{"id":"https://openalex.org/W2507342188","doi":null,"title":"Characterization of NUMB as a Regulator of Anaplastic Lymphoma Kinase","display_name":"Characterization of NUMB as a Regulator of Anaplastic Lymphoma Kinase","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2507342188","mag":"2507342188"},"language":"en","primary_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-5477","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/3804","pdf_url":"https://ir.lib.uwo.ca/etd/3804","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.lib.uwo.ca/etd/3804","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034863656","display_name":"Ran Wei","orcid":"https://orcid.org/0009-0007-2395-1692","observed_orcids":["https://orcid.org/0009-0007-2395-1692"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ran Wei","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-2395-1692","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5034863656"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.1103999987244606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.1103999987244606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.07840000092983246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies","score":0.07500000298023224,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/numb","display_name":"Numb","score":0.9620000123977661},{"id":"https://openalex.org/keywords/anaplastic-lymphoma-kinase","display_name":"anaplastic lymphoma kinase","score":0.9079999923706055},{"id":"https://openalex.org/keywords/ptb-domain","display_name":"PTB domain","score":0.9860000014305115},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8309999704360962},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.7590000033378601},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.9829999804496765},{"id":"https://openalex.org/keywords/kinase-regulation","display_name":"kinase regulation","score":0.5730000138282776},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.62413090467453},{"id":"https://openalex.org/C2776746469","wikidata":"https://www.wikidata.org/wiki/Q18033185","display_name":"NUMB","level":2,"score":0.5514057874679565},{"id":"https://openalex.org/C117643217","wikidata":"https://www.wikidata.org/wiki/Q17824987","display_name":"Anaplastic lymphoma kinase","level":4,"score":0.47570499777793884},{"id":"https://openalex.org/C2777872185","wikidata":"https://www.wikidata.org/wiki/Q486090","display_name":"Anaplastic large-cell lymphoma","level":3,"score":0.4593013525009155},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.3972287178039551},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37648165225982666},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33801013231277466},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2209058701992035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19831892848014832},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.1446952521800995},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12916910648345947},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11754757165908813},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1048421561717987},{"id":"https://openalex.org/C2776232967","wikidata":"https://www.wikidata.org/wiki/Q6743514","display_name":"Malignant pleural effusion","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ir.lib.uwo.ca:etd-5477","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/3804","pdf_url":"https://ir.lib.uwo.ca/etd/3804","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},{"id":"pmh:oai:uwo.scholaris.ca:20.500.14721/33798","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14721/33798","pdf_url":null,"source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"thesis"},{"id":"mag:2507342188","doi":null,"is_oa":false,"landing_page_url":"https://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=5477&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ir.lib.uwo.ca:etd-5477","doi":null,"is_oa":true,"landing_page_url":"https://ir.lib.uwo.ca/etd/3804","pdf_url":"https://ir.lib.uwo.ca/etd/3804","source":{"id":"https://openalex.org/S4306400648","display_name":"Scholarship@Western (Western University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I125749732","host_organization_name":"Western University","host_organization_lineage":["https://openalex.org/I125749732"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Thesis and Dissertation Repository","raw_type":"text"},"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2507342188.pdf","grobid_xml":"https://content.openalex.org/works/W2507342188.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1969914656","https://openalex.org/W1974096298","https://openalex.org/W1977468876","https://openalex.org/W1986567188","https://openalex.org/W2033726122","https://openalex.org/W2034072755","https://openalex.org/W2038586807","https://openalex.org/W2038978453","https://openalex.org/W2072555538","https://openalex.org/W2153371646"],"related_works":["https://openalex.org/W7027383132","https://openalex.org/W2912512893","https://openalex.org/W2085850363","https://openalex.org/W2045784733","https://openalex.org/W2917304077","https://openalex.org/W4401412982","https://openalex.org/W2606204310","https://openalex.org/W2570714197","https://openalex.org/W1984364536","https://openalex.org/W3203220422"],"abstract_inverted_index":{"Cellular":[0],"events":[1],"rely":[2],"on":[3,117,141],"protein-protein":[4],"interactions":[5,48],"that":[6,34,99,162],"are":[7,89],"often":[8],"mediated":[9],"by":[10,64,174],"modular":[11,51],"domains":[12],"which":[13,127],"recognize":[14],"particular":[15],"sequence":[16],"motifs":[17,150],"in":[18,37,93,130,151,153,156,169,196],"binding":[19,78,106],"partners.":[20],"The":[21,84],"NUMB":[22,44,100,121,195],"protein":[23,47,71],"is":[24,35],"the":[25,61,94,97,118,138,191,199],"first":[26],"described":[27],"cell":[28],"fate":[29],"determinant":[30],"and":[31,72,80,122,155,202],"multifaceted":[32],"adaptor":[33],"involved":[36],"a":[38,57,104,131,205],"wide":[39],"variety":[40],"of":[41,60,108,133,194,207],"cellular":[42],"events.":[43],"mainly":[45],"mediates":[46],"via":[49],"its":[50],"PTB":[52],"domain.":[53],"Here":[54],"we":[55,115],"present":[56],"systematic":[58],"investigation":[59],"NUMB-PTB":[62,77,145],"interactome":[63],"employing":[65],"an":[66,170],"integrative":[67],"strategy":[68],"combining":[69],"both":[70],"peptide":[73],"arrays.":[74],"We":[75],"profiled":[76],"specificity":[79],"interacting":[81],"proteins":[82],"genome-wide.":[83],"receptor":[85],"tyrosine":[86],"kinases":[87],"(RTKs)":[88],"found":[90],"highly":[91],"enriched":[92],"interactome,":[95],"raising":[96],"possibility":[98],"may":[101],"act":[102],"as":[103],"universal":[105],"partner":[107],"RTKs.":[109],"To":[110],"further":[111,203],"validate":[112],"this":[113],"hypothesis,":[114],"focused":[116],"interaction":[119,164],"between":[120],"Anaplastic":[123],"Lymphoma":[124],"Kinase":[125],"(ALK),":[126],"promotes":[128],"oncogenesis":[129],"number":[132],"cancer":[134],"types.":[135],"Consistent":[136],"with":[137],"prediction":[139],"based":[140],"our":[142],"proteomic":[143],"study,":[144],"directly":[146],"binds":[147],"to":[148,177],"two":[149],"ALK":[152,166,176,188],"vitro":[154],"vivo.":[157],"Intriguingly,":[158],"functional":[159],"analysis":[160],"reveals":[161,204],"NUMB-ALK":[163],"regulates":[165],"activity":[167],"antagonistically":[168],"isoform":[171],"dependent":[172],"manner,":[173],"directing":[175],"distinct":[178],"post-endocytic":[179],"trafficking":[180],"destinations.":[181],"Our":[182],"study":[183],"provides":[184],"mechanistic":[185],"insight":[186],"into":[187],"regulation,":[189],"explains":[190],"controversial":[192],"behaviors":[193],"tumorigenesis":[197],"at":[198],"molecular":[200],"level,":[201],"biomarker":[206],"potential":[208],"clinical":[209],"value.":[210]},"counts_by_year":[],"updated_date":"2026-09-02T18:50:13.731487","created_date":"2016-09-16T00:00:00"}
