{"id":"https://openalex.org/W2507199542","doi":"https://doi.org/10.2147/copd.s114566","title":"The efficacy of aclidinium/formoterol on lung function and symptoms in patients with COPD categorized by symptom status: a pooled analysis","display_name":"The efficacy of aclidinium/formoterol on lung function and symptoms in patients with COPD categorized by symptom status: a pooled analysis","publication_year":2016,"publication_date":"2016-08-01","ids":{"openalex":"https://openalex.org/W2507199542","doi":"https://doi.org/10.2147/copd.s114566","mag":"2507199542","pmid":"https://pubmed.ncbi.nlm.nih.gov/27621610","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5012634"},"language":"en","primary_location":{"id":"doi:10.2147/copd.s114566","doi":"https://doi.org/10.2147/copd.s114566","is_oa":true,"landing_page_url":"https://doi.org/10.2147/copd.s114566","pdf_url":null,"source":{"id":"https://openalex.org/S105319247","display_name":"International Journal of COPD","issn_l":"1176-9106","issn":["1176-9106","1178-2005"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Chronic Obstructive Pulmonary Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.2147/copd.s114566","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071831143","display_name":"Marc Miravitlles","orcid":"https://orcid.org/0000-0002-9850-9520","observed_orcids":["https://orcid.org/0000-0002-9850-9520"]},"institutions":[{"id":"https://openalex.org/I4210099160","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias","ror":"https://ror.org/0119pby33","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210099160","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Marc Miravitlles","raw_affiliation_strings":["Department of Pneumology, Vall d'Hebron University Hospital, CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pneumology, Vall d'Hebron University Hospital, CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain","institution_ids":["https://openalex.org/I4210099160","https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036017418","display_name":"Kenneth R. Chapman","orcid":"https://orcid.org/0000-0002-2498-9859","observed_orcids":["https://orcid.org/0000-0002-2498-9859"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2799337515","display_name":"Toronto Western Hospital","ror":"https://ror.org/03qv8yq19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2799337515"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kenneth Chapman","raw_affiliation_strings":["Asthma & Airway Centre, University Health Network, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asthma & Airway Centre, University Health Network, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I2799337515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038136376","display_name":"Ferran Chuecos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149424","display_name":"AstraZeneca (Spain)","ror":"https://ror.org/05qqrnb63","country_code":"ES","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210149424"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ferran Chuecos","raw_affiliation_strings":["Global Medicines Development, AstraZeneca PLC, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Medicines Development, AstraZeneca PLC, Barcelona, Spain","institution_ids":["https://openalex.org/I4210149424"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anna Ribera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149424","display_name":"AstraZeneca (Spain)","ror":"https://ror.org/05qqrnb63","country_code":"ES","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210149424"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Anna Ribera","raw_affiliation_strings":["Global Medical Affairs, AstraZeneca PLC, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Medical Affairs, AstraZeneca PLC, Barcelona, Spain","institution_ids":["https://openalex.org/I4210149424"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006619671","display_name":"Esther Garc\u00eda-Gil","orcid":"https://orcid.org/0000-0002-1530-3173","observed_orcids":["https://orcid.org/0000-0002-1530-3173"]},"institutions":[{"id":"https://openalex.org/I4210149424","display_name":"AstraZeneca (Spain)","ror":"https://ror.org/05qqrnb63","country_code":"ES","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210149424"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Esther Garc\u00eda-Gil","raw_affiliation_strings":["Global Medicines Development, AstraZeneca PLC, Barcelona, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Medicines Development, AstraZeneca PLC, Barcelona, Spain;","institution_ids":["https://openalex.org/I4210149424"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5071831143"],"corresponding_institution_ids":["https://openalex.org/I4210099160","https://openalex.org/I4210127641"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":3.4456,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.92773094,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"Volume 11","issue":null,"first_page":"2041","last_page":"2053"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ol","display_name":"ol","score":0.6940000057220459},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9279999732971191},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.6869999766349792},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.7770000100135803},{"id":"https://openalex.org/keywords/dyspnea","display_name":"dyspnea","score":0.921999990940094},{"id":"https://openalex.org/keywords/respiratory-symptoms","display_name":"respiratory symptoms","score":0.9079999923706055},{"id":"https://openalex.org/keywords/symptom-severity","display_name":"symptom severity","score":0.7570000290870667},{"id":"https://openalex.org/keywords/nocturnal-symptoms","display_name":"nocturnal symptoms","score":0.5479999780654907},{"id":"https://openalex.org/keywords/acute-exacerbation-of-copd","display_name":"COPD exacerbations","score":0.6690000295639038},{"id":"https://openalex.org/keywords/long-acting-muscarinic-antagonist","display_name":"long-acting muscarinic antagonist","score":0.718999981880188},{"id":"https://openalex.org/keywords/long-acting-beta-agonists","display_name":"long-acting beta2-agonists","score":0.8820000290870667},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5040000081062317},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.746999979019165},{"id":"https://openalex.org/keywords/activity-limitation","display_name":"activity limitation","score":0.39899998903274536},{"id":"https://openalex.org/keywords/monotherapy-comparison","display_name":"monotherapy comparison","score":0.4729999899864197},{"id":"https://openalex.org/keywords/formoterol","display_name":"formoterol","score":0.5220000147819519},{"id":"https://openalex.org/keywords/aclidinium","display_name":"aclidinium","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C2779871671","wikidata":"https://www.wikidata.org/wiki/Q637247","display_name":"Formoterol","level":4,"score":0.9635530710220337},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9149141311645508},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7707894444465637},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7378897666931152},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.6137564182281494},{"id":"https://openalex.org/C2909086917","wikidata":"https://www.wikidata.org/wiki/Q637247","display_name":"Formoterol Fumarate","level":5,"score":0.48971012234687805},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48727643489837646},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.4830234944820404},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3804125189781189},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.16159123182296753},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2776136866","wikidata":"https://www.wikidata.org/wiki/Q422212","display_name":"Budesonide","level":3,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068759","descriptor_name":"Formoterol Fumarate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000068759","descriptor_name":"Formoterol Fumarate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014326","descriptor_name":"Tropanes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014326","descriptor_name":"Tropanes","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017079","descriptor_name":"Exercise Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017326","descriptor_name":"Clinical Trials, Phase III as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D058666","descriptor_name":"Adrenergic beta-2 Receptor Agonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D058666","descriptor_name":"Adrenergic beta-2 Receptor Agonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.2147/copd.s114566","doi":"https://doi.org/10.2147/copd.s114566","is_oa":true,"landing_page_url":"https://doi.org/10.2147/copd.s114566","pdf_url":null,"source":{"id":"https://openalex.org/S105319247","display_name":"International Journal of COPD","issn_l":"1176-9106","issn":["1176-9106","1178-2005"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Chronic Obstructive Pulmonary Disease","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3979182","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5012634","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27621610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27621610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of chronic obstructive pulmonary disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5012634","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5012634/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Chron Obstruct Pulmon Dis","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8f3a9825df32478f86397a415307a47e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8f3a9825df32478f86397a415307a47e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of COPD, Vol Volume 11, Pp 2041-2053 (2016)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/28664","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/the-efficacy-of-aclidiniumformoterol-on-lung-function-and-symptoms-in--peer-reviewed-article-COPD","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/copd.s114566","doi":"https://doi.org/10.2147/copd.s114566","is_oa":true,"landing_page_url":"https://doi.org/10.2147/copd.s114566","pdf_url":null,"source":{"id":"https://openalex.org/S105319247","display_name":"International Journal of COPD","issn_l":"1176-9106","issn":["1176-9106","1178-2005"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Chronic Obstructive Pulmonary Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320331744","display_name":"Almirall","ror":"https://ror.org/03qsven24"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1753770952","https://openalex.org/W2022829670","https://openalex.org/W2030987445","https://openalex.org/W2039237831","https://openalex.org/W2045616259","https://openalex.org/W2056040906","https://openalex.org/W2077523026","https://openalex.org/W2097430954","https://openalex.org/W2100749668","https://openalex.org/W2120356269","https://openalex.org/W2123132046","https://openalex.org/W2124820536","https://openalex.org/W2127951128","https://openalex.org/W2140200862","https://openalex.org/W2142449488","https://openalex.org/W2159803589","https://openalex.org/W2162689366","https://openalex.org/W2166780351","https://openalex.org/W2330401785","https://openalex.org/W2396947503","https://openalex.org/W6658774588"],"related_works":["https://openalex.org/W2329214458","https://openalex.org/W2562940338","https://openalex.org/W2123118974","https://openalex.org/W2781066543","https://openalex.org/W2917918130","https://openalex.org/W2124820536","https://openalex.org/W2056040906","https://openalex.org/W2142821027","https://openalex.org/W4386192306","https://openalex.org/W2496257167"],"abstract_inverted_index":{"BACKGROUND:":[0],"Patients":[1],"with":[2,31,251,281,291,298],"chronic":[3],"obstructive":[4],"pulmonary":[5],"disease":[6],"(COPD)":[7],"experience":[8],"respiratory":[9],"symptoms,":[10],"which":[11],"impair":[12],"quality":[13],"of":[14,19,27,47,67,121,142,207,231,246,285],"life.":[15],"This":[16],"pooled":[17,40],"analysis":[18],"two":[20,42],"Phase":[21],"III":[22],"studies":[23,46],"assessed":[24],"the":[25,65,286],"impact":[26],"aclidinium/formoterol":[28,49,68,148,223,252,299],"on":[29],"patients":[30,74,130,197,217,280,290],"COPD":[32,54],"categorized":[33],"by":[34,79],"symptom":[35,117,203,294],"status.":[36],"METHODS:":[37],"Data":[38,127],"were":[39,131,182,191],"from":[41,154,170,234],"24-week,":[43],"randomized,":[44],"placebo-controlled":[45],"twice-daily":[48],"400/12":[50,261],"\u00b5g":[51,262],"in":[52,73,104,172,184,194,211,255,266,277,302],"moderate-to-severe":[53,282],"(ACLIFORM":[55],"[NCT01462942]":[56],"and":[57,87,97,115,123,144,162,178,205,214,229,238,268,272,306],"AUGMENT":[58],"[NCT01437397]).":[59],"These":[60],"post":[61],"hoc":[62],"analyses":[63],"evaluated":[64],"efficacy":[66],"versus":[69,159,175,189,209,236,253,270,275,300],"placebo":[70,160,176,210,237,254,276],"or":[71,240],"monotherapies":[72,164,242,271,301],"defined":[75],"as":[76],"less/more":[77],"symptomatic":[78,146,186,196,216,221,257,279],"a)":[80],"Evaluating":[81],"Respiratory":[82],"Symptoms":[83],"(E-RS\u2122)":[84],"score":[85,92,228],"\u226510/<10":[86],"b)":[88],"Baseline":[89],"Dyspnea":[90,109],"Index":[91],"<7/\u22657.":[93],"Endpoints":[94],"included":[95],"trough":[96,168],"1-hour":[98,150],"morning":[99,151],"postdose":[100,152,303],"forced":[101],"expiratory":[102],"volume":[103],"1":[105],"second":[106],"(FEV1),":[107],"Transition":[108],"Index,":[110],"E-RS":[111,226],"total":[112,227],"score,":[113],"early-morning":[114,119,202,307],"nighttime":[116,232],"severity,":[118,204],"limitation":[120,206],"activities,":[122],"exacerbation":[124],"rate.":[125],"RESULTS:":[126],"for":[128],"3,394":[129],"analyzed":[132],"(mean":[133],"age:":[134],"63.5":[135],"years;":[136],"60.5%":[137],"male).":[138],"In":[139,219],"both":[140,163,173,212,241],"definitions":[141],"less":[143,213],"more":[145,185,195,215,220,256,278],"patients,":[147,222],"improved":[149,167,200,225],"FEV1":[153,169],"baseline":[155,171,235],"at":[156],"week":[157],"24":[158],"(P<0.001)":[161],"(P<0.05).":[165,198,243],"Aclidinium/formoterol":[166,199,260],"groups":[174],"(P<0.05)":[177],"formoterol":[179],"(P<0.05);":[180],"improvements":[181,265],"greater":[183],"patients.":[187,258],"Improvements":[188],"aclidinium":[190],"also":[192,224],"observed":[193],"dyspnea,":[201,305],"activities":[208],"(P<0.001).":[218],"severity":[230],"symptoms":[233,269],"one":[239],"The":[244],"rate":[245],"moderate/severe":[247],"exacerbations":[248,274],"was":[249],"reduced":[250,273],"CONCLUSION:":[259],"provided":[263],"consistent":[264],"bronchodilation":[267],"COPD,":[283],"regardless":[284],"definition":[287],"used.":[288],"Furthermore,":[289],"a":[292],"low":[293],"burden":[295],"achieved":[296],"benefits":[297],"FEV1,":[304],"symptoms.":[308]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-09-16T00:00:00"}