{"id":"https://openalex.org/W2508847481","doi":null,"title":"The Effects of Recombinant Osteoactivin on Murine Osteoclastogenesis","display_name":"The Effects of Recombinant Osteoactivin on Murine Osteoclastogenesis","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2508847481","mag":"2508847481"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:ne2mh1424053380","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ne2mh1424053380","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ne2mh1424053380","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=ne2mh1424053380","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ne2mh1424053380","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087358893","display_name":"Matthew Khol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew Khol","raw_affiliation_strings":["Northeast Ohio Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeast Ohio Medical University","institution_ids":["https://openalex.org/I95240055"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087358893"],"corresponding_institution_ids":["https://openalex.org/I95240055"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13328","display_name":"Osteomyelitis and Bone Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gpnmb","display_name":"GPNMB","score":0.9929999709129333},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/osteoclast-progenitor-cells","display_name":"osteoclast progenitor cells","score":0.843999981880188},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.9120000004768372},{"id":"https://openalex.org/keywords/osteoclast-survival","display_name":"osteoclast survival","score":0.652999997138977},{"id":"https://openalex.org/keywords/tartrate-resistant-acid-phosphatase","display_name":"tartrate-resistant acid phosphatase","score":0.7760000228881836},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.49799999594688416},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.414000004529953},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.5090000033378601},{"id":"https://openalex.org/keywords/macrophage-colony-stimulating-factor","display_name":"macrophage colony-stimulating factor","score":0.8019999861717224},{"id":"https://openalex.org/keywords/rankl","display_name":"RANKL","score":0.753000020980835},{"id":"https://openalex.org/keywords/recombinant-protein","display_name":"recombinant protein","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6281504034996033},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36868956685066223},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35979217290878296},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3383469581604004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3336537480354309},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22717517614364624},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16261857748031616}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:ne2mh1424053380","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ne2mh1424053380","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ne2mh1424053380","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=ne2mh1424053380","raw_type":"text"},{"id":"mag:2508847481","doi":null,"is_oa":false,"landing_page_url":"https://etd.ohiolink.edu/ap/10?0::NO:10:P10_ACCESSION_NUM:ne2mh1424053380","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:ne2mh1424053380","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ne2mh1424053380","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ne2mh1424053380","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=ne2mh1424053380","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2508847481.pdf","grobid_xml":"https://content.openalex.org/works/W2508847481.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1557709535","https://openalex.org/W1602919907","https://openalex.org/W1677973650","https://openalex.org/W1880717070","https://openalex.org/W1964031097","https://openalex.org/W1968214785","https://openalex.org/W1970007595","https://openalex.org/W1976402969","https://openalex.org/W1979395101","https://openalex.org/W2005866131","https://openalex.org/W2008265399","https://openalex.org/W2012815797","https://openalex.org/W2022209206","https://openalex.org/W2032394856","https://openalex.org/W2037565537","https://openalex.org/W2039547032","https://openalex.org/W2045938432","https://openalex.org/W2052361599","https://openalex.org/W2054720114","https://openalex.org/W2077958519","https://openalex.org/W2086671663","https://openalex.org/W2093252878","https://openalex.org/W2094839445","https://openalex.org/W2105797231","https://openalex.org/W2111148911","https://openalex.org/W2113371364","https://openalex.org/W2114935509","https://openalex.org/W2131017606","https://openalex.org/W2138889138","https://openalex.org/W2142820105","https://openalex.org/W2144268541","https://openalex.org/W2150428981","https://openalex.org/W2412856998","https://openalex.org/W2732353950"],"related_works":["https://openalex.org/W2518584144","https://openalex.org/W3134811769","https://openalex.org/W2014640240","https://openalex.org/W3135403254","https://openalex.org/W7061258479","https://openalex.org/W6884915081","https://openalex.org/W2896478748","https://openalex.org/W2084327158","https://openalex.org/W1984623659","https://openalex.org/W3047820419"],"abstract_inverted_index":{"Introduction:":[0],"Healthy":[1],"bone":[2,9,13,65,71,89,96,142,249,365],"constantly":[3],"remodels,":[4],"in":[5,16,22,38,44,62,92,169,195,209,255,262,270,330,362],"balance":[6],"between":[7,54],"osteoclast":[8,19,192,202,259,268,310],"resorption":[10,66,260],"and":[11,29,52,59,81,111,144,151,162,177,182,222,239,246,288,346],"osteoblast":[12,109],"formation.Osteoclasts":[14],"differentiate":[15,37],"vitro":[17,39],"from":[18,40,157,293],"progenitor":[20,153,193,203,285],"cells":[21,43,154,194,204],"the":[23,45,55,113,133,170,191,196,201,210,263,271,306,336,363],"presence":[24,46,171,197,211,264,272],"of":[25,47,57,74,115,165,172,198,212,265,273,309,324,349],"macrophage-colony":[26,184],"stimulating":[27,185],"factor":[28,33,91,186,282],"receptor":[30,279],"activated":[31,280],"nuclear":[32,281],"\uf06bB-ligand,":[34],"while":[35],"osteoblasts":[36,60],"mesenchymal":[41],"stem":[42],"ascorbic":[48],"acid,":[49],"\uf062-glycerol":[50],"phosphate,":[51],"dexamethasone.Imbalance":[53],"function":[56],"osteoclasts":[58,118,208,236,332],"results":[61],"disease.In":[63],"osteoporosis,":[64],"dominates,":[67],"leading":[68],"to":[69,77,107,257],"decreased":[70,357],"mass.Osteoporosis":[72],"is":[73,86],"critical":[75],"concern":[76],"an":[78,87],"aging":[79],"population,":[80],"new":[82],"treatments":[83],"are":[84,119],"needed.Osteoactivin":[85],"anabolic":[88],"growth":[90],"vivo,":[93],"causing":[94],"increased":[95,351],"mass":[97],"when":[98,295,300,316],"injected":[99],"into":[100,207],"mice.In":[101],"vitro,":[102],"osteoactivin":[103,116,130,135,275,302,327,341],"has":[104],"been":[105],"shown":[106],"increase":[108],"differentiation":[110,350],"function.However,":[112],"effects":[114],"on":[117,190,305,318,343],"not":[120,360],"as":[121,224,253],"well":[122,254],"defined.In":[123],"this":[124],"study,":[125],"we":[126],"hypothesized":[127],"that":[128],"recombinant":[129,174,199,213,266,274,298,301,326,340],"inhibits":[131],"osteoclastogenesis.In":[132],"future,":[134],"could":[136],"be":[137],"a":[138,225],"therapeutic":[139],"agent":[140],"for":[141,227,235],"healing":[143],"preventing":[145],"or":[146,321],"even":[147],"reversing":[148],"osteoporosis.":[149],"Material":[150],"Methods:Osteoclast":[152],"were":[155,167,188,205,251,313],"isolated":[156],"C57BL/6":[158],"murine":[159],"tibias,":[160],"femurs,":[161],"humeri.Several":[163],"aspects":[164],"osteoclastogenesis":[166],"tested":[168,277],"dose-dependent":[173],"osteoactivin.First,":[175],"proliferation":[176,287],"survival":[178,269,289],"iii":[179],"assays,":[180,243],"with":[181,297,333],"without":[183,278],"respectively,":[187],"conducted":[189],"osteoactivin.Next,":[200],"differentiated":[206,229],"osteoactivin.Osteoclast":[214],"tartrate":[215],"resistant":[216],"acid":[217],"phosphatase":[218],"activity":[219,261],"was":[220,233,276,303],"measured":[221],"stained":[223],"marker":[226],"terminally":[228],"osteoclasts.Differential":[230],"cell":[231,286],"counting":[232],"performed":[234,252],"containing":[237],"3-20":[238],">20":[240,334],"nuclei.Two":[241],"functional":[242,338,367],"Corning":[244,337],"surface":[245],"cortical":[247,364],"bovine":[248],"slices,":[250],"order":[256],"quantify":[258],"osteoactivin.Finally,":[267],"kB-ligand.Results:":[283],"Osteoclast":[284],"showed":[290],"no":[291],"differences":[292],"control":[294],"treated":[296],"osteoactivin.Likewise,":[299],"added":[304],"first":[307],"day":[308,319,322,344,347,354],"differentiation,":[311,325],"there":[312],"negligible":[314],"changes.However,":[315],"administered":[317,342],"4":[320,348],"6":[323,355],"treatment":[328],"resulted":[329],"fewer":[331],"nuclei.In":[335],"assay,":[339,368],"1":[345],"resorption,":[352,358],"but":[353],"administration":[356],"although":[359],"significantly.Meanwhile,":[361],"slice":[366],"previ":[369]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-08-30T07:30:35.949966","created_date":"2016-09-16T00:00:00"}
