{"id":"https://openalex.org/W250685044","doi":null,"title":"Neurosteroids Induce Allosteric Effects on the NMDA Receptor : Nanomolar Concentrations of Neurosteroids Exert Non-Genomic Effects on the NMDA Receptor Complex","display_name":"Neurosteroids Induce Allosteric Effects on the NMDA Receptor : Nanomolar Concentrations of Neurosteroids Exert Non-Genomic Effects on the NMDA Receptor Complex","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W250685044","mag":"250685044"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-8503","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8503","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8503","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053560920","display_name":"Tobias Johansson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tobias Johansson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5053560920"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurosteroids","display_name":"neurosteroids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/allosteric-modulation","display_name":"allosteric modulation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/non-genomic-steroid-action","display_name":"non-genomic steroid action","score":0.6710000038146973},{"id":"https://openalex.org/keywords/pregnenolone-sulfate","display_name":"pregnenolone sulfate","score":0.968999981880188},{"id":"https://openalex.org/keywords/nr2b-subunit","display_name":"NR2B subunit","score":0.8999999761581421},{"id":"https://openalex.org/keywords/ifenprodil","display_name":"ifenprodil","score":0.925000011920929},{"id":"https://openalex.org/keywords/sigma-1-receptor","display_name":"sigma-1 receptor","score":0.968999981880188},{"id":"https://openalex.org/keywords/sigma-2-receptor","display_name":"sigma-2 receptor","score":0.875},{"id":"https://openalex.org/keywords/anabolic-androgenic-steroids","display_name":"anabolic steroids","score":0.9380000233650208},{"id":"https://openalex.org/keywords/nandrolone-decanoate","display_name":"nandrolone decanoate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dehydroepiandrosterone-sulfate","display_name":"dehydroepiandrosterone sulfate","score":0.9440000057220459},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.8320000171661377},{"id":"https://openalex.org/keywords/ng108-15-cells","display_name":"NG108-15 cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9100000262260437},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.531000018119812},{"id":"https://openalex.org/keywords/calcium-imaging","display_name":"calcium imaging","score":0.6330000162124634},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C2780376555","wikidata":"https://www.wikidata.org/wiki/Q5991156","display_name":"Ifenprodil","level":4,"score":0.9932355880737305},{"id":"https://openalex.org/C44796713","wikidata":"https://www.wikidata.org/wiki/Q2659374","display_name":"Neuroactive steroid","level":4,"score":0.8938578367233276},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.8836255669593811},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.6604286432266235},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5570881962776184},{"id":"https://openalex.org/C2780193516","wikidata":"https://www.wikidata.org/wiki/Q412158","display_name":"Pregnenolone","level":4,"score":0.5166683197021484},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5058922171592712},{"id":"https://openalex.org/C2776801781","wikidata":"https://www.wikidata.org/wiki/Q18344323","display_name":"Pregnanolone","level":5,"score":0.4836517572402954},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4581294655799866},{"id":"https://openalex.org/C2780957381","wikidata":"https://www.wikidata.org/wiki/Q7239912","display_name":"Pregnenolone sulfate","level":5,"score":0.436481773853302},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32632970809936523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3012917637825012},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.28092992305755615},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2545889616012573},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.0},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-8503","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8503","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:250685044","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/8361","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-8503","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8503","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":333,"referenced_works":["https://openalex.org/W28614200","https://openalex.org/W68989059","https://openalex.org/W72526168","https://openalex.org/W76685386","https://openalex.org/W80750782","https://openalex.org/W81923356","https://openalex.org/W83395442","https://openalex.org/W147580689","https://openalex.org/W179339392","https://openalex.org/W183555454","https://openalex.org/W184092676","https://openalex.org/W185818889","https://openalex.org/W1499205986","https://openalex.org/W1507029368","https://openalex.org/W1511301017","https://openalex.org/W1513940883","https://openalex.org/W1547273789","https://openalex.org/W1549179580","https://openalex.org/W1561309798","https://openalex.org/W1564311086","https://openalex.org/W1573534810","https://openalex.org/W1574849955","https://openalex.org/W1595929882","https://openalex.org/W1775749144","https://openalex.org/W1825212126","https://openalex.org/W1835461337","https://openalex.org/W1867953867","https://openalex.org/W1871698893","https://openalex.org/W1881159824","https://openalex.org/W1893941881","https://openalex.org/W1898334791","https://openalex.org/W1900414416","https://openalex.org/W1905166029","https://openalex.org/W1912224219","https://openalex.org/W1916809719","https://openalex.org/W1939813705","https://openalex.org/W1948622783","https://openalex.org/W1951533674","https://openalex.org/W1958648255","https://openalex.org/W1962254068","https://openalex.org/W1964427298","https://openalex.org/W1964544239","https://openalex.org/W1965370016","https://openalex.org/W1965507834","https://openalex.org/W1965879244","https://openalex.org/W1966045029","https://openalex.org/W1966719975","https://openalex.org/W1966751481","https://openalex.org/W1967407038","https://openalex.org/W1968162468","https://openalex.org/W1968166735","https://openalex.org/W1968406318","https://openalex.org/W1969313300","https://openalex.org/W1970377013","https://openalex.org/W1970503530","https://openalex.org/W1971547182","https://openalex.org/W1971708762","https://openalex.org/W1971919583","https://openalex.org/W1973428925","https://openalex.org/W1974438719","https://openalex.org/W1975522748","https://openalex.org/W1975843462","https://openalex.org/W1975941800","https://openalex.org/W1976558028","https://openalex.org/W1976834249","https://openalex.org/W1979930380","https://openalex.org/W1980307070","https://openalex.org/W1981091899","https://openalex.org/W1981258864","https://openalex.org/W1981475053","https://openalex.org/W1982442226","https://openalex.org/W1983320935","https://openalex.org/W1983675510","https://openalex.org/W1983781822","https://openalex.org/W1984272514","https://openalex.org/W1984917548","https://openalex.org/W1985995877","https://openalex.org/W1986618663","https://openalex.org/W1987074221","https://openalex.org/W1987322407","https://openalex.org/W1987336992","https://openalex.org/W1987990912","https://openalex.org/W1988066106","https://openalex.org/W1988180868","https://openalex.org/W1989147055","https://openalex.org/W1989645958","https://openalex.org/W1989888504","https://openalex.org/W1990035343","https://openalex.org/W1990390455","https://openalex.org/W1991514185","https://openalex.org/W1992763610","https://openalex.org/W1992768650","https://openalex.org/W1993097947","https://openalex.org/W1993725582","https://openalex.org/W1994166466","https://openalex.org/W1994224293","https://openalex.org/W1994924064","https://openalex.org/W1995552213","https://openalex.org/W1995683118","https://openalex.org/W1996374928","https://openalex.org/W1996553708","https://openalex.org/W1997263765","https://openalex.org/W1997568797","https://openalex.org/W1998347917","https://openalex.org/W1998510465","https://openalex.org/W2001950396","https://openalex.org/W2002206629","https://openalex.org/W2002906554","https://openalex.org/W2006098580","https://openalex.org/W2006283790","https://openalex.org/W2006442321","https://openalex.org/W2007253677","https://openalex.org/W2007767935","https://openalex.org/W2009806490","https://openalex.org/W2009831300","https://openalex.org/W2010908655","https://openalex.org/W2010963787","https://openalex.org/W2012298500","https://openalex.org/W2013164642","https://openalex.org/W2014064649","https://openalex.org/W2014315711","https://openalex.org/W2014482741","https://openalex.org/W2014668639","https://openalex.org/W2018566513","https://openalex.org/W2018831144","https://openalex.org/W2019357760","https://openalex.org/W2019841343","https://openalex.org/W2020036669","https://openalex.org/W2020060588","https://openalex.org/W2021191520","https://openalex.org/W2021489439","https://openalex.org/W2021706041","https://openalex.org/W2022668453","https://openalex.org/W2022844214","https://openalex.org/W2023152311","https://openalex.org/W2023471562","https://openalex.org/W2023479166","https://openalex.org/W2023786216","https://openalex.org/W2025153148","https://openalex.org/W2025302434","https://openalex.org/W2025363664","https://openalex.org/W2026020867","https://openalex.org/W2026429446","https://openalex.org/W2026482590","https://openalex.org/W2026557273","https://openalex.org/W2027537591","https://openalex.org/W2027587367","https://openalex.org/W2027874857","https://openalex.org/W2028133023","https://openalex.org/W2028948355","https://openalex.org/W2029922642","https://openalex.org/W2030194659","https://openalex.org/W2030236055","https://openalex.org/W2030945444","https://openalex.org/W2032232947","https://openalex.org/W2033041856","https://openalex.org/W2033226647","https://openalex.org/W2033525233","https://openalex.org/W2033752311","https://openalex.org/W2033877263","https://openalex.org/W2034341467","https://openalex.org/W2034377493","https://openalex.org/W2035069150","https://openalex.org/W2036010230","https://openalex.org/W2036137643","https://openalex.org/W2036572764","https://openalex.org/W2036781116","https://openalex.org/W2039320407","https://openalex.org/W2040249614","https://openalex.org/W2040462226","https://openalex.org/W2040592517","https://openalex.org/W2041024256","https://openalex.org/W2041266263","https://openalex.org/W2042648593","https://openalex.org/W2042921203","https://openalex.org/W2043145448","https://openalex.org/W2043649737","https://openalex.org/W2043855124","https://openalex.org/W2044081646","https://openalex.org/W2046485926","https://openalex.org/W2047726099","https://openalex.org/W2048011585","https://openalex.org/W2048263472","https://openalex.org/W2048440366","https://openalex.org/W2049321118","https://openalex.org/W2049329288","https://openalex.org/W2049361571","https://openalex.org/W2050452861","https://openalex.org/W2050822353","https://openalex.org/W2051707916","https://openalex.org/W2052096625","https://openalex.org/W2052341111","https://openalex.org/W2052795247","https://openalex.org/W2053585116","https://openalex.org/W2053743479","https://openalex.org/W2053980736","https://openalex.org/W2054066717","https://openalex.org/W2054162552","https://openalex.org/W2055109204","https://openalex.org/W2055112994","https://openalex.org/W2056422818","https://openalex.org/W2057232983","https://openalex.org/W2057315110","https://openalex.org/W2057831654","https://openalex.org/W2058663262","https://openalex.org/W2058870251","https://openalex.org/W2059401172","https://openalex.org/W2059680237","https://openalex.org/W2060070215","https://openalex.org/W2061407282","https://openalex.org/W2062502420","https://openalex.org/W2063032404","https://openalex.org/W2064331789","https://openalex.org/W2065169750","https://openalex.org/W2065441702","https://openalex.org/W2066385861","https://openalex.org/W2067669919","https://openalex.org/W2068120156","https://openalex.org/W2068463910","https://openalex.org/W2068826283","https://openalex.org/W2069783285","https://openalex.org/W2069935024","https://openalex.org/W2070043641","https://openalex.org/W2070510853","https://openalex.org/W2071702912","https://openalex.org/W2071992850","https://openalex.org/W2072900447","https://openalex.org/W2074631079","https://openalex.org/W2074933440","https://openalex.org/W2075367071","https://openalex.org/W2076150851","https://openalex.org/W2077055769","https://openalex.org/W2077678165","https://openalex.org/W2078365959","https://openalex.org/W2079933314","https://openalex.org/W2080589549","https://openalex.org/W2080710662","https://openalex.org/W2081476984","https://openalex.org/W2081678712","https://openalex.org/W2082051545","https://openalex.org/W2082992505","https://openalex.org/W2083105433","https://openalex.org/W2083372094","https://openalex.org/W2083552615","https://openalex.org/W2084201554","https://openalex.org/W2085607238","https://openalex.org/W2086608701","https://openalex.org/W2086837049","https://openalex.org/W2087495709","https://openalex.org/W2087807424","https://openalex.org/W2088516321","https://openalex.org/W2088846483","https://openalex.org/W2089379946","https://openalex.org/W2090716323","https://openalex.org/W2091471302","https://openalex.org/W2091765514","https://openalex.org/W2091919523","https://openalex.org/W2092102996","https://openalex.org/W2092190455","https://openalex.org/W2093248761","https://openalex.org/W2095558762","https://openalex.org/W2095929050","https://openalex.org/W2096331515","https://openalex.org/W2100095860","https://openalex.org/W2102660990","https://openalex.org/W2103001937","https://openalex.org/W2106115586","https://openalex.org/W2106942479","https://openalex.org/W2107022380","https://openalex.org/W2107308874","https://openalex.org/W2107438925","https://openalex.org/W2107844030","https://openalex.org/W2110881042","https://openalex.org/W2111216015","https://openalex.org/W2114669966","https://openalex.org/W2116319355","https://openalex.org/W2118790060","https://openalex.org/W2119754481","https://openalex.org/W2121637838","https://openalex.org/W2122080942","https://openalex.org/W2122595342","https://openalex.org/W2123615043","https://openalex.org/W2124079471","https://openalex.org/W2125440566","https://openalex.org/W2127483997","https://openalex.org/W2128645913","https://openalex.org/W2128754068","https://openalex.org/W2129263428","https://openalex.org/W2130287184","https://openalex.org/W2131873693","https://openalex.org/W2136044742","https://openalex.org/W2138927391","https://openalex.org/W2141858760","https://openalex.org/W2144724143","https://openalex.org/W2146299550","https://openalex.org/W2148503630","https://openalex.org/W2150857791","https://openalex.org/W2152712199","https://openalex.org/W2155297588","https://openalex.org/W2160752085","https://openalex.org/W2161322400","https://openalex.org/W2162400220","https://openalex.org/W2164787803","https://openalex.org/W2169453051","https://openalex.org/W2171187981","https://openalex.org/W2174668858","https://openalex.org/W2242726375","https://openalex.org/W2285071408","https://openalex.org/W2311599000","https://openalex.org/W2326289669","https://openalex.org/W2336180525","https://openalex.org/W2336350647","https://openalex.org/W2399429989","https://openalex.org/W2412013136","https://openalex.org/W2414424400","https://openalex.org/W2415173698","https://openalex.org/W2415625347","https://openalex.org/W2425019931","https://openalex.org/W2471146193","https://openalex.org/W2471244872","https://openalex.org/W2471500291","https://openalex.org/W2471754035","https://openalex.org/W2529230938","https://openalex.org/W2949574343","https://openalex.org/W3025891904","https://openalex.org/W4235076935","https://openalex.org/W4255797405","https://openalex.org/W4406057286","https://openalex.org/W4406059073","https://openalex.org/W4406061008","https://openalex.org/W4406066447","https://openalex.org/W4406433889","https://openalex.org/W4406985630"],"related_works":["https://openalex.org/W615033288","https://openalex.org/W310536242","https://openalex.org/W2125803416","https://openalex.org/W2084350399","https://openalex.org/W2021191520","https://openalex.org/W7135882471","https://openalex.org/W2156316871","https://openalex.org/W7135790265","https://openalex.org/W1998379428","https://openalex.org/W2033964653"],"abstract_inverted_index":{"The":[0,58,68,93,129,234,263,285,303],"neurosteroids":[1,88,98,175,193,240,268,306],"constitute":[2],"a":[3,19,141],"group":[4],"of":[5,21,60,70,84,87,163,192,200,211],"powerful":[6,169],"hormones":[7],"synthesized":[8],"and":[9,28,31,53,76,102,122,153,226,247,294],"acting":[10],"in":[11,18,140,159,179,194,277,292,322],"the":[12,45,49,54,78,82,90,97,108,112,115,126,190,195,201,208,216,221,230,239,244,253,259,267,270,278,295,311],"central":[13,23],"nervous":[14],"system.":[15],"They":[16],"participate":[17],"number":[20],"important":[22],"processes,":[24],"such":[25,43],"as":[26,44],"memory":[27],"learning,":[29],"mood":[30,180],"neuroprotection.":[32],"Their":[33],"effects":[34,83,130,170,210,321],"emerge":[35],"from":[36,64,243],"rapid":[37],"interactions":[38],"with":[39,189,282,308],"membrane":[40],"bound":[41],"receptors,":[42],"N-methyl-D-aspartate":[46],"(NMDA)":[47],"receptor,":[48,110,218],"gamma-amino-butyric":[50],"acid":[51],"receptor":[52,117,273,287,297,313],"sigma":[55,231,245,260,271],"1":[56,232,246,261,272],"receptor.":[57,92,233,262],"mechanisms":[59,80],"action":[61,191],"are":[62],"separate":[63,123],"classical":[65],"genomic":[66],"interactions.":[67],"aims":[69],"this":[71],"thesis":[72],"were":[73,137],"to":[74,133,229,318],"identify":[75],"characterize":[77],"molecular":[79],"underlying":[81],"nanomolar":[85],"concentrations":[86],"at":[89,125,215,258,269,310],"NMDA":[91,109,116,217,286,296,312],"results":[94,235],"show":[95],"that":[96,131,151,185,238,305],"pregnenolone":[99],"sulfate":[100,104,228],"(PS)":[101],"pregnanolone":[103],"3\u03b15\u03b2S)":[105],"differently":[106],"modulate":[107],"changing":[111],"kinetics":[113],"for":[114,223,256,266],"antagonist":[118,298],"ifenprodil,":[119],"through":[120],"unique":[121],"targets":[124],"NR2B":[127],"subunit.":[128],"appear":[132],"be":[134,183,275,315],"temperature":[135],"independent":[136],"further":[138],"confirmed":[139],"calcium":[142],"imagining":[143],"functional":[144,148],"assay.":[145],"A":[146],"second":[147],"study":[149],"demonstrated":[150],"PS":[152,212],"3\u03b15\u03b2S":[154,214,225],"affect":[155],"glutamate-stimulated":[156],"neurite":[157],"outgrowth":[158],"NG108-15":[160],"cells.":[161],"Misuse":[162],"anabolic":[164],"androgenic":[165],"steroids":[166],"(AAS)":[167],"has":[168],"on":[171],"emotional":[172],"states.":[173],"Since":[174],"regulate":[176],"processes":[177],"involved":[178,276,291],"it":[181],"can":[182,187],"hypothesised":[184],"AAS":[186,202,283],"interact":[188,307],"brain.":[196],"However,":[197],"chronic":[198],"administration":[199],"nandrolone":[203],"decanoate":[204],"did":[205],"not":[206],"alter":[207],"allosteric":[209],"or":[213],"but":[219],"changed":[220],"affinity":[222,265],"PS,":[224],"dehydroepiandrosterone":[227],"also":[236],"showed":[237],"displace":[241],"3H-ifenprodil":[242,257],"2":[248],"receptors":[249],"without":[250],"directly":[251],"sharing":[252],"binding":[254],"site":[255],"decreased":[264],"may":[274,314],"depressive":[279],"symptoms":[280],"associated":[281],"misuse.":[284],"system":[288],"is":[289],"deeply":[290],"neurodegeneration":[293],"ifenprodil":[299,309],"exert":[300],"neuroprotective":[301,323],"actions.":[302],"findings":[304],"an":[316],"opportunity":[317],"obtain":[319],"synergistic":[320],"treatment.":[324]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}