{"id":"https://openalex.org/W2510993151","doi":null,"title":"Association of the +49 A/G Polymorphism of CTLA4 Gene with Idiopathic Recurrent Spontaneous Abortion in Women in Southwest of Iran.","display_name":"Association of the +49 A/G Polymorphism of CTLA4 Gene with Idiopathic Recurrent Spontaneous Abortion in Women in Southwest of Iran.","publication_year":2016,"publication_date":"2016-07-01","ids":{"openalex":"https://openalex.org/W2510993151","mag":"2510993151","pmid":"https://pubmed.ncbi.nlm.nih.gov/27478768","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4947202"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4947202","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4947202/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4947202/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Reprod Infertil","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4947202/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076202756","display_name":"Zarnegar Rasti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146840","display_name":"Islamic Azad University of Arsanjan","ror":"https://ror.org/05fbv2v73","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I4210146840"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Zarnegar Rasti","raw_affiliation_strings":["Department of Biology, Islamic Azad University, Arsanjan branch, Arsanjan, Iran; Young Researchers and Elite Club, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Islamic Azad University, Arsanjan branch, Arsanjan, Iran; Young Researchers and Elite Club, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran","institution_ids":["https://openalex.org/I4210146840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055173507","display_name":"Mahboobeh Nasiri","orcid":"https://orcid.org/0000-0003-1370-6849","observed_orcids":["https://orcid.org/0000-0003-1370-6849"]},"institutions":[{"id":"https://openalex.org/I4210146840","display_name":"Islamic Azad University of Arsanjan","ror":"https://ror.org/05fbv2v73","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I4210146840"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mahboobeh Nasiri","raw_affiliation_strings":["Department of Biology, Islamic Azad University, Arsanjan branch, Arsanjan, Iran; Young Researchers and Elite Club, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Islamic Azad University, Arsanjan branch, Arsanjan, Iran; Young Researchers and Elite Club, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran","institution_ids":["https://openalex.org/I4210146840"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210146840"],"apc_list":null,"apc_paid":null,"fwci":1.6097,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.81022649,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"17","issue":"3","first_page":"151","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.8769999742507935},{"id":"https://openalex.org/keywords/recurrent-pregnancy-loss","display_name":"recurrent pregnancy loss","score":0.984000027179718},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6370000243186951},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.47099998593330383},{"id":"https://openalex.org/keywords/fetal-allograft-tolerance","display_name":"fetal allograft tolerance","score":0.6710000038146973},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.7414820790290833},{"id":"https://openalex.org/C2778642596","wikidata":"https://www.wikidata.org/wiki/Q8452","display_name":"Abortion","level":3,"score":0.6890802979469299},{"id":"https://openalex.org/C2779245376","wikidata":"https://www.wikidata.org/wiki/Q28693","display_name":"Miscarriage","level":3,"score":0.6385210156440735},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6253945231437683},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.5425001978874207},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4551049470901489},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.4512622654438019},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.4416372776031494},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4310791492462158},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4214846193790436},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.41929495334625244},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36332452297210693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3545101284980774},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2641475796699524},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24715176224708557},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09637653827667236},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4947202","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4947202/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4947202/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Reprod Infertil","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:3925260","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4947202","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27478768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27478768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of reproduction & infertility","raw_type":"Journal Article"},{"id":"mag:2510993151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27478768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4947202","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4947202/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4947202/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Reprod Infertil","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2510993151.pdf","grobid_xml":"https://content.openalex.org/works/W2510993151.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W49611453","https://openalex.org/W1519521580","https://openalex.org/W1967889234","https://openalex.org/W1988599657","https://openalex.org/W1989282995","https://openalex.org/W1991892396","https://openalex.org/W1993208556","https://openalex.org/W1996836002","https://openalex.org/W1996857500","https://openalex.org/W2009963809","https://openalex.org/W2017051726","https://openalex.org/W2026857804","https://openalex.org/W2036048737","https://openalex.org/W2045004726","https://openalex.org/W2045691392","https://openalex.org/W2065488982","https://openalex.org/W2073032752","https://openalex.org/W2101094698","https://openalex.org/W2101822729","https://openalex.org/W2103293297","https://openalex.org/W2113610605","https://openalex.org/W2118357635","https://openalex.org/W2122285115","https://openalex.org/W2134139698","https://openalex.org/W2146283287","https://openalex.org/W2148246556","https://openalex.org/W2151486856","https://openalex.org/W2151983841","https://openalex.org/W2157816811","https://openalex.org/W2165291980","https://openalex.org/W2167664101","https://openalex.org/W2317170392","https://openalex.org/W4211211389"],"related_works":["https://openalex.org/W2065488982","https://openalex.org/W4381660712","https://openalex.org/W2372226205","https://openalex.org/W7166669743","https://openalex.org/W2898076185","https://openalex.org/W4416317389","https://openalex.org/W4405162949","https://openalex.org/W2906638053","https://openalex.org/W2626304615","https://openalex.org/W2525095818"],"abstract_inverted_index":{"BACKGROUND:":[0],"Survival":[1],"of":[2,17,32,41,127,132,183,192,224,228,233],"the":[3,13,33,42,51,79,119,124,128,133,149,158,178,190,199,202,222,231],"semi-allograft":[4],"fetus":[5],"during":[6],"pregnancy":[7],"opens":[8],"a":[9,29,99,115,217],"new":[10],"area":[11],"for":[12,161],"immunological":[14],"based":[15],"causes":[16],"recurrent":[18],"spontaneous":[19],"abortion":[20],"(RSA).":[21],"Cytotoxic":[22],"T":[23],"lymphocyte-associated":[24],"antigen":[25],"4":[26],"(CTLA4)":[27],"is":[28,185],"negative":[30],"regulator":[31],"T-cell":[34],"activation,":[35],"which":[36],"may":[37,214],"modulate":[38],"peripheral":[39],"self-tolerance":[40],"allogeneic":[43],"fetus.":[44],"The":[45,62,82,101,112,130,181],"present":[46],"study":[47],"aimed":[48],"to":[49,59],"investigate":[50],"+49":[52,83],"A/G":[53,84],"CTLA4":[54],"genetic":[55],"polymorphism":[56,85],"and":[57,73,138,142,156,220],"predisposition":[58],"RSA.":[60,129,225],"METHODS:":[61],"total":[63],"participants":[64],"were":[65,104],"120":[66,74],"women":[67,77,194,200],"with":[68,123,174,198],"at":[69],"least":[70],"two":[71],"miscarriages":[72],"healthy":[75],"post-menopausal":[76],"as":[78,216],"control":[80,203],"group.":[81],"was":[86,94,140],"genotyped":[87],"using":[88],"PCR-RFLP":[89],"method.":[90],"Required":[91],"demographic":[92],"information":[93],"collected":[95],"through":[96],"filling":[97],"out":[98],"questionnaire.":[100],"obtained":[102],"data":[103],"fed":[105],"into":[106],"SPSS":[107],"software":[108],"version":[109],"16.":[110],"RESULTS:":[111],"results":[113],"showed":[114,171],"significant":[116,172],"association":[117,173],"between":[118],"minor":[120],"alleles":[121],"(G)":[122],"decreased":[125],"risk":[126,223,232],"frequency":[131,182],"G":[134,163],"allele":[135,162,213,219],"in":[136,148,157,196,201],"controls":[137],"patients":[139],"25%":[141],"12%,":[143],"respectively.":[144],"A":[145],"GG":[146],"genotype":[147],"co-dominance":[150],"model":[151,160],"(OR:":[152,167],"0.25,":[153],"95%CI:":[154,169],"0.09-0.66)":[155],"dominant":[159,218],"(GG+AG":[164],"vs.":[165],"AA)":[166],"0.84,":[168],"0.8-0.87)":[170],"RSA":[175,193,234],"by":[176],"imposing":[177],"protective":[179],"role.":[180],"miscarriage":[184,229],"significantly":[186],"(p=0.04)":[187],"higher":[188],"among":[189,235],"relatives":[191],"(33.3%)":[195],"comparison":[197],"group":[204],"(21.7%).":[205],"CONCLUSION:":[206],"It":[207],"can":[208],"be":[209],"concluded":[210],"that":[211],"+49G":[212],"act":[215],"reduce":[221],"Family":[226],"history":[227],"increased":[230],"women.":[236]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-09-16T00:00:00"}