{"id":"https://openalex.org/W2513624345","doi":"https://doi.org/10.3164/jcbn.16-26","title":"Exendin-4 induces extracellular-superoxide dismutase through histone H3 acetylation in human retinal endothelial cells","display_name":"Exendin-4 induces extracellular-superoxide dismutase through histone H3 acetylation in human retinal endothelial cells","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2513624345","doi":"https://doi.org/10.3164/jcbn.16-26","mag":"2513624345","pmid":"https://pubmed.ncbi.nlm.nih.gov/27895384","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5110938"},"language":"en","primary_location":{"id":"doi:10.3164/jcbn.16-26","doi":"https://doi.org/10.3164/jcbn.16-26","is_oa":true,"landing_page_url":"https://doi.org/10.3164/jcbn.16-26","pdf_url":"https://www.jstage.jst.go.jp/article/jcbn/59/3/59_16-26/_pdf","source":{"id":"https://openalex.org/S10422625","display_name":"Journal of Clinical Biochemistry and Nutrition","issn_l":"0912-0009","issn":["0912-0009","1880-5086"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4353105724","host_organization_name":"Society for Free Radical Research Japan","host_organization_lineage":["https://openalex.org/P4353105724"],"host_organization_lineage_names":["Society for Free Radical Research Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Biochemistry and Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/jcbn/59/3/59_16-26/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039673051","display_name":"Hiroyuki Yasuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Yasuda","raw_affiliation_strings":["Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University","institution_ids":["https://openalex.org/I173865709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044576492","display_name":"Atsuko Ohashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsuko Ohashi","raw_affiliation_strings":["Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University","institution_ids":["https://openalex.org/I173865709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065200598","display_name":"Shohei Nishida","orcid":"https://orcid.org/0000-0003-4193-4806","observed_orcids":["https://orcid.org/0000-0003-4193-4806"]},"institutions":[{"id":"https://openalex.org/I4210105815","display_name":"Gifu University Hospital","ror":"https://ror.org/01kqdxr19","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210105815"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shohei Nishida","raw_affiliation_strings":["Department of Pharmacy, Gifu University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Gifu University Hospital","institution_ids":["https://openalex.org/I4210105815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053025807","display_name":"Tetsuro Kamiya","orcid":"https://orcid.org/0000-0002-6650-2981","observed_orcids":["https://orcid.org/0000-0002-6650-2981"]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuro Kamiya","raw_affiliation_strings":["Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University","institution_ids":["https://openalex.org/I173865709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043929472","display_name":"Tetsuya Suwa","orcid":"https://orcid.org/0000-0002-6409-8129","observed_orcids":["https://orcid.org/0000-0002-6409-8129"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuya Suwa","raw_affiliation_strings":["Department of Diabetes and Endocrinology, Gifu University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetes and Endocrinology, Gifu University School of Medicine","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081038450","display_name":"Hirokazu Hara","orcid":"https://orcid.org/0000-0002-7928-002X","observed_orcids":["https://orcid.org/0000-0002-7928-002X"]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirokazu Hara","raw_affiliation_strings":["Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University","institution_ids":["https://openalex.org/I173865709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081550907","display_name":"Jun Takeda","orcid":"https://orcid.org/0000-0002-6195-8971","observed_orcids":["https://orcid.org/0000-0002-6195-8971"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Takeda","raw_affiliation_strings":["Department of Diabetes and Endocrinology, Gifu University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetes and Endocrinology, Gifu University School of Medicine","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013232618","display_name":"Yoshinori Itoh","orcid":"https://orcid.org/0000-0002-3707-4893","observed_orcids":["https://orcid.org/0000-0002-3707-4893"]},"institutions":[{"id":"https://openalex.org/I4210105815","display_name":"Gifu University Hospital","ror":"https://ror.org/01kqdxr19","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210105815"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinori Itoh","raw_affiliation_strings":["Department of Pharmacy, Gifu University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Gifu University Hospital","institution_ids":["https://openalex.org/I4210105815"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105412703","display_name":"Tetsuo Adachi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tetsuo Adachi","raw_affiliation_strings":["Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University","institution_ids":["https://openalex.org/I173865709"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5105412703"],"corresponding_institution_ids":["https://openalex.org/I173865709"],"apc_list":null,"apc_paid":null,"fwci":4.3213,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.94169795,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"59","issue":"3","first_page":"174","last_page":"181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.06019999831914902,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exendin-4","display_name":"exendin-4","score":0.9789999723434448},{"id":"https://openalex.org/keywords/extracellular-superoxide-dismutase","display_name":"extracellular superoxide dismutase","score":0.9810000061988831},{"id":"https://openalex.org/keywords/sod3","display_name":"SOD3","score":0.9940000176429749},{"id":"https://openalex.org/keywords/histone-h3-acetylation","display_name":"histone H3 acetylation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9160000085830688},{"id":"https://openalex.org/keywords/incretin-based-therapy","display_name":"incretin-based therapy","score":0.7459999918937683},{"id":"https://openalex.org/keywords/retinal-microvascular-endothelial-cells","display_name":"retinal microvascular endothelial cells","score":0.9300000071525574},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.8140000104904175},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9860000014305115},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.972000002861023},{"id":"https://openalex.org/keywords/promoter","display_name":"promoter","score":0.5299999713897705},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.7329999804496765},{"id":"https://openalex.org/keywords/anti-oxidative-activity","display_name":"anti-oxidative activity","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.7438877820968628},{"id":"https://openalex.org/C2778881409","wikidata":"https://www.wikidata.org/wiki/Q1420402","display_name":"Incretin","level":4,"score":0.5547352433204651},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5080933570861816},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5039519667625427},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.46619075536727905},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46607089042663574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4062112867832184},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3773690164089203},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3240087628364563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20123499631881714},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.1840955913066864},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.15797749161720276}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3164/jcbn.16-26","doi":"https://doi.org/10.3164/jcbn.16-26","is_oa":true,"landing_page_url":"https://doi.org/10.3164/jcbn.16-26","pdf_url":"https://www.jstage.jst.go.jp/article/jcbn/59/3/59_16-26/_pdf","source":{"id":"https://openalex.org/S10422625","display_name":"Journal of Clinical Biochemistry and Nutrition","issn_l":"0912-0009","issn":["0912-0009","1880-5086"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4353105724","host_organization_name":"Society for Free Radical Research Japan","host_organization_lineage":["https://openalex.org/P4353105724"],"host_organization_lineage_names":["Society for Free Radical Research Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Biochemistry and Nutrition","raw_type":"journal-article"},{"id":"pmid:27895384","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27895384","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical biochemistry and nutrition","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5110938","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5110938/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Biochem Nutr","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3164/jcbn.16-26","doi":"https://doi.org/10.3164/jcbn.16-26","is_oa":true,"landing_page_url":"https://doi.org/10.3164/jcbn.16-26","pdf_url":"https://www.jstage.jst.go.jp/article/jcbn/59/3/59_16-26/_pdf","source":{"id":"https://openalex.org/S10422625","display_name":"Journal of Clinical Biochemistry and Nutrition","issn_l":"0912-0009","issn":["0912-0009","1880-5086"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4353105724","host_organization_name":"Society for Free Radical Research Japan","host_organization_lineage":["https://openalex.org/P4353105724"],"host_organization_lineage_names":["Society for Free Radical Research Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Biochemistry and Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4531713920","display_name":"Direct intervention of incretin to protect the blood-retinal barrier  - Suppression on onset and progression of diabetic retinopathy -","funder_award_id":"25460654","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2513624345.pdf","grobid_xml":"https://content.openalex.org/works/W2513624345.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W231825674","https://openalex.org/W1563624749","https://openalex.org/W1580883143","https://openalex.org/W1845284039","https://openalex.org/W1870696988","https://openalex.org/W1899087901","https://openalex.org/W1965262464","https://openalex.org/W1970928392","https://openalex.org/W1982806380","https://openalex.org/W1985063313","https://openalex.org/W1986085856","https://openalex.org/W1993046839","https://openalex.org/W1995620318","https://openalex.org/W1996024251","https://openalex.org/W2000976083","https://openalex.org/W2008686569","https://openalex.org/W2016353888","https://openalex.org/W2019084941","https://openalex.org/W2023437193","https://openalex.org/W2023703768","https://openalex.org/W2040314752","https://openalex.org/W2047255460","https://openalex.org/W2050931169","https://openalex.org/W2053855438","https://openalex.org/W2060628888","https://openalex.org/W2063966891","https://openalex.org/W2066387256","https://openalex.org/W2069717852","https://openalex.org/W2070001955","https://openalex.org/W2072750268","https://openalex.org/W2077916251","https://openalex.org/W2079846805","https://openalex.org/W2082278578","https://openalex.org/W2093014171","https://openalex.org/W2095953797","https://openalex.org/W2103900156","https://openalex.org/W2120612885","https://openalex.org/W2125053565","https://openalex.org/W2133813163","https://openalex.org/W2134087142","https://openalex.org/W2142903571","https://openalex.org/W2147707416","https://openalex.org/W2151251857","https://openalex.org/W2159691173","https://openalex.org/W2161872363","https://openalex.org/W2170048668","https://openalex.org/W2185301162","https://openalex.org/W2238802835","https://openalex.org/W4233036449"],"related_works":["https://openalex.org/W2238802835","https://openalex.org/W2406582462","https://openalex.org/W2090627646","https://openalex.org/W3185218386","https://openalex.org/W7095279367","https://openalex.org/W3160092845","https://openalex.org/W2123351765","https://openalex.org/W1492867279","https://openalex.org/W1979632477","https://openalex.org/W4388295002"],"abstract_inverted_index":{"Extracellular-superoxide":[0],"dismutase":[1,44,117,141,155],"(genetic":[2],"name":[3],"SOD3)":[4],"is":[5,88],"a":[6,107],"secreted":[7],"anti-oxidative":[8,181],"enzyme,":[9],"and":[10],"its":[11],"presence":[12],"in":[13,21,34,42,65,92,97,118,157,173],"vascular":[14,24],"walls":[15],"may":[16,168],"play":[17],"an":[18],"important":[19],"role":[20],"protecting":[22],"the":[23,35,50,66,84,113,130,137,147],"system":[25],"against":[26],"oxidative":[27],"stress.":[28],"Oxidative":[29],"stress":[30],"has":[31],"been":[32,46],"implicated":[33],"pathogenesis":[36],"of":[37,52,68,115,129,139],"diabetic":[38,53,158],"retinopathy;":[39],"therefore,":[40],"increases":[41],"extracellular-superoxide":[43,116,140,154],"have":[45],"suggested":[47],"to":[48,78,175],"inhibit":[49],"progression":[51],"retinopathy.":[54],"Incretin-based":[55],"drugs":[56],"such":[57],"as":[58,80],"glucagon-like":[59,85,108],"peptide-1":[60,73,86,109],"receptor":[61,74,87,110],"agonists":[62,75],"are":[63,76],"used":[64],"treatment":[67],"type":[69],"2":[70],"diabetes.":[71],"Glucagon-like":[72],"expected":[77],"function":[79],"extrapancreatic":[81,171],"agents":[82],"because":[83],"expressed":[89],"not":[90],"only":[91],"pancreatic":[93],"tissues,":[94],"but":[95],"also":[96],"many":[98],"other":[99],"tissue":[100],"types.":[101],"We":[102],"herein":[103],"demonstrated":[104,133],"that":[105,134],"exendin-4,":[106],"agonist,":[111],"induced":[112,136],"expression":[114,138],"human":[119],"retinal":[120],"microvascular":[121],"endothelial":[122],"cells":[123],"through":[124,142],"epigenetic":[125],"regulation.":[126],"The":[127],"results":[128],"present":[131],"study":[132],"exendin-4":[135],"histone":[143],"H3":[144],"acetylation":[145],"at":[146],"SOD3":[148],"proximal":[149],"promoter":[150],"region.":[151],"Moreover,":[152],"plasma":[153],"concentrations":[156],"patients":[159],"were":[160],"elevated":[161],"by":[162,179],"incretin-based":[163,166],"therapies.":[164],"Therefore,":[165],"therapies":[167],"exert":[169],"direct":[170],"effects":[172],"order":[174],"protect":[176],"blood":[177],"vessels":[178],"enhancing":[180],"activity.":[182]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-09-16T00:00:00"}