{"id":"https://openalex.org/W251180950","doi":null,"title":"ROLE OF REACTIVE OXYGEN SPECIES IN PLATELET FUNCTION IN NORMAL STATES AND CHRONIC MYELOPROLIFERATIVE DISORDERS","display_name":"ROLE OF REACTIVE OXYGEN SPECIES IN PLATELET FUNCTION IN NORMAL STATES AND CHRONIC MYELOPROLIFERATIVE DISORDERS","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W251180950","mag":"251180950"},"language":"en","primary_location":{"id":"mag:251180950","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Horia_Bumbea/publication/235324319_ROLE_OF_REACTIVE_OXYGEN_SPECIES_IN_PLATELET_FUNCTION_IN_NORMAL_STATES_AND_CHRONIC_MYELOPROLIFERATIVE_DISORDERS/links/0fcfd510bfcdc2af2f000000.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110013396","display_name":"Ana Maria Vl\u0103d\u0103reanu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Maria Vl\u0103d\u0103reanu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013064330","display_name":"Viola Maria Popov","orcid":"https://orcid.org/0000-0002-1200-379X","observed_orcids":["https://orcid.org/0000-0002-1200-379X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Viola Maria Popov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018081871","display_name":"S\u00e2nziana Radesi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S\u00e2nziana Radesi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017928525","display_name":"Minodora Onis\u00e2i","orcid":"https://orcid.org/0000-0002-7272-4513","observed_orcids":["https://orcid.org/0000-0002-7272-4513"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Minodora Onis\u00e2i","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7272-4513","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5038716318","display_name":"Horia Bumbea","orcid":"https://orcid.org/0000-0002-3706-3166","observed_orcids":["https://orcid.org/0000-0002-3706-3166"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Horia Bumbea","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3706-3166","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"45","issue":"2","first_page":"221","last_page":"232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":1.0},{"id":"https://openalex.org/keywords/platelet-function","display_name":"platelet function","score":0.7609999775886536},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.8289999961853027},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.996999979019165},{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.8539999723434448},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9769999980926514},{"id":"https://openalex.org/keywords/bcr-abl-tyrosine-kinase","display_name":"BCR-ABL tyrosine kinase","score":0.9470000267028809},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.8130000233650208},{"id":"https://openalex.org/keywords/integrin-signaling","display_name":"integrin signaling","score":0.9279999732971191},{"id":"https://openalex.org/keywords/primary-hemostasis","display_name":"primary hemostasis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/arterial-thrombosis","display_name":"arterial thrombosis","score":0.9589999914169312}],"concepts":[{"id":"https://openalex.org/C2910274570","wikidata":"https://www.wikidata.org/wiki/Q1898104","display_name":"Myeloproliferative Disorders","level":2,"score":0.5844754576683044},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5754731297492981},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5287232995033264},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5238340497016907},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5040730237960815},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.49098876118659973},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.46620357036590576},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4456669092178345},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4201757311820984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3857592046260834},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3633390963077545},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32702112197875977},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2396484613418579}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:251180950","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Horia_Bumbea/publication/235324319_ROLE_OF_REACTIVE_OXYGEN_SPECIES_IN_PLATELET_FUNCTION_IN_NORMAL_STATES_AND_CHRONIC_MYELOPROLIFERATIVE_DISORDERS/links/0fcfd510bfcdc2af2f000000.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W47433990","https://openalex.org/W1972355020","https://openalex.org/W1983760732","https://openalex.org/W1997553392","https://openalex.org/W2003241255","https://openalex.org/W2006917576","https://openalex.org/W2014349550","https://openalex.org/W2014561544","https://openalex.org/W2015408128","https://openalex.org/W2016656445","https://openalex.org/W2028362773","https://openalex.org/W2029736231","https://openalex.org/W2030851349","https://openalex.org/W2034842935","https://openalex.org/W2035619942","https://openalex.org/W2036363804","https://openalex.org/W2039881470","https://openalex.org/W2040396943","https://openalex.org/W2042101459","https://openalex.org/W2043549608","https://openalex.org/W2051281245","https://openalex.org/W2055478604","https://openalex.org/W2058217708","https://openalex.org/W2062285122","https://openalex.org/W2063021479","https://openalex.org/W2064061284","https://openalex.org/W2065940829","https://openalex.org/W2068866313","https://openalex.org/W2070968009","https://openalex.org/W2078581807","https://openalex.org/W2082668438","https://openalex.org/W2086727094","https://openalex.org/W2097155911","https://openalex.org/W2106567819","https://openalex.org/W2117462751","https://openalex.org/W2128978853","https://openalex.org/W2132886980","https://openalex.org/W2133249296","https://openalex.org/W2145028149","https://openalex.org/W2145220191","https://openalex.org/W2148959908","https://openalex.org/W2160657553","https://openalex.org/W2161488081","https://openalex.org/W2165122118","https://openalex.org/W2169979796","https://openalex.org/W2171065062","https://openalex.org/W2181224617","https://openalex.org/W3198337823"],"related_works":["https://openalex.org/W4224238016","https://openalex.org/W2063021479","https://openalex.org/W4406070661","https://openalex.org/W2604383915","https://openalex.org/W3121195231","https://openalex.org/W2795472364","https://openalex.org/W2085334497","https://openalex.org/W2148959908","https://openalex.org/W3028696619","https://openalex.org/W7099825927"],"abstract_inverted_index":{"Platelets":[0],"play":[1],"a":[2,32],"crucial":[3],"role":[4,35],"in":[5,36],"physiological":[6],"and":[7,14,52,62],"pathophysiological":[8],"processes":[9],"such":[10],"as":[11,82],"primary":[12],"hemostasis":[13],"arterial":[15],"thrombosis.":[16],"Growing":[17],"evidence":[18],"indicates":[19],"that":[20],"reactive":[21],"oxygen":[22],"species,":[23],"mainly":[24],"superoxide":[25],"generated":[26],"by":[27,45],"transmembrane":[28],"NAD(P)H":[29],"oxidase,":[30],"have":[31],"key":[33],"regulatory":[34],"platelets.":[37],"They":[38],"mediate":[39],"the":[40,53,69],"intracellular":[41],"signaling":[42,55],"pathways":[43],"activated":[44],"growth":[46],"factors":[47],"through":[48,56],"tyrosine":[49,71],"kinase":[50,72,77],"receptors":[51],"bidirectional":[54],"integrins,":[57],"influencing":[58],"thus":[59],"platelet":[60],"activation":[61],"subsequent":[63],"aggregation.":[64],"In":[65],"chronic":[66],"myeloid":[67],"leukemia,":[68],"BCR-ABL":[70],"receptor":[73],"is":[74],"constitutively":[75],"active,":[76],"inhibitors":[78],"being":[79],"currently":[80],"used":[81],"anti-mieloproliferative":[83],"drugs.":[84]},"counts_by_year":[{"year":2020,"cited_by_count":2}],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}