{"id":"https://openalex.org/W2509525534","doi":null,"title":"Functional diversity and bilobe targeting by the MORN Domain Proteins of Leishmania major","display_name":"Functional diversity and bilobe targeting by the MORN Domain Proteins of Leishmania major","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2509525534","mag":"2509525534"},"language":"en","primary_location":{"id":"pmh:oai:ueaeprints.uea.ac.uk:57166","doi":null,"is_oa":false,"landing_page_url":"https://ueaeprints.uea.ac.uk/57166/1/MSc_Thesis._MJobe.pdf","pdf_url":"https://ueaeprints.uea.ac.uk/57166/1/MSc_Thesis._MJobe.pdf","source":{"id":"https://openalex.org/S4306400384","display_name":"UEA Digital Repository (University of East Anglia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1118541","host_organization_name":"University of East Anglia","host_organization_lineage":["https://openalex.org/I1118541"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022476296","display_name":"Momodou Jobe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Momodou Jobe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5022476296"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leishmania-major","display_name":"Leishmania major","score":0.875},{"id":"https://openalex.org/keywords/golgi-biogenesis","display_name":"Golgi biogenesis","score":0.7239999771118164},{"id":"https://openalex.org/keywords/basal-bodies","display_name":"basal bodies","score":0.5230000019073486},{"id":"https://openalex.org/keywords/flagella","display_name":"flagella","score":0.921999990940094},{"id":"https://openalex.org/keywords/protein-localization","display_name":"protein localization","score":0.6320000290870667},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.5680000185966492},{"id":"https://openalex.org/keywords/parasite-infectivity","display_name":"parasite infectivity","score":0.6690000295639038},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.675000011920929},{"id":"https://openalex.org/keywords/kinetoplastids","display_name":"kinetoplastids","score":0.7089999914169312},{"id":"https://openalex.org/keywords/functional-diversity","display_name":"functional diversity","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8158017992973328},{"id":"https://openalex.org/C115811362","wikidata":"https://www.wikidata.org/wiki/Q189998","display_name":"Flagellum","level":3,"score":0.6308375000953674},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.6248793601989746},{"id":"https://openalex.org/C2781092759","wikidata":"https://www.wikidata.org/wiki/Q524818","display_name":"Leishmania","level":3,"score":0.5256553888320923},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.525004506111145},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.49415162205696106},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47801148891448975},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.47308069467544556},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.4465939402580261},{"id":"https://openalex.org/C2780599195","wikidata":"https://www.wikidata.org/wiki/Q1950715","display_name":"Leishmania major","level":4,"score":0.4299386143684387},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.42293819785118103},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3911218047142029},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.28108349442481995},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.19785112142562866},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.16689473390579224},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1484794020652771},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ueaeprints.uea.ac.uk:57166","doi":null,"is_oa":false,"landing_page_url":"https://ueaeprints.uea.ac.uk/57166/1/MSc_Thesis._MJobe.pdf","pdf_url":"https://ueaeprints.uea.ac.uk/57166/1/MSc_Thesis._MJobe.pdf","source":{"id":"https://openalex.org/S4306400384","display_name":"UEA Digital Repository (University of East Anglia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1118541","host_organization_name":"University of East Anglia","host_organization_lineage":["https://openalex.org/I1118541"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2509525534","doi":null,"is_oa":false,"landing_page_url":"https://ueaeprints.uea.ac.uk/id/eprint/57166/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1493572438","https://openalex.org/W1523928530","https://openalex.org/W1532199762","https://openalex.org/W1606277263","https://openalex.org/W1910381980","https://openalex.org/W1921149115","https://openalex.org/W1968473596","https://openalex.org/W1973030143","https://openalex.org/W1974077996","https://openalex.org/W1976502466","https://openalex.org/W1976528399","https://openalex.org/W1977332101","https://openalex.org/W1978841613","https://openalex.org/W1990065094","https://openalex.org/W1994496764","https://openalex.org/W1995628893","https://openalex.org/W1997549848","https://openalex.org/W1998394184","https://openalex.org/W1999212105","https://openalex.org/W2001399448","https://openalex.org/W2004182243","https://openalex.org/W2008255270","https://openalex.org/W2011630686","https://openalex.org/W2013465778","https://openalex.org/W2015425628","https://openalex.org/W2018574166","https://openalex.org/W2020216656","https://openalex.org/W2022530238","https://openalex.org/W2027743939","https://openalex.org/W2028654873","https://openalex.org/W2030399625","https://openalex.org/W2030939638","https://openalex.org/W2037755199","https://openalex.org/W2046068908","https://openalex.org/W2049225095","https://openalex.org/W2060695219","https://openalex.org/W2061717363","https://openalex.org/W2066034930","https://openalex.org/W2066390791","https://openalex.org/W2069285715","https://openalex.org/W2070893008","https://openalex.org/W2072706007","https://openalex.org/W2073968743","https://openalex.org/W2075490509","https://openalex.org/W2076746539","https://openalex.org/W2095445890","https://openalex.org/W2098972229","https://openalex.org/W2100837269","https://openalex.org/W2101553897","https://openalex.org/W2104782422","https://openalex.org/W2109380145","https://openalex.org/W2112973255","https://openalex.org/W2113447712","https://openalex.org/W2114014156","https://openalex.org/W2117626458","https://openalex.org/W2125089548","https://openalex.org/W2131533260","https://openalex.org/W2133192672","https://openalex.org/W2137529106","https://openalex.org/W2142398823","https://openalex.org/W2143414586","https://openalex.org/W2145657197","https://openalex.org/W2145970276","https://openalex.org/W2148507499","https://openalex.org/W2148674149","https://openalex.org/W2159289924","https://openalex.org/W2159356176","https://openalex.org/W2168967957","https://openalex.org/W2171540907","https://openalex.org/W2171704754"],"related_works":["https://openalex.org/W7019311754","https://openalex.org/W1994496764","https://openalex.org/W157451730","https://openalex.org/W2012844770","https://openalex.org/W7098154715","https://openalex.org/W2084952166","https://openalex.org/W3200379092","https://openalex.org/W2976036993","https://openalex.org/W2065972421","https://openalex.org/W2119804694"],"abstract_inverted_index":{"Leishmania":[0,18],"is":[1,64],"a":[2,7,34,217,249,253,278,291],"protozoan":[3],"parasite":[4],"responsible":[5,76],"for":[6,31,77,166,259],"spectrum":[8],"of":[9,17,20,23,57,66,102,121,126,238],"diseases":[10],"known":[11],"as":[12,252],"leishmaniasis.":[13],"The":[14,142],"cell":[15],"body":[16],"consists":[19],"single":[21],"copies":[22],"several":[24],"organelles":[25],"whose":[26],"faithful":[27],"duplication":[28],"are":[29,75],"crucial":[30],"survival.":[32],"Previously,":[33],"novel":[35],"cytoskeletal":[36,213],"organelle":[37],"called":[38],"the":[39,52,58,73,93,99,124,135,182,185,192,209,236,260,275,296],"bilobe":[40,59,79,167,183,210,276],"was":[41,144],"discovered":[42],"while":[43,134,188,286],"studying":[44],"Golgi":[45],"biogenesis":[46],"in":[47,89,117,160,270,277,283,295],"T.":[48,90,284],"brucei.":[49],"TbMORN1":[50,63,282],"became":[51],"first":[53,261],"identified":[54],"structural":[55,218],"component":[56],"with":[60,208],"exclusive":[61],"localization.":[62],"composed":[65],"15":[67],"MORN-repeats":[68,74,116,129],"which":[69,122],"may":[70],"imply":[71],"that":[72,82,176,273],"its":[78,226],"targeting.":[80],"Given":[81],"MORN":[83,100,265],"proteins":[84,101,111,266],"have":[85],"only":[86],"been":[87],"characterized":[88],"brucei":[91],"among":[92],"kinetoplastids,":[94],"I":[95,174,257],"chose":[96],"to":[97,114,145,232,243,281,289],"study":[98],"L.":[103,118,161,271],"major":[104,162,272],"an":[105],"important":[106],"experimental":[107],"model.":[108],"22":[109],"uncharacterized":[110],"were":[112,199],"annotated":[113],"contain":[115],"major,":[119],"14":[120],"share":[123],"feature":[125],"exclusively":[127],"containing":[128],"ranging":[130],"from":[131,154,158],"3-15":[132],"repeats,":[133],"remaining":[136],"7":[137],"carry":[138],"additional":[139],"functional":[140,293],"domains.":[141],"strategy":[143],"express":[146],"two":[147,222,263],"apparently":[148],"varied":[149],"LmaMORNs":[150],"(LmaMORN5":[151,267],"and":[152,157,169,179,184,211,241,268],"LmaMORN6)":[153,269],"each":[155,287],"other":[156,212,264],"MORN1":[159],"promastigotes,":[163],"screen":[164],"them":[165],"localization":[168],"investigate":[170],"their":[171],"possible":[172,250],"function.":[173,196],"showed":[175],"both":[177],"LmaMORN5":[178,220],"LmaMORN6":[180,189],"target":[181],"basal":[186],"bodies":[187],"additionally":[190],"stained":[191],"flagellum":[193],"indicating":[194],"flagellar":[195],"These":[197],"localizations":[198],"true":[200],"even":[201],"after":[202],"detergent":[203],"extraction,":[204],"implying":[205],"intimate":[206],"associations":[207],"structures,":[214],"hinting":[215],"at":[216],"role.":[219],"contained":[221],"compartmentalized":[223],"regions":[224],"along":[225],"sequence":[227],"under":[228],"selective":[229],"pressure,":[230],"shown":[231],"be":[233],"secreted":[234],"into":[235],"cytoplasm":[237],"infected":[239],"macrophages":[240],"seemed":[242],"increased":[244],"parasites":[245],"infectivity":[246],"six-fold,":[247],"suggesting":[248],"role":[251,294],"virulence":[254],"factor.":[255],"Thus,":[256],"reported":[258],"time":[262],"targets":[274],"manner":[279],"similar":[280],"brucei,":[285],"appear":[288],"display":[290],"differential":[292],"parasite\u2019s":[297],"biology.":[298]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-09-16T00:00:00"}