma Research","issn_l":"2394-5079","issn":["2394-5079","2454-2520"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatoma Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://hrjournal.net/article/download/1516","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089006287","display_name":"Fathia Abd Elwahid Mannaa","orcid":"https://orcid.org/0000-0003-2999-9906","observed_orcids":["https://orcid.org/0000-0003-2999-9906"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Fathia A. Mannaa","raw_affiliation_strings":["Department of Medical Physiology, National Research Centre, Dokki, Cairo 12622, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physiology, National Research Centre, Dokki, Cairo 12622, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052056925","display_name":"Khaled G. Abdel-Wahhab","orcid":"https://orcid.org/0000-0002-1154-1959","observed_orcids":["https://orcid.org/0000-0002-1154-1959"]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Khaled G. Abdel-Wahhab","raw_affiliation_strings":["Department of Medical Physiology, National Research Centre, Dokki, Cairo 12622, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physiology, National Research Centre, Dokki, Cairo 12622, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089006287"],"corresponding_institution_ids":["https://openalex.org/I4210131959"],"apc_list":null,"apc_paid":null,"fwci":0.5787,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.69982289,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"2","issue":"6","first_page":"131","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9506999850273132,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":1.0},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.8840000033378601},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.9380000233650208},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cytokine-antagonists","display_name":"cytokine antagonists","score":0.781000018119812},{"id":"https://openalex.org/keywords/soluble-cytokine-receptors","display_name":"soluble cytokine receptors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytokine-induction","display_name":"cytokine induction","score":0.4749999940395355},{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.36899998784065247},{"id":"https://openalex.org/keywords/toxins","display_name":"toxins","score":0.6959999799728394},{"id":"https://openalex.org/keywords/viral-hepatitis","display_name":"viral hepatitis","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8886627554893494},{"id":"https://openalex.org/C2777381055","wikidata":"https://www.wikidata.org/wiki/Q308922","display_name":"Damages","level":2,"score":0.8334334492683411},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.692517101764679},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5254387259483337},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3617238402366638},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.32911980152130127},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32536229491233826},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2698202133178711},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20517/2394-5079.2015.58","doi":"https://doi.org/10.20517/2394-5079.2015.58","is_oa":true,"landing_page_url":"https://doi.org/10.20517/2394-5079.2015.58","pdf_url":"https://hrjournal.net/article/download/1516","source":{"id":"https://openalex.org/S4210208932","display_name":"Hepatoma Research","issn_l":"2394-5079","issn":["2394-5079","2454-2520"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatoma Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.20517/2394-5079.2015.58","doi":"https://doi.org/10.20517/2394-5079.2015.58","is_oa":true,"landing_page_url":"https://doi.org/10.20517/2394-5079.2015.58","pdf_url":"https://hrjournal.net/article/download/1516","source":{"id":"https://openalex.org/S4210208932","display_name":"Hepatoma Research","issn_l":"2394-5079","issn":["2394-5079","2454-2520"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatoma Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2513675909.pdf","grobid_xml":"https://content.openalex.org/works/W2513675909.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W48584652","https://openalex.org/W49436223","https://openalex.org/W111047767","https://openalex.org/W178818394","https://openalex.org/W184027621","https://openalex.org/W193903826","https://openalex.org/W653008055","https://openalex.org/W1456504179","https://openalex.org/W1580305871","https://openalex.org/W1864210574","https://openalex.org/W1933670444","https://openalex.org/W1964390988","https://openalex.org/W1966490902","https://openalex.org/W1971372512","https://openalex.org/W1971814947","https://openalex.org/W1972706775","https://openalex.org/W1975752601","https://openalex.org/W1982138002","https://openalex.org/W1983357763","https://openalex.org/W1988613128","https://openalex.org/W1990345011","https://openalex.org/W1992142684","https://openalex.org/W1997064567","https://openalex.org/W1997383546","https://openalex.org/W2007492870","https://openalex.org/W2008313071","https://openalex.org/W2009009216","https://openalex.org/W2009523307","https://openalex.org/W2019188625","https://openalex.org/W2028990156","https://openalex.org/W2030380453","https://openalex.org/W2031298306","https://openalex.org/W2034755592","https://openalex.org/W2037555606","https://openalex.org/W2038773198","https://openalex.org/W2043663429","https://openalex.org/W2049150074","https://openalex.org/W2053305845","https://openalex.org/W2053923770","https://openalex.org/W2057210516","https://openalex.org/W2059511498","https://openalex.org/W2063482586","https://openalex.org/W2066142228","https://openalex.org/W2068099179","https://openalex.org/W2073727412","https://openalex.org/W2076862430","https://openalex.org/W2077887863","https://openalex.org/W2078147093","https://openalex.org/W2079290054","https://openalex.org/W2082559028","https://openalex.org/W2086237916","https://openalex.org/W2086396801","https://openalex.org/W2087633509","https://openalex.org/W2090616861","https://openalex.org/W2094342114","https://openalex.org/W2099091315","https://openalex.org/W2102298532","https://openalex.org/W2104434638","https://openalex.org/W2107257792","https://openalex.org/W2108394390","https://openalex.org/W2109511235","https://openalex.org/W2112560263","https://openalex.org/W2115871198","https://openalex.org/W2124147826","https://openalex.org/W2139926695","https://openalex.org/W2144267534","https://openalex.org/W2144351349","https://openalex.org/W2163483059","https://openalex.org/W2171459379","https://openalex.org/W2323965552","https://openalex.org/W2404457105","https://openalex.org/W2413531993","https://openalex.org/W2469664169","https://openalex.org/W4243729710","https://openalex.org/W4255629099","https://openalex.org/W4256356431","https://openalex.org/W4313308262"],"related_works":["https://openalex.org/W89643401","https://openalex.org/W2084223046","https://openalex.org/W4416301100","https://openalex.org/W105370177","https://openalex.org/W2001877887","https://openalex.org/W1972689256","https://openalex.org/W4251782759","https://openalex.org/W2220342541","https://openalex.org/W2007882007","https://openalex.org/W4226475834"],"abstract_inverted_index":{"Cytokines":[0],"are":[1,10],"soluble":[2,103],"extracellular":[3],"small":[4],"molecular":[5],"weight":[6],"protein":[7],"or":[8,31,54,89],"peptide.They":[9],"produced":[11],"by":[12],"virtually":[13],"every":[14],"nucleated":[15],"cell":[16],"type":[17],"in":[18,46,108],"response":[19],"to":[20,23,118],"injurious":[21],"stimuli":[22],"control":[24],"body":[25],"metabolism,":[26],"infection,":[27],"inflammation":[28],"and":[29,40,44,62,70,74,102],"tissue":[30],"neuronal":[32],"damage;":[33],"therefore":[34],"acting":[35],"as":[36,64,66],"messengers":[37],"between":[38],"tissues":[39],"the":[41,76],"immune":[42],"system;":[43],"participating":[45],"many":[47,67],"physiological":[48],"processes":[49],"through":[50],"their":[51,111],"either":[52],"anti-inflammatory":[53],"pro-inflammatory":[55],"characteristics.Many":[56],"cytokines":[57,94],"have":[58],"multiple":[59],"cellular":[60],"sources":[61],"targets,":[63],"well":[65],"natural":[68],"inducers":[69],"inhibitors.In":[71],"pathophysiological":[72],"conditions":[73],"during":[75],"early":[77],"phase":[78],"of":[79,93,99],"chronic":[80],"liver":[81],"diseases,":[82],"agent":[83],"like":[84],"virus,":[85],"bacteria,":[86],"parasites,":[87],"ethanol,":[88],"toxins,":[90],"induce":[91],"secretion":[92],"at":[95],"high":[96],"levels.The":[97],"presence":[98],"cytokine":[100,104,113],"antagonists":[101],"receptors,":[105],"often":[106],"released":[107],"concert":[109],"with":[110],"respective":[112],"agonist,":[114],"presents":[115],"additional":[116],"complexity":[117],"interpretation.":[119]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-09-16T00:00:00"}
