{"id":"https://openalex.org/W2504287313","doi":"https://doi.org/10.1021/acs.biochem.6b00504","title":"Multitasking Human Lectin Galectin-3 Interacts with Sulfated Glycosaminoglycans and Chondroitin Sulfate Proteoglycans","display_name":"Multitasking Human Lectin Galectin-3 Interacts with Sulfated Glycosaminoglycans and Chondroitin Sulfate Proteoglycans","publication_year":2016,"publication_date":"2016-07-18","ids":{"openalex":"https://openalex.org/W2504287313","doi":"https://doi.org/10.1021/acs.biochem.6b00504","mag":"2504287313","pmid":"https://pubmed.ncbi.nlm.nih.gov/27427828"},"language":"en","primary_location":{"id":"doi:10.1021/acs.biochem.6b00504","doi":"https://doi.org/10.1021/acs.biochem.6b00504","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.6b00504","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000708379","display_name":"Melanie L. Talaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie L. Talaga","raw_affiliation_strings":["Laboratory of Mechanistic Glycobiology, Department of Chemistry, \u2021Department of Biological\rSciences, \u00a7Life Science and Technology Institute, Michigan Technological University, Houghton, Michigan 49931, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Mechanistic Glycobiology, Department of Chemistry, \u2021Department of Biological\rSciences, \u00a7Life Science and Technology Institute, Michigan Technological University, Houghton, Michigan 49931, United States","institution_ids":["https://openalex.org/I11957088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067469709","display_name":"Ni Fan","orcid":"https://orcid.org/0000-0002-3828-4243","observed_orcids":["https://orcid.org/0000-0002-3828-4243"]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ni Fan","raw_affiliation_strings":["Laboratory of Mechanistic Glycobiology, Department of Chemistry, \u2021Department of Biological\rSciences, \u00a7Life Science and Technology Institute, Michigan Technological University, Houghton, Michigan 49931, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Mechanistic Glycobiology, Department of Chemistry, \u2021Department of Biological\rSciences, \u00a7Life Science and Technology Institute, Michigan Technological University, Houghton, Michigan 49931, United States","institution_ids":["https://openalex.org/I11957088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021388085","display_name":"Ashli L. Fueri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashli L. Fueri","raw_affiliation_strings":["Laboratory of Mechanistic Glycobiology, Department of Chemistry, \u2021Department of Biological\rSciences, \u00a7Life Science and Technology Institute, Michigan Technological University, Houghton, Michigan 49931, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Mechanistic Glycobiology, Department of Chemistry, \u2021Department of Biological\rSciences, \u00a7Life Science and Technology Institute, Michigan Technological University, Houghton, Michigan 49931, United States","institution_ids":["https://openalex.org/I11957088"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert K. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert K. Brown","raw_affiliation_strings":["Laboratory of Mechanistic Glycobiology, Department of Chemistry, \u2021Department of Biological\rSciences, \u00a7Life Science and Technology Institute, Michigan Technological University, Houghton, Michigan 49931, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Mechanistic Glycobiology, Department of Chemistry, \u2021Department of Biological\rSciences, \u00a7Life Science and Technology Institute, Michigan Technological University, Houghton, Michigan 49931, United States","institution_ids":["https://openalex.org/I11957088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051207367","display_name":"Purnima Bandyopadhyay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Purnima Bandyopadhyay","raw_affiliation_strings":["Laboratory of Mechanistic Glycobiology, Department of Chemistry, \u2021Department of Biological\rSciences, \u00a7Life Science and Technology Institute, Michigan Technological University, Houghton, Michigan 49931, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Mechanistic Glycobiology, Department of Chemistry, \u2021Department of Biological\rSciences, \u00a7Life Science and Technology Institute, Michigan Technological University, Houghton, Michigan 49931, United States","institution_ids":["https://openalex.org/I11957088"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071296330","display_name":"Tarun Kanti Dam","orcid":"https://orcid.org/0009-0008-3548-1007","observed_orcids":["https://orcid.org/0009-0008-3548-1007"]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tarun K. Dam","raw_affiliation_strings":["Laboratory of Mechanistic Glycobiology, Department of Chemistry, \u2021Department of Biological\rSciences, \u00a7Life Science and Technology Institute, Michigan Technological University, Houghton, Michigan 49931, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Mechanistic Glycobiology, Department of Chemistry, \u2021Department of Biological\rSciences, \u00a7Life Science and Technology Institute, Michigan Technological University, Houghton, Michigan 49931, United States","institution_ids":["https://openalex.org/I11957088"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071296330"],"corresponding_institution_ids":["https://openalex.org/I11957088"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.7707,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.82738504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"55","issue":"32","first_page":"4541","last_page":"4551"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.6987000107765198,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.6987000107765198,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.2815000116825104,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galectin-3","display_name":"galectin-3","score":1.0},{"id":"https://openalex.org/keywords/glycosaminoglycan-binding-proteins","display_name":"glycosaminoglycan-binding proteins","score":0.9539999961853027},{"id":"https://openalex.org/keywords/sulfated-glycosaminoglycans","display_name":"sulfated glycosaminoglycans","score":0.9309999942779541},{"id":"https://openalex.org/keywords/chondroitin-sulfate-proteoglycans","display_name":"chondroitin sulfate proteoglycans","score":0.9610000252723694},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.9269999861717224},{"id":"https://openalex.org/keywords/multivalent-binding","display_name":"multivalent binding","score":0.8510000109672546},{"id":"https://openalex.org/keywords/non-covalent-crosslinking","display_name":"non-covalent crosslinking","score":0.7570000290870667},{"id":"https://openalex.org/keywords/beta-lactose","display_name":"beta-lactose","score":0.6800000071525574},{"id":"https://openalex.org/keywords/negative-cooperativity","display_name":"negative cooperativity","score":0.824999988079071},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.5450000166893005},{"id":"https://openalex.org/keywords/lectin-glycan-interactions","display_name":"lectin-glycan interactions","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C2779553658","wikidata":"https://www.wikidata.org/wiki/Q408014","display_name":"Chondroitin sulfate","level":3,"score":0.6729870438575745},{"id":"https://openalex.org/C156293190","wikidata":"https://www.wikidata.org/wiki/Q83138026","display_name":"Galectin","level":2,"score":0.6712948679924011},{"id":"https://openalex.org/C2779794767","wikidata":"https://www.wikidata.org/wiki/Q18248676","display_name":"Decorin","level":4,"score":0.6284604072570801},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6281532645225525},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.6146754622459412},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6090053915977478},{"id":"https://openalex.org/C155138218","wikidata":"https://www.wikidata.org/wiki/Q994559","display_name":"Sulfation","level":2,"score":0.598303496837616},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.5283582806587219},{"id":"https://openalex.org/C2780758401","wikidata":"https://www.wikidata.org/wiki/Q408693","display_name":"Lectin","level":2,"score":0.5248517990112305},{"id":"https://openalex.org/C2778230131","wikidata":"https://www.wikidata.org/wiki/Q2457767","display_name":"Keratan sulfate","level":4,"score":0.5099254846572876},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.49428749084472656},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.48180168867111206},{"id":"https://openalex.org/C13426554","wikidata":"https://www.wikidata.org/wiki/Q416019","display_name":"Glycoconjugate","level":2,"score":0.45638445019721985},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.44980326294898987},{"id":"https://openalex.org/C2775895372","wikidata":"https://www.wikidata.org/wiki/Q5104536","display_name":"Chondroitin sulfate proteoglycan","level":4,"score":0.44881975650787354},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.43929511308670044},{"id":"https://openalex.org/C2776735749","wikidata":"https://www.wikidata.org/wiki/Q4862650","display_name":"Chondroitin","level":3,"score":0.4389477074146271},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4385656416416168},{"id":"https://openalex.org/C2778041096","wikidata":"https://www.wikidata.org/wiki/Q424668","display_name":"Heparan sulfate","level":3,"score":0.4199366867542267},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.28208956122398376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23855486512184143}],"mesh":[{"descriptor_ui":"D000606","descriptor_name":"Amino Sugars","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000606","descriptor_name":"Amino Sugars","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003871","descriptor_name":"Dermatan Sulfate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007785","descriptor_name":"Lactose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011508","descriptor_name":"Chondroitin Sulfate Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D037502","descriptor_name":"Galectin 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D037502","descriptor_name":"Galectin 3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.biochem.6b00504","doi":"https://doi.org/10.1021/acs.biochem.6b00504","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biochem.6b00504","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:27427828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27427828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.mtu.edu:michigantech-p-27094","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.mtu.edu/michigantech-p/7792","pdf_url":null,"source":{"id":"https://openalex.org/S4377196391","display_name":"Digital Commons - Michigan Tech (Michigan Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I11957088","host_organization_name":"Michigan Technological University","host_organization_lineage":["https://openalex.org/I11957088"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Michigan Tech Publications, Part 1","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W12332796","https://openalex.org/W1903208355","https://openalex.org/W1941554275","https://openalex.org/W1951701014","https://openalex.org/W1975881312","https://openalex.org/W1978147073","https://openalex.org/W1986012385","https://openalex.org/W1998768389","https://openalex.org/W2003769189","https://openalex.org/W2009388678","https://openalex.org/W2013354887","https://openalex.org/W2013565370","https://openalex.org/W2020696662","https://openalex.org/W2022607259","https://openalex.org/W2025178368","https://openalex.org/W2031354813","https://openalex.org/W2036569396","https://openalex.org/W2039003066","https://openalex.org/W2042667862","https://openalex.org/W2068507353","https://openalex.org/W2070678457","https://openalex.org/W2088606742","https://openalex.org/W2090602226","https://openalex.org/W2092457960","https://openalex.org/W2092482613","https://openalex.org/W2095072180","https://openalex.org/W2100240574","https://openalex.org/W2104467744","https://openalex.org/W2114715176","https://openalex.org/W2117672117","https://openalex.org/W2117899071","https://openalex.org/W2130812849","https://openalex.org/W2132432391","https://openalex.org/W2136891755","https://openalex.org/W2152821878","https://openalex.org/W2156700198","https://openalex.org/W2164471400","https://openalex.org/W2164833764","https://openalex.org/W2169595400","https://openalex.org/W2278738121"],"related_works":["https://openalex.org/W2915140989","https://openalex.org/W4220682894","https://openalex.org/W2518015460","https://openalex.org/W7166567782","https://openalex.org/W2348979388","https://openalex.org/W2112572787","https://openalex.org/W2079767760","https://openalex.org/W3089161951","https://openalex.org/W904802307","https://openalex.org/W178158537"],"abstract_inverted_index":{"Glycosaminoglycan":[0],"(GAG)":[1],"binding":[2,70,81,153,201,214],"proteins":[3,51],"(GAGBPs),":[4],"including":[5],"growth":[6],"factors,":[7],"cytokines,":[8],"morphogens,":[9],"and":[10,19,32,43,48,96,117,130,145,156,183,218,248],"extracellular":[11,33],"matrix":[12],"proteins,":[13,71],"interact":[14],"with":[15,109,133,154,161,175,226],"both":[16],"free":[17],"GAGs":[18,167,196,247],"those":[20],"covalently":[21],"linked":[22],"to":[23,86,222,239],"proteoglycans.":[24,249],"Such":[25],"interactions":[26],"modulate":[27],"a":[28,79,105,146,219,235],"variety":[29],"of":[30,57,68,104,138,165,178,203,208,215,232,243],"cellular":[31],"events,":[34],"such":[35],"as":[36,120,122,234],"cell":[37],"growth,":[38],"metastasis,":[39],"morphogenesis,":[40],"neural":[41],"development,":[42],"inflammation.":[44],"GAGBPs":[45,60],"are":[46,61],"structurally":[47],"evolutionarily":[49],"unrelated":[50],"that":[52,83,99,195,212],"typically":[53],"recognize":[54],"internal":[55],"sequences":[56],"sulfated":[58,166],"GAGs.":[59],"distinct":[62],"from":[63],"the":[64,102,136,162,184,199,213],"other":[65],"major":[66],"group":[67],"glycan":[69],"lectins.":[72],"The":[73],"multifunctional":[74],"human":[75],"galectin-3":[76],"(Gal-3)":[77],"is":[78,140,224],"\u03b2-galactoside":[80],"lectin":[82],"preferentially":[84],"binds":[85],"N-acetyllactosamine":[87],"moieties":[88],"on":[89],"glycoconjugates.":[90],"Here,":[91],"we":[92],"demonstrate":[93],"through":[94],"microcalorimetric":[95],"spectroscopic":[97],"data":[98,210],"Gal-3":[100,107,155,172,179,223,233,244],"possesses":[101],"characteristics":[103],"GAGBP.":[106],"interacts":[108],"unmodified":[110],"heparin,":[111,128],"chondroitin":[112,123],"sulfate-A":[113],"(CSA),":[114],"-B":[115],"(CSB),":[116],"-C":[118],"(CSC)":[119],"well":[121],"sulfate":[124],"proteoglycans":[125],"(CSPGs).":[126],"While":[127],"CSA,":[129,143,181,216],"CSC":[131],"bind":[132],"micromolar":[134],"affinity,":[135],"affinity":[137],"CSPGs":[139],"nanomolar.":[141],"Significantly,":[142],"CSC,":[144,182,217],"bovine":[147,185,220],"CSPG":[148,186,221],"were":[149],"engaged":[150],"in":[151],"multivalent":[152],"formed":[157],"noncovalent":[158],"cross-linked":[159],"complexes":[160],"lectin.":[163],"Binding":[164],"was":[168,173,187],"completely":[169],"abolished":[170],"when":[171],"preincubated":[174],"\u03b2-lactose.":[176,190],"Cross-linking":[177],"by":[180,189,246],"reversed":[188],"Both":[191],"observations":[192],"strongly":[193],"suggest":[194],"primarily":[197],"occupy":[198],"lactose/LacNAc":[200],"site":[202],"Gal-3.":[204],"Hill":[205],"plot":[206],"analysis":[207],"calorimetric":[209],"reveals":[211],"associated":[225],"progressive":[227],"negative":[228],"cooperativity":[229],"effects.":[230],"Identification":[231],"GAGBP":[236],"should":[237],"help":[238],"reveal":[240],"new":[241],"functions":[242],"mediated":[245]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-08-23T00:00:00"}
