{"id":"https://openalex.org/W2509706485","doi":"https://doi.org/10.1111/liv.13238","title":"Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis","display_name":"Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis","publication_year":2016,"publication_date":"2016-08-25","ids":{"openalex":"https://openalex.org/W2509706485","doi":"https://doi.org/10.1111/liv.13238","mag":"2509706485","pmid":"https://pubmed.ncbi.nlm.nih.gov/27558072"},"language":"en","primary_location":{"id":"doi:10.1111/liv.13238","doi":"https://doi.org/10.1111/liv.13238","is_oa":false,"landing_page_url":"https://doi.org/10.1111/liv.13238","pdf_url":null,"source":{"id":"https://openalex.org/S206392846","display_name":"Liver International","issn_l":"0106-9543","issn":["0106-9543","1478-3223","1478-3231","1600-0676"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087109628","display_name":"Johannes R. Hov","orcid":"https://orcid.org/0000-0002-5900-8096","observed_orcids":["https://orcid.org/0000-0002-5900-8096"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Johannes R. Hov","raw_affiliation_strings":["Division of Surgery, Department of Transplantation Medicine, Inflammatory Medicine and Transplantation, Norwegian PSC Research Center, Oslo University Hospital Rikshospitalet, Oslo, Norway","Division of Surgery, Inflammatory Medicine and Transplantation, Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway","Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","K.G.Jebsen Inflammation Research Centre, Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","Section of Gastroenterology, Division of Surgery, Department of Transplantation Medicine, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway"],"raw_orcid":"https://orcid.org/0000-0002-5900-8096","affiliations":[{"raw_affiliation_string":"Division of Surgery, Department of Transplantation Medicine, Inflammatory Medicine and Transplantation, Norwegian PSC Research Center, Oslo University Hospital Rikshospitalet, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Division of Surgery, Inflammatory Medicine and Transplantation, Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"K.G.Jebsen Inflammation Research Centre, Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Section of Gastroenterology, Division of Surgery, Department of Transplantation Medicine, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039584975","display_name":"Kirsten Muri Boberg","orcid":"https://orcid.org/0000-0001-5567-9928","observed_orcids":["https://orcid.org/0000-0001-5567-9928"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Kirsten M. Boberg","raw_affiliation_strings":["Division of Surgery, Department of Transplantation Medicine, Inflammatory Medicine and Transplantation, Norwegian PSC Research Center, Oslo University Hospital Rikshospitalet, Oslo, Norway","Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","Section of Gastroenterology, Division of Surgery, Department of Transplantation Medicine, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgery, Department of Transplantation Medicine, Inflammatory Medicine and Transplantation, Norwegian PSC Research Center, Oslo University Hospital Rikshospitalet, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Section of Gastroenterology, Division of Surgery, Department of Transplantation Medicine, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037219930","display_name":"Eli Taraldsrud","orcid":"https://orcid.org/0000-0002-5239-1854","observed_orcids":["https://orcid.org/0000-0002-5239-1854","https://orcid.org/0000-0003-4721-8851"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Eli Taraldsrud","raw_affiliation_strings":["Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway","Faculty of Medicine Institute of Clinical Medicine University of Oslo  Oslo Norway","K.G.Jebsen Inflammation Research Centre, Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Faculty of Medicine Institute of Clinical Medicine University of Oslo  Oslo Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"K.G.Jebsen Inflammation Research Centre, Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049378318","display_name":"Mette N\u00e5mdal Vesterhus","orcid":"https://orcid.org/0000-0003-1493-2303","observed_orcids":["https://orcid.org/0000-0003-1493-2303","https://orcid.org/0000-0003-2994-2723"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Mette Vesterhus","raw_affiliation_strings":["Division of Surgery, Department of Transplantation Medicine, Inflammatory Medicine and Transplantation, Norwegian PSC Research Center, Oslo University Hospital Rikshospitalet, Oslo, Norway","National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgery, Department of Transplantation Medicine, Inflammatory Medicine and Transplantation, Norwegian PSC Research Center, Oslo University Hospital Rikshospitalet, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway","institution_ids":["https://openalex.org/I2800740805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079736615","display_name":"Maria Boyadzhieva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30147112","display_name":"Medical University of Sofia","ror":"https://ror.org/01n9zy652","country_code":"BG","type":"education","lineage":["https://openalex.org/I30147112"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Maria Boyadzhieva","raw_affiliation_strings":["Clinical Center of Endocrinology, Medical University Sofia, Sofia, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Center of Endocrinology, Medical University Sofia, Sofia, Bulgaria","institution_ids":["https://openalex.org/I30147112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020925385","display_name":"Inger Camilla Solberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Inger Camilla Solberg","raw_affiliation_strings":["Division of Medicine Department of Gastroenterology Oslo University Hospital Ullev\u00e5l  Oslo Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicine Department of Gastroenterology Oslo University Hospital Ullev\u00e5l  Oslo Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103418821","display_name":"Erik Schrumpf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Erik Schrumpf","raw_affiliation_strings":["Division of Surgery, Department of Transplantation Medicine, Inflammatory Medicine and Transplantation, Norwegian PSC Research Center, Oslo University Hospital Rikshospitalet, Oslo, Norway","Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgery, Department of Transplantation Medicine, Inflammatory Medicine and Transplantation, Norwegian PSC Research Center, Oslo University Hospital Rikshospitalet, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103473689","display_name":"Morten Harald Vatn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I2800192669","display_name":"Akershus University Hospital","ror":"https://ror.org/0331wat71","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800192669"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Morten H. Vatn","raw_affiliation_strings":["EpiGen Institute, Campus AHUS, Akershus University Hospital, Nordbyhagen, Norway","Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EpiGen Institute, Campus AHUS, Akershus University Hospital, Nordbyhagen, Norway","institution_ids":["https://openalex.org/I2800192669"]},{"raw_affiliation_string":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108123537","display_name":"Benedicte A. Lie","orcid":"https://orcid.org/0000-0002-1159-7004","observed_orcids":["https://orcid.org/0000-0002-1159-7004"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Benedicte A. Lie","raw_affiliation_strings":["Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway","Faculty of Medicine Institute of Clinical Medicine University of Oslo  Oslo Norway","K.G.Jebsen Inflammation Research Centre, Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Faculty of Medicine Institute of Clinical Medicine University of Oslo  Oslo Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"K.G.Jebsen Inflammation Research Centre, Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010386565","display_name":"\u00d8yvind Molberg","orcid":"https://orcid.org/0000-0003-4493-8853","observed_orcids":["https://orcid.org/0000-0003-4493-8853"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"\u00d8yvind Molberg","raw_affiliation_strings":["Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","Rheumatology Unit, Oslo University Hospital Rikshospitalet, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Rheumatology Unit, Oslo University Hospital Rikshospitalet, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041223207","display_name":"Tom H. Karlsen","orcid":"https://orcid.org/0000-0002-8289-9931","observed_orcids":["https://orcid.org/0000-0002-8289-9931"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Tom H. Karlsen","raw_affiliation_strings":["Division of Surgery, Department of Transplantation Medicine, Inflammatory Medicine and Transplantation, Norwegian PSC Research Center, Oslo University Hospital Rikshospitalet, Oslo, Norway","Division of Surgery, Inflammatory Medicine and Transplantation, Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway","Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","K.G.Jebsen Inflammation Research Centre, Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","Section of Gastroenterology, Division of Surgery, Department of Transplantation Medicine, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgery, Department of Transplantation Medicine, Inflammatory Medicine and Transplantation, Norwegian PSC Research Center, Oslo University Hospital Rikshospitalet, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Division of Surgery, Inflammatory Medicine and Transplantation, Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"K.G.Jebsen Inflammation Research Centre, Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Section of Gastroenterology, Division of Surgery, Department of Transplantation Medicine, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5087109628"],"corresponding_institution_ids":["https://openalex.org/I1281400175","https://openalex.org/I184942183"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":2.6997,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.89807637,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"37","issue":"3","first_page":"458","last_page":"465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-sclerosing-cholangitis","display_name":"primary sclerosing cholangitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antineutrophil-cytoplasmic-antibodies","display_name":"antineutrophil cytoplasmic antibodies","score":0.9950000047683716},{"id":"https://openalex.org/keywords/p-anca","display_name":"p-ANCA","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hla-drb1-03","display_name":"HLA-DRB1*03","score":0.9169999957084656},{"id":"https://openalex.org/keywords/hla-b-08","display_name":"HLA-B*08","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hla-complex","display_name":"HLA complex","score":0.6819999814033508},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.796999990940094},{"id":"https://openalex.org/keywords/biliary-tract-cancer","display_name":"biliary tract cancer","score":0.7459999918937683},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.8289999961853027},{"id":"https://openalex.org/keywords/disease-spectrum","display_name":"disease spectrum","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C2778579378","wikidata":"https://www.wikidata.org/wiki/Q7130185","display_name":"Panca","level":5,"score":0.9304617643356323},{"id":"https://openalex.org/C2780615123","wikidata":"https://www.wikidata.org/wiki/Q1058608","display_name":"Primary sclerosing cholangitis","level":3,"score":0.9257266521453857},{"id":"https://openalex.org/C24040308","wikidata":"https://www.wikidata.org/wiki/Q574727","display_name":"Anti-neutrophil cytoplasmic antibody","level":4,"score":0.8853641748428345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8543528914451599},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.6495844721794128},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5734857320785522},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5341310501098633},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5268857479095459},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.4490422308444977},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.44519880414009094},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40986815094947815},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.30598706007003784},{"id":"https://openalex.org/C2776015282","wikidata":"https://www.wikidata.org/wiki/Q644318","display_name":"Vasculitis","level":3,"score":0.2008276879787445},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.18483346700668335}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009664","descriptor_name":"Norway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015209","descriptor_name":"Cholangitis, Sclerosing","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015209","descriptor_name":"Cholangitis, Sclerosing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015796","descriptor_name":"HLA-B27 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019268","descriptor_name":"Antibodies, Antineutrophil Cytoplasmic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059811","descriptor_name":"HLA-DRB1 Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/liv.13238","doi":"https://doi.org/10.1111/liv.13238","is_oa":false,"landing_page_url":"https://doi.org/10.1111/liv.13238","pdf_url":null,"source":{"id":"https://openalex.org/S206392846","display_name":"Liver International","issn_l":"0106-9543","issn":["0106-9543","1478-3223","1478-3231","1600-0676"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver International","raw_type":"journal-article"},{"id":"pmid:27558072","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27558072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver international : official journal of the International Association for the Study of the Liver","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G8448077259","display_name":null,"funder_award_id":"240787/F20","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"}],"funders":[{"id":"https://openalex.org/F4320323299","display_name":"Norges Forskningsr\u00e5d","ror":"https://ror.org/00epmv149"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W94779788","https://openalex.org/W1964890547","https://openalex.org/W1968001375","https://openalex.org/W1984257565","https://openalex.org/W1987551179","https://openalex.org/W1992431640","https://openalex.org/W1996745451","https://openalex.org/W2000292638","https://openalex.org/W2003011813","https://openalex.org/W2004335197","https://openalex.org/W2005687210","https://openalex.org/W2007272132","https://openalex.org/W2011555335","https://openalex.org/W2020040349","https://openalex.org/W2038248019","https://openalex.org/W2045153586","https://openalex.org/W2046653318","https://openalex.org/W2065637841","https://openalex.org/W2069628948","https://openalex.org/W2080459269","https://openalex.org/W2081454675","https://openalex.org/W2087747538","https://openalex.org/W2090365041","https://openalex.org/W2102495280","https://openalex.org/W2108329405","https://openalex.org/W2117569516","https://openalex.org/W2121421374","https://openalex.org/W2121925321","https://openalex.org/W2125054439","https://openalex.org/W2130462669","https://openalex.org/W2140198584","https://openalex.org/W2143030437","https://openalex.org/W2143350483","https://openalex.org/W2163729637","https://openalex.org/W2182205274","https://openalex.org/W2317186316","https://openalex.org/W2328865893","https://openalex.org/W4233893512"],"related_works":["https://openalex.org/W2156877459","https://openalex.org/W2121925321","https://openalex.org/W2009448977","https://openalex.org/W7066408661","https://openalex.org/W2034439815","https://openalex.org/W3027335955","https://openalex.org/W2000292638","https://openalex.org/W2069179535","https://openalex.org/W3126585140","https://openalex.org/W1745867474"],"abstract_inverted_index":{"BACKGROUND":[0],"&":[1],"AIMS:":[2],"The":[3,188],"strongest":[4],"genetic":[5,49,227],"risk":[6,160],"factors":[7,161],"in":[8,15,26,53,64,75,79,108,117,164,173,209,239],"primary":[9],"sclerosing":[10],"cholangitis":[11],"(PSC)":[12],"are":[13,40],"encoded":[14],"the":[16,76,112,157,194,240],"HLA":[17],"complex.":[18],"Antineutrophil":[19,56,103,217],"cytoplasmic":[20,57,104,218],"antibodies":[21,58,105,219],"(ANCA)":[22],"have":[23],"been":[24],"reported":[25],"up":[27],"to":[28,45,196],"94%":[29],"of":[30,51,111,129,136],"PSC":[31,67,113,130,148,159,221],"patients,":[32,114],"but":[33],"their":[34],"clinical":[35,47,225],"significance":[36],"and":[37,48,70,78,88,131,151,167,182,226],"immunogenetic":[38],"basis":[39],"ill":[41],"defined.":[42],"We":[43],"aimed":[44],"characterize":[46],"associations":[50],"ANCA":[52,86,125,231],"PSC.":[54],"METHODS:":[55],"were":[59,90,106,122,144,170,190],"analysed":[60],"with":[61,115,150,212,223],"indirect":[62],"immunofluorescence":[63],"241":[65],"Norwegian":[66],"patients.":[68,198],"HLA-B":[69],"HLA-DRB1":[71,89],"genotyping":[72],"was":[73,206],"performed":[74],"patients":[77,97,121,149,177,201,214,222],"368":[80],"healthy":[81,165],"controls.":[82],"Data":[83],"on":[84],"perinuclear":[85],"(pANCA)":[87],"available":[91],"from":[92],"274":[93],"ulcerative":[94],"colitis":[95],"(UC)":[96],"without":[98,152,202],"known":[99],"liver":[100,203],"disease.":[101,155],"RESULTS:":[102],"found":[107],"193":[109],"(80%)":[110],"pANCA":[116],"169":[118],"(70%).":[119],"ANCA-positive":[120,174],"younger":[123],"than":[124,175],"negative":[126],"at":[127],"diagnosis":[128],"had":[132],"a":[133,234],"lower":[134],"frequency":[135],"biliary":[137],"cancer":[138],"(9%":[139],"vs":[140,179,184],"19%,":[141],"P=.047).":[142],"There":[143],"no":[145],"differences":[146],"between":[147],"inflammatory":[153],"bowel":[154],"Genetically,":[156],"strong":[158],"HLA-B*08":[162],"(frequency":[163],"13%)":[166],"DRB1*03":[168],"(14%)":[169],"more":[171,207],"prevalent":[172,208],"-negative":[176,213],"(43%":[178],"25%,":[180,185],"P=.0012":[181],"43%":[183],"P=.0015":[186],"respectively).":[187],"results":[189],"similar":[191],"when":[192],"restricting":[193],"analysis":[195],"pANCA-positive":[197,210],"In":[199],"UC":[200],"disease,":[204],"HLA-DRB1*03":[205],"compared":[211],"(P=.03).":[215],"CONCLUSIONS:":[216],"identified":[220],"particular":[224],"characteristics,":[228],"suggesting":[229],"that":[230],"may":[232],"mark":[233],"clinically":[235],"relevant":[236],"pathogenetic":[237],"subgroup":[238],"PSC-UC":[241],"disease":[242],"spectrum.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-09-16T00:00:00"}