{"id":"https://openalex.org/W2507564322","doi":"https://doi.org/10.1371/journal.pntd.0004900","title":"Morinda citrifolia Linn. Reduces Parasite Load and Modulates Cytokines and Extracellular Matrix Proteins in C57BL/6 Mice Infected with Leishmania (Leishmania) amazonensis","display_name":"Morinda citrifolia Linn. Reduces Parasite Load and Modulates Cytokines and Extracellular Matrix Proteins in C57BL/6 Mice Infected with Leishmania (Leishmania) amazonensis","publication_year":2016,"publication_date":"2016-08-31","ids":{"openalex":"https://openalex.org/W2507564322","doi":"https://doi.org/10.1371/journal.pntd.0004900","mag":"2507564322","pmid":"https://pubmed.ncbi.nlm.nih.gov/27579922","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5006983"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pntd.0004900","doi":"https://doi.org/10.1371/journal.pntd.0004900","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0004900","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0004900&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0004900&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039316458","display_name":"Fernando Almeida-Souza","orcid":"https://orcid.org/0000-0003-0047-6159","observed_orcids":["https://orcid.org/0000-0003-0047-6159"]},"institutions":[{"id":"https://openalex.org/I4210148707","display_name":"Universidade Estadual do Maranh\u00e3o","ror":"https://ror.org/04ja5n907","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210148707"]},{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fernando Almeida-Souza","raw_affiliation_strings":["Departamento de Patologia, Universidade Estadual do Maranh\u00e3o, S\u00e3o Lu\u00eds, Brazil","Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Protozoologia, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Patologia, Universidade Estadual do Maranh\u00e3o, S\u00e3o Lu\u00eds, Brazil","institution_ids":["https://openalex.org/I4210148707"]},{"raw_affiliation_string":"Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Protozoologia, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038069933","display_name":"Fl\u00e1via de Oliveira Cardoso","orcid":"https://orcid.org/0000-0002-2026-1836","observed_orcids":["https://orcid.org/0000-0002-2026-1836"]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fl\u00e1via de Oliveira Cardoso","raw_affiliation_strings":["Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Protozoologia, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Protozoologia, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033376914","display_name":"Bruno Vinicius da Concei\u00e7\u00e3o Souza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bruno Vinicius da Concei\u00e7\u00e3o Souza","raw_affiliation_strings":["Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Protozoologia, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Protozoologia, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079257552","display_name":"T\u00e2nia Zaverucha do Valle","orcid":"https://orcid.org/0000-0001-7773-8239","observed_orcids":["https://orcid.org/0000-0001-7773-8239"]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"T\u00e2nia Zaverucha do Valle","raw_affiliation_strings":["Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Protozoologia, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Protozoologia, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077731970","display_name":"Joicy Cortez de S\u00e1 Sousa","orcid":"https://orcid.org/0000-0001-8678-0244","observed_orcids":["https://orcid.org/0000-0001-8678-0244"]},"institutions":[{"id":"https://openalex.org/I4210148707","display_name":"Universidade Estadual do Maranh\u00e3o","ror":"https://ror.org/04ja5n907","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210148707"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Joicy Cortez de S\u00e1","raw_affiliation_strings":["Departamento de Patologia, Universidade Estadual do Maranh\u00e3o, S\u00e3o Lu\u00eds, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Patologia, Universidade Estadual do Maranh\u00e3o, S\u00e3o Lu\u00eds, Brazil","institution_ids":["https://openalex.org/I4210148707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111107961","display_name":"Iara dos Santos da Silva Oliveira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148707","display_name":"Universidade Estadual do Maranh\u00e3o","ror":"https://ror.org/04ja5n907","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210148707"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Iara dos Santos da Silva Oliveira","raw_affiliation_strings":["Departamento de Patologia, Universidade Estadual do Maranh\u00e3o, S\u00e3o Lu\u00eds, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Patologia, Universidade Estadual do Maranh\u00e3o, S\u00e3o Lu\u00eds, Brazil","institution_ids":["https://openalex.org/I4210148707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016015011","display_name":"Celeste da Silva Freitas de Souza","orcid":"https://orcid.org/0000-0003-0577-0728","observed_orcids":["https://orcid.org/0000-0003-0577-0728"]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Celeste da Silva Freitas de Souza","raw_affiliation_strings":["Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Protozoologia, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Protozoologia, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020331899","display_name":"Carla Junqueira Moragas-Tellis","orcid":"https://orcid.org/0000-0002-6984-6974","observed_orcids":["https://orcid.org/0000-0002-6984-6974"]},"institutions":[{"id":"https://openalex.org/I4405287365","display_name":"Instituto de Tecnologia em F\u00e1rmacos","ror":"https://ror.org/04zshw128","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405287365","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carla Junqueira Moragas Tellis","raw_affiliation_strings":["Departamento de Produtos Naturais, Farmanguinhos-Fiocruz, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Produtos Naturais, Farmanguinhos-Fiocruz, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405287365","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042981244","display_name":"Maria do Socorro dos Santos Chagas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287365","display_name":"Instituto de Tecnologia em F\u00e1rmacos","ror":"https://ror.org/04zshw128","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405287365","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria do Socorro dos Santos Chagas","raw_affiliation_strings":["Departamento de Produtos Naturais, Farmanguinhos-Fiocruz, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Produtos Naturais, Farmanguinhos-Fiocruz, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405287365","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112488314","display_name":"Maria Dutra Behrens","orcid":"https://orcid.org/0000-0002-1097-2909","observed_orcids":["https://orcid.org/0000-0002-1097-2909"]},"institutions":[{"id":"https://openalex.org/I4405287365","display_name":"Instituto de Tecnologia em F\u00e1rmacos","ror":"https://ror.org/04zshw128","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405287365","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Dutra Behrens","raw_affiliation_strings":["Departamento de Produtos Naturais, Farmanguinhos-Fiocruz, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Produtos Naturais, Farmanguinhos-Fiocruz, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405287365","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010791576","display_name":"Ana L\u00facia Abreu\u2010Silva","orcid":"https://orcid.org/0000-0003-2167-3725","observed_orcids":["https://orcid.org/0000-0003-2167-3725"]},"institutions":[{"id":"https://openalex.org/I4210148707","display_name":"Universidade Estadual do Maranh\u00e3o","ror":"https://ror.org/04ja5n907","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210148707"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Ana L\u00facia Abreu-Silva","raw_affiliation_strings":["Departamento de Patologia, Universidade Estadual do Maranh\u00e3o, S\u00e3o Lu\u00eds, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Patologia, Universidade Estadual do Maranh\u00e3o, S\u00e3o Lu\u00eds, Brazil","institution_ids":["https://openalex.org/I4210148707"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062300832","display_name":"K\u00e1tia da Silva Calabrese","orcid":"https://orcid.org/0000-0002-1884-3765","observed_orcids":["https://orcid.org/0000-0002-1884-3765"]},"institutions":[{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"K\u00e1tia da Silva Calabrese","raw_affiliation_strings":["Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Protozoologia, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Protozoologia, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010791576"],"corresponding_institution_ids":["https://openalex.org/I4210148707"],"apc_list":{"value":2670,"currency":"USD","value_usd":2670},"apc_paid":{"value":2670,"currency":"USD","value_usd":2670},"fwci":2.1984,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.87845909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"10","issue":"8","first_page":"e0004900","last_page":"e0004900"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13792","display_name":"Morinda citrifolia extract uses","score":0.15919999778270721,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morinda-citrifolia","display_name":"Morinda citrifolia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/noni-juice","display_name":"noni juice","score":0.9390000104904175},{"id":"https://openalex.org/keywords/leishmania-amazonensis","display_name":"Leishmania amazonensis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cutaneous-leishmaniasis","display_name":"cutaneous leishmaniasis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/antileishmanial-activity","display_name":"antileishmanial activity","score":0.9879999756813049},{"id":"https://openalex.org/keywords/parasite-load","display_name":"infection intensity","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8019999861717224},{"id":"https://openalex.org/keywords/extracellular-matrix-proteins","display_name":"extracellular matrix proteins","score":0.8899999856948853},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.6899999976158142},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9240000247955322},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9760000109672546},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6359999775886536},{"id":"https://openalex.org/keywords/asperulosidic-acid","display_name":"asperulosidic acid","score":0.9879999756813049}],"concepts":[{"id":"https://openalex.org/C2781092759","wikidata":"https://www.wikidata.org/wiki/Q524818","display_name":"Leishmania","level":3,"score":0.6101388931274414},{"id":"https://openalex.org/C2779308761","wikidata":"https://www.wikidata.org/wiki/Q850491","display_name":"Morinda","level":2,"score":0.592376708984375},{"id":"https://openalex.org/C2776555147","wikidata":"https://www.wikidata.org/wiki/Q331283","display_name":"Leishmaniasis","level":2,"score":0.5667717456817627},{"id":"https://openalex.org/C2775993617","wikidata":"https://www.wikidata.org/wiki/Q7135939","display_name":"Parasite load","level":3,"score":0.5214149951934814},{"id":"https://openalex.org/C98319499","wikidata":"https://www.wikidata.org/wiki/Q455445","display_name":"Amastigote","level":4,"score":0.4976072609424591},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4961462914943695},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.49229729175567627},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4813185930252075},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4578389823436737},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4113295376300812},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36742809414863586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.362165629863739},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.25586044788360596},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.1970500349998474},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1934686005115509},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.15284347534179688},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000067030","descriptor_name":"Fruit and Vegetable Juices","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007891","descriptor_name":"Leishmania","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007896","descriptor_name":"Leishmaniasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016054","descriptor_name":"DNA, Protozoan","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D032066","descriptor_name":"Morinda","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059208","descriptor_name":"Parasite Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pntd.0004900","doi":"https://doi.org/10.1371/journal.pntd.0004900","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0004900","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0004900&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3991974","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5006983","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27579922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27579922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS neglected tropical diseases","raw_type":"Journal Article"},{"id":"pmh:oai:americanae.aecid.es:2321533","doi":null,"is_oa":true,"landing_page_url":"https://www.arca.fiocruz.br/handle/icict/16557","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da FIOCRUZ (ARCA)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pubmedcentral.nih.gov:5006983","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5006983/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Negl Trop Dis","raw_type":"Text"},{"id":"pmh:oai:arca.fiocruz.br:icict/16557","doi":null,"is_oa":true,"landing_page_url":"https://arca.fiocruz.br/handle/icict/16557","pdf_url":null,"source":{"id":"https://openalex.org/S7407055450","display_name":"Arca - Reposit\u00f3rio Institucional da Fiocruz","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:7b77ed341fc9418994919996953db5b6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7b77ed341fc9418994919996953db5b6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Neglected Tropical Diseases, Vol 10, Iss 8, p e0004900 (2016)","raw_type":"article"},{"id":"pmh:oai:www.arca.fiocruz.br:icict/16557","doi":null,"is_oa":true,"landing_page_url":"https://www.arca.fiocruz.br/handle/icict/16557","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da FIOCRUZ (ARCA)","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1371/journal.pntd.0004900","doi":"https://doi.org/10.1371/journal.pntd.0004900","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0004900","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0004900&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1869912188","display_name":null,"funder_award_id":"APP-00844/09","funder_id":"https://openalex.org/F4320322137","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o"},{"id":"https://openalex.org/G3522277005","display_name":null,"funder_award_id":"Ponex-241709/2014","funder_id":"https://openalex.org/F4320322137","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o"},{"id":"https://openalex.org/G5095546578","display_name":null,"funder_award_id":"407831/2012.6","funder_id":"https://openalex.org/F4320322749","funder_display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro"},{"id":"https://openalex.org/G5287587467","display_name":null,"funder_award_id":"APP-00844/09","funder_id":"https://openalex.org/F4320322749","funder_display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro"},{"id":"https://openalex.org/G6486318040","display_name":null,"funder_award_id":"309542/2013-8","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G7000822758","display_name":null,"funder_award_id":"E-26/111.252/2014","funder_id":"https://openalex.org/F4320322749","funder_display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro"},{"id":"https://openalex.org/G7495512006","display_name":null,"funder_award_id":"Pronex 241709/2014","funder_id":"https://openalex.org/F4320322137","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o"},{"id":"https://openalex.org/G7714085665","display_name":null,"funder_award_id":"407831/2012.6","funder_id":"https://openalex.org/F4320322137","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o"},{"id":"https://openalex.org/G7804802547","display_name":null,"funder_award_id":"407831/2012.6","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"}],"funders":[{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322137","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","ror":"https://ror.org/03vqm2n93"},{"id":"https://openalex.org/F4320322749","display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","ror":"https://ror.org/03kk0s825"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2507564322.pdf","grobid_xml":"https://content.openalex.org/works/W2507564322.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W29106008","https://openalex.org/W199449746","https://openalex.org/W309233092","https://openalex.org/W1482689801","https://openalex.org/W1889135827","https://openalex.org/W1910976715","https://openalex.org/W1914449220","https://openalex.org/W1969954916","https://openalex.org/W1983741028","https://openalex.org/W1991987376","https://openalex.org/W1992837217","https://openalex.org/W2004018147","https://openalex.org/W2008362458","https://openalex.org/W2008473451","https://openalex.org/W2010619374","https://openalex.org/W2012727632","https://openalex.org/W2025125023","https://openalex.org/W2028808955","https://openalex.org/W2043916183","https://openalex.org/W2057028848","https://openalex.org/W2058959579","https://openalex.org/W2059851713","https://openalex.org/W2078387591","https://openalex.org/W2081180882","https://openalex.org/W2081350230","https://openalex.org/W2082625060","https://openalex.org/W2091063659","https://openalex.org/W2102868829","https://openalex.org/W2114413554","https://openalex.org/W2120425435","https://openalex.org/W2120986025","https://openalex.org/W2122684688","https://openalex.org/W2123789998","https://openalex.org/W2143157380","https://openalex.org/W2144634347","https://openalex.org/W2145904172","https://openalex.org/W2170740792","https://openalex.org/W2396691851","https://openalex.org/W2400665923","https://openalex.org/W2405596464","https://openalex.org/W2429185489","https://openalex.org/W2804007336","https://openalex.org/W4255943186"],"related_works":["https://openalex.org/W2767964007","https://openalex.org/W2429185489","https://openalex.org/W2400665923","https://openalex.org/W2884801973","https://openalex.org/W4403961435","https://openalex.org/W2798244425","https://openalex.org/W3128272115","https://openalex.org/W7120650587","https://openalex.org/W1977569986","https://openalex.org/W2046502686"],"abstract_inverted_index":{"The":[0,162,186],"absence":[1],"of":[2,36,49,75,111,127,136,155,188,217,247,254],"an":[3],"effective":[4],"vaccine":[5],"and":[6,82,97,122,142,152,175,195,203,221,231,234],"the":[7,13,45,67,72,80,128,137,148,172,179,206,212,224,237,245,252],"debilitating":[8],"chemotherapy":[9],"for":[10,15,168,199],"Leishmaniasis":[11],"demonstrate":[12],"need":[14],"developing":[16],"alternative":[17],"treatments.":[18],"Several":[19],"studies":[20],"conducted":[21],"with":[22,103,182],"Morinda":[23],"citrifolia":[24,51,63],"have":[25],"shown":[26,71],"various":[27],"biological":[28],"activities,":[29],"including":[30],"antileishmanial":[31],"activity,":[32],"however":[33],"its":[34],"mechanisms":[35],"action":[37],"are":[38],"unknown.":[39],"This":[40],"study":[41],"aimed":[42],"to":[43,146],"analyze":[44],"in":[46,59,116,178,223,236],"vivo":[47],"activity":[48],"M.":[50,62],"fruit":[52,64],"juice":[53,65],"(Noni)":[54],"against":[55],"Leishmania":[56],"(Leishmania)":[57],"amazonensis":[58,114],"C57BL/6":[60,117],"mice.":[61,118],"from":[66,157],"Brazilian":[68],"Amazon":[69],"has":[70],"same":[73],"constitution":[74],"other":[76,207],"juices":[77],"produced":[78],"around":[79],"world":[81],"liquid":[83],"chromatography-mass":[84],"spectrometry":[85],"analysis":[86],"identified":[87],"five":[88],"compounds:":[89],"deacetylasperulosidic":[90],"acid,":[91,93],"asperulosidic":[92],"rutin,":[94],"nonioside":[95,98],"B":[96],"C.":[99],"Daily":[100],"intragastric":[101],"treatment":[102,164,210],"Noni":[104,163,209,255],"was":[105,242],"carried":[106],"out":[107],"after":[108],"55":[109],"days":[110,170],"L.":[112,183],"(L.)":[113,184],"infection":[115,189],"Parasitic":[119],"loads,":[120],"cytokine":[121,197],"extracellular":[123,213],"protein":[124,215],"matrix":[125,214],"expressions":[126,198,216],"lesion":[129,138,173],"site":[130,187],"were":[131,144,159],"analyzed":[132],"by":[133],"qPCR.":[134],"Histopathology":[135],"site,":[139],"lymph":[140],"nodes":[141],"liver":[143],"performed":[145],"evaluate":[147],"inflammatory":[149,193],"processes.":[150],"Cytokines":[151],"biochemical":[153],"parameters":[154],"toxicity":[156,241],"sera":[158],"also":[160,190],"evaluated.":[161],"at":[165,244],"500":[166],"mg.kg-1.day-1":[167],"60":[169],"decreased":[171,192,196],"size":[174],"parasitic":[176],"load":[177],"footpad":[180,226],"infected":[181,225],"amazonensis.":[185],"showed":[191],"infiltrates":[194],"IL-12,":[200],"TNF-\u03b1,":[201],"TGF-\u03b2":[202],"IL-10.":[204],"On":[205],"hand,":[208],"enhanced":[211],"collagen":[218,229],"IV,":[219],"fibronectin":[220,233],"laminin":[222,235],"as":[227],"well":[228],"I":[230],"II,":[232],"mock-infected":[238],"footpads.":[239],"No":[240],"observed":[243],"end":[246],"treatment.":[248,256],"These":[249],"data":[250],"show":[251],"efficacy":[253]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-09-16T00:00:00"}