{"id":"https://openalex.org/W250508076","doi":null,"title":"Induction of suppressor cells by staphylococcal enterotoxin B: identification of a suppressor cell circuit in the generation of suppressor-effector cells.","display_name":"Induction of suppressor cells by staphylococcal enterotoxin B: identification of a suppressor cell circuit in the generation of suppressor-effector cells.","publication_year":1988,"publication_date":"1988-08-01","ids":{"openalex":"https://openalex.org/W250508076","mag":"250508076","pmid":"https://pubmed.ncbi.nlm.nih.gov/2971607","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384985"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1384985","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384985","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384985","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056830230","display_name":"Maureen Holly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Holly","raw_affiliation_strings":["Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109155198","display_name":"Yee-Shin Lin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y S Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5074854724","display_name":"Thomas J. Rogers","orcid":"https://orcid.org/0000-0002-9189-8105","observed_orcids":["https://orcid.org/0000-0002-9189-8105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T J Rogers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6064,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.83197259,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"64","issue":"4","first_page":"643","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcal-enterotoxin-b","display_name":"staphylococcal enterotoxin B","score":0.9980000257492065},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.7870000004768372},{"id":"https://openalex.org/keywords/lyt-1-2-t-cells","display_name":"Lyt-1+2- T cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/antibody-response-suppression","display_name":"antibody response suppression","score":0.8550000190734863},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.5849999785423279},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.6169999837875366},{"id":"https://openalex.org/keywords/t-cell-depletion","display_name":"T cell depletion","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.8189475536346436},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6850655674934387},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6551399827003479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6490755081176758},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5502123236656189},{"id":"https://openalex.org/C55721878","wikidata":"https://www.wikidata.org/wiki/Q15220362","display_name":"Myeloid-derived Suppressor Cell","level":4,"score":0.5104030966758728},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.49374160170555115},{"id":"https://openalex.org/C66999527","wikidata":"https://www.wikidata.org/wiki/Q421978","display_name":"Enterotoxin","level":4,"score":0.47495365142822266},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4682862460613251},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.45895180106163025},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.42351600527763367},{"id":"https://openalex.org/C2225953","wikidata":"https://www.wikidata.org/wiki/Q1661899","display_name":"Inducer","level":3,"score":0.41228264570236206},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38581931591033936},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1756574809551239},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10376900434494019},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10245072841644287},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.059388041496276855},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000950","descriptor_name":"Antigens, Ly","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1384985","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384985","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:2971607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2971607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:250508076","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2971607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1384985","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1384985","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W197781038","https://openalex.org/W1496447930","https://openalex.org/W1532846703","https://openalex.org/W1559408723","https://openalex.org/W1588758672","https://openalex.org/W1600662889","https://openalex.org/W1620558774","https://openalex.org/W1623302931","https://openalex.org/W1655400650","https://openalex.org/W1929817730","https://openalex.org/W1936085417","https://openalex.org/W1963998459","https://openalex.org/W1986145880","https://openalex.org/W1994948666","https://openalex.org/W2026049625","https://openalex.org/W2070437307","https://openalex.org/W2099939483","https://openalex.org/W2106875731","https://openalex.org/W2118655639","https://openalex.org/W2125106798","https://openalex.org/W2131624029","https://openalex.org/W2144445149","https://openalex.org/W2145336791","https://openalex.org/W2155853708","https://openalex.org/W2166659122","https://openalex.org/W4313311575","https://openalex.org/W4313314115"],"related_works":["https://openalex.org/W1986145880","https://openalex.org/W1529566182","https://openalex.org/W2027622323","https://openalex.org/W1559777299","https://openalex.org/W2094763164","https://openalex.org/W1615531076","https://openalex.org/W1963648111","https://openalex.org/W2040529234","https://openalex.org/W1974824861","https://openalex.org/W2059141457"],"abstract_inverted_index":{"We":[0],"have":[1],"shown":[2,38],"previously":[3],"that":[4,39,66,97,136,139,154],"staphylococcal":[5],"enterotoxin":[6],"B":[7],"(SEB)":[8],"has":[9,37],"the":[10,20,28,34,40,49,67,70,83,87,98,106,121,128,137,147,167,170,176,183],"capacity":[11],"to":[12],"non-specifically":[13],"inhibit":[14],"antibody":[15,101,129,171],"responses":[16],"in":[17,63,99,127,142,166],"vitro":[18,64,100],"through":[19],"induction":[21,68],"of":[22,33,42,54,69,116,164,169,178,185],"a":[23,117],"suppressor":[24,107,122,180],"cell":[25,123,187],"population.":[26,58],"In":[27],"present":[29],"studies,":[30],"an":[31,55,143],"analysis":[32],"cellular":[35],"dynamics":[36],"generation":[41,177],"Lyt-1-2+":[43],"suppressor-effector":[44,71],"cells":[45,108,181],"is":[46,80,90,103,131,189],"dependent":[47],"on":[48],"initial":[50],"activation":[51,184],"by":[52,82,92],"SEB":[53],"Lyt-1+2-":[56],"suppressor-inducer":[57,84],"Co-culture":[59],"experiments":[60],"carried":[61],"out":[62],"suggest":[65,135],"population":[72,124,138],"requires":[73],"at":[74,155],"least":[75,156],"two":[76],"signals:":[77],"one":[78],"signal":[79,89],"provided":[81,91],"population,":[85],"and":[86,182],"second":[88],"SEB.":[93],"Studies":[94],"also":[95],"show":[96],"response":[102,130,145],"suppressed":[104],"when":[105],"are":[109,162],"added":[110],"as":[111,113],"late":[112,141],"Day":[114],"4":[115],"5-day":[118],"culture.":[119],"While":[120],"activated":[125],"early":[126],"Lyt-1-2+,":[132],"depletion":[133],"studies":[134],"acts":[140],"ongoing":[144],"bears":[146],"Lyt-1+2+":[148],"surface":[149],"phenotype.":[150],"The":[151,173],"results":[152],"demonstrate":[153],"three":[157],"distinct":[158],"SEB-induced":[159],"T-cell":[160],"populations":[161],"capable":[163],"participating":[165],"suppression":[168],"response.":[172],"relationship":[174],"between":[175],"non-specific":[179],"antigen-specific":[186],"circuits":[188],"discussed.":[190]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}