{"id":"https://openalex.org/W250793923","doi":null,"title":"Checkpoint kinase (Chk1) and reactive oxygen species induced oncotic cell death during the cell cycle in LLC-PK1 cells.","display_name":"Checkpoint kinase (Chk1) and reactive oxygen species induced oncotic cell death during the cell cycle in LLC-PK1 cells.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W250793923","mag":"250793923"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.654.9559","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.654.9559","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.innspub.net/wp-content/uploads/file/IJB-V2No6-p24-31.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076108417","display_name":"Hashimul Ehsan","orcid":"https://orcid.org/0000-0002-4464-6765","observed_orcids":["https://orcid.org/0000-0002-4464-6765"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hashimul Ehsan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4464-6765","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076108417"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"6","first_page":"24","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.4077000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.4077000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.16869999468326569,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.16830000281333923,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chk1","display_name":"Chk1","score":0.8069999814033508},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9879999756813049},{"id":"https://openalex.org/keywords/llc-pk1-cells","display_name":"LLC-PK1 cells","score":0.8320000171661377},{"id":"https://openalex.org/keywords/proximal-tubular-epithelial-cells","display_name":"proximal tubular epithelial cells","score":0.9559999704360962},{"id":"https://openalex.org/keywords/single-strand-breaks","display_name":"single-strand breaks","score":0.6439999938011169},{"id":"https://openalex.org/keywords/growth-arrest","display_name":"growth arrest","score":0.7429999709129333},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mitotic-catastrophe","display_name":"mitotic catastrophe","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.6549999713897705},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C186000732","wikidata":"https://www.wikidata.org/wiki/Q6881914","display_name":"Mitotic catastrophe","level":4,"score":0.6947633624076843},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6895939111709595},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5710315704345703},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.5600646734237671},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5494151711463928},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5354134440422058},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5336281657218933},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4690096080303192},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.46804165840148926},{"id":"https://openalex.org/C2777550763","wikidata":"https://www.wikidata.org/wiki/Q419164","display_name":"Hydroquinone","level":2,"score":0.43237069249153137},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.42047107219696045},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3963305354118347},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38431084156036377},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36792051792144775},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3532527685165405},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3149906098842621},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09561702609062195}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.654.9559","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.654.9559","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.innspub.net/wp-content/uploads/file/IJB-V2No6-p24-31.pdf","raw_type":"text"},{"id":"mag:250793923","doi":null,"is_oa":false,"landing_page_url":"http://www.innspub.net/wp-content/uploads/file/IJB-V2No6-p24-31.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210228880","display_name":"International Journal of Biosciences (IJB)","issn_l":"2220-6655","issn":["2220-6655","2222-5234"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Biosciences","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1677118171","https://openalex.org/W1752089945","https://openalex.org/W1968552183","https://openalex.org/W1974788629","https://openalex.org/W1994909028","https://openalex.org/W2002467561","https://openalex.org/W2011568772","https://openalex.org/W2012357824","https://openalex.org/W2043895957","https://openalex.org/W2049508647","https://openalex.org/W2062774389","https://openalex.org/W2067655540","https://openalex.org/W2078842115","https://openalex.org/W2117273743","https://openalex.org/W2126028475","https://openalex.org/W2128252882","https://openalex.org/W2139550352","https://openalex.org/W2145845829","https://openalex.org/W2162369786","https://openalex.org/W2168249220","https://openalex.org/W2336083576","https://openalex.org/W7024847899"],"related_works":["https://openalex.org/W1911709929","https://openalex.org/W155531722","https://openalex.org/W3177246407","https://openalex.org/W2011568772","https://openalex.org/W2134066718","https://openalex.org/W1974166421","https://openalex.org/W1937114139","https://openalex.org/W2116501627","https://openalex.org/W391688391","https://openalex.org/W1954837472"],"abstract_inverted_index":{"tris-(Glutathion-S-yl)hydroquinone":[0],"(TGHQ)":[1],"is":[2],"a":[3,77],"reactive":[4],"oxygen":[5],"species":[6],"(ROS)":[7],"generating":[8],"metabolite":[9],"of":[10,25,43,56,66,80],"the":[11,23,39,54,57],"nephotoxicant,":[12],"hydroquinone.":[13],"In":[14],"renal":[15],"proximal":[16],"tubule":[17],"epithelial":[18],"cells":[19,46,72],"(LLC-PK1),":[20],"TGHQ":[21,48],"catalyzes":[22],"formation":[24],"single":[26],"strand":[27],"breaks":[28],"in":[29,53,68,83],"DNA,":[30],"followed":[31],"by":[32],"growth":[33],"arrest":[34],"and":[35],"oncotic/necrotic":[36],"death":[37,82],"during":[38],"cell":[40,81],"cycle.":[41],"Treatment":[42],"synchronized":[44,70],"LLC-PK1":[45,71],"with":[47],"causes":[49],"an":[50],"initial":[51],"decrease":[52],"expression":[55],"DNA":[58],"damage":[59],"inducible":[60],"protein":[61],"kinase":[62],"chk1.":[63],"The":[64],"degradation":[65],"chk1":[67],"highly":[69],"might":[73],"induce":[74],"mitotic":[75],"catastrophe,":[76],"potential":[78],"mechanism":[79],"this":[84],"model.":[85]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}