{"id":"https://openalex.org/W2507635883","doi":"https://doi.org/10.1371/journal.pone.0161012","title":"Low Input Whole-Exome Sequencing to Determine the Representation of the Tumor Exome in Circulating DNA of Non-Small Cell Lung Cancer Patients","display_name":"Low Input Whole-Exome Sequencing to Determine the Representation of the Tumor Exome in Circulating DNA of Non-Small Cell Lung Cancer Patients","publication_year":2016,"publication_date":"2016-08-16","ids":{"openalex":"https://openalex.org/W2507635883","doi":"https://doi.org/10.1371/journal.pone.0161012","mag":"2507635883","pmid":"https://pubmed.ncbi.nlm.nih.gov/27529345","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4987014"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0161012","doi":"https://doi.org/10.1371/journal.pone.0161012","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0161012","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0161012&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0161012&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083292435","display_name":"Steffen Dietz","orcid":"https://orcid.org/0000-0003-1478-3969","observed_orcids":["https://orcid.org/0000-0003-1478-3969"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Steffen Dietz","raw_affiliation_strings":["Cancer Genome Research Group, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg, Germany","Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genome Research Group, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4210111460"]},{"raw_affiliation_string":"Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany","institution_ids":["https://openalex.org/I4210129183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091203090","display_name":"Uwe Bernd Schirmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Uwe Schirmer","raw_affiliation_strings":["Cancer Genome Research Group, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg, Germany","Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genome Research Group, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4210111460"]},{"raw_affiliation_string":"Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany","institution_ids":["https://openalex.org/I4210129183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066186230","display_name":"Cl\u00e9mentine Merc\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Cl\u00e9mentine Merc\u00e9","raw_affiliation_strings":["Cancer Genome Research Group, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg, Germany","Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genome Research Group, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4210111460"]},{"raw_affiliation_string":"Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany","institution_ids":["https://openalex.org/I4210129183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069241167","display_name":"Nikolas C. C. von Bubnoff","orcid":"https://orcid.org/0000-0001-9593-8947","observed_orcids":["https://orcid.org/0000-0001-9593-8947"]},"institutions":[{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nikolas von Bubnoff","raw_affiliation_strings":["Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg, Germany","German Cancer Consortium (DKTK), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I2801240073"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), Heidelberg, Germany","institution_ids":["https://openalex.org/I4391767962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042448145","display_name":"Edgar Dahl","orcid":"https://orcid.org/0000-0002-8439-7994","observed_orcids":["https://orcid.org/0000-0002-8439-7994"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Edgar Dahl","raw_affiliation_strings":["Molecular Oncology Group, Institute of Pathology, RWTH Aachen University, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology Group, Institute of Pathology, RWTH Aachen University, Aachen, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040695029","display_name":"Michael A. Meister","orcid":"https://orcid.org/0000-0002-2242-1696","observed_orcids":["https://orcid.org/0000-0002-2242-1696"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Meister","raw_affiliation_strings":["Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany","Translational Research Unit, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany","institution_ids":["https://openalex.org/I4210129183"]},{"raw_affiliation_string":"Translational Research Unit, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085505239","display_name":"Thomas Muley","orcid":"https://orcid.org/0000-0002-8141-0604","observed_orcids":["https://orcid.org/0000-0002-8141-0604"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Muley","raw_affiliation_strings":["Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany","Translational Research Unit, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany","institution_ids":["https://openalex.org/I4210129183"]},{"raw_affiliation_string":"Translational Research Unit, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101492076","display_name":"Michael Thomas","orcid":"https://orcid.org/0000-0001-9511-055X","observed_orcids":["https://orcid.org/0000-0001-9511-055X","https://orcid.org/0009-0008-0971-388X"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Thomas","raw_affiliation_strings":["Department of Oncology, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany","Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany","institution_ids":["https://openalex.org/I4210129183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025249874","display_name":"Holger S\u00fcltmann","orcid":"https://orcid.org/0000-0002-5257-8600","observed_orcids":["https://orcid.org/0000-0002-5257-8600"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Holger S\u00fcltmann","raw_affiliation_strings":["Cancer Genome Research Group, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg, Germany","German Cancer Consortium (DKTK), Heidelberg, Germany","Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genome Research Group, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4210111460"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), Heidelberg, Germany","institution_ids":["https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Translational Lung Research Center (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany","institution_ids":["https://openalex.org/I4210129183"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5025249874"],"corresponding_institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4210111460","https://openalex.org/I4210129183","https://openalex.org/I4391767962"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.9567,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.91317341,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"11","issue":"8","first_page":"e0161012","last_page":"e0161012"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.953000009059906},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8960000276565552},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.6859999895095825},{"id":"https://openalex.org/keywords/tumor-tissue-comparison","display_name":"tumor tissue comparison","score":0.39899998903274536},{"id":"https://openalex.org/keywords/pik3ca","display_name":"PIK3CA","score":0.7110000252723694},{"id":"https://openalex.org/keywords/anaplastic-lymphoma-kinase","display_name":"anaplastic lymphoma kinase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cosmic-mutations","display_name":"COSMIC mutations","score":0.7419999837875366},{"id":"https://openalex.org/keywords/metastatic-clones","display_name":"metastatic clones","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.876133382320404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5938466787338257},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.5892799496650696},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.5867483019828796},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5606275796890259},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.5056817531585693},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4375549852848053},{"id":"https://openalex.org/C132917006","wikidata":"https://www.wikidata.org/wiki/Q5250436","display_name":"Deep sequencing","level":4,"score":0.4309884011745453},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.41572490334510803},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.37972337007522583},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3551858067512512},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3350318670272827},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2857072055339813},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2831130027770996},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.24300014972686768},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22791942954063416},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19514593482017517},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.15890628099441528},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.06999576091766357},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0161012","doi":"https://doi.org/10.1371/journal.pone.0161012","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0161012","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0161012&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:27529345","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27529345","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4987014","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4987014/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:96574f3cfdac4143b0ca7907812319c8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/96574f3cfdac4143b0ca7907812319c8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 11, Iss 8, p e0161012 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/3607353","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Low_Input_Whole-Exome_Sequencing_to_Determine_the_Representation_of_the_Tumor_Exome_in_Circulating_DNA_of_Non-Small_Cell_Lung_Cancer_Patients/3607353","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0161012","doi":"https://doi.org/10.1371/journal.pone.0161012","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0161012","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0161012&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310693","display_name":"Deutsches Krebsforschungszentrum","ror":"https://ror.org/04cdgtt98"},{"id":"https://openalex.org/F4320326487","display_name":"Deutsches Zentrum f\u00fcr Lungenforschung","ror":"https://ror.org/03dx11k66"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2507635883.pdf","grobid_xml":"https://content.openalex.org/works/W2507635883.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1608841013","https://openalex.org/W1757407923","https://openalex.org/W1893269340","https://openalex.org/W1940268157","https://openalex.org/W1973702005","https://openalex.org/W1973878786","https://openalex.org/W1983466841","https://openalex.org/W1987754412","https://openalex.org/W1989498651","https://openalex.org/W1997437810","https://openalex.org/W2015438948","https://openalex.org/W2021341670","https://openalex.org/W2022714591","https://openalex.org/W2027735722","https://openalex.org/W2035022458","https://openalex.org/W2041142042","https://openalex.org/W2043855745","https://openalex.org/W2044433401","https://openalex.org/W2045846358","https://openalex.org/W2056534115","https://openalex.org/W2067904749","https://openalex.org/W2068403109","https://openalex.org/W2074791509","https://openalex.org/W2079345276","https://openalex.org/W2097383747","https://openalex.org/W2103441770","https://openalex.org/W2104549677","https://openalex.org/W2106578986","https://openalex.org/W2108234281","https://openalex.org/W2108371618","https://openalex.org/W2109130949","https://openalex.org/W2114031931","https://openalex.org/W2119048498","https://openalex.org/W2119180969","https://openalex.org/W2120869188","https://openalex.org/W2121320489","https://openalex.org/W2123370218","https://openalex.org/W2129665615","https://openalex.org/W2131256900","https://openalex.org/W2135924719","https://openalex.org/W2140575188","https://openalex.org/W2149992227","https://openalex.org/W2150575159","https://openalex.org/W2156407908","https://openalex.org/W2158297569","https://openalex.org/W2160444236","https://openalex.org/W2162144873","https://openalex.org/W2171237493","https://openalex.org/W2180481128","https://openalex.org/W2188896492","https://openalex.org/W2239118478","https://openalex.org/W2275877493","https://openalex.org/W4234746319","https://openalex.org/W4235642752"],"related_works":["https://openalex.org/W2269331124","https://openalex.org/W2504609731","https://openalex.org/W4387949866","https://openalex.org/W2767339719","https://openalex.org/W2995345513","https://openalex.org/W3204919027","https://openalex.org/W4386788336","https://openalex.org/W2770787976","https://openalex.org/W1893953214","https://openalex.org/W2947917786"],"abstract_inverted_index":{"Circulating":[0],"cell-free":[1],"DNA":[2],"(cfDNA)":[3],"released":[4],"from":[5,40,76,94,135,216,226],"cancerous":[6],"tissues":[7],"has":[8],"been":[9],"found":[10],"to":[11,16,54,133,149,169],"harbor":[12],"tumor-associated":[13],"alterations":[14],"and":[15,50,82,89,102,125,144,185,244],"represent":[17],"the":[18,22,33,45,56,60,150,165,172,212,221,245,249],"molecular":[19,57,238],"composition":[20],"of":[21,35,38,47,59,74,87,111,119,128,153,171,220,232,248],"tumor.":[23],"Recent":[24],"advances":[25],"in":[26,29,63,164,177,182,195,205,211],"technologies,":[27],"especially":[28],"next-generation":[30],"sequencing,":[31],"enable":[32],"analysis":[34],"low":[36,77],"amounts":[37],"cfDNA":[39,75,112,129,179,201,233],"body":[41],"fluids.":[42],"We":[43],"analyzed":[44],"exomes":[46],"tumor":[48,61,91,173,224],"tissue":[49,92,145,159],"matched":[51,90,136,166,178,213],"serum":[52,78,88,143],"samples":[53,93],"investigate":[55],"representation":[58],"exome":[62],"cfDNA.":[64],"To":[65],"this":[66],"end,":[67],"we":[68],"implemented":[69],"a":[70,203,227],"workflow":[71],"for":[72],"sequencing":[73,85,126],"volumes":[79],"(200":[80],"\u03bcl)":[81],"performed":[83],"whole-exome":[84],"(WES)":[86],"six":[95,197],"non-small":[96],"cell":[97],"lung":[98],"cancer":[99],"(NSCLC)":[100],"patients":[101,198],"two":[103],"control":[104],"sera.":[105],"Exomes,":[106],"including":[107],"untranslated":[108],"regions":[109],"(UTRs)":[110],"were":[113,131,140,175],"sequenced":[114],"with":[115,180],"an":[116,217],"average":[117],"coverage":[118],"68.5x.":[120],"Enrichment":[121],"efficiency,":[122],"target":[123],"coverage,":[124],"depth":[127],"reads":[130],"comparable":[132],"those":[134],"tissues.":[137],"Discovered":[138],"variants":[139,160,174,190],"compared":[141],"between":[142],"as":[146,148,187,189],"well":[147,188],"COSMIC":[151,192],"database":[152],"known":[154],"mutations.":[155],"Although":[156],"not":[157,209],"all":[158,196],"could":[161],"be":[162],"confirmed":[163],"serum,":[167],"up":[168],"57%":[170],"reflected":[176],"mutations":[181,243],"PIK3CA,":[183],"ALK,":[184],"PTEN":[186],"at":[191],"annotated":[193],"sites":[194],"analyzed.":[199],"Moreover,":[200],"revealed":[202],"mutation":[204],"MTOR,":[206],"which":[207],"was":[208],"detected":[210],"tissue,":[214],"potentially":[215],"untested":[218],"region":[219],"heterogeneous":[222],"primary":[223],"or":[225],"distant":[228],"metastatic":[229],"clone.":[230],"WES":[231],"may":[234],"provide":[235],"additional":[236],"complementary":[237],"information":[239],"about":[240],"clinically":[241],"relevant":[242],"clonal":[246],"heterogeneity":[247],"tumors.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-09-16T00:00:00"}