{"id":"https://openalex.org/W2509946779","doi":"https://doi.org/10.1146/annurev-cancerbio-041916-065808","title":"The Two Faces of Reactive Oxygen Species in Cancer","display_name":"The Two Faces of Reactive Oxygen Species in Cancer","publication_year":2016,"publication_date":"2016-08-27","ids":{"openalex":"https://openalex.org/W2509946779","doi":"https://doi.org/10.1146/annurev-cancerbio-041916-065808","mag":"2509946779","pmid":"https://pubmed.ncbi.nlm.nih.gov/40034143","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11875389"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-cancerbio-041916-065808","doi":"https://doi.org/10.1146/annurev-cancerbio-041916-065808","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-cancerbio-041916-065808","pdf_url":null,"source":{"id":"https://openalex.org/S4210178937","display_name":"Annual Review of Cancer Biology","issn_l":"2472-3428","issn":["2472-3428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Cancer Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11875389/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034029445","display_name":"Colleen R. Reczek","orcid":"https://orcid.org/0000-0002-9106-5912","observed_orcids":["https://orcid.org/0000-0002-9106-5912"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen R. Reczek","raw_affiliation_strings":["Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611","Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611;","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046518034","display_name":"Navdeep S. Chandel","orcid":"https://orcid.org/0000-0001-7208-3886","observed_orcids":["https://orcid.org/0000-0001-7208-3886"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navdeep S. Chandel","raw_affiliation_strings":["Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611","Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611;","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":1.9055,"has_fulltext":false,"cited_by_count":634,"citation_normalized_percentile":{"value":0.8895247,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"1","issue":"1","first_page":"79","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":1.0},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.7860000133514404},{"id":"https://openalex.org/keywords/ros-signaling","display_name":"ROS signaling","score":0.6970000267028809},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7829999923706055},{"id":"https://openalex.org/keywords/tumor-cell-death","display_name":"cancer cell death","score":0.871999979019165},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7210000157356262},{"id":"https://openalex.org/keywords/antioxidant-capacity","display_name":"antioxidant capacity","score":0.8349999785423279},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.4320000112056732},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6260299682617188},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5020043849945068},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.41285771131515503},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34271395206451416},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28633779287338257},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17319080233573914},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11995035409927368},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1146/annurev-cancerbio-041916-065808","doi":"https://doi.org/10.1146/annurev-cancerbio-041916-065808","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-cancerbio-041916-065808","pdf_url":null,"source":{"id":"https://openalex.org/S4210178937","display_name":"Annual Review of Cancer Biology","issn_l":"2472-3428","issn":["2472-3428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Cancer Biology","raw_type":"journal-article"},{"id":"pmid:40034143","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40034143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of cancer biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11875389","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11875389/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Annu Rev Cancer Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11875389","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11875389/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Annu Rev Cancer Biol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6146645324","display_name":"Mitochondrial Metabolism and ROS Regulate Lung Cancer","funder_award_id":"R01CA123067","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000920350","display_name":"Training Program in Lung Sciences","funder_award_id":"T32HL076139","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":150,"referenced_works":["https://openalex.org/W274770","https://openalex.org/W114440940","https://openalex.org/W1535828429","https://openalex.org/W1585889626","https://openalex.org/W1809723326","https://openalex.org/W1857597751","https://openalex.org/W1881064736","https://openalex.org/W1890766043","https://openalex.org/W1964691523","https://openalex.org/W1966163762","https://openalex.org/W1969268163","https://openalex.org/W1969524738","https://openalex.org/W1969789360","https://openalex.org/W1970405699","https://openalex.org/W1972779889","https://openalex.org/W1974133167","https://openalex.org/W1974560134","https://openalex.org/W1975084717","https://openalex.org/W1975755652","https://openalex.org/W1976599392","https://openalex.org/W1978631786","https://openalex.org/W1979657965","https://openalex.org/W1980181091","https://openalex.org/W1980239332","https://openalex.org/W1980605560","https://openalex.org/W1982330633","https://openalex.org/W1983078193","https://openalex.org/W1988377666","https://openalex.org/W1990632141","https://openalex.org/W1992724001","https://openalex.org/W1993238109","https://openalex.org/W1993238514","https://openalex.org/W1994133951","https://openalex.org/W1995986855","https://openalex.org/W1996311090","https://openalex.org/W1998728654","https://openalex.org/W2000144783","https://openalex.org/W2002583208","https://openalex.org/W2002617338","https://openalex.org/W2002825673","https://openalex.org/W2006985176","https://openalex.org/W2007636933","https://openalex.org/W2009476974","https://openalex.org/W2010023860","https://openalex.org/W2010077871","https://openalex.org/W2011074645","https://openalex.org/W2011810742","https://openalex.org/W2013911798","https://openalex.org/W2016031481","https://openalex.org/W2017035524","https://openalex.org/W2017275974","https://openalex.org/W2017642315","https://openalex.org/W2020177773","https://openalex.org/W2020498032","https://openalex.org/W2023677185","https://openalex.org/W2023947368","https://openalex.org/W2024728867","https://openalex.org/W2028298372","https://openalex.org/W2028793854","https://openalex.org/W2031022790","https://openalex.org/W2033910705","https://openalex.org/W2033958147","https://openalex.org/W2034580062","https://openalex.org/W2036449456","https://openalex.org/W2039374791","https://openalex.org/W2041399911","https://openalex.org/W2041499308","https://openalex.org/W2048569323","https://openalex.org/W2049637089","https://openalex.org/W2049713754","https://openalex.org/W2051173337","https://openalex.org/W2053928409","https://openalex.org/W2058169199","https://openalex.org/W2063961339","https://openalex.org/W2067107606","https://openalex.org/W2067138633","https://openalex.org/W2070143299","https://openalex.org/W2070732456","https://openalex.org/W2072569792","https://openalex.org/W2073331259","https://openalex.org/W2074847845","https://openalex.org/W2076935230","https://openalex.org/W2077168519","https://openalex.org/W2077669333","https://openalex.org/W2078553155","https://openalex.org/W2084472730","https://openalex.org/W2085128107","https://openalex.org/W2085719701","https://openalex.org/W2086667809","https://openalex.org/W2087350238","https://openalex.org/W2087377825","https://openalex.org/W2089097264","https://openalex.org/W2089818796","https://openalex.org/W2090023298","https://openalex.org/W2092180337","https://openalex.org/W2093147450","https://openalex.org/W2096294661","https://openalex.org/W2096752472","https://openalex.org/W2098131661","https://openalex.org/W2099792161","https://openalex.org/W2100628426","https://openalex.org/W2102472842","https://openalex.org/W2104105936","https://openalex.org/W2106912600","https://openalex.org/W2107400278","https://openalex.org/W2109734459","https://openalex.org/W2112849045","https://openalex.org/W2113710155","https://openalex.org/W2113714326","https://openalex.org/W2115338196","https://openalex.org/W2115708356","https://openalex.org/W2116938728","https://openalex.org/W2118758371","https://openalex.org/W2119239003","https://openalex.org/W2119518512","https://openalex.org/W2119994407","https://openalex.org/W2122341467","https://openalex.org/W2132399579","https://openalex.org/W2135410441","https://openalex.org/W2138271341","https://openalex.org/W2139305993","https://openalex.org/W2140068099","https://openalex.org/W2140525205","https://openalex.org/W2142141154","https://openalex.org/W2143182501","https://openalex.org/W2144836619","https://openalex.org/W2145755327","https://openalex.org/W2147268550","https://openalex.org/W2148332345","https://openalex.org/W2148652623","https://openalex.org/W2150140277","https://openalex.org/W2152476041","https://openalex.org/W2154553542","https://openalex.org/W2155324869","https://openalex.org/W2159725132","https://openalex.org/W2161925283","https://openalex.org/W2163404652","https://openalex.org/W2166499489","https://openalex.org/W2168735777","https://openalex.org/W2171565634","https://openalex.org/W2173466127","https://openalex.org/W2200781451","https://openalex.org/W2229843619","https://openalex.org/W2259949170","https://openalex.org/W2273522842","https://openalex.org/W2284388501","https://openalex.org/W2286515888","https://openalex.org/W2291790203","https://openalex.org/W2312291090","https://openalex.org/W2317242858"],"related_works":["https://openalex.org/W3153831334","https://openalex.org/W2529021964","https://openalex.org/W2621333085","https://openalex.org/W7140304439","https://openalex.org/W3036711795","https://openalex.org/W7105685558","https://openalex.org/W2141603634","https://openalex.org/W2986932560","https://openalex.org/W3197880075","https://openalex.org/W7172266548"],"abstract_inverted_index":{"Reactive":[0],"oxygen":[1],"species":[2],"(ROS),":[3],"now":[4],"appreciated":[5],"for":[6,58],"their":[7,66,89,105],"cellular":[8,59],"signaling":[9,43,55],"capabilities,":[10],"have":[11],"a":[12],"dual":[13],"role":[14],"in":[15,76,120],"cancer.":[16],"On":[17,35],"the":[18,36,53,115,122,129],"one":[19],"hand,":[20,38],"ROS":[21,39,69,80,119,126],"can":[22,40],"promote":[23,41],"protumorigenic":[24],"signaling,":[25,127],"facilitating":[26],"cancer":[27,48,63,86,101,131],"cell":[28,49,54,84],"proliferation,":[29],"survival,":[30],"and":[31,44,61,82,128],"adaptation":[32],"to":[33,78,107,134],"hypoxia.":[34],"other":[37],"antitumorigenic":[42],"trigger":[45],"oxidative":[46],"stress-induced":[47],"death.":[50],"To":[51],"hyperactivate":[52],"pathways":[56],"necessary":[57],"transformation":[60],"tumorigenesis,":[62],"cells":[64,87,102],"increase":[65,88,104],"rate":[67],"of":[68,100,118],"production":[70],"compared":[71],"with":[72,93],"normal":[73,94],"cells.":[74],"Concomitantly,":[75],"order":[77],"maintain":[79],"homeostasis":[81],"evade":[83],"death,":[85],"antioxidant":[90],"capacity.":[91],"Compared":[92],"cells,":[95],"this":[96,111],"altered":[97],"redox":[98],"environment":[99],"may":[103],"susceptibility":[106],"ROS-manipulation":[108],"therapies.":[109],"In":[110],"review,":[112],"we":[113],"discuss":[114],"two":[116],"faces":[117],"cancer,":[121],"potential":[123],"mechanisms":[124],"underlying":[125],"opposing":[130],"therapeutic":[132],"approaches":[133],"targeting":[135],"ROS.":[136]},"counts_by_year":[{"year":2026,"cited_by_count":86},{"year":2025,"cited_by_count":54},{"year":2024,"cited_by_count":65},{"year":2023,"cited_by_count":78},{"year":2022,"cited_by_count":130},{"year":2021,"cited_by_count":100},{"year":2020,"cited_by_count":55},{"year":2019,"cited_by_count":38},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-09-16T00:00:00"}